scholarly journals In Vitro and In Vivo Bioequivalence Study of 3D-Printed Instant-Dissolving Levetiracetam Tablets and Subsequent Personalized Dosing for Chinese Children Based on Physiological Pharmacokinetic Modeling

Pharmaceutics ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 20
Author(s):  
Xianfu Li ◽  
En Liang ◽  
Xiaoxuan Hong ◽  
Xiaolu Han ◽  
Conghui Li ◽  
...  
Keyword(s):  
3D Printing ◽  
Pbpk Model ◽  
Dose Range ◽  
Chinese Children ◽  
Pbpk Modeling ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Pbpk Models ◽  
3D Printed

Recently, the development of Binder Jet 3D printing technology has promoted the research and application of personalized formulations, which are especially useful for children’s medications. Additionally, physiological pharmacokinetic (PBPK) modeling can be used to guide drug development and drug dose selection. Multiple technologies can be used in combination to increase the safety and effectiveness of drug administration. In this study, we performed in vivo pharmacokinetic experiments in dogs with preprepared 3D-printed levetiracetam instant-dissolving tablets (LEV-IDTs). Bioequivalence analysis showed that the tablets were bioequivalent to commercially available preparations (Spritam®) for dogs. Additionally, we evaluated the bioequivalence of 3D-printed LEV-IDTs with Spritam® by a population-based simulation based on the established PBPK model of levetiracetam for Chinese adults. Finally, we established a PBPK model of oral levetiracetam in Chinese children by combining the physiological parameters of children, and we simulated the PK (pharmacokinetics) curves of Chinese children aged 4 and 6 years that were administered the drug to provide precise guidance on adjusting the dose according to the effective dose range of the drug. Briefly, utilizing both Binder jet 3D printing technology and PBPK models is a promising route for personalized drug delivery with various age groups.

scholarly journals Vascularized Bone Regeneration Accelerated by 3D-Printed Nanosilicate-Functionalized Polycaprolactone Scaffold

2021 ◽  
Author(s):  
Xiongcheng Xu ◽  
Long Xiao ◽  
Yanmei Xu ◽  
Jin Zhuo ◽  
Xue Yang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Regeneration ◽  
Bone Repair ◽  
Cytokine Secretion ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Vascularized Bone

Abstract Critical oral-maxillofacial bone defects, damaged by trauma and tumors, not only affect the physiological functions and mental health of patients but are also highly challenging to reconstruct. Personalized biomaterials customized by 3D printing technology have the potential to match oral-maxillofacial bone repair and regeneration requirements. Laponite nanosilicates have been added to biomaterials to achieve biofunctional modification owing to their excellent biocompatibility and bioactivity. Herein, porous nanosilicate-functionalized polycaprolactone (PCL/LAP) was fabricated by 3D printing technology, and its bioactivities in bone regeneration were investigated in vitro and in vivo. In vitro experiments demonstrated that PCL/LAP exhibited good cytocompatibility and enhanced the viability of BMSCs. PCL/LAP functioned to stimulate osteogenic differentiation of BMSCs at the mRNA and protein levels and elevated angiogenic gene expression and cytokine secretion. Moreover, BMSCs cultured on PCL/LAP promoted the angiogenesis potential of endothelial cells by angiogenic cytokine secretion. Then, PCL/LAP scaffolds were implanted into the calvarial defect model. Toxicological safety of PCL/LAP was confirmed, and significant enhancement of vascularized bone formation was observed. Taken together, 3D-printed PCL/LAP scaffolds with brilliant osteogenesis to enhance bone regeneration could be envisaged as an outstanding bone substitute for a promising change in oral-maxillofacial bone defect reconstruction.

scholarly journals Development of Physiologically Based Pharmacokinetic Model for Orally Administered Fexuprazan in Humans

Pharmaceutics ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 813
Author(s):  
Yoo-Seong Jeong ◽  
Min-Soo Kim ◽  
Nora Lee ◽  
Areum Lee ◽  
Yoon-Jee Chae ◽  
...  
Keyword(s):  
Gastric Acid ◽  
Pbpk Model ◽  
Pbpk Modeling ◽  
Drug Candidate ◽  
Metabolite Formation ◽  
Pbpk Models ◽  
Physiologically Based Pharmacokinetic ◽  
Physiologically Based

Fexuprazan is a new drug candidate in the potassium-competitive acid blocker (P-CAB) family. As proton pump inhibitors (PPIs), P-CABs inhibit gastric acid secretion and can be used to treat gastric acid-related disorders such as gastroesophageal reflux disease (GERD). Physiologically based pharmacokinetic (PBPK) models predict drug interactions as pharmacokinetic profiles in biological matrices can be mechanistically simulated. Here, we propose an optimized and validated PBPK model for fexuprazan by integrating in vitro, in vivo, and in silico data. The extent of fexuprazan tissue distribution in humans was predicted using tissue-to-plasma partition coefficients in rats and the allometric relationships of fexuprazan distribution volumes (VSS) among preclinical species. Urinary fexuprazan excretion was minimal (0.29–2.02%), and this drug was eliminated primarily by the liver and metabolite formation. The fraction absorbed (Fa) of 0.761, estimated from the PBPK modeling, was consistent with the physicochemical properties of fexuprazan, including its in vitro solubility and permeability. The predicted oral bioavailability of fexuprazan (38.4–38.6%) was within the range of the preclinical datasets. The Cmax, AUClast, and time-concentration profiles predicted by the PBPK model established by the learning set were accurately predicted for the validation sets.

scholarly journals A millifluidic chip for cultivation of fish embryos and toxicity testing fabricated by 3D printing technology

RSC Advances ◽  
2021 ◽  
Vol 11 (33) ◽  
pp. 20507-20518
Author(s):  
Petr Panuška ◽  
Zuzana Nejedlá ◽  
Jiří Smejkal ◽  
Petr Aubrecht ◽  
Michaela Liegertová ◽  
...  
Keyword(s):  
3D Printing ◽  
Toxicity Testing ◽  
Toxicity Screening ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fish Embryos ◽  
3D Printed ◽  
Novel Design

A novel design of 3D printed zebrafish millifluidic system for embryonic long-term cultivation and toxicity screening has been developed. The chip unit provides 24 cultivation chambers and a selective individual embryo removal functionality.

scholarly journals 3D-Printed Nanocellulose-Based Cushioning–Antibacterial Dual-Function Food Packaging Aerogel

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3543
Author(s):  
Wei Zhou ◽  
Jiawei Fang ◽  
Shuwei Tang ◽  
Zhengguo Wu ◽  
Xiaoying Wang
Keyword(s):  
3D Printing ◽  
Food Packaging ◽  
Fruits And Vegetables ◽  
Antibacterial Effect ◽  
Dual Function ◽  
Printing Technology ◽  
E Coli ◽  
3D Printing Technology ◽  
The Core ◽  
3D Printed

Cushioning and antibacterial packaging are the requirements of the storage and transportation of fruits and vegetables, which are essential for reducing the irreversible quality loss during the process. Herein, the composite of carboxymethyl nanocellulose, glycerin, and acrylamide derivatives acted as the shell and chitosan/AgNPs were immobilized in the core by using coaxial 3D-printing technology. Thus, the 3D-printed cushioning–antibacterial dual-function packaging aerogel with a shell–core structure (CNGA/C–AgNPs) was obtained. The CNGA/C–AgNPs packaging aerogel had good cushioning and resilience performance, and the average compression resilience rate was more than 90%. Although AgNPs was slowly released, CNGA/C–AgNPs packaging aerogel had an obvious antibacterial effect on E. coli and S. aureus. Moreover, the CNGA/C–AgNPs packaging aerogel was biodegradable. Due to the customization capabilities of 3D-printing technology, the prepared packaging aerogel can be adapted to more application scenarios by accurately designing and regulating the microstructure of aerogels, which provides a new idea for the development of food intelligent packaging.

APPLICATION OF 3D PRINTING TECHNOLOGY FOR RAPID TOOLING IN SHEET METAL FORMING

2020 ◽  
Vol 3 ◽  
pp. 20-30
Author(s):  
M.A. SEREZHKIN ◽  
D.O. KLIMYUK ◽  
A.I. PLOKHIKH
Keyword(s):  
3D Printing ◽  
Sheet Metal ◽  
Sheet Metal Forming ◽  
Metal Forming ◽  
Rapid Tooling ◽  
Printing Technology ◽  
3D Printing Technology ◽  
3D Printed ◽  
Printed Materials ◽  
Printing Parameters

The article presents the study of the application of 3D printing technology for rapid tooling in sheet metal forming for custom or small–lot manufacturing. The main issue of the usage of 3D printing technology for die tooling was discovered. It is proposed to use the method of mathematical modelling to investigate how the printing parameters affect the compressive strength of FDM 3D–printed parts. Using expert research methods, the printing parameters most strongly affecting the strength of products were identified for further experiments. A method for testing the strength of 3D–printed materials has been developed and tested.

scholarly journals Implementation of 3D Printing Technology in the Food Industry

2021 ◽  
pp. 50-54
Author(s):  
Nor Aiman Sukindar ◽  
Noorazizi Mohd Samsuddin ◽  
Sharifah Imihezri Bt. Syed Shaharuddin ◽  
Shafie Kamaruddin ◽  
Ahmad Zahirani Ahmad Azhar ◽  
...  
Keyword(s):  
3D Printing ◽  
New Product Development ◽  
Food Industry ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Fabrication Cost ◽  
Food Packages ◽  
3D Printed ◽  
The Cost ◽  
Fabrication Time

This project involves the implementation of 3D printing technology on designing and fabricating food holders in the food industry. Food holders are designed to hold the food packages in the filling line for food manufacturing industries that apply retort technology. Therefore, this study aims to implement the 3D printing technology in particular FDM to fabricate food holders for the food processing industry. The approach of using this technology is focused on giving more view on the capability of 3D printing technology, aiming at reducing the overall process fabrication cost and fabrication time. Hence, the fabrication cost and time between FDM and conventional machining methods were compared. This study revealed that Organic Gain food industry was able to reduce the cost and fabrication time for the food holder up to approximately 96.3% and 72% respectively. This project gives an insight into the ability of 3D printing technology in delivering the demands of the industry in producing parts as well as the adaptability of the technology to the industry in new product development. The project was carried out successfully and the 3D printed food holder has been tested and functions smoothly.

scholarly journals Promising Applications of Additive-Manufactured (3D-printed) Electrochemical Sensors for Forensic Chemistry

2021 ◽  
Author(s):  
Sílvia Castro ◽  
Raquel Rocha ◽  
Afonso João ◽  
Eduardo Richter ◽  
Rodrigo Munoz
Keyword(s):  
3D Printing ◽  
Illicit Drugs ◽  
Industrial Revolution ◽  
Electrochemical Sensors ◽  
Forensic Chemistry ◽  
Recent Contribution ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Wide Range ◽  
3D Printed

Additive-manufacturing is one of the major pillars of the new industrial revolution and the three-dimensional (3D) printing technology has been highlighted in this scenario. Among the many areas benefited by 3D-printing, the development of electrochemical sensors has appeared in evidence in the last years. One potential application of 3D-printed electrochemical sensors is devoted to forensic chemistry, which demands for portable analytical methods that can provide on-site measurements and thus bring a relevant information in loco. In this context, this review highlights the recent contribution of 3D-printing technology on the development of electrochemical sensors with great promises for on-site analysis in “real-world” forensic scenarios. From the detection of trace explosives, gunshot residues, illicit drugs and chemical threats, to the measurement of adulterants in food and fuels, we show the wide range of applications that 3D-printed electrochemical sensors have been proposed and future demands that can be addressed by such a powerful, affordable, and accessible tool.

3D Printing Technology in Drug Delivery: Recent Progress and Application

2019 ◽  
Vol 24 (42) ◽  
pp. 5039-5048 ◽  
Author(s):  
Sabna Kotta ◽  
Anroop Nair ◽  
Nimer Alsabeelah
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Pharmaceutical Manufacturing ◽  
Layer By Layer ◽  
Printing Technology ◽  
Drug Dosing ◽  
3D Printing Technology ◽  
3D Printed

Background: 3D printing technology is a new chapter in pharmaceutical manufacturing and has gained vast interest in the recent past as it offers significant advantages over traditional pharmaceutical processes. Advances in technologies can lead to the design of suitable 3D printing device capable of producing formulations with intended drug release. Methods: This review summarizes the applications of 3D printing technology in various drug delivery systems. The applications are well arranged in different sections like uses in personalized drug dosing, complex drugrelease profiles, personalized topical treatment devices, novel dosage forms and drug delivery devices and 3D printed polypills. Results: This niche technology seems to be a transformative tool with more flexibility in pharmaceutical manufacturing. Typically, 3D printing is a layer-by-layer process having the ability to fabricate 3D formulations by depositing the product components by digital control. This additive manufacturing process can provide tailored and individualized dosing for treatment of patients different backgrounds with varied customs and metabolism pattern. In addition, this printing technology has the capacity for dispensing low volumes with accuracy along with accurate spatial control for customized drug delivery. After the FDA approval of first 3D printed tablet Spritam, the 3D printing technology is extensively explored in the arena of drug delivery. Conclusion: There is enormous scope for this promising technology in designing various delivery systems and provides customized patient-compatible formulations with polypills. The future of this technology will rely on its prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve.

scholarly journals Calculating the activation energies of nickel, manufactured using 3D printing technology, with multichannel hydrogen diffusion model

2019 ◽  
Vol 121 ◽  
pp. 04017
Author(s):  
Petr Zumberov ◽  
Sergey Kolesov ◽  
Vladimir Polyansky ◽  
Evgeniy Varshavchik
Keyword(s):  
3D Printing ◽  
Hydrogen Diffusion ◽  
Mathematic Model ◽  
Activation Energies ◽  
Modern World ◽  
Printing Technology ◽  
High Entropy ◽  
3D Printing Technology ◽  
3D Printed ◽  
Vacuum Heating

In modern world more and more materials with extreme properties are being used: high alloys, high-entropy alloys, nanostructured materials, etc. The extreme properties of these materials make them especially sensitive to hydrogen diffusion. Hydrogen can severely impair their properties and cause failures in structures and machines the material is used in. Nowadays, when structures and components are becoming increasingly complex, the use of 3D printing technology is becoming more widespread. Components made using 3D printing technologies are usually layered, which increase the amount of hydrogen that can diffuse into the material. The amount of hydrogen concentration in 3D printed nickel samples has been determined using vacuum heating method in hydrogen analyzer AV-1. The samples were held at different constant temperatures and the total amount of hydrogen extracted at those temperatures was calculated. A mathematic model was developed to evaluate the amount of hydrogen extracted at a given temperature. The evaluation was then compared to the experiment results, and the validity of the mathematical model and the selected hydrogen activation energies was verified.

scholarly journals Investigation of the Anisotropic Characteristics of Layered Rocks under Uniaxial Compression Based on the 3D Printing Technology and the Combined Finite-Discrete Element Method

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Fan He ◽  
Quansheng Liu ◽  
Penghai Deng
Keyword(s):  
3D Printing ◽  
Discrete Element Method ◽  
Numerical Models ◽  
Discrete Element ◽  
Printing Technology ◽  
3D Printing Technology ◽  
Transverse Isotropic ◽  
3D Printed ◽  
Inclined Angle ◽  
Element Method

The excavation in layered rocks is an issue for a number of geoengineering applications; these kinds of rocks all exhibit transverse isotropic features due to the process of metamorphic differentiation. This paper focuses on providing two methods, i.e., the 3D printing technology and the combined finite-discrete element method, to simulate the anisotropic characteristics of layered rocks. The results showed that both the 3D-printed samples and the FDEM numerical models are considered as a good match, and both revealed that as the inclined angle increased, the UCS of the sample first decreased and then increased, showing a U-shaped pattern. The results of this paper served as a reference to the promotion of the 3D printing technology and the combined finite-discrete element method in the geotechnical engineering field and laboratory test research.

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