scholarly journals Encapsulation of Activated Carbon into a Hollow-Type Spherical Bacterial Cellulose Gel and Its Indole-Adsorption Ability Aimed at Kidney Failure Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1076
Author(s):  
Toru Hoshi ◽  
Masahito Endo ◽  
Aya Hirai ◽  
Masashige Suzuki ◽  
Takao Aoyagi

For reducing side effects and improvement of swallowing, we studied the encapsulation of activated carbon formulations with a hollow-type spherical bacterial cellulose (HSBC) gel using two kinds of encapsulating methods: Methods A and B. In Method A, the BC gelatinous membrane was biosynthesized using Komagataeibacter xylinus (K. xylinus) at the interface between the silicone oil and cell suspension containing activated carbon. In Method B, the bacterial cellulose (BC) gelatinous membrane was formed at the interface between the cell suspension attached to the alginate gel containing activated carbon and the silicone oil. After the BC gelatinous membrane was biosynthesized by K. xylnus, alginate gel was removed by soaking in a phosphate buffer. The activated carbon encapsulated these methods could neither pass through the BC gelatinous membrane of the HSBC gel nor leak from the interior cavity of the HSBC gel. The adsorption ability was evaluated using indole, which is a precursor of the uremic causative agent. From curve-fitting, the adsorption process followed the pseudo-first-order and intra-particle diffusion models, and the diffusion of the indole molecules at the surface of the encapsulated activated carbon within the HSBC gel was dominant at the initial stage of adsorption. It was observed that the adsorption of the encapsulated activated carbon by the intraparticle diffusion process became dominant with longer adsorption times.

2019 ◽  
Vol 20 (19) ◽  
pp. 4919 ◽  
Author(s):  
Toru Hoshi ◽  
Masashige Suzuki ◽  
Mayu Ishikawa ◽  
Masahito Endo ◽  
Takao Aoyagi

A hollow-type spherical bacterial cellulose (HSBC) gel prepared using conventional methods cannot load particles larger than the pore size of the cellulose nanofiber network of bacterial cellulose (BC) gelatinous membranes. In this study, we prepared a HSBC gel encapsulating target substances larger than the pore size of the BC gelatinous membranes using two encapsulating methods. The first method involved producing the BC gelatinous membrane on the surface of the core that was a spherical alginate gel with a diameter of 2 to 3 mm containing the target substances. With this method, the BC gelatinous membrane was biosynthesized using Gluconacetobacter xylinus at the interface between the cell suspension attached onto the alginate gel and the silicone oil. The second method involved producing the BC gel membrane on the interface between the silicone oil and cell suspension, as well as the spherical alginate gel with a diameter of about 1 mm containing target substances. After the BC gelatinous membrane was biosynthesized, an alginate gel was dissolved in a phosphate buffer to prepare an HSBC gel with the target substances. These encapsulated substances could neither pass through the BC gelatinous membrane of the HSBC gel nor leak from the interior space of the HSBC gel. These results suggest that the HSBC gel had a molecular sieving function. The HSBC gel walls prepared using these methods were observed to be uniform and would be useful for encapsulating bioactive molecules, such as immobilized enzymes in HSBC gel, which is expected to be used as a drug carrier.


2021 ◽  
Vol 11 (4) ◽  
pp. 1211-1223
Author(s):  
Attika Malik ◽  
Shamaila Sajjad ◽  
Sajjad Ahmed Khan Leghari ◽  
Youmna Naz ◽  
Maria Masood ◽  
...  

2018 ◽  
Vol 54 (14) ◽  
pp. 2180-2193 ◽  
Author(s):  
Arnon Khamkeaw ◽  
Bunjerd Jongsomjit ◽  
Jonah Robison ◽  
Muenduen Phisalaphong

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 192
Author(s):  
Tatiana G. Volova ◽  
Svetlana V. Prudnikova ◽  
Evgeniy G. Kiselev ◽  
Ivan V. Nemtsev ◽  
Alexander D. Vasiliev ◽  
...  

The synthesis of bacterial cellulose (BC) by Komagataeibacter xylinus strain B-12068 was investigated on various C-substrates, under submerged conditions with stirring and in static surface cultures. We implemented the synthesis of BC on glycerol, glucose, beet molasses, sprat oil, and a mixture of glucose with sunflower oil. The most productive process was obtained during the production of inoculum in submerged culture and subsequent growth of large BC films (up to 0.2 m2 and more) in a static surface culture. The highest productivity of the BC synthesis process was obtained with the growth of bacteria on molasses and glycerol, 1.20 and 1.45 g/L per day, respectively. We obtained BC composites with silver nanoparticles (BC/AgNPs) and antibacterial drugs (chlorhexidine, baneocin, cefotaxime, and doripenem), and investigated the structure, physicochemical, and mechanical properties of composites. The disc-diffusion method showed pronounced antibacterial activity of BC composites against E. coli ATCC 25922 and S. aureus ATCC 25923.


2019 ◽  
Vol 64 (3) ◽  
pp. 4582-4585
Author(s):  
Paola Méndez ◽  
Christian Nuñez ◽  
Jaime R. Cabrera-Pardo ◽  
Cristian Paz ◽  
Juan Manuel Barraza ◽  
...  

Author(s):  
Malgorzata M. Sturgill ◽  
Elaine Cohen ◽  
Richard F. Riesenfeld

Abstract During early stages of design, the mere presence of items, their relative positioning, and their interrelationships can be more significant than fine details, like exact dimensions, whether a hole is counterbored, or the exact cross-sectional shape of a groove. Most CAD systems have little, if any, support for this critical, incipient design stage, In addressing this economically compelling and highly leveraged area, we present an intuitive, feature-based approach to 3-D design which permits a complete first pass through the design-manufacturing cycle even before a detailed specification is complete. We report a functioning 3-D design front-end for a solid modeling system that has been used for fast intra-part and inter-part, visual, generalized feature specification, a frontend that is intimately connected to the system so that both visual and detailed design can be carried out concurrently on the same model to meet designer needs. Hence, the design that is “captured” during the sketch and modify phase using this approach is fully usable for activities that traditionally require a fully detailed solid model, such as rendering, finite element and other analysis, assembly analysis, process planning, and manufacturing at this initial stage instead of the traditionally late stages.


2020 ◽  
Vol 117 (7) ◽  
pp. 2165-2176 ◽  
Author(s):  
Long‐Hui Huang ◽  
Qi‐Jing Liu ◽  
Xue‐Wen Sun ◽  
Xue‐Jing Li ◽  
Miao Liu ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document