scholarly journals Bartonella Associated Cutaneous Lesions (BACL) in People with Neuropsychiatric Symptoms

Pathogens ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 1023
Author(s):  
Edward B. Breitschwerdt ◽  
Julie M. Bradley ◽  
Ricardo G. Maggi ◽  
Erin Lashnits ◽  
Paul Reicherter
Keyword(s):  
Imaging Techniques ◽  
Neuropsychiatric Symptoms ◽  
Cutaneous Lesion ◽  
Diagnostic Testing ◽  
Emerging Pathogens ◽  
Bartonella Species ◽  
Cutaneous Lesions ◽  
Concurrent Development ◽  
Study Participants ◽  
Alpha Proteobacteria

Bartonella species are globally important emerging pathogens that were not known to infect animals or humans in North America prior to the human immunodeficiency virus (HIV) epidemic. Ongoing improvements in diagnostic testing modalities have allowed for the discovery of Bartonella species (spp.) DNA in blood; cerebrospinal fluid; and the skin of patients with cutaneous lesions, fatigue, myalgia, and neurological symptoms. We describe Bartonella spp. test results for participants reporting neuropsychiatric symptoms, the majority of whom reported the concurrent development of cutaneous lesions. Study participants completed a medical history, a risk factor questionnaire, and provided cutaneous lesion photographs. Bartonella spp. serology and Bartonella alpha proteobacteria enrichment blood culture/PCR were assessed. Within a 14-month period, 33 participants enrolled; 29/33 had serological and/or PCR evidence supporting Bartonella spp. infection, of whom 24 reported concurrent cutaneous lesions since neuropsychiatric symptom onset. We conclude that cutaneous lesions were common among people reporting neuropsychiatric symptoms and Bartonella spp. infection or exposure. Additional studies, using sensitive microbiological and imaging techniques, are needed to determine if, or to what extent, Bartonella spp. might contribute to cutaneous lesions and neuropsychiatric symptoms in patients.

scholarly journals Acanthamoeba spp. as Agents of Disease in Humans

2003 ◽  
Vol 16 (2) ◽  
pp. 273-307 ◽  
Author(s):  
Francine Marciano-Cabral ◽  
Guy Cabral
Keyword(s):  
Cerebrospinal Fluid ◽  
Cutaneous Lesion ◽  
Laboratory Diagnosis ◽  
Immune Defense ◽  
In Vitro Cultivation ◽  
Cutaneous Lesions ◽  
Trophozoite Stage ◽  
Biopsy Material ◽  
Pathogenic Potential

SUMMARY Acanthamoeba spp. are free-living amebae that inhabit a variety of air, soil, and water environments. However, these amebae can also act as opportunistic as well as nonopportunistic pathogens. They are the causative agents of granulomatous amebic encephalitis and amebic keratitis and have been associated with cutaneous lesions and sinusitis. Immuno compromised individuals, including AIDS patients, are particularly susceptible to infections with Acanthamoeba. The immune defense mechanisms that operate against Acanthamoeba have not been well characterized, but it has been proposed that both innate and acquired immunity play a role. The ameba's life cycle includes an active feeding trophozoite stage and a dormant cyst stage. Trophozoites feed on bacteria, yeast, and algae. However, both trophozoites and cysts can retain viable bacteria and may serve as reservoirs for bacteria with human pathogenic potential. Diagnosis of infection includes direct microscopy of wet mounts of cerebrospinal fluid or stained smears of cerebrospinal fluid sediment, light or electron microscopy of tissues, in vitro cultivation of Acanthamoeba, and histological assessment of frozen or paraffin-embedded sections of brain or cutaneous lesion biopsy material. Immunocytochemistry, chemifluorescent dye staining, PCR, and analysis of DNA sequence variation also have been employed for laboratory diagnosis. Treatment of Acanthamoeba infections has met with mixed results. However, chlorhexidine gluconate, alone or in combination with propamidene isethionate, is effective in some patients. Furthermore, effective treatment is complicated since patients may present with underlying disease and Acanthamoeba infection may not be recognized. Since an increase in the number of cases of Acanthamoeba infections has occurred worldwide, these protozoa have become increasingly important as agents of human disease.

scholarly journals Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

2016 ◽  
Vol 36 (7) ◽  
pp. 617-624
Author(s):  
Napoleão M. Argolo Neto ◽  
Ricardo J. Del Carlo ◽  
Betânia S. Monteiro ◽  
Nance B. Nardi ◽  
Pedro C. Chagastelles ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Platelet Rich Plasma ◽  
Cutaneous Lesion ◽  
Healing Time ◽  
Diabetic Mice ◽  
Cutaneous Lesions ◽  
Cutaneous Wounds ◽  
Autologous Mesenchymal Stem Cells ◽  
Treatment Of Wounds

Abstract: Chronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce diabetes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey's test average. It was noticed that the animals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better results than just the daily asepsis of the lesions with saline or covering them with semi-permeable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment.

Dementia in Parkinson's disease: Case report

2011 ◽  
Vol 26 (S2) ◽  
pp. 846-846
Author(s):  
S.G. Oliveira ◽  
S.M. Pereira ◽  
J. Mendes
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Case Report ◽  
Psychiatric Hospitalization ◽  
Psychological Symptoms ◽  
Neuropsychiatric Symptoms ◽  
Diagnostic Testing ◽  
Visual Hallucinations ◽  
Psychomotor Agitation ◽  
Disease Case

IntroductionParkinson's disease (PD) dementia is a rapidly growing global health problem. Dementia in PD is often accompanied with neuropsychiatric manifestations, such as depression, insomnia, visual hallucinations and psychomotor agitation, which need psychiatric attention.ObjectivesThe authors’ aim is to report a case of a 76-year-old female suffering from PD who was admitted to the psychiatric yard exhibiting neuropsychiatric symptoms. A literature's review about PD dementia was also made.Case reportPatient had one psychiatric hospitalization at age 41, due to depressive symptoms. PD diagnose was made at age 65 and initially responded well to levodopa. Over the subsequent years, motor fluctuations and dyskinesias as well as autonomic, cognitive and psychological symptoms gradually developed. At 75 years, patient's family stated that she had been more forgetful, impulsive, showing signs of anxiety and dysphoria. She was hospitalized exhibiting psychomotor agitation, disorientation, insomnia and mainly nocturnal visual hallucinations with persons. Diagnostic testing included: cranial tomography which showed mild generalized atrophy but no other structural cause of her symptoms; laboratory tests with B12, folic acid, thyroid function; syphilis detection test and examinations of serum and urine were normal. The MMSE scored 19. Attention deficits and constructional apraxia were present in clock drawing test. Treatment was initiated with memantine and a low dose of quetiapine. She was discharged after 20 days with improvement of neuropsychiatric symptoms.ConclusionsEarly diagnosis and treatment of dementia in PD may prevent psychiatric hospitalization and avoid patient's and family's distress.

scholarly journals Characterization of Leishmania parasites isolated from provinces of the Islamic Republic of Iran

2002 ◽  
Vol 8 (2-3) ◽  
pp. 338-344
Author(s):  
H. Motazedian ◽  
B. Noamanpoor ◽  
S. Ardehali
Keyword(s):  
Random Amplified Polymorphic Dna ◽  
Cutaneous Lesion ◽  
Recent Change ◽  
Islamic Republic ◽  
Cutaneous Lesions ◽  
Rapd Pcr ◽  
Islamic Republic Of Iran ◽  
Polymerase Chain ◽  
Leishmania Parasites

Leishmania parasites isolated in the Islamic Republic of Iran were studied by a random amplified polymorphic DNA polymerase chain reaction [RAPD-PCR]. Of 82 isolates, 80 were from cutaneous lesions, 1 from a human throat lesion and 1 from a dog. Of these, 42 isolates were L. tropica, 36 were L. major and 2 were L. infantum. There were 2 unidentified isolates [from the throat lesion and a cutaneous lesion] and these demonstrated 52% and 48% similarity with L. tropica and L. infantum. Both L. tropica and L. major were isolated from four provinces indicating a recent change in the epidemiology of cutaneous leishmaniasis. L. tropica was isolated from three provinces; L. major from one province. L. infantum was isolated from a human cutaneous lesion and from a dog in Bushehr province.

scholarly journals Dermatologic clue to renal cell carcinoma: a case report

2019 ◽  
Vol 6 (4) ◽  
pp. 1353
Author(s):  
Ajeet Singh Chaudhary ◽  
Vinay Tuteja ◽  
M. K. Agarwal ◽  
Gunja Jain ◽  
Hemant Luniwal
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cutaneous Lesion ◽  
Final Diagnosis ◽  
Skin Lesions ◽  
Cutaneous Metastasis ◽  
Systematic Evaluation ◽  
Systemic Diseases ◽  
Cutaneous Lesions

Visceral malignancies often present as cutaneous lesion and are an important clue towards the diagnosis. Authors report a case of a 64 years old male, who presented to us with right hemiparesis and multiple purple-red skin lesions. Systematic evaluation, thorough history and histological examination of the skin lesion showing the characteristic lesion lead to a final diagnosis of Renal Cell Carcinoma. Although in the history and physical examination there was no sign of Renal Cell Carcinoma, but eventually the case turned out to be an extensively spread cancer. This kind of Cutaneous lesions in a case of RCC is a rare phenomenon and has not been frequently mentioned in the previous literature, thus this case reminds us about the importance of a detailed clinical look out in each and every patient and various clues to make a correct and timely diagnosis of systemic diseases. The list of visceral malignancies causing cutaneous metastasis is quite long and requires a battery of test to diagnose the same.

scholarly journals A clinical study of various cutaneous manifestations in neonates

2019 ◽  
Vol 5 (1) ◽  
pp. 8
Author(s):  
Shams Zia Usmani ◽  
Kshitij Saxena ◽  
Venkatarao Koti ◽  
Shrish Bhatnagar ◽  
Gaurav Paliwal ◽  
...  
Keyword(s):  
Neonatal Period ◽  
Cutaneous Lesion ◽  
Skin Lesions ◽  
Good Prognosis ◽  
Cutaneous Lesions ◽  
Cutaneous Manifestations ◽  
Medical College ◽  
Variable Nature ◽  
Detailed Assessment ◽  
Neonatal Skin

<p class="abstract"><strong>Background:</strong> Cutaneous manifestations are common in neonates. Transient and pathological neonatal dermatoses should be differentiated to avoid unnecessary treatment and thus considering the variable nature and severity of neonatal skin lesions, it is important to be aware of the transient skin lesions in newborn and to differentiate these from other serious conditions which will avoid unnecessary therapy to the neonates and the parents can be assured of good prognosis of these skin manifestations. The present study has been carried out to study the clinical pattern of cutaneous lesion in neonatal period.</p><p class="abstract"><strong>Methods:</strong> A total of 255 neonates from Department of Dermatology in collaboration of Department of Pediatrics, Era’s Lucknow Medical College and Hospital were evaluated for cutaneous manifestations. A detailed assessment regarding history, clinical examination and investigations were recorded and analyzed.<strong></strong></p><p class="abstract"><strong>Results:</strong> Out of 255 neonates, 138 (54.1%) were males and 117 (45.9%) were females. The sex ratio (M:F) was 1.18. The most common dermatoses were physiological desquamation (54.1%) and mongolian spots (37.6%) followed by milia (19.6%), miliaria (14%), epstein pearls (10.2%).</p><p class="abstract"><strong>Conclusions:</strong> The physiological and transient cutaneous lesions are common are in neonates. Physiological cutaneous manifestations were quite frequent apart from birthmarks/congenital cutaneous manifestations. An understanding of these manifestations helps in managing and deciding the appropriate manifestation.</p>

scholarly journals Serial Excision- an Aesthetically Pleasing Way for Removal of Large Cutaneous Lesions on the Face

2013 ◽  
Vol 1 (1) ◽  
pp. 14-16
Author(s):  
Firdous Quader Minu ◽  
Muhammad Hasibur Rahman ◽  
Rubaiya Ali ◽  
Md Asifuzzaman ◽  
Sayeed Ahmed Siddiky
Keyword(s):  
Cutaneous Lesion ◽  
Skin Grafting ◽  
Patient Needs ◽  
Aesthetic Outcome ◽  
Cutaneous Lesions ◽  
Community Based ◽  
Different Types ◽  
The Face ◽  
The Aesthetic ◽  
Serial Excision

Face is a very prominent part of our body. It is the first feature that we notice when we meet someone. When there is a large cutaneous lesion /scar on the face it stands out, and can make a person very self conscious. So it becomes a source of concern and embarrassment for the person involved. As such when a patient with this type of problem presents to a cosmetic surgeon, he has to take great care as to how it can be removed and what will be the aesthetic outcome of the treatment. This is especially important if the patient is young. Different types of flaps like nasolabial flaps, forehead flaps, deltopectoral flaps etc. are commonly used for reconstruction of defects following excision of large lesions. Sometimes tissue expanders are also used. Of course skin grafting is probably the easiest way to cover large areas when flaps cannot be used. But all of these procedures leave big scars which are often not acceptable to the patients. We have found that serial excision is a good way of removal of large lesions or scars especially when it involves the face. Although the patient needs two or more sittings for completion of the procedure, the final outcome is much more acceptable to the patient. DOI: http://dx.doi.org/10.3329/cbmj.v1i1.13823 Community Based Medical Journal Vol.1(1) 2012 14-16

scholarly journals Paracoccidioidomycosis: infiltrated, sarcoid-like cutaneous lesions misinterpreted as tuberculoid leprosy

2008 ◽  
Vol 50 (1) ◽  
pp. 47-50 ◽  
Author(s):  
Sílvio Alencar Marques ◽  
Joel Carlos Lastória ◽  
Maria Stella de M.A. Putinatti ◽  
Rosangela Maria Pires de Camargo ◽  
Mariangela E. A. Marques
Keyword(s):  
Young Patient ◽  
Histological Examination ◽  
Clinical Course ◽  
Inflammatory Diseases ◽  
Cutaneous Lesion ◽  
Initial Presentation ◽  
Cutaneous Lesions ◽  
Sulfonamide Derivative ◽  
Tuberculoid Leprosy ◽  
Juvenile Type

The authors report a case of paracoccidioidomycosis misinterpreted as tuberculoid leprosy, both on clinical and histological examination. Sarcoid-like cutaneous lesion as the initial presentation is rare in young patient with paracoccidioidomycosis and can simulate other infectious or inflammatory diseases. On histology, tuberculoid granuloma presented similar difficulties. Treatment with dapsone, a sulfonamide derivative, could have delayed the presumed natural clinical course to the classical juvenile type of paracoccidioidomycosis, observed only 24 months after the patient had been treated for leprosy.

scholarly journals Chronic traumatic encephalopathy—a blueprint for the bridge between neurological and psychiatric disorders

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Onder Albayram ◽  
Sait Albayram ◽  
Rebekkah Mannix
Keyword(s):  
Brain Injuries ◽  
Chronic Traumatic Encephalopathy ◽  
Imaging Techniques ◽  
Neuropsychiatric Symptoms ◽  
Case Series ◽  
Mental Illnesses ◽  
Diverse Range ◽  
Clinical Criteria ◽  
Wide Range ◽  
Behavioral Impairments

AbstractChronic traumatic encephalopathy (CTE) is a perplexing condition characterized by a broad and diverse range of neuropathology and psychopathology. While there are no agreed upon or validated clinical criteria for CTE, case series of CTE have described a wide range of neuropsychiatric symptoms that have been attributed to repetitive traumatic brain injuries (rTBI). However, the direct links between the psychopathology of psychiatric and neurological conditions from rTBI to CTE remains poorly understood. Prior studies suggest that repetitive cerebral injuries are associated with damage to neural circuitry involved in emotional and memory processes, but these studies do not offer longitudinal assessments that prove causation. More recent studies on novel targets, such as transmission of misfolded proteins, as well as newly advanced non-invasive imaging techniques may offer more direct evidence of the pathogenesis of CTE by tracing the progression of pathology and display of related behavioral impairments. Understanding this interface in the context of rTBI can play an important role in future approaches to the definition, assessment, prevention, and treatment of CTE and mental illnesses.

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