scholarly journals Accuracy and Impact on Patient Management of New Tools for Diagnosis of Sepsis: Experience with the T2 Magnetic Resonance Bacteria Panel

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1132
Author(s):  
Riccardo Paggi ◽  
Elio Cenci ◽  
Giuseppe Vittorio De Socio ◽  
Alessandra Belati ◽  
Daniele Marini ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Patient Management ◽  
Positive Impact ◽  
High Sensitivity ◽  
Empiric Therapy ◽  
Accurate Identification ◽  
Blood Samples ◽  
Causative Agents ◽  
Short Time

The rapid and accurate identification of pathogens responsible for sepsis is essential for prompt and effective antimicrobial therapy. Molecular technologies have been developed to detect the most common causative agents, with high sensitivity and short time to result (TTR). T2 Bacteria Panel (T2), based on a combination of PCR and T2 magnetic resonance, can identify directly in blood samples Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Enterococcus faecium, and Acinetobacter baumannii pathogens. This study evaluates the role of T2 in the diagnosis of sepsis and its impact on patient management, specifically in terms of TTR and the switch from empirical to directed therapy, comparing results of blood culture (BC) and T2 assay in 82 patients with sepsis. T2 significantly improved the detection of the causative agents of sepsis. For pathogens included in the panel, T2 sensitivity was 100% (95% CI 86.3–100.0), significantly higher than that of BC (54.8%, 95% CI 36.0–72.7). The TTR (median, IQR) of positive T2 (3.66 h, 3.59–4.31) was significantly shorter than that of the positive BC (37.58 h, 20.10–47.32). A significant reduction in the duration of empiric therapy and an increase in the percentage of patients with switched therapy was observed in patients with a positive T2 result. In conclusion, T2 can shorten and improve the etiological diagnosis of sepsis with a positive impact on patient management.

“ROLE OF SPECTROSCOPY IN MAGNETIC RESONANCE IMAGING: A CLINICAL REVIEW”

2021 ◽  
pp. 20-23
Author(s):  
R. Adityan ◽  
Sajith Selvaganesan
Keyword(s):  
Magnetic Resonance ◽  
High Sensitivity ◽  
Benign Tumors ◽  
Resonance Spectroscopy ◽  
Clinical Implementation ◽  
Cardiac Muscles ◽  
Biochemical Evaluation ◽  
Malignant And Benign Tumors ◽  
Methylene Group

Magnetic Resonance Spectroscopy (MRS) is used in diagnostic imaging for disease metabolism evaluation. The H MRS is highly used because of the abundance, high sensitivity, etc. The various clinical implementation includes whole-brain MRS is used in measuring metabolites of different brain areas simultaneously. The breast MRS is used in malignant and benign tumors differentiation by the total choline compound. The prostate MRS is used to map the metabolites like citrate, choline, and creatinine. For spinal cord MRS, the myoinositol and N acetyl aspartate were 31 23 1 considered markers for various diseases. The MRS uses nuclei like P, Na, and H for metabolic and biochemical evaluation of cardiac muscles. The liver MRS spectrum has mainly methylene group of lipid, methyl groups of choline, and water. The MRS measures choline, creatinine, lactate, and lipid peaks in uterine leiomyoma and myometrium. Hence there are organ-specic metabolites used as a reference to map the metabolic process by using spectroscopy, making it one of the commonly preferred technique.

scholarly journals Small bowel cancer diagnosis: role of nuclear magnetic resonance

2015 ◽  
Vol 9 (3) ◽  
Author(s):  
Alessandro Morotti ◽  
Dario Gned ◽  
Leonardo Di Martino ◽  
Claudia Vaccheris ◽  
Salvatore Lia ◽  
...  
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Magnetic Resonance ◽  
Small Bowel ◽  
High Sensitivity ◽  
Modern Medicine ◽  
Bowel Cancer ◽  
Computed Tomography Scan ◽  
Tomography Scan ◽  
Nuclear Magnetic

The diagnosis of small intestine tumors is challenging. Even in the era of modern medicine, standard approaches including echography, computed tomography-scan and conventional endoscopy are unable to reveal small bowel lesions. Video-capsule has substantially improved the evaluation of small bowel; however this procedure cannot be proposed to all patients and in particular to those experiencing intestine sub-occlusion. Nuclear magnetic resonance (NRM) of the abdomen is an additional diagnostic approach that offers high sensitivity in the identification of small bowel lesions. Here, we describe a case of small bowel neoplasia indentified with NRM of the abdomen.

scholarly journals Society for Cardiovascular Magnetic Resonance 2020 Case of the Week series

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Jason N. Johnson ◽  
Jason G. Mandell ◽  
Adam Christopher ◽  
Laura J. Olivieri ◽  
Yue-Hin Loke ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Patient Management ◽  
Clinical Presentation ◽  
Case Series ◽  
Digital Archive ◽  
Research Education ◽  
Similar Search

AbstractThe Society for Cardiovascular Magnetic Resonance (SCMR) is an international society focused on the research, education, and clinical application of cardiovascular magnetic resonance (CMR). Case of the week is a case series hosted on the SCMR website (https://www.scmr.org) that demonstrates the utility and importance of CMR in the clinical diagnosis and management of cardiovascular disease. Each case consists of the clinical presentation and a discussion of the condition and the role of CMR in diagnosis and guiding clinical management. The cases are all instructive and helpful in the approach to patient management. We present a digital archive of the 2020 Case of the Week series of 11 cases as a means of further enhancing the education of those interested in CMR and as a means of more readily identifying these cases using a PubMed or similar search engine.

scholarly journals Comparative methods for the quantification of post-IMA myocardial damage

2021 ◽  
Author(s):  
Maiello Vincenzo ◽  
Iacono Maria ◽  
Cangiano Valerio ◽  
Calligari Dalila ◽  
Scarfato Emma ◽  
...  
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Myocardial Perfusion ◽  
Diagnostic Imaging ◽  
Myocardial Damage ◽  
High Sensitivity ◽  
Ischemic Damage ◽  
Laboratory Methods ◽  
Regional Myocardial Perfusion

This work aims to make a comparison between laboratory methods, especially by evaluating the role of troponin dosage and diagnostic imaging methods, specifically SPECT and cardiac magnetic resonance in the post-IMA evaluation. In both methods, we want to understand which one is able to be more predictive in terms of quantifying the extension of the infarcted area. Given the high sensitivity of troponin, even a very small damage can result from this examination, which SPECT or MRI cannot do. It must be said, however, that the initial high sensitivity troponin is not predictive of how much ischemic damage will be but is only useful for prognosis. The objective of the study was to determine the feasibility and diagnostic accuracy of an RMC stress protocol with the combined assessment of regional myocardial perfusion and contractility in the recognition of patients with significant coronary atherosclerotic disease leading to AMI, correlating the results with what would have been the study in SPECT.

scholarly journals Emerging role of cardiovascular magnetic resonance imaging in the management of pulmonary hypertension

2020 ◽  
Vol 29 (156) ◽  
pp. 190138
Author(s):  
Sudeep R. Aryal ◽  
Oleg F. Sharifov ◽  
Steven G. Lloyd
Keyword(s):  
Pulmonary Hypertension ◽  
Cardiovascular Magnetic Resonance ◽  
Magnetic Resonance ◽  
Pulmonary Artery ◽  
Right Ventricle ◽  
Prognostic Significance ◽  
High Sensitivity ◽  
Diagnosis And Management ◽  
Right Heart Catheterisation

Pulmonary hypertension (PH) is a clinical condition characterised by elevation of pulmonary arterial pressure (PAP) above normal range due to various aetiologies. While cardiac right-heart catheterisation (RHC) remains the gold standard and mandatory for establishing the diagnosis of PH, noninvasive imaging of the heart plays a central role in the diagnosis and management of all forms of PH. Although Doppler echocardiography (ECHO) can measure a range of haemodynamic and anatomical variables, it has limited utility for visualisation of the pulmonary artery and, oftentimes, the right ventricle. Cardiovascular magnetic resonance (CMR) provides comprehensive information about the anatomical and functional aspects of the pulmonary artery and right ventricle that are of prognostic significance for assessment of long-term outcomes in disease progression. CMR is suited for serial follow-up of patients with PH due to its noninvasive nature, high sensitivity to changes in anatomical and functional parameters, and high reproducibility. In recent years, there has been growing interest in the use of CMR derived parameters as surrogate endpoints for early-phase PH clinical trials. This review will discuss the role of CMR in the diagnosis and management of PH, including current applications and future developments, in comparison to other existing major imaging modalities.

The Role of Magnetic Resonance Imaging in Central Hearing Deficits: Beyond the Acoustic Schwannoma

1997 ◽  
Vol 10 (4) ◽  
pp. 409-416
Author(s):  
L. Manfrè ◽  
T. Angileri ◽  
S. Ferrara ◽  
M. Accardi ◽  
R. Raineri ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Sensitivity ◽  
Resonance Imaging ◽  
Common Cause ◽  
Clinical Syndromes ◽  
Acoustic Schwannoma ◽  
Magnetic Resonance Imaging Mri ◽  
Sensory Neural

Acoustic schwannoma is assumed to be the most common cause of sensory-neural hearing loss (SNHL), and many papers have described the role of magnetic resonance imaging (MRI) in the diagnosis of cerebello-pontine angle (CPA) tumours, particularly schwannoma. We retrospectively examined 72 patients complaining of different clinical syndromes and SNHL or different kinds of acoustic impairment who underwent MRI brain study excluding the presence of acoustic schwannoma and other CPA masses. In conclusion, although acoustic schwannoma is the most common cause of acquired HD, a lesion involving the neural centers of the acoustic pathway can also determine SNHL or HD. Considering the high sensitivity of MRI in the detection of acoustic intra-axial pathway lesions, an in-depth MRI examination of the brain stem and the temporal lobe is mandatory when SNHL or HD occur in patients not affected by acoustic schwannoma.

Fibrinolytic Activity of Cerebro-Spinal Fluid and the Development of Artificial Cerebral Haematomas in Dogs

1969 ◽  
Vol 21 (02) ◽  
pp. 294-303 ◽  
Author(s):  
H Mihara ◽  
T Fujii ◽  
S Okamoto
Keyword(s):  
Cerebrospinal Fluid ◽  
Carboxylic Acid ◽  
Fibrinolytic Activity ◽  
Clinical Implications ◽  
Trans Form ◽  
Plate Method ◽  
Blood Samples ◽  
Fibrin Plate ◽  
The Brain

SummaryBlood was injected into the brains of dogs to produce artificial haematomas, and paraffin injected to produce intracerebral paraffin masses. Cerebrospinal fluid (CSF) and peripheral blood samples were withdrawn at regular intervals and their fibrinolytic activities estimated by the fibrin plate method. Trans-form aminomethylcyclohexane-carboxylic acid (t-AMCHA) was administered to some individuals. Genera] relationships were found between changes in CSF fibrinolytic activity, area of tissue damage and survival time. t-AMCHA was clearly beneficial to those animals given a programme of administration. Tissue activator was extracted from the brain tissue after death or sacrifice for haematoma examination. The possible role of tissue activator in relation to haematoma development, and clinical implications of the results, are discussed.

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