scholarly journals The Rotavirus Vaccine Landscape, an Update

Pathogens ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 520
Author(s):  
Roberto Cárcamo-Calvo ◽  
Carlos Muñoz ◽  
Javier Buesa ◽  
Jesús Rodríguez-Díaz ◽  
Roberto Gozalbo-Rovira
Keyword(s):  
Developing Countries ◽  
Mortality Rate ◽  
Low Income ◽  
State Of The Art ◽  
The State ◽  
Cold Chain ◽  
Low Income Countries ◽  
Rotavirus Vaccine ◽  
Oral Vaccines

Rotavirus is the leading cause of severe acute childhood gastroenteritis, responsible for more than 128,500 deaths per year, mainly in low-income countries. Although the mortality rate has dropped significantly since the introduction of the first vaccines around 2006, an estimated 83,158 deaths are still preventable. The two main vaccines currently deployed, Rotarix and RotaTeq, both live oral vaccines, have been shown to be less effective in developing countries. In addition, they have been associated with a slight risk of intussusception, and the need for cold chain maintenance limits the accessibility of these vaccines to certain areas, leaving 65% of children worldwide unvaccinated and therefore unprotected. Against this backdrop, here we review the main vaccines under development and the state of the art on potential alternatives.

Health Informatics Education in the Third World

1989 ◽  
Vol 28 (04) ◽  
pp. 270-272 ◽  
Author(s):  
O. Rienhoff
Keyword(s):  
Developing Countries ◽  
Health Informatics ◽  
Third World ◽  
State Of The Art ◽  
The State ◽  
Collaboration Network ◽  
Educational Tools ◽  
The Third ◽  
The Third World

Abstract:The state of the art is summarized showing many efforts but only few results which can serve as demonstration examples for developing countries. Education in health informatics in developing countries is still mainly dealing with the type of health informatics known from the industrialized world. Educational tools or curricula geared to the matter of development are rarely to be found. Some WHO activities suggest that it is time for a collaboration network to derive tools and curricula within the next decade.

scholarly journals Why Do Developing Countries Tax So Little?

2014 ◽  
Vol 28 (4) ◽  
pp. 99-120 ◽  
Author(s):  
Timothy Besley ◽  
Torsten Persson
Keyword(s):  
Developing Countries ◽  
Low Income ◽  
News Media ◽  
Weak Sense ◽  
Cultural Factors ◽  
Low Income Countries ◽  
Tax Revenue ◽  
Weak Institutions ◽  
Social And Cultural Factors ◽  
A Share

Low-income countries typically collect taxes of between 10 to 20 percent of GDP while the average for high-income countries is more like 40 percent. In order to understand taxation, economic development, and the relationships between them, we need to think about the forces that drive the development process. Poor countries are poor for certain reasons, and these reasons can also help to explain their weakness in raising tax revenue. We begin by laying out some basic relationships regarding how tax revenue as a share of GDP varies with per capita income and with the breadth of a country's tax base. We sketch a baseline model of what determines a country's tax revenue as a share of GDP. We then turn to our primary focus: why do developing countries tax so little? We begin with factors related to the economic structure of these economies. But we argue that there is also an important role for political factors, such as weak institutions, fragmented polities, and a lack of transparency due to weak news media. Moreover, sociological and cultural factors—such as a weak sense of national identity and a poor norm for compliance—may stifle the collection of tax revenue. In each case, we suggest the need for a dynamic approach that encompasses the two-way interactions between these political, social, and cultural factors and the economy.

Application of high-throughput serological tests for controlling zoonotic viral infection in Amazon rainforest and as a strategy to prevent future pandemics (Preprint)

2021 ◽  
Author(s):  
Marcela Santiago Pacheco De Azevedo ◽  
Daniela Gomes Ribeiro ◽  
Felipe Rocha Da Silva Santos ◽  
Siomar De Castro Soares ◽  
Vasco Ariston De Carvalho Azevedo ◽  
...  
Keyword(s):  
Developing Countries ◽  
High Throughput ◽  
Low Income ◽  
Dna Sequences ◽  
Scientific Information ◽  
Preventive Health Care ◽  
Amazon Rainforest ◽  
Low Income Countries ◽  
Sequencing Data ◽  
Serological Tests

UNSTRUCTURED From the bubonic plague on the 14th century to the new Coronavirus disease 2019 (COVID-19), pandemics have profoundly changed societies function. Infectious disease outbreaks are getting shorter and shorter due to our densely populated cities, global travel, and nature mass exploration. In this regard, there is a particular concern about fires occurring in Brazil's Amazon rainforest, one of the most biodiverse places on earth that facilitates cross-species transmission giving rise to the emergency of new virulent pathogens. Situation is further complicated because Amazon spans across eight developing countries with limited preventive health care services. In this perspective, this review highlights the role of new methodologies best suited for epidemiological monitoring in low-income countries, such as high-throughput serological tests. Phage immunoprecipitation sequencing (Phip-Seq), for example, can evaluate antibody-repertoire binding specificities using oligonucleotides libraries encoding epitopes covering the DNA sequences from all human pathogenic viruses or all Arboviruses already described. After incubation with an individual's serum, these libraries can be immunoprecipitated for subsequent analysis by DNA sequencing. Data are analyzed revealing peptides recognized by the antibodies present in the sample. Being a technique at a relatively low cost, its implementation in developing countries is feasible and can generate very interesting scientific information.

Case Report: Severe Dental Abscess Complications in Rural Sierra Leone

2021 ◽  
Author(s):  
Rosa Roemers ◽  
Aminata I. Sesay ◽  
Musa G. Sesay ◽  
Jan Henk Dubbink ◽  
Heleen M. Koudijs ◽  
...  
Keyword(s):  
Case Report ◽  
Mortality Rate ◽  
Sierra Leone ◽  
Low Income ◽  
Case Series ◽  
Low Income Countries ◽  
Prevalence Data ◽  
Dental Abscess ◽  
Dental Infections

Prevalence data on severe dental infections is scarce, particularly for low-income countries. Patients with dental abscess complications who presented from September 2020 until December 2020 in two hospitals in Tonkolili District, Sierra Leone, were included into this case series. We report on a total of 20 patients, median age 28 years, with severe complications of dental abscesses, with a mortality rate of 45%. This case series illustrates the severity of the dire consequences of the absence of access to basic dental and oral healthcare.

A Systems Approach for Sustainably Reducing Childhood Diarrheal Deaths in Developing Countries

2016 ◽  
pp. 1208-1227
Author(s):  
Monica Gray
Keyword(s):  
Developing Countries ◽  
Low Income ◽  
Systems Approach ◽  
Developed Countries ◽  
Lessons Learned ◽  
Sub Saharan Africa ◽  
Low Income Countries ◽  
Health Crisis ◽  
Industrialized Nations ◽  
Sub Saharan

Diarrhea is the second leading cause of death and is the major cause of malnutrition in children under age 5 worldwide. More than 50 percent of the cases occur in developing countries, particularly in sub-Saharan Africa and Southeast Asia. Open defecation, substandard fecal disposal systems, and contaminated water supplies are the typical causes of diarrheal diseases. This public health crisis in low income countries mirrors the experiences of today's industrialized nations two centuries ago. The lessons learned from their sanitary evolution can be instructive in charting a sustainable path towards saving the lives of almost 2 million children annually. In this chapter a case study of Cuba's sanitary reformation is also presented to showcase successes, similar to those of developed countries, within a developing country and economically challenging context.

Social Sciences in Contemporary Turkey

1971 ◽  
Vol 5 (2) ◽  
pp. 72-82
Author(s):  
Walter F. Weiker
Keyword(s):  
Social Sciences ◽  
Developing Countries ◽  
Social Science ◽  
Social Research ◽  
State Of The Art ◽  
The State ◽  
Previous Article ◽  
Social Scientists ◽  
Time Space ◽  
Growing Body

In a previous article I sought to appraise the field of Turkish studies, for the most part among western (predominantly American) scholars (MESA Bulletin, Vol. 3, No. 3, October 15, 1969). To fill out the picture, it is appropriate to also view the state of social research among the rapidly growing body of Turkish teachers and researchers. This article is not, however, a direct parallel to others in the MESA “State of the Art” series, in that it is not basically bibliographical. Such a review would require far more time, space, and knowledge in depth of several other social science disciplines than is currently available to me, because despite the remarks made below about problems of definition, the quantity and technical sophistication of work by Turkish researchers is quite large and is growing rapidly. Furthermore, since most of the research referred to below is in Turkish, the number of persons to whom a bibliographic review might be useful is quite limited. Instead, I think it would be more interesting to MESA members and other American social scientists to examine the characteristics and problems of what is probably one of the most vigorous social science communities in the “developing” countries, with a view (among other things) to helping facilitate increased cooperation between Turkish and American scholars in our common endeavors of advancing the state of knowledge.

scholarly journals Evaluating farm-level livestock interventions in low-income countries: a scoping review of what works, how, and why

2020 ◽  
pp. 1-14
Author(s):  
Johanna F. Lindahl ◽  
Florence Mutua ◽  
Delia Grace
Keyword(s):  
Developing Countries ◽  
Scoping Review ◽  
Low Income ◽  
Controlled Trial ◽  
Animal Health ◽  
Well Being ◽  
Good Evidence ◽  
Low Income Countries ◽  
Livestock Products ◽  
Development Outcomes

Abstract Livestock interventions can improve nutrition, health, and economic well-being of communities. The objectives of this review were to identify and characterize livestock interventions in developing countries and to assess their effectiveness in achieving development outcomes. A scoping review, guided by a search strategy, was conducted. Papers needed to be written in English, published in peer-reviewed journals, and describe interventions in animal health and production. Out of 2739 publications systematically screened at the title, abstract, and full publication levels, 70 met our inclusion criteria and were considered in the study. Eight relatively high-quality papers were identified and added, resulting in 78 reviewed publications. Only 15 studies used randomized controlled trial designs making it possible to confidently link interventions with the resulting outcomes. Eight studies had human nutrition or health as outcomes, 11 focused on disease control, and four were on livestock production. Eight interventions were considered successful, but only four were scalable. We found good evidence that livestock-transfer programs, leveraging livestock products for nutrition, and helping farmers manage priority diseases, can improve human well-being. Our report highlights challenges in garnering evidence for livestock interventions in developing countries and provides suggestions on how to improve the quantity and quality of future evaluations.

scholarly journals Evaluating strategies to improve rotavirus vaccine impact during the second year of life in Malawi

2019 ◽  
Vol 11 (505) ◽  
pp. eaav6419 ◽  
Author(s):  
Virginia E. Pitzer ◽  
Aisleen Bennett ◽  
Naor Bar-Zeev ◽  
Khuzwayo C. Jere ◽  
Benjamin A. Lopman ◽  
...  
Keyword(s):  
Low Income ◽  
Transmission Rate ◽  
Natural Infection ◽  
Vaccine Effectiveness ◽  
Low Income Countries ◽  
Rotavirus Vaccine ◽  
Second Year Of Life ◽  
Vaccine Impact ◽  
Second Year ◽  
Induced Immunity

Rotavirus vaccination has substantially reduced the incidence of rotavirus-associated gastroenteritis (RVGE) in high-income countries, but vaccine impact and estimated effectiveness are lower in low-income countries for reasons that are poorly understood. We used mathematical modeling to quantify rotavirus vaccine impact and investigate reduced vaccine effectiveness, particularly during the second year of life, in Malawi, where vaccination was introduced in October 2012 with doses at 6 and 10 weeks. We fitted models to 12 years of prevaccination data and validated the models against postvaccination data to evaluate the magnitude and duration of vaccine protection. The observed rollout of vaccination in Malawi was predicted to lead to a 26 to 77% decrease in the overall incidence of moderate-to-severe RVGE in 2016, depending on assumptions about waning of vaccine-induced immunity and heterogeneity in vaccine response. Vaccine effectiveness estimates were predicted to be higher among 4- to 11-month-olds than 12- to 23-month-olds, even when vaccine-induced immunity did not wane, due to differences in the rate at which vaccinated and unvaccinated individuals acquire immunity from natural infection. We found that vaccine effectiveness during the first and second years of life could potentially be improved by increasing the proportion of infants who respond to vaccination or by lowering the rotavirus transmission rate. An additional dose of rotavirus vaccine at 9 months of age was predicted to lead to higher estimated vaccine effectiveness but to only modest (5 to 16%) reductions in RVGE incidence over the first 3 years after introduction, regardless of assumptions about waning of vaccine-induced immunity.

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