scholarly journals The Influence of Plant Isoflavones Daidzein and Equol on Female Reproductive Processes

2021 ◽  
Vol 14 (4) ◽  
pp. 373
Author(s):  
Alexander V. Sirotkin ◽  
Saleh Hamad Alwasel ◽  
Abdel Halim Harrath
Keyword(s):  
Environmental Stressors ◽  
Oxygen Species ◽  
Female Reproduction ◽  
Inhibitory Effects ◽  
Hormone Production ◽  
Ovarian Cell ◽  
Cell Functions ◽  
Physiological Processes ◽  
Proliferation And Apoptosis ◽  
Reproductive Processes

In this review, we explore the current literature on the influence of the plant isoflavone daidzein and its metabolite equol on animal and human physiological processes, with an emphasis on female reproduction including ovarian functions (the ovarian cycle; follicullo- and oogenesis), fundamental ovarian-cell functions (viability, proliferation, and apoptosis), the pituitary and ovarian endocrine regulators of these functions, and the possible intracellular mechanisms of daidzein action. Furthermore, we discuss the applicability of daidzein for the control of animal and human female reproductive processes, and how to make this application more efficient. The existing literature demonstrates the influence of daidzein and its metabolite equol on various nonreproductive and reproductive processes and their disorders. Daidzein and equol can both up- and downregulate the ovarian reception of gonadotropins, healthy and cancerous ovarian-cell proliferation, apoptosis, viability, ovarian growth, follicullo- and oogenesis, and follicular atresia. These effects could be mediated by daidzein and equol on hormone production and reception, reactive oxygen species, and intracellular regulators of proliferation and apoptosis. Both the stimulatory and the inhibitory effects of daidzein and equol could be useful for reproductive stimulation, the prevention and mitigation of cancer development, and the adverse effects of environmental stressors in reproductive biology and medicine.

scholarly journals The Influence of Turmeric and Curcumin on Female Reproductive Processes

Planta Medica ◽  
2021 ◽  
Author(s):  
Alexander V. Sirotkin
Keyword(s):  
Female Reproduction ◽  
Reproductive Disorders ◽  
Ovarian Cells ◽  
Physiological Processes ◽  
Intracellular Signalling Pathways ◽  
Proliferation And Apoptosis ◽  
Oxidative Processes ◽  
Reproductive Processes

AbstractThe present review summarizes the available knowledge concerning the action of curcumin, the best-known polyphenol among the rhizomes of Curcumas, on female reproductive processes and their dysfunctions. Curcumin affects a number of physiological processes, including female reproduction (puberty, reproductive aging, ovarian follicullogenesis and oogenesis, and fecundity). Curcumin can affect these processes via changes in the release and reception of pituitary and ovarian hormones, growth factors and cytokines. Furthermore, it can influence the response of ovarian cells to these substances and external environmental factors. Finally, curcumin can affect oxidative processes within the ovary and numerous intracellular signalling pathways related to ovarian cell proliferation and apoptosis. These effects suggest the applicability of curcumin for stimulation of female reproductive processes in vivo and in vitro, as well as for the prevention, mitigation, and treatment of various reproductive disorders from ovarian insufficiency and infertility to polycystic ovarian syndrome and ovarian cancer.

scholarly journals The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction

2021 ◽  
Vol 14 (9) ◽  
pp. 881
Author(s):  
Adriana Kolesarova ◽  
Simona Baldovska ◽  
Shubhadeep Roychoudhury
Keyword(s):  
Intracellular Signaling ◽  
Current Knowledge ◽  
Health Hazard ◽  
Secretory Activity ◽  
The Body ◽  
Female Reproduction ◽  
Promising Tool ◽  
Physiological Processes ◽  
Potential Applicability ◽  
Reproductive Processes

The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductive processes, particularly in the female. Amygdalin influences physiological processes including female reproduction at various regulatory levels via extra- and intracellular signaling pathways regulating secretory activity, cell viability, steroidogenesis, proliferation, and apoptosis. On the other hand, while being metabolized in the body, amygdalin releases significant amounts of cyanide, which may lead to acute health hazard in those individuals who may be at risk. Despite some contradictions in the available data about benefits and toxic effects of amygdalin, its potential applicability at low doses may present a promising tool for regulation of various reproductive and other physiological processes including disease management primarily in cancer phytotherapy, animal production, medicine, and biotechnology. However, further research involving carefully designed dose–response studies is required to overcome the possible side effects of amygdalin and assure its safety as a therapeutic agent.

scholarly journals Oxidative Stress in Muscle Growth and Adaptation to Physical Exercise

2015 ◽  
Vol 2 (1) ◽  
pp. 61-69
Author(s):  
Ihor Yurkevych
Keyword(s):  
Oxidative Stress ◽  
Reactive Nitrogen Species ◽  
Muscle Hypertrophy ◽  
Muscle Growth ◽  
Oxygen Species ◽  
Cell Functions ◽  
Skeletal Muscle Hypertrophy ◽  
Adaptation To Physical Exercise ◽  
Hormetic Effect ◽  
Proliferation And Apoptosis

In a few last decades oxidative stress detected in a variety of physiological processeswhere reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a central role. Theyare directly involved in oxidation of proteins, lipids and nucleic acids. In certain concentrationsthey are necessary for cell division, proliferation and apoptosis. Contractile muscle tissue at aerobicconditions form high ROS flow that may modulate a variety of cell functions, for exampleproliferation. However, slight increase in ROS level provide hormetic effect which may participatein adaptation to heavy weight training resulted in hypertrophy and proliferation of skeletal musclefibers. This review will discuss ROS types, sites of generation, strategies to increase forceproduction and achieve skeletal muscle hypertrophy

scholarly journals Direct inhibitory effect of flaxseed on porcine ovarian granulosa cell functions

2019 ◽  
Vol 44 (5) ◽  
pp. 507-511
Author(s):  
Aneta Štochmal’ová ◽  
Abdel Halim Harrath ◽  
Saleh Alwasel ◽  
Alexander V. Sirotkin
Keyword(s):  
Cell Proliferation ◽  
Granulosa Cells ◽  
Inhibitory Effect ◽  
Ovarian Cell ◽  
Cell Functions ◽  
Ovarian Granulosa Cell ◽  
Igf I ◽  
Direct Inhibitory Effect ◽  
Reproductive Processes ◽  
Flaxseed Extract

Flaxseed is useful as a functional food and alternative medicine owing to its beneficial health effects. Its action on ovarian cell functions and interrelationships with the upstream hormonal regulators remain unknown. Our aim was to examine the direct influence of flaxseed extract on basal porcine ovarian functions (proliferation, apoptosis), leptin release, and response to insulin-like growth factor I (IGF-I). First, we examined the effect of flaxseed extract on the accumulation of proliferation (PCNA) and apoptosis (Bax) markers and on leptin release in cultured porcine ovarian granulosa cells. Next, granulosa cells were cultured with IGF-I with and without flaxseed extract and analyzed for PCNA and Bax accumulation by quantitative immunocytochemistry and for leptin release by radioimmunoassay. Flaxseed decreased the accumulation of PCNA and increased that of Bax at all doses and reduced leptin output at 100 μg/mL. In contrast, IGF-I promoted PCNA accumulation and suppressed Bax. Flaxseed did not modify IGF-I action on these parameters. Thus, we showed that flaxseed influences porcine reproductive processes, having a direct effect on the ovary and the ability to affect ovarian cell proliferation, apoptosis, and leptin release. Furthermore, we confirmed the pro-proliferative and antiapoptotic actions of IGF-I but showed that flaxseed action on ovarian cell proliferation and apoptosis is not due to changes in the cell response to IGF-I. The potential direct anti-reproductive action of flaxseed needs to be considered during its application in nutrition, medicine, and animal production.

Mitochondria-Targeted Ratiometric Fluorescent Imaging of Cysteine

The Analyst ◽  
2021 ◽  
Author(s):  
Ya-Nan Wei ◽  
Bo Lin ◽  
Yang Shu ◽  
Jian-Hua Wang
Keyword(s):  
Reactive Oxygen Species ◽  
Redox Homeostasis ◽  
Reactive Oxygen ◽  
Fluorescent Imaging ◽  
Oxygen Species ◽  
Cellular Redox ◽  
Critical Part ◽  
Physiological Processes

As an indispensable biothiol, cysteine (Cys) plays a critical part in cellular redox homeostasis, pathological and physiological processes. One of the main sources of reactive oxygen species (ROS) in human...

scholarly journals Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

2021 ◽  
Vol 22 (8) ◽  
pp. 3974
Author(s):  
Tuba M. Ansary ◽  
Md. Razib Hossain ◽  
Koji Kamiya ◽  
Mayumi Komine ◽  
Mamitaro Ohtsuki
Keyword(s):  
Ultraviolet Radiation ◽  
Air Pollutants ◽  
Skin Aging ◽  
Environmental Stressors ◽  
Oxygen Species ◽  
Delayed Wound Healing ◽  
Different Types ◽  
Aged Skin ◽  
Inflammatory Molecules ◽  
Complex Organ

Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.

scholarly journals Inhibitory effects of a selective Jak2 inhibitor on adrenocorticotropic hormone production and proliferation of corticotroph tumor AtT20 cells

2017 ◽  
Vol Volume 10 ◽  
pp. 4329-4338 ◽  
Author(s):  
Yuko Asari ◽  
Kazunori Kageyama ◽  
Yuki Nakada ◽  
Mizuki Tasso ◽  
Shinobu Takayasu ◽  
...  
Keyword(s):  
Adrenocorticotropic Hormone ◽  
Inhibitory Effects ◽  
Hormone Production ◽  
Jak2 Inhibitor

scholarly journals Three Lipid Emulsions Reduce Staphylococcus aureus-Stimulated Phagocytosis in Mouse RAW264.7 Cells

2021 ◽  
Vol 9 (12) ◽  
pp. 2479
Author(s):  
Ming-Shan Chen ◽  
Yi-Wei Tung ◽  
Chia-Lin Hu ◽  
Hui-Ju Chang ◽  
Wen-Chun Lin ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Modulation ◽  
Medium Chain Triglyceride ◽  
Nutritional Requirements ◽  
Ros Production ◽  
Lipid Emulsions ◽  
Oxygen Species ◽  
Bacterial Survival ◽  
Inhibitory Effects ◽  
Raw264.7 Macrophages

Soybean oil (SO)-, SO medium-chain triglyceride (MCT)-, olive oil (OO)-, and fish oil (FO)-based lipid emulsions are generally applied in clinical practice via intravenous injection for patients with nutritional requirements. The function of lipid emulsions on immune modulation remains inconsistent, and their effects on macrophages are limited. In the present study, we used a model of S. aureus-infected mouse RAW264.7 macrophages to determine the influence of three different compositions of lipid emulsions (Lipofundin, ClinOleic, and Omegaven) on reactive oxygen species (ROS) production, phagocytosis, and bacterial survival. The three individual lipid emulsions similarly enhanced bacterial survival but reduced S. aureus-stimulated ROS, phagocytosis of S. aureus bioparticles conjugate, polymerization of F-actin, and phosphorylation of AKT, JNK, and ERK. Compared with the JNK and ERK inhibitors, the PI3K inhibitor markedly suppressed the phagocytosis of S. aureus bioparticles conjugate and the polymerization of F-actin, whereas it significantly increased the bacterial survival. These results suggest that the three lipid emulsions diminished ROS production and phagocytosis, resulting in increased bacterial survival. PI3K predominantly mediated the inhibitory effects of the lipid emulsions on the phagocytosis of mouse RAW264.7 macrophages.

Kisspeptin as autocrine/paracrine regulator of human ovarian cell functions: Possible interrelationships with FSH and its receptor

2022 ◽  
Vol 22 (1) ◽  
pp. 100580
Author(s):  
Zuzana Fabová ◽  
Barbora Loncová ◽  
Miloš Mlynček ◽  
Alexander V. Sirotkin
Keyword(s):  
Ovarian Cell ◽  
Cell Functions
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