Antibacterial Nanocomposites Based on Thermosetting Polymers Derived from Vegetable Oils and Metal Oxide Nanoparticles

Thermosetting polymers derived from vegetable oils (VOs) exhibit a wide range of outstanding properties that make them suitable for coatings, paints, adhesives, food packaging, and other industrial appliances. In addition, some of them show remarkable antimicrobial activity. Nonetheless, the antibacterial properties of these materials can be significantly improved via incorporation of very small amounts of metal oxide nanoparticles (MO-NPs) such as TiO2, ZnO, CuO, or Fe3O4. The antimicrobial efficiency of these NPs correlates with their structural properties like size, shape, and mainly on their concentration and degree of functionalization. Owing to their nanoscale dimensions, high specific surface area and tailorable surface chemistry, MO-NPs can discriminate bacterial cells from mammalian ones, offering long-term antibacterial action. MO-NPs provoke bacterial toxicity through generation of reactive oxygen species (ROS) that can target physical structures, metabolic paths, as well as DNA synthesis, thereby leading to cell decease. Furthermore, other modes of action—including lipid peroxidation, cell membrane lysis, redox reactions at the NP–cell interface, bacterial phagocytosis, etc.—have been reported. In this work, a brief description of current literature on the antimicrobial effect of VO-based thermosetting polymers incorporating MO-NPs is provided. Specifically, the preparation of the nanocomposites, their morphology, and antibacterial properties are comparatively discussed. A critical analysis of the current state-of-art on these nanomaterials improves our understanding to overcome antibiotic resistance and offers alternatives to struggle bacterial infections in public places.

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A comparison of the radiosensitisation ability of 22 different element metal oxide nanoparticles using clinical megavoltage X-rays

Cancer Nanotechnology ◽

10.1186/s12645-019-0057-9 ◽

2019 ◽

Vol 10 (1) ◽

Cited By ~ 1

Author(s):

Alexandra Guerreiro ◽

Nicholas Chatterton ◽

Eleanor M. Crabb ◽

Jon P. Golding

Keyword(s):

Dna Damage ◽

Metal Oxide ◽

Hydroxyl Radical ◽

Singlet Oxygen ◽

Hydroxyl Radicals ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

X Rays ◽

X Ray ◽

Wide Range

Abstract Background A wide range of nanoparticles (NPs), composed of different elements and their compounds, are being developed by several groups as possible radiosensitisers, with some already in clinical trials. However, no systematic experimental survey of the clinical X-ray radiosensitising potential of different element nanoparticles has been made. Here, we directly compare the irradiation-induced (10 Gy of 6-MV X-ray photon) production of hydroxyl radicals, superoxide anion radicals and singlet oxygen in aqueous solutions of the following metal oxide nanoparticles: Al2O3, SiO2, Sc2O3, TiO2, V2O5, Cr2O3, MnO2, Fe3O4, CoO, NiO, CuO, ZnO, ZrO2, MoO3, Nd2O3, Sm2O3, Eu2O3, Gd2O3, Tb4O7, Dy2O3, Er2O3 and HfO2. We also examine DNA damage due to these NPs in unirradiated and irradiated conditions. Results Without any X-rays, several NPs produced more radicals than water alone. Thus, V2O5 NPs produced around 5-times more hydroxyl radicals and superoxide radicals. MnO2 NPs produced around 10-times more superoxide anions and Tb4O7 produced around 3-times more singlet oxygen. Lanthanides produce fewer hydroxyl radicals than water. Following irradiation, V2O5 NPs produced nearly 10-times more hydroxyl radicals than water. Changes in radical concentrations were determined by subtracting unirradiated values from irradiated values. These were then compared with irradiation-induced changes in water only. Irradiation-specific increases in hydroxyl radical were seen with most NPs, but these were only significantly above the values of water for V2O5, while the Lanthanides showed irradiation-specific decreases in hydroxyl radical, compared to water. Only TiO2 showed a trend of irradiation-specific increase in superoxides, while V2O5, MnO2, CoO, CuO, MoO3 and Tb4O7 all demonstrated significant irradiation-specific decreases in superoxide, compared to water. No irradiation-specific increases in singlet oxygen were seen, but V2O5, NiO, CuO, MoO3 and the lanthanides demonstrated irradiation-specific decreases in singlet oxygen, compared to water. MoO3 and CuO produced DNA damage in the absence of radiation, while the highest irradiation-specific DNA damage was observed with CuO. In contrast, MnO2, Fe3O4 and CoO were slightly protective against irradiation-induced DNA damage. Conclusions Beyond identifying promising metal oxide NP radiosensitisers and radioprotectors, our broad comparisons reveal unexpected differences that suggest the surface chemistry of NP radiosensitisers is an important criterion for their success.

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Biosynthesis of Metal and Metal Oxide Nanoparticles for Food Packaging and Preservation: A Green Expertise

Food Biosynthesis ◽

10.1016/b978-0-12-811372-1.00010-5 ◽

2017 ◽

pp. 293-316 ◽

Cited By ~ 2

Author(s):

V.N. Kalpana ◽

V. Devi Rajeswari

Keyword(s):

Metal Oxide ◽

Food Packaging ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles

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A comparison of conventional methods for the quantification of bacterial cells after exposure to metal oxide nanoparticles

BMC Microbiology ◽

10.1186/s12866-014-0222-6 ◽

2014 ◽

Vol 14 (1) ◽

Cited By ~ 33

Author(s):

Hongmiao Pan ◽

Yongbin Zhang ◽

Gui-Xin He ◽

Namrata Katagori ◽

Huizhong Chen

Keyword(s):

Metal Oxide ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Bacterial Cells ◽

Conventional Methods

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Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics

International Journal of Molecular Sciences ◽

10.3390/ijms22179596 ◽

2021 ◽

Vol 22 (17) ◽

pp. 9596

Author(s):

Harshada Kotrange ◽

Agnieszka Najda ◽

Aarti Bains ◽

Robert Gruszecki ◽

Prince Chawla ◽

...

Keyword(s):

Metal Oxide ◽

Metal Nanoparticles ◽

Bacterial Resistance ◽

Metal Oxide Nanoparticles ◽

Antibacterial Properties ◽

Metal Oxide Nanoparticle ◽

Wide Range ◽

Direct Delivery ◽

Oxide Nanoparticle ◽

Antibiotic Delivery

In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioactive components. As a consequence of their ability to inhibit the growth of bacteria, nanoparticles have been shown to have significant antibacterial, antifungal, antiviral, and antiparasitic efficacy in the battle against antibiotic resistance in microorganisms. As a result, this study covers bacterial tolerance to antibiotics, the antibacterial properties of various metal nanoparticles, their mechanisms, and the use of various metal and metal oxide nanoparticles as novel antibiotic carriers for direct antibiotic delivery.

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Antibacterial Properties of Aqueous Colloid Solutions of Metal and Metal Oxide Nanoparticles against Dental Plaque Bacteria

Nanotechnologies in Russia ◽

10.1134/s1995078018020040 ◽

2018 ◽

Vol 13 (3-4) ◽

pp. 195-198 ◽

Cited By ~ 4

Author(s):

V. K. Leont’ev ◽

I. P. Pogorel’skii ◽

G. A. Frolov ◽

Ya. N. Karasenkov ◽

A. A. Gusev ◽

...

Keyword(s):

Metal Oxide ◽

Dental Plaque ◽

Metal Oxide Nanoparticles ◽

Antibacterial Properties ◽

Oxide Nanoparticles

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Metal oxide nanoparticles for safe active and intelligent food packaging

Trends in Food Science & Technology ◽

10.1016/j.tifs.2021.08.019 ◽

2021 ◽

Author(s):

Maria Vesna Nikolic ◽

Zorka Z. Vasiljevic ◽

Sandrine Auger ◽

Jasmina Vidic

Keyword(s):

Metal Oxide ◽

Food Packaging ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles

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Bio-Mediated Synthesis of Nanomaterials for Packaging Applications

Materials Research Foundations - Bioinspired Nanomaterials ◽

10.21741/9781644901571-4 ◽

2021 ◽

pp. 96-117

Keyword(s):

Thermal Stability ◽

Metal Oxide ◽

Food Packaging ◽

Metal Oxide Nanoparticles ◽

Antimicrobial Properties ◽

Oxide Nanoparticles ◽

Packaging Materials ◽

New Variety ◽

Metal Metal ◽

Mechanical Tensile

Change in lifestyle of humans in this present generation with huge dependence on packaging materials has encouraged several studies on development of new variety of packaging materials. Emphasis on replacement of existing non-biodegradable packaging materials with biodegradable materials paved the way for the use of biopolymers. Lack of properties, such as thermal stability and mechanical strength in biopolymers led to the development of biopolymer nanocomposites by adding metal/metal oxide nanoparticles as fillers into the biopolymers. Metal/metal oxide nanoparticles improve mechanical/tensile strength, thermal stability as well as antimicrobial properties of the binding and receiving polymer matrix. Bio-mediated synthesis of metal/metal oxide nanoparticles result in the development of novel packaging materials at a low cost and without releasing hazardous wastes into the environments. Novel packaging materials with metal/metal oxide nanoparticles as additives are capable of increasing the shelf life of food, in certain cases they act as indicators of quality food inside the package. Summarily, this present chapter focuses on bio-mediated synthesis of various metal/metal oxide nanoparticles and their applications in food packaging.

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Antibacterial Metal Oxide Nanoparticles: Challenges in Interpreting the Literature

Current Pharmaceutical Design ◽

10.2174/1381612824666180219130659 ◽

2018 ◽

Vol 24 (8) ◽

pp. 896-903 ◽

Cited By ~ 27

Author(s):

Usha Kadiyala ◽

Nicholas A. Kotov ◽

J. Scott VanEpps

Keyword(s):

Metal Oxide ◽

Metal Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Bacterial Strains ◽

Assessment Protocol ◽

Global Issue ◽

Wide Range ◽

Experimental Variability ◽

In Vitro Assessment

Metal oxide nanoparticles (MO-NPs) are known to effectively inhibit the growth of a wide range of Gram-positive and Gram-negative bacteria. They have emerged as promising candidates to challenge the rising global issue of antimicrobial resistance. However, a comprehensive understanding of their mechanism of action and identifying the most promising NP materials for future clinical translation remain a major challenge due to variations in NP preparation and testing methods. With various types of MO-NPs being rapidly developed, a robust, standardized, in vitro assessment protocol for evaluating the antibacterial potency and efficiency of these NPs is needed. Calculating the number of NPs that actively interact with each bacterial cell is critical for assessing the dose response for toxicity. Here we discuss methods to evaluate MO-NPs antibacterial efficiency with focus on issues related to NPs in these assays. We also highlight sources of experimental variability including NP preparation, initial bacterial concentration, bacterial strains tested, culture microenvironment, and reported dose.

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