scholarly journals Potentially Inappropriate Medication Use in Older Hospitalized Patients with Type 2 Diabetes: A Cross-Sectional Study

Pharmacy ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 219
Author(s):  
Rishabh Sharma ◽  
Manik Chhabra ◽  
Kota Vidyasagar ◽  
Muhammed Rashid ◽  
Daniela Fialova ◽  
...  

Background: Older patients with type 2 diabetes mellitus (T2DM) are at greater risk of receiving potentially inappropriate medications (PIM) during hospitalization which may result in adverse outcomes. Aim: To evaluate the extent of PIM use in the older population with T2DM during hospitalization in a tertiary care hospital in India. Methods: A cross-sectional study was carried out from August 2019 to January 2020 in a tertiary care teaching hospital among the older population (aged ≥ 65 years) hospitalized with T2DM. Medications prescribed during hospitalization were reviewed following Beers Criteria 2019 to identify the extent of polypharmacy and PIM use. Binary logistic regression was applied to determine the factors associated with PIM use. Results: The mean age of the 150 patients hospitalized with T2DM was 68.85 ± 5.51 years, most of whom were men (54.7%). The participants had at least four comorbidities and were receiving an average of nine medications per day; the median length of hospital stay was 8 days (interquartile range (IQR): 4–19 days). Overall, three quarters (74%) of the participants had at least one PIM prescribed during their hospitalization as per Beers Criteria. Significant factors associated with the use of PIM during hospitalization are patients taking a higher number of medications (odds ratio (OR): 7.85, 95% CI 1.49–41.10), lower creatinine clearance values (OR: 12.90, 95% CI 2.81–59.28) and female patients (OR: 2.29; 95% CI: 1.05–4.97). Conclusions: PIM use is frequently observed in older T2DM patients during hospitalization. Polypharmacy, reduced renal function and female gender are associated with higher PIM use. Engaging clinical pharmacists in evaluating medication appropriateness can improve the outcomes of older patients.

2018 ◽  
Vol 19 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Ayumi Kaji ◽  
Yoshitaka Hashimoto ◽  
Yukiko Kobayashi ◽  
Ryosuke Sakai ◽  
Takuro Okamura ◽  
...  

2020 ◽  
Vol 9 (36) ◽  
pp. 2630-2635
Author(s):  
Aaliya Rukhsar Mohammad Ashfaque ◽  
Najnin Khanam ◽  
Farhan Khan ◽  
Rutuj Narendra Waghmare ◽  
Shobha Kanhaiyalal Joshi

2013 ◽  
Vol 22 (13-14) ◽  
pp. 1926-1932 ◽  
Author(s):  
Jui-Chu Huang ◽  
Yun-Shing Peng ◽  
Jun-Yu Fan ◽  
Sui-Whi Jane ◽  
Liang-Tse Tu ◽  
...  

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e111849 ◽  
Author(s):  
Sinna P. Ulrichsen ◽  
Anil Mor ◽  
Elisabeth Svensson ◽  
Finn B. Larsen ◽  
Reimar W. Thomsen

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e040532
Author(s):  
Xueyu Li ◽  
Kaushik Chattopadhyay ◽  
Shengnan Xu ◽  
Yanshu Chen ◽  
Miao Xu ◽  
...  

ObjectivesTo determine the prevalence of comorbidities in patients with type 2 diabetes mellitus (T2DM) and identify the factors independently associated with comorbidities in a tertiary care department in Ningbo, China.DesignA computerised medical records database was used to conduct a cross-sectional study.SettingThe study was conducted in a tertiary care department in Ningbo, China.ParticipantsThe study was conducted on adult patients with T2DM, and it included 8 years of data, from 1 January 2012 to 31 December 2019.The primary outcome measureComorbidity was defined as the coexistence of at least one other chronic condition, that is, either a physical non-communicable disease (duration ≥3 months), a mental health condition (duration ≥3 months) or an infectious disease (duration ≥3 months).ResultsIn total, 4777 patients with T2DM satisfied the eligibility criteria. Over 8 years, the prevalence of comorbidities was 93.7%. The odds of comorbidities increased with the age of patients (18 to 39 years: 1; 40 to 59 years: OR 2.80, 95% CI 1.98 to 3.96; 60 to 69 years: OR 4.43, 95% CI 3.04 to 6.44; and ≥70 years: OR 10.97, 95% CI 7.17 to 16.77). The odds were lower in female patients (OR 0.66, 95% CI 0.51 to 0.84), patients residing in rural areas (OR 0.75, 95% CI 0.59 to 0.95) and patients without health insurance (OR 0.62, 95% CI 0.46 to 0.83). The odds were higher in single/divorced/widowed patients compared with those in married patients (OR 1.95, 95% CI 1.21 to 3.12).ConclusionsA large percentage of patients with T2DM in the tertiary care department in Ningbo, China, had comorbidities, and the factors associated with comorbidities were identified. The findings could be used in developing, evaluating and implementing interventions aimed at improving outcomes in patients with T2DM with comorbidities.


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