scholarly journals Metal and Metal Oxide Nanoparticle as a Novel Antibiotic Carrier for the Direct Delivery of Antibiotics

2021 ◽  
Vol 22 (17) ◽  
pp. 9596
Author(s):  
Harshada Kotrange ◽  
Agnieszka Najda ◽  
Aarti Bains ◽  
Robert Gruszecki ◽  
Prince Chawla ◽  
...  
Keyword(s):  
Metal Oxide ◽  
Metal Nanoparticles ◽  
Bacterial Resistance ◽  
Metal Oxide Nanoparticles ◽  
Antibacterial Properties ◽  
Metal Oxide Nanoparticle ◽  
Wide Range ◽  
Direct Delivery ◽  
Oxide Nanoparticle ◽  
Antibiotic Delivery

In addition to the benefits, increasing the constant need for antibiotics has resulted in the development of antibiotic bacterial resistance over time. Antibiotic tolerance mainly evolves in these bacteria through efflux pumps and biofilms. Leading to its modern and profitable uses, emerging nanotechnology is a significant field of research that is considered as the most important scientific breakthrough in recent years. Metal nanoparticles as nanocarriers are currently attracting a lot of interest from scientists, because of their wide range of applications and higher compatibility with bioactive components. As a consequence of their ability to inhibit the growth of bacteria, nanoparticles have been shown to have significant antibacterial, antifungal, antiviral, and antiparasitic efficacy in the battle against antibiotic resistance in microorganisms. As a result, this study covers bacterial tolerance to antibiotics, the antibacterial properties of various metal nanoparticles, their mechanisms, and the use of various metal and metal oxide nanoparticles as novel antibiotic carriers for direct antibiotic delivery.

scholarly journals Photoinduced electron transfer from semiconductor quantum dots to metal oxide nanoparticles

2010 ◽  
Vol 108 (1) ◽  
pp. 29-34 ◽  
Author(s):  
Kevin Tvrdy ◽  
Pavel A. Frantsuzov ◽  
Prashant V. Kamat
Keyword(s):  
Electron Transfer ◽  
Quantum Dot ◽  
Metal Oxide ◽  
Transfer Rate ◽  
Metal Oxide Nanoparticles ◽  
Strong Dependence ◽  
Hot Electron ◽  
Electron Transfer Rate ◽  
Metal Oxide Nanoparticle ◽  
Oxide Nanoparticle

Quantum dot-metal oxide junctions are an integral part of next-generation solar cells, light emitting diodes, and nanostructured electronic arrays. Here we present a comprehensive examination of electron transfer at these junctions, using a series of CdSe quantum dot donors (sizes 2.8, 3.3, 4.0, and 4.2 nm in diameter) and metal oxide nanoparticle acceptors (SnO2, TiO2, and ZnO). Apparent electron transfer rate constants showed strong dependence on change in system free energy, exhibiting a sharp rise at small driving forces followed by a modest rise further away from the characteristic reorganization energy. The observed trend mimics the predicted behavior of electron transfer from a single quantum state to a continuum of electron accepting states, such as those present in the conduction band of a metal oxide nanoparticle. In contrast with dye-sensitized metal oxide electron transfer studies, our systems did not exhibit unthermalized hot-electron injection due to relatively large ratios of electron cooling rate to electron transfer rate. To investigate the implications of these findings in photovoltaic cells, quantum dot-metal oxide working electrodes were constructed in an identical fashion to the films used for the electron transfer portion of the study. Interestingly, the films which exhibited the fastest electron transfer rates (SnO2) were not the same as those which showed the highest photocurrent (TiO2). These findings suggest that, in addition to electron transfer at the quantum dot-metal oxide interface, other electron transfer reactions play key roles in the determination of overall device efficiency.

Thermal Properties of Composites Containing Metal Oxide Nanoparticles

2011 ◽  
Vol 694 ◽  
pp. 146-149
Author(s):  
Ji Fen Wang ◽  
Hua Qing Xie ◽  
Zhong Xin ◽  
Yang Li ◽  
Jing Li
Keyword(s):  
Thermal Conductivity ◽  
Metal Oxide ◽  
Phase Change ◽  
Metal Oxide Nanoparticles ◽  
Hot Wire ◽  
Metal Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Latent Heat Capacity ◽  
Transient Short Hot Wire ◽  
Properties Of Composites

We prepared a series of paraffin wax (PW) based phase change composite containing ZnO, Al2O3 and Fe2O3 nanoparticles, respectively. DSC results showed that there is a decrease trend in phase change latent heat capacity (Ls) with an increase of metal oxide nanoparticle loadings. ZnO/PW has higher Ls than those of Fe2O3/PW and Al2O3/PW with same metal oxide nanoparticle loadings. Transient short-hot-wire (SHW) method was used to measure thermal conductivity of these composites. The results showed that nanoparticle addition leads to substantial enhancement in the thermal conductivity of the composites. The highest thermal conductivity of the measured composites is about 0.27 W/(m•K) of Fe2O3/PW with 3.0 wt% nanoparticles and Al2O3/PW with 5.0 wt% nanoparticles at 15 oC, which higher than that of PW by about 30%. The lowest thermal conductivity of composites is that of Al2O3/PW and ZnO/PW with 1.0 wt% nanoparticles at 60 oC, which higher than that of PW by about 7%.

Impact of pH changes on metal oxide nanoparticle behaviour during artificial digestion

2021 ◽  
Author(s):  
Thomas Schneider ◽  
Anna Mittag ◽  
Martin Westermann ◽  
Michael Glei
Keyword(s):  
Metal Oxide ◽  
Digestive Tract ◽  
Ph Value ◽  
Metal Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Ph Changes ◽  
Metal Oxide Nanoparticle ◽  
Artificial Digestion ◽  
Oxide Nanoparticle ◽  
Ingested Nanoparticles

The properties of orally ingested nanoparticles can be influenced by the conditions prevailing in the digestive tract. The influence of the pH value on the fate of metal oxide nanoparticles was demonstrated using a simplified digestion approach.

Controlling metal oxide nanoparticle size and shape with supercritical fluid synthesis

2019 ◽  
Vol 21 (14) ◽  
pp. 3769-3781 ◽  
Author(s):  
Mary Kate Mitchell Lane ◽  
Julie B. Zimmerman
Keyword(s):  
Metal Oxide ◽  
Supercritical Fluid ◽  
Metal Oxide Nanoparticles ◽  
Nanoparticle Synthesis ◽  
Oxide Nanoparticles ◽  
Green Solvents ◽  
Synthetic Route ◽  
Size And Shape ◽  
Metal Oxide Nanoparticle ◽  
Oxide Nanoparticle

Supercritical fluid nanoparticle synthesis (SCF nano synthesis) can robustly and readily control size and shape of metal oxide nanoparticles, while offering a potentially greener synthetic route through the employment of green solvents.

scholarly journals REVIEW OF THE SYNTHESIS, CHARACTERIZATION AND APPLICATION OF ZIRCONIA MIXED METAL OXIDE NANOPARTICLES

2018 ◽  
Vol 6 (8) ◽  
pp. 136-145
Author(s):  
Ayodeji Precious Ayanwale ◽  
Alejandro Donohué Cornejo ◽  
Juan Carlos Cuevas González ◽  
León Francisco Espinosa Cristóbal ◽  
Simón Yobanny Reyes López
Keyword(s):  
Metal Oxide ◽  
Physicochemical Properties ◽  
Metal Oxide Nanoparticles ◽  
Sol Gel ◽  
Synthetic Methods ◽  
Mixed Metal Oxide ◽  
Oxide Nanoparticles ◽  
Mixed Metal ◽  
Metal Oxide Nanoparticle ◽  
Oxide Nanoparticle

There has been different synthetic route used for the synthesis of zirconia mixed metal oxide nanoparticles. The different synthetic methods coupled with other factors like concentration, PH, type of precursor used etc help to synthesize zirconia mixed metal oxide nanoparticles having different physicochemical properties. This paper discusses the different synthetic routes of sol-gel, hydrothermal and coprecipitation method for the formation of zirconia in combination with other metal oxide to form zirconia mixed metal oxide nanoparticles, the physicochemical properties of the synthesized zirconia mixed metal oxide nanoparticle, their characterization and application.

scholarly journals Antibacterial Nanocomposites Based on Thermosetting Polymers Derived from Vegetable Oils and Metal Oxide Nanoparticles

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1790 ◽  
Author(s):  
Ana Maria Diez-Pascual
Keyword(s):  
Metal Oxide ◽  
Vegetable Oils ◽  
Bacterial Infections ◽  
Food Packaging ◽  
Metal Oxide Nanoparticles ◽  
Antibacterial Properties ◽  
Oxide Nanoparticles ◽  
Bacterial Cells ◽  
Thermosetting Polymers ◽  
Wide Range

Thermosetting polymers derived from vegetable oils (VOs) exhibit a wide range of outstanding properties that make them suitable for coatings, paints, adhesives, food packaging, and other industrial appliances. In addition, some of them show remarkable antimicrobial activity. Nonetheless, the antibacterial properties of these materials can be significantly improved via incorporation of very small amounts of metal oxide nanoparticles (MO-NPs) such as TiO2, ZnO, CuO, or Fe3O4. The antimicrobial efficiency of these NPs correlates with their structural properties like size, shape, and mainly on their concentration and degree of functionalization. Owing to their nanoscale dimensions, high specific surface area and tailorable surface chemistry, MO-NPs can discriminate bacterial cells from mammalian ones, offering long-term antibacterial action. MO-NPs provoke bacterial toxicity through generation of reactive oxygen species (ROS) that can target physical structures, metabolic paths, as well as DNA synthesis, thereby leading to cell decease. Furthermore, other modes of action—including lipid peroxidation, cell membrane lysis, redox reactions at the NP–cell interface, bacterial phagocytosis, etc.—have been reported. In this work, a brief description of current literature on the antimicrobial effect of VO-based thermosetting polymers incorporating MO-NPs is provided. Specifically, the preparation of the nanocomposites, their morphology, and antibacterial properties are comparatively discussed. A critical analysis of the current state-of-art on these nanomaterials improves our understanding to overcome antibiotic resistance and offers alternatives to struggle bacterial infections in public places.

An Assessment of Fluorescence- and Absorbance-Based Assays to Study Metal-Oxide Nanoparticle ROS Production and Effects on Bacterial Membranes

Small ◽  
2012 ◽  
Vol 9 (9-10) ◽  
pp. 1753-1764 ◽  
Author(s):  
Allison M. Horst ◽  
Raja Vukanti ◽  
John H. Priester ◽  
Patricia A. Holden
Keyword(s):  
Metal Oxide ◽  
Ros Production ◽  
Bacterial Membranes ◽  
Metal Oxide Nanoparticle ◽  
Oxide Nanoparticle

scholarly journals N-Dopant-Mediated Growth of Metal Oxide Nanoparticles on Carbon Nanotubes

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1882
Author(s):  
Jin Ah Lee ◽  
Won Jun Lee ◽  
Joonwon Lim ◽  
Sang Ouk Kim
Keyword(s):  
Carbon Nanotubes ◽  
Metal Oxide ◽  
Carbon Nanomaterials ◽  
Wide Spectrum ◽  
Metal Oxide Nanoparticles ◽  
Nucleation And Growth ◽  
Oxide Nanoparticles ◽  
Metal Oxide Nanoparticle ◽  
Nucleation Sites ◽  
Direct Growth

Metal oxide nanoparticles supported on heteroatom-doped graphitic surfaces have been pursued for several decades for a wide spectrum of applications. Despite extensive research on functional metal oxide nanoparticle/doped carbon nanomaterial hybrids, the role of the heteroatom dopant in the hybridization process of doped carbon nanomaterials has been overlooked. Here, the direct growth of MnOx and RuOx nanoparticles in nitrogen (N)-doped sites of carbon nanotubes (NCNTs) is presented. The quaternary nitrogen (NQ) sites of CNTs actively participate in the nucleation and growth of the metal nanoparticles. The evenly distributed NQ nucleation sites mediate the generation of uniformly dispersed <10 nm diameter MnOx and RuOx nanoparticles, directly decorated on NCNT surfaces. The electrochemical performance of the resultant hybridized materials was evaluated using cyclic voltammetry. This novel hybridization method using the dopant-mediated nucleation and growth of metal oxides suggests ways that heteroatom dopants can be utilized to optimize the structure, interface and corresponding properties of graphitic carbon-based hybrid materials.

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