scholarly journals A Comparative Statistical Analysis on the Incidence of Developmental, Inflammatory and Neoplastic Odontogenic Cysts—A Single Center Retrospective Analysis from Italy

Oral ◽  
2021 ◽  
Vol 1 (1) ◽  
pp. 15-22
Author(s):  
Antonio Barresi ◽  
Giacomo Oteri ◽  
Angela Alibrandi ◽  
Matteo Peditto ◽  
Silvia Rapisarda ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
University Hospital ◽  
Odontogenic Cysts ◽  
Age And Gender ◽  
Patient Gender ◽  
Male Patients ◽  
Comparative Statistical Analysis ◽  
And Gender ◽  
The University ◽  
Maxillary Region

The aim of this study was a comparative statistical analysis of three categories of maxillary odontogenic cysts, evaluating frequency in relation to localization (mandibular or maxillary region), age and gender of patients. The study was a retrospective cohort study conducted at the University Hospital of Messina. Three hundred and fifty-six maxillary odontogenic cysts were classified into 283 inflammatory, 43 developmental and 30 neoplastic cysts. Female patients are more affected by developmental odontogenic cysts, while male patients are more affected by inflammatory odontogenic cysts. Both the mandibular and maxillary regions were affected mainly by inflammatory odontogenic cysts; no significantly statistic relationship was found between lesions and age. A significant association between odontogenic cyst lesions and patient gender was found. No significant association between histological features of lesion and age of patient was observed, nor subtype of odontogenic disease and localization (mandibular or maxillary).

scholarly journals Respiratory changes in Parkinson's disease may be unrelated to dopaminergic dysfunction

2012 ◽  
Vol 70 (11) ◽  
pp. 847-851 ◽  
Author(s):  
Luciana Ulhôa Guedes ◽  
Juliana Melo Rodrigues ◽  
Aline Andrioni Fernandes ◽  
Francisco E. Cardoso ◽  
Verônica Franco Parreira
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Statistical Analysis ◽  
Healthy Controls ◽  
Maximal Inspiratory Pressure ◽  
Age And Gender ◽  
Dopaminergic Dysfunction ◽  
And Gender ◽  
Student’S T ◽  
Student’S T Test

OBJECTIVE: To investigate the maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) in patients with Parkinson's disease (PD) during the on and off periods of levodopa and to compare with healthy controls. METHODS: Twenty-six patients were analyzed with Hoehn and Yahr scores (2-3) and 26 age and gender matched-controls. Statistical analysis was performed with Student's t-test for paired and independent samples. RESULTS: MIP and MEP values in patients were significantly lower than the values obtained in controls both for off and on stages -excepted for MIP in women (p=0.28). For patients with PD, the studied parameters did not differ between stages on and off, with the exception of MEP in women (p=0.00). CONCLUSIONS: Patients with PD have respiratory pressure lower than controls, even in early stages of the disease, and dopamine replacement has little impact over these respiratory pressures. These findings suggest that respiratory changes in PD may be unrelated to dopaminergic dysfunction.

scholarly journals Influence of Gender on Cardiac and Encephalic Inflammation in the Elderly with Cysticercosis: A Case Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6
Author(s):  
Camila Lourencini Cavellani ◽  
Rosana Rosa Miranda Corrêa ◽  
Mara Lúcia Fonseca Ferraz ◽  
Laura Penna Rocha ◽  
Ana Carolina Guimarães Faleiros ◽  
...  
Keyword(s):  
Inflammatory Infiltrate ◽  
Case Control Study ◽  
The Elderly ◽  
Brain Parenchyma ◽  
Elderly Group ◽  
University Hospital ◽  
Evolutionary Stage ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

Background. The present study explores the influence of the host’s age and gender upon the inflammatory infiltrate. We aimed to quantify the inflammatory infiltrate caused by cysticercosis, which is related to aging, in the heart and in the encephalon.Methods. 75 autopsy protocols with cysticercosis diagnosis from department of pathology at a university hospital from 1970 to 2008 were reviewed. Two groups were formed: elderly with cysticercosis and nonelderly with cysticercosis. We used KS-300 (Kontron-Zeiss) software for morphometric analysis of the inflammation.Results.The elderly had an average of3.1±2.5cysticerci, whereas the non-elderly had2.7±3.8parasites. The non-elderly group with cysticercosis had significantly more inflammation, both cardiac and encephalic, than the elderly group. The elderly females with cysticercosis had more cardiac and encephalic inflammation.Conclusions. In this study, we showed that the non-elderly had significantly more cardiac and encephalic inflammation than the elderly, and that such inflammatory infiltrate decreases with age and depends upon the evolutionary stage of the cysticercus. Furthermore, there are differences concerning gender in the intensity of the inflammatory response due to cysticerci in the heart and brain parenchyma during senescence. Even during this period, women continue to have a more intense response to the parasitosis.

Reference interval by the indirect approach of serum thyrotropin (TSH) in a Mediterranean adult population and the association with age and gender

2019 ◽  
Vol 57 (10) ◽  
pp. 1587-1594 ◽  
Author(s):  
Bruna Lo Sasso ◽  
Matteo Vidali ◽  
Concetta Scazzone ◽  
Luisa Agnello ◽  
Marcello Ciaccio
Keyword(s):  
Healthy Subjects ◽  
Indirect Method ◽  
Adult Population ◽  
Reference Interval ◽  
University Hospital ◽  
Thyroid Peroxidase ◽  
Free Triiodothyronine ◽  
Age And Gender ◽  
And Gender ◽  
Effect Of Age

Abstract Background The serum concentration of thyrotropin (TSH) represents a first-line test in diagnostic algorithms. The estimation of TSH reference intervals (RIs) is still a matter of debate due to the high prevalence of subclinical disease making difficult the definition of truly healthy subjects. The aim of this study was to estimate TSH RIs in healthy subjects and to evaluate the effect of age and gender on TSH concentration. Methods Forty-four thousand one hundred and fifty-six TSH data were collected between July 2012 and April 2018 at the Department of Laboratory Medicine, University-Hospital, Palermo. Common and sex-specific RIs were estimated by Arzideh’s indirect method after exclusion of individuals younger than 15 years, subjects with repeated TSH tests and with abnormal free thyroxine (fT4), free triiodothyronine (fT3) or anti-thyroid-peroxidase antibodies. The combined effect of age and gender on TSH values was evaluated. Results RIs estimated in the selected individuals (n = 22602) were, respectively, 0.18–3.54 mIU/L (general), 0.19–3.23 mIU/L (men) and 0.18–3.94 mIU/L (women). Women showed significantly higher median TSH than men (1.46 vs. 1.39 mIU/L; p < 0.0001). Both in men and in women, median TSH decreased along with age; however, although up to 60 years in both men and women showed similar values, afterwards women showed constantly higher TSH than men. Accordingly, statistical analysis showed a significant interaction between gender and age (p = 0.001), suggesting that the effect of age on TSH is different between genders. Conclusions Our findings suggest that the indirect method, with appropriate cleaning of data, could be useful to define TSH RIs.

scholarly journals Susceptibility to Ulcerative Colitis and Genetic Polymorphisms of A251G SOD1 and C-262T CAT

2016 ◽  
Vol 35 (3) ◽  
pp. 333-336 ◽  
Author(s):  
Gadier El-Kheshen ◽  
Maryam Moeini ◽  
Mostafa Saadat
Keyword(s):  
Ulcerative Colitis ◽  
Statistical Analysis ◽  
Genetic Polymorphisms ◽  
Intestinal Inflammation ◽  
Reactive Oxygen ◽  
Protective Role ◽  
Reactive Oxygen Metabolites ◽  
Age And Gender ◽  
And Gender ◽  
Chronic Intestinal Inflammation

SummaryBackground: Reactive oxygen species can attack and damage almost every molecule found in living cells, including proteins, carbohydrates, lipids, and DNA. For this reason, their production is normally tightly controlled. Among the most important defenses against these radicals are the super oxide dismutase (SOD) enzymes and catalase (CAT). In creasing attention has been given to the role of reactive oxygen metabolites in the pathogenesis of ulcerative colitis (UC), which is defined as an idiopathic and chronic intestinal inflammation. Accordingly, we hypothesized a relation between genetic polymorphisms in the two antioxidant enzymes SOD1 A251G (rs2070424) and CAT C-262T (rs1001179) and the risk of UC.Methods: The present case-control study included 109 UC patients (46 males and 50 females) and 186 (67 males and 119 females) gender-matched healthy controls. Genotyping was done by the PCR-RFLP method.Results: After adjusting for age and gender, a significant association was observed between the AG+GG genotypes of SOD1 A251G polymorphism (vs. AA genotype) and risk of UC (OR=0.29, 95% CI: 0.10-0.86, P= 0.025) after adjusting for age and gender. Our statistical analysis revealed that the CAT C-262T polymorphism did not associate with the risk of UC before and/or after adjusting for age and gender.Conclusions: Based on the present statistical analysis, the G allele of the SOD1 A251G polymorphism decreases the risk of UC, thus it might be assumed that the G allele has a protective role.

Serum prolactin levels and sexual dysfunctions in antipsychotic medication, such as risperidone: a review

2000 ◽  
Vol 12 (1) ◽  
pp. 19-26 ◽  
Author(s):  
H. Knegtering ◽  
P.A. Lambers ◽  
G. Prakken ◽  
C. ten Brink
Keyword(s):  
Antipsychotic Medication ◽  
Antipsychotic Drugs ◽  
University Hospital ◽  
Serum Prolactin ◽  
Sexual Dysfunctions ◽  
Receptor Blockade ◽  
Naturalistic Study ◽  
Serotonergic Receptor ◽  
Male Patients ◽  
The University

SUMMARYClassical antipsychotic drugs increase the level of serum prolactin. The atypical antipsychotic clozapine barely increases prolactin levels. An open naturalistic study in the University Hospital of Groningen suggests that treatment with risperidone in comparison to classical antipsychotics seems to increase the risk of erectile and ejaculatory disorders in male patients and to menstrual disturbances in female patients. In the literature reviewed, risperidone is associated with higher prolactin levels in comparison to classical antipsychotics. It is still unclear which mechanism is responsible for the increase of serum prolactin levels and sexual dysfunctions in patients using risperidone. Dopaminergic and serotonergic receptor blockade seems to play an important role. Other mechanisms are discussed.

Nasal Carriage ofStaphylococcus aureusAmong Patients Receiving Allergen-Injection Immunotherapy: Associated Factors and Quantitative Nasal Cultures

2001 ◽  
Vol 22 (12) ◽  
pp. 741-745 ◽  
Author(s):  
Stefano Bassetti ◽  
Donnie P. Dunagan ◽  
Ralph B. D'Agostino ◽  
Robert J. Sherertz
Keyword(s):  
Atopic Dermatitis ◽  
Independent Predictor ◽  
Statistical Significance ◽  
Nasal Carriage ◽  
University Hospital ◽  
Carriage Rate ◽  
Age And Gender ◽  
Desensitization Therapy ◽  
Second Year ◽  
And Gender

AbstractObjective:To compare the prevalence of nasalStaphylococcus aureuscarriage among outpatients receiving allergen-injection immunotherapy with the prevalence among healthy controls and to determine predictors of nasalS aureuscarriage.Design:Survey.Setting:Allergy clinic of a university hospital.Participants:A volunteer sample consisting of 45 outpatients undergoing desensitization therapy and 84 first- and second-year medical students.Results:The nasalS aureuscarriage rate was significantly higher among patients (46.7%) than among students (26.2%;P=.019). In a multivariate model adjusted for age and gender, the presence of atopic dermatitis or eczema was the only independent predictor of nasal Saureuscarriage (odds ratio [OR], 4.4; 95% confidence interval [CI95], 1.2-16.0;P=.02). The only other participant characteristic associated with nasalS aureuscarriage was immunotherapy with allergen injections (OR, 1.98; CI95, 0.7-6.0), but this association did not reach statistical significance (P=.23). The probability of nasalS aureuscarriage was 88.9% for patients receiving allergen injections and having atopic dermatitis or eczema, and 36.1% for patients receiving allergen injections without atopic dermatitis or eczema.Conclusions:Patients undergoing desensitization have a higher nasal carriage rate ofS aureus.However, factors other than the regular use of needles, and in particular abnormalities related to the atopic constitution of these patients, may predispose this population forS aureuscarriage.

scholarly journals Gender dimorphism in body composition abnormalities in acromegaly: males are more affected than females

2008 ◽  
Vol 159 (6) ◽  
pp. 773-779 ◽  
Author(s):  
N Sucunza ◽  
M J Barahona ◽  
E Resmini ◽  
J M Fernández-Real ◽  
J Farrerons ◽  
...  
Keyword(s):  
Body Composition ◽  
Total Mass ◽  
Mineral Content ◽  
Gender Dimorphism ◽  
Age And Gender ◽  
X Ray ◽  
Male Patients ◽  
And Gender ◽  
Design And Methods

BackgroundAcromegaly changes body composition (BC), but long-term gender differences have not been reported.ObjectiveTo evaluate BC in active and controlled acromegalic patients.Design and methodsClinical and biochemical variables and BC (by dual-energy X-ray absorptiometry) were evaluated in 60 acromegalic patients (19 active, 41 controlled) and 105 controls, matched for age and gender.ResultsAcromegalic males (n=24) had more total mass (89±13 vs 76.5±15.3 kg, P<0.001), lean body mass (LBM; 64.6±8.7 vs 56.4±5.8 kg, P<0.001), and bone mineral content (BMC; 2.9±0.5 vs 2.6±0.3 kg, P<0.05) than controls (n=33). Controlled male patients (n=14) had more total mass (89±14.7 vs 76.5±15.3 kg, P<0.05) and a trend to have more LBM (61.8±9.4 vs 56.4±5.8 kg, P=0.065) than controls. Only in active disease was a decrease in fat mass (FM) observed, compared with controlled patients and controls (males: 19.5±5.3 vs 27±6.2 and 25.9±4%, P<0.001; females: 30.3±6.7 vs 37.1±5.8 and 36.5±6.6%, P<0.01). In females, no further differences were observed. No differences in BMC were found between eugonadal and hypogonadal acromegalic patients, but in hypogonadal females, acromegaly appeared to prevent the BMC loss seen in hypogonadal postmenopausal controls. GH and IGF1 levels were negatively correlated with FM (males, P<0.05; females, P<0.001), but in the regression analysis GH was a predictor of FM only in women.ConclusionsControl of acromegaly reverts decreased FM in both genders; only in males more total mass and a trend for more LBM persist. The anabolic effect of GH on bone reverted in cured males, but persisted in females and appeared to override the bone loss of menopause.

scholarly journals COVID-19 Clinical Profile in Latin American Migrants Living in Spain: Does the Geographical Origin Matter?

2021 ◽  
Vol 10 (22) ◽  
pp. 5213
Author(s):  
Abiu Sempere ◽  
Fernando Salvador ◽  
Arnau Monforte ◽  
Júlia Sampol ◽  
Juan Espinosa-Pereiro ◽  
...  
Keyword(s):  
Latin America ◽  
Latin American ◽  
Geographical Origin ◽  
Vital Signs ◽  
Hospitalized Patients ◽  
University Hospital ◽  
Retrospective Case ◽  
Age And Gender ◽  
And Gender ◽  
Control Study

The aim of this study was to describe and compare the clinical characteristics of hospitalized patients with COVID-19 pneumonia according to their geographical origin. This is a retrospective case-control study of hospitalized patients with confirmed COVID-19 pneumonia treated at Vall d’Hebron University Hospital (Barcelona) during the first wave of the pandemic. Cases were defined as patients born in Latin America and controls were randomly selected among Spanish patients matched by age and gender. Demographic and clinical variables were collected, including comorbidities, symptoms, vital signs and analytical parameters, intensive care unit admission and outcome at 28 days after admission. Overall, 1080 hospitalized patients were registered: 774 (71.6%) from Spain, 142 (13.1%) from Latin America and the rest from other countries. Patients from Latin America were considered as cases and 558 Spanish patients were randomly selected as controls. Latin American patients had a higher proportion of anosmia, rhinorrhea and odynophagia, as well as higher mean levels of platelets and lower mean levels of ferritin than Spanish patients. No differences were found in oxygen requirement and mortality at 28 days after admission, but there was a higher proportion of ICU admissions (28.2% vs. 20.2%, p = 0.0310). An increased proportion of ICU admissions were found in patients from Latin America compared with native Spanish patients when adjusted by age and gender, with no significant differences in in-hospital mortality.

scholarly journals Clinical and epidemiological features of 123 cases of cryptococcosis in Mato Grosso do Sul, Brazil

2008 ◽  
Vol 50 (2) ◽  
pp. 75-78 ◽  
Author(s):  
Andrea De Siqueira Campos Lindenberg ◽  
Marilene Rodrigues Chang ◽  
Anamaria Melo Miranda Paniago ◽  
Márcia Dos Santos Lazéra ◽  
Paula Maria Frank Moncada ◽  
...  
Keyword(s):  
Medical Records ◽  
University Hospital ◽  
Mato Grosso ◽  
Drug Of Choice ◽  
Cryptococcus Species ◽  
The Central Nervous System ◽  
Male Patients ◽  
Epidemiological Profile ◽  
The University ◽  
Mato Grosso Do Sul

To identify the clinical and epidemiological profile of cryptococcosis diagnosed at the University Hospital of the Federal University of Mato Grosso do Sul, Brazil, medical records of 123 patients admitted from January 1995 to December 2005 were analyzed. One hundred and four cases (84.5%) had HIV infection, six (4.9%) had other predisposing conditions and 13 (10.6%) were immunocompetent. Male patients predominated (68.3%) and their age ranged from 19 to 69 years (mean: 35.9). Most patients (73.2%) were born and lived lifelong in the state of Mato Grosso do Sul. Involvement of the central nervous system occurred in 103 patients (83.7%) and headache and vomiting were the most frequent symptoms. In 77 cases it was possible to identify the Cryptococcus species: 69 (89.6%) C. neoformans and eight (10.4%) C. gattii. Amphotericin B was the drug of choice for treatment (106/123), followed by fluconazole in 60% of cases. The overall lethality rate was 49.6%, being 51% among the HIV infected patients and 41.2% among the non-HIV infected (p > 0.05). Although cryptococcosis exhibited in our region a similar behavior to that described in the literature, the detection of an important rate of immunocompetent individuals and five C. gattii cryptococcosis in HIV-infected patients is noteworthy.

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