scholarly journals Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 977 ◽  
Author(s):  
Yiluo Hu ◽  
Daham Jeong ◽  
Yohan Kim ◽  
Seonmok Kim ◽  
Seunho Jung
Keyword(s):  
Drug Delivery ◽  
Visible Light ◽  
Sinorhizobium Meliloti ◽  
Environmental Changes ◽  
Controlled Drug Delivery ◽  
Attenuated Total Reflection ◽  
Extracellular Polysaccharides ◽  
Rheological Analysis ◽  
Wide Range ◽  
Potential Applications

Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

scholarly journals Excited state dynamics for visible-light sensitization of a photochromic benzil-subsituted phenoxyl-imidazolyl radical

2019 ◽  
Vol 15 ◽  
pp. 2369-2379
Author(s):  
Yoichi Kobayashi ◽  
Yukie Mamiya ◽  
Katsuya Mutoh ◽  
Hikaru Sotome ◽  
Masafumi Koga ◽  
...  
Keyword(s):  
Visible Light ◽  
Rational Design ◽  
Materials Science ◽  
Transient Absorption ◽  
Life Sciences ◽  
Transient Absorption Spectroscopy ◽  
Back Reaction ◽  
Switching Speed ◽  
Wide Range ◽  
Potential Applications

Visible-light sensitized photoswitches have been paid particular attention in the fields of life sciences and materials science because long-wavelength light reduces photodegradation, transmits deep inside of matters, and achieves the selective excitation in condensed systems. Among various photoswitch molecules, the phenoxyl-imidazolyl radical complex (PIC) is a recently developed thermally reversible photochromic molecule whose thermal back reaction can be tuned from tens of nanoseconds to tens of seconds by rational design of the molecular structure. While the wide range of tunability of the switching speed of PIC opened up various potential applications, no photosensitivity to visible light limits its applications. In this study, we synthesized a visible-light sensitized PIC derivative conjugated with a benzil unit. Femtosecond transient absorption spectroscopy revealed that the benzil unit acts as a singlet photosensitizer for PIC by the Dexter-type energy transfer. Visible-light sensitized photochromic reactions of PIC are important for expanding the versatility of potential applications to life sciences and materials science.

scholarly journals Excited State Dynamics for Visible Light Sensitization of Fast Photochromic Phenoxyl-Imidazolyl Radical Complex with Aryl Ketone

2019 ◽  
Author(s):  
Yoichi Kobayashi ◽  
Yukie Mamiya ◽  
Katsuya Mutoh ◽  
Hikaru Sotome ◽  
Masafumi Koga ◽  
...  
Keyword(s):  
Visible Light ◽  
Life Science ◽  
Materials Science ◽  
Transient Absorption ◽  
Transient Absorption Spectroscopy ◽  
Back Reaction ◽  
Switching Speed ◽  
Radical Complex ◽  
Wide Range ◽  
Potential Applications

Visible light sensitized photoswitches have been paid particular attention in the fields of life science and materials science because long-wavelength light reduces photodegradation, transmits deep inside of matters, and achieves the selective excitation in condensed systems.Among various photoswitch molecules, phenoxyl-imidazolyl radical complex (PIC) is a recently developed thermally-reversible photochromic molecule whose thermal back reaction can be tuned from tens of nanoseconds to tens of seconds by rational designs of the molecular structure. While the wide range of tunability of the switching speed of PIC opened up various potential applications, no photosensitivity to visible light limits its applications. In this study, we synthesized a visible light sensitized PIC derivative conjugated with a benzil unit. Femtosecond transient absorption spectroscopy revealed that the benzil unit acts as a singlet photosensitizer for PIC by the Dexter-type energy transfer. Visible light sensitized photochromic reactions of PIC are important for expanding the versatility of potential applications to life science and material science.

Stimulus-cleavable chemistry in the field of controlled drug delivery

2021 ◽  
Author(s):  
Yufei Xue ◽  
Hua Bai ◽  
Bo Peng ◽  
Bin Fang ◽  
Jonathan Baell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Research Areas ◽  
Potential Applications

This review comprehensively summarises stimulus-cleavable linkers from various research areas and their cleavage mechanisms, thus provides an insightful guideline to extend their potential applications to controlled drug release from nanomaterials.

Nanotechnology Derived Nanotools in Biomedical Perspectives: An Update

2018 ◽  
Vol 15 (2) ◽  
pp. 137-146 ◽  
Author(s):  
Akshay Patil ◽  
Vijay Mishra ◽  
Sourav Thakur ◽  
Bushra Riyaz ◽  
Amanjot Kaur ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Web Of Science ◽  
Polymeric Micelles ◽  
Relevant Literature ◽  
Global Market ◽  
Site Specific ◽  
Current Review ◽  
Wide Range ◽  
Potential Applications

Background: In recent years, nanotechnology is gaining more attention of analytical and biomedical researchers. Nanotechnology derived nanotools deal with the nanoscale length size (i.e., 10-9 m). The particles having size below 100 nm displayed improved properties for attaining increased efficacy, better patient compliance, improved biodistribution and site-specific drug delivery. Method: Google, PubMed, Web of Science portals have been searched for potentially relevant literature to get latest developments and updated information related to different aspects of nanotechnology derived nanocarriers including biomedical applications. Results: Available literature demonstrated that nanotechnology-based nanocarriers like liposomes, dendrimers, polymeric micelles, carbon dots, quantum dots, carbon nanotubes, magnetic nanoparticles, silica nanoparticles, silver nanoparticles and gold nanoparticles have enormous potential applications in the pharmaceutical field. The current review focuses on the drug delivery, bioimaging, tissue engineering and therapeutic applications of different nanotools. Besides these, scope and opportunities, as well as the global market scenario of nanotechnology derived nanotools, have also been discussed. The practice of nanotechnology in the arena of medicine will transform the strategies of detection and treatment of a wide range of diseases in the upcoming years.

scholarly journals Fabrication of Flexible pH-Responsive Agarose/Succinoglycan Hydrogels for Controlled Drug Release

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2049
Author(s):  
Yiluo Hu ◽  
Yohan Kim ◽  
Inki Hong ◽  
Moosung Kim ◽  
Seunho Jung
Keyword(s):  
Drug Delivery ◽  
Sinorhizobium Meliloti ◽  
Controlled Drug Release ◽  
Attenuated Total Reflection ◽  
Cytotoxicity Test ◽  
Basic Solution ◽  
Ph Responsive ◽  
X Ray Diffraction ◽  
Natural Biomaterial ◽  
Instrumental Methods

Agarose/succinoglycan hydrogels were prepared as pH-responsive drug delivery systems with significantly improved flexibility, thermostability, and porosity compared to agarose gels alone. Agarose/succinoglycan hydrogels were made using agarose and succinoglycan, a polysaccharide directly isolated from Sinorhizobium meliloti. Mechanical and physical properties of agarose/succinoglycan hydrogels were investigated using various instrumental methods such as rheological measurements, attenuated total reflection–Fourier transform infrared (ATR-FTIR) spectroscopic analysis, X-ray diffraction (XRD), and field-emission scanning electron microscopy (FE-SEM). The results showed that the agarose/succinoglycan hydrogels became flexible and stable network gels with an improved swelling pattern in basic solution compared to the hard and brittle agarose gel alone. In addition, these hydrogels showed a pH-responsive delivery of ciprofloxacin (CPFX), with a cumulative release of ~41% within 35 h at pH 1.2 and complete release at pH 7.4. Agarose/succinoglycan hydrogels also proved to be non-toxic as a result of the cell cytotoxicity test, suggesting that these hydrogels would be a potential natural biomaterial for biomedical applications such as various drug delivery system and cell culture scaffolds.

Synthesis of Chitosan-Gold Nanoparticles for Drug Delivery

2014 ◽  
Vol 896 ◽  
pp. 280-283 ◽  
Author(s):  
Hanani Yazid ◽  
Amirah Mohd Yassin ◽  
Ahmad Zahid Ruslan ◽  
Siti Hajar Alias ◽  
Rohana Adnan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Gold Nanoparticles ◽  
Environmental Remediation ◽  
Gold Salt ◽  
Au Nps ◽  
Chitosan Concentration ◽  
Wide Range ◽  
Potential Applications ◽  
Au Particle Size

Gold nanoparticles (Au NPs) have potential applications in catalysis, drug delivery, sensors and environmental remediation. This wide range application is due to its amenability of synthesis and functionalization, less toxicity and ease of detection. The present work focuses on functionalization of Au NPs with chitosan for further application in biomedical research. Gold nanoparticles (Au NPs) functionalized chitosan were prepared by reducing gold salt solution at various pH medium in the presence of sodium borohydride. The effect of pH and chitosan concentration on the Au particle size and distribution are studied. The results revealed the dependence of Au particle size on the pH of the solution. The smallest Au particle size is found to form in a range of 10.22 ± 2.96 nm at 0.2% chitosan concentration. In this study, we anticipate the Au NPs functionalized chitosan can be used for drug delivery applications.

The use of natural materials in film coating for controlled oral drug release.

2020 ◽  
Vol 27 ◽  
Author(s):  
Phuong Tran ◽  
Thao Tran
Keyword(s):  
Drug Delivery ◽  
Oral Delivery ◽  
Oral Drug Delivery ◽  
Controlled Drug Delivery ◽  
Film Coating ◽  
Oral Drug ◽  
Natural Materials ◽  
Synthetic Materials ◽  
Potential Applications ◽  
Future Utilization

Although synthetic materials have been used in film coating processes for drug delivery for many years, substantial studies on natural materials have also been conducted because of their biodegradable and unique properties. Because of the ability to form and modify films for controlled oral drug delivery, increasing attention has been shown to these materials in the design of film coating systems in recent research. This review aims to provide an overview of natural materials focusing on film coating for oral delivery, specifically in terms of their classification, and their combinations in film coating formulations for adjusting the desired properties for controlled drug delivery. Discussing natural materials and their potential applications in film coating would benefit the optimization of processes and strategies for future utilization.

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