Synthesis of Chitosan-Gold Nanoparticles for Drug Delivery

2014 ◽  
Vol 896 ◽  
pp. 280-283 ◽  
Author(s):  
Hanani Yazid ◽  
Amirah Mohd Yassin ◽  
Ahmad Zahid Ruslan ◽  
Siti Hajar Alias ◽  
Rohana Adnan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Particle Size ◽  
Gold Nanoparticles ◽  
Environmental Remediation ◽  
Gold Salt ◽  
Au Nps ◽  
Chitosan Concentration ◽  
Wide Range ◽  
Potential Applications ◽  
Au Particle Size

Gold nanoparticles (Au NPs) have potential applications in catalysis, drug delivery, sensors and environmental remediation. This wide range application is due to its amenability of synthesis and functionalization, less toxicity and ease of detection. The present work focuses on functionalization of Au NPs with chitosan for further application in biomedical research. Gold nanoparticles (Au NPs) functionalized chitosan were prepared by reducing gold salt solution at various pH medium in the presence of sodium borohydride. The effect of pH and chitosan concentration on the Au particle size and distribution are studied. The results revealed the dependence of Au particle size on the pH of the solution. The smallest Au particle size is found to form in a range of 10.22 ± 2.96 nm at 0.2% chitosan concentration. In this study, we anticipate the Au NPs functionalized chitosan can be used for drug delivery applications.

scholarly journals Continuous citrate‐capped gold nanoparticle synthesis in a two‐phase flow reactor

2021 ◽  
Author(s):  
Spyridon Damilos ◽  
Ioannis Alissandratos ◽  
Luca Panariello ◽  
Anand N. P. Radhakrishnan ◽  
Enhong Cao ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Residence Time ◽  
Flow Reactor ◽  
Phase Flow ◽  
Continuous Manufacturing ◽  
Two Phase ◽  
Process Yield ◽  
Au Nps ◽  
Manufacturing Platform

AbstractA continuous manufacturing platform was developed for the synthesis of aqueous colloidal 10–20 nm gold nanoparticles (Au NPs) in a flow reactor using chloroauric acid, sodium citrate and citric acid at 95 oC and 2.3 bar(a) pressure. The use of a two-phase flow system – using heptane as the continuous phase – prevented fouling on the reactor walls, while improving the residence time distribution. Continuous syntheses for up to 2 h demonstrated its potential application for continuous manufacturing, while live quality control was established using online UV-Vis photospectrometry that monitored the particle size and process yield. The synthesis was stable and reproducible over time for gold precursor concentration above 0.23 mM (after mixing), resulting in average particle size between 12 and 15 nm. A hydrophobic membrane separator provided successful separation of the aqueous and organic phases and collection of colloidal Au NPs in flow. Process yield increased at higher inlet flow rates (from 70 % to almost 100 %), due to lower residence time of the colloidal solution in the separator resulting in less fouling in the PTFE membrane. This study addresses the challenges for the translation of the synthesis from batch to flow and provides tools for the development of a continuous manufacturing platform for gold nanoparticles.Graphical abstract

scholarly journals Preparation of Succinoglycan Hydrogel Coordinated With Fe3+ Ions for Controlled Drug Delivery

Polymers ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 977 ◽  
Author(s):  
Yiluo Hu ◽  
Daham Jeong ◽  
Yohan Kim ◽  
Seonmok Kim ◽  
Seunho Jung
Keyword(s):  
Drug Delivery ◽  
Visible Light ◽  
Sinorhizobium Meliloti ◽  
Environmental Changes ◽  
Controlled Drug Delivery ◽  
Attenuated Total Reflection ◽  
Extracellular Polysaccharides ◽  
Rheological Analysis ◽  
Wide Range ◽  
Potential Applications

Hydrogel materials with a gel-sol conversion due to external environmental changes have potential applications in a wide range of fields, including controlled drug delivery. Succinoglycans are anionic extracellular polysaccharides produced by various bacteria, including Sinorhizobium species, which have diverse applications. In this study, the rheological analysis confirmed that succinoglycan produced by Sinorhizobium meliloti Rm 1021 binds weakly to various metal ions, including Fe2+ cations, to maintain a sol form, and binds strongly to Fe3+ cations to maintain a gel form. The Fe3+-coordinated succinoglycan (Fe3+-SG) hydrogel was analyzed by attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, circular dichroism (CD), and field-emission scanning electron microscopy (FE-SEM). Our results revealed that the Fe3+ cations that coordinated with succinoglycan were converted to Fe2+ by a reducing agent and visible light, promoting a gel-sol conversion. The Fe3+-SG hydrogel was then successfully used for controlled drug delivery based on gel-sol conversion in the presence of reducing agents and visible light. As succinoglycan is nontoxic, it is a potential material for controlled drug delivery.

scholarly journals Functionalization of Gold Nanoparticles by Inorganic Entities

Nanomaterials ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 548 ◽  
Author(s):  
Frédéric Dumur ◽  
Eddy Dumas ◽  
Cédric R. Mayer
Keyword(s):  
Gold Nanoparticles ◽  
Rapid Development ◽  
Gold Surface ◽  
Intrinsic Properties ◽  
Au Nps ◽  
Gold Core ◽  
Inorganic Systems ◽  
Wide Range ◽  
Different Types ◽  
Electron Donating Groups

The great affinity of gold surface for numerous electron-donating groups has largely contributed to the rapid development of functionalized gold nanoparticles (Au-NPs). In the last years, a new subclass of nanocomposite has emerged, based on the association of inorganic molecular entities (IME) with Au-NPs. This highly extended and diversified subclass was promoted by the synergy between the intrinsic properties of the shell and the gold core. This review—divided into four main parts—focuses on an introductory section of the basic notions related to the stabilization of gold nanoparticles and defines in a second part the key role played by the functionalizing agent. Then, we present a wide range of inorganic molecular entities used to prepare these nanocomposites (NCs). In particular, we focus on four different types of inorganic systems, their topologies, and their current applications. Finally, the most recent applications are described before an overview of this new emerging field of research.

scholarly journals Thermal Atomic Layer Deposition of Gold Nanoparticles: Controlled Growth and Size Selection for Photocatalysis

2019 ◽  
Author(s):  
Fatemeh Sadat Minaye Hashemi ◽  
Fabio Grillo ◽  
Vikram Ravikumar ◽  
dominik Benz ◽  
Ankit Shekhar ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Atomic Layer Deposition ◽  
Au Nanoparticles ◽  
Atomic Layer ◽  
Structure Property ◽  
Structure Property Relationships ◽  
Layer Deposition ◽  
Catalytically Active ◽  
Au Particle Size

Gold nanoparticles have been extensively studied for their applications in catalysis. For Au nanoparticles to be catalytically active, controlling the particle size is crucial. Here we present a low temperature (105 °C) thermal atomic layer deposition approach for depositing gold nanoparticles on TiO<sub>2</sub> with controlled size and loading using trimethylphosphino-trimethylgold (III) and two co-reactants (ozone and water) in a fluidized bed reactor. We show that the exposure time of the precursors is a variable that can be used to decouple the Au particle size from the Au loading. Longer exposures of ozone narrow the particle size distribution while longer exposures of water broaden it. By studying the photocatalytic activity of Au/TiO<sub>2</sub> nanocomposites we show how the ability to control particle size and loading independently can be used not only to enhance performance but also to investigate structure-property relationships. This study provides insights into the mechanism underlying formation and evolution of Au nanoparticles via a vapor phase technique which eliminates the shortcomings of conventional liquid-base processes.

scholarly journals The Physical Properties and Applications of Gold Nanoparticles (Au NPs): Review

2021 ◽  
Vol 3 (1) ◽  
pp. 74-86
Author(s):  
Rusul Adnan Al-wardy . ◽  
Saad Khalid Rahi .
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Gold Nanoparticles ◽  
Physical Properties ◽  
Current Work ◽  
Spherical Nanoparticles ◽  
Au Nps ◽  
3 Dimensional ◽  
Nano Rods ◽  
Catalytic Applications

Nanoparticles of gold that for years have been recognized are the concept of an increasingly rising reports number and of promising for electronic, optical, magnetic, biomedical and catalytic applications in century of 21st. Because of Nanoparticles of gold stability, an interest in such research is a reason for performing the current work. There are various types of AuNPs: Zero-dimensional AuNps: quantum dots, spherical nanoparticles. AuNPs as 1-dimensional: nanowires, nano-rods, nano-belts, nanotubes. AuNPs as 2-dimensional: nano-plates of gold, nano-shell and, AuNPs as 3 dimensional: nano tadpoles of gold, nano- dumbbells of gold (AuNDs), AuNPs being spread, for example, nano-dendrites of gold, nano-pods, and nano-stars. Au NPs, in the field of medicine are investigated for several applications include vectors of drug delivery, agents of contrast, and therapy of localized heat, biomarkers of ultra-sensitive and more. AuNPs are very attractive material for biosensor, chemosensory, genosensor and immunosensor production

scholarly journals Shaped femtosecond laser induced photoreduction for highly controllable Au nanoparticles based on localized field enhancement and their SERS applications

Nanophotonics ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 691-702 ◽  
Author(s):  
Chen Li ◽  
Jie Hu ◽  
Lan Jiang ◽  
Chenyang Xu ◽  
Xiaowei Li ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Field Enhancement ◽  
Localized Surface Plasmon ◽  
Silicon Substrates ◽  
Au Nps ◽  
Sers Substrates ◽  
Wide Range ◽  
Resonance Properties ◽  
Surface Enhanced Raman ◽  
Potential Applications

AbstractGold nanoparticles (Au NPs) have a wide range of applications because of their localized surface plasmon resonance properties. Femtosecond laser is considered to be an effective method for preparing Au NPs because of its characteristics of ultrashort irradiation periods and ultrahigh intensities. In this study, a novel method is proposed to produce an Au NP-attached substrate using the spatially and temporally shaped femtosecond laser. Laser-induced periodic surface structures (LIPSS) are designed to obtain the localized optical field enhancement, which leads to the femtosecond laser spatially reshaping, enabling the deposition of Au NPs by photoreduction on silicon substrates. The Au NPs prepared by this method exhibit morphological controllability and chemical stability, especially excellent spatial selectivity and uniformity, resulting in the tunable and stable surface-enhanced Raman scattering (SERS) applications. Also, the temporally shaped femtosecond pulses are introduced to further increase the enhancement factors of the SERS. This method successfully achieves the controllable morphology synthesis and selective deposition of Au NPs on the substrate simultaneously, which provides a promising candidate for SERS substrates fabrication, and holds potential applications in optoelectronics, such as molecular detection and biosensors.

Microwave Accelerated Green Synthesis of Gold Nanoparticles Using Gum Arabic and their Physico-Chemical Properties Assessments

2018 ◽  
Vol 232 (3) ◽  
pp. 325-343 ◽  
Author(s):  
Maryam Eskandari-Nojehdehi ◽  
Hoda Jafarizadeh-Malmiri ◽  
Abbas Jafarizad
Keyword(s):  
Electron Microscopy ◽  
Particle Size ◽  
Gold Nanoparticles ◽  
Exposure Time ◽  
Chemical Properties ◽  
Gum Arabic ◽  
Au Nps ◽  
Synthesis Conditions ◽  
Microwave Exposure ◽  
Physico Chemical

AbstractMicrowave enhanced gold nanoparticles (Au NPs) were synthesized using gum Arabic as both reducing and stabilizing agents. Response surface methodology was applied to study effects of the Au NPs synthesized parameters, namely, microwave exposure time (90–180 s) and the amount of AgNO3solution (1–10 mL) on the mean particle size, mixture solution color and concentration of the synthesized Au NPs. The colloidal solution containing well-dispersed and spherical fabricated Au NPs with mean particle size (22 nm) and maximum concentration (159 ppm) and color (1.12 absorbance unit, a.u.), were obtained at the optimal synthesis conditions, using 8.17 mL of HAuCl4(1 mM) and 2 mL of gum Arabic solution (4% w/v) during microwave exposure time of 180 s. The physico-chemical properties of the synthesized Au NPs at obtained optimum synthesis conditions were characterized by Fourier transform-infrared spectroscopy, UV-Vis spectroscopy, dynamic light scattering, X-ray diffraction, transmission electron microscopy and field emission scanning electron microscopy.

scholarly journals Gold nanoparticles for diagnosis and therapy of oncological diseases

2018 ◽  
pp. 79-85
Author(s):  
P.B. Kurapov ◽  
E.Yu. Bakhtenko
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Targeted Drug Delivery ◽  
High Ratio ◽  
Contrast Enhanced ◽  
Wide Range ◽  
Diagnostic Agents ◽  
Oncological Diseases ◽  
Targeted Drug

Due to chemical stability, low toxicity, and relative simplicity of synthesis/modification techniques, gold nanoparticles (NP) enjoy a wide range of biomedical applications, including in vitro diagnostics, targeted drug delivery, contrast-enhanced radiation therapy, and photothermal therapy. The high ratio of the gold NP surface area to their volume facilitates design of complex nanoplatforms for various therapeutic and diagnostic purposes. Unique electrical and optical properties of gold NP known as surface plasmon resonance assist medical diagnosis. In this work we look at the basic methods for gold NP synthesis and modification, including the so-called green chemistry, talk about the pharmacological aspects of their application and highlight their potential as diagnostic agents. We believe that due to their unique properties, gold-based nanoplatforms for targeted drug delivery and theranostics have indisputable advantages over other nanoparticles.

scholarly journals Comparison of pharmacokinetics and biodistribution of laser-synthesized plasmonic Au and TiN nanoparticles

2021 ◽  
Vol 2058 (1) ◽  
pp. 012004
Author(s):  
Anton A Popov ◽  
Ivan V Zelepukin ◽  
Gleb V Tikhonowski ◽  
Elena A Popova-Kuznecova ◽  
Gleb I Tselikov ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Photoacoustic Imaging ◽  
Plasmonic Nanostructures ◽  
Mice Model ◽  
Au Nps ◽  
Tin Nanoparticles ◽  
Wide Range ◽  
Potential Applications ◽  
20 Nm ◽  
By Products

Abstract Plasmonic nanostructures offer wide range of diagnostic and therapeutic functionalities for biomedical applications. Gold nanoparticles (Au NPs) present one of the most explored nanomaterial in this field, while titanium nitride nanoparticles (TiN NPs) is a new promising nanomaterial with superior plasmonic properties for biomedicine. However conventional chemical techniques for the synthesis of these nanomaterials cannot always match stringent requirements for toxicity levels and surface conditioning. Laser-synthesized Au and TiN NPs offer exceptional purity (no contamination by by-products or ligands) and unusual surface chemistry. Therefore, these NPs present a viable alternative to chemically synthesized counterparts. This work presents comparative analysis of pharmacokinetics and biodistribution of laser-synthesized 20 nm Au and TiN NPs under intravenous administration in mice model. Our data show that Au NPs and bare TiN NPs are rapidly eliminated from the blood circulation and accumulate preferentially in liver and spleen, while coating of TiN NPs by hydrophilic polymer polyethylene glycol (PEG) significantly prolongates blood circulation time and improves delivery of the NPs to tumor. We finally discuss potential applications of laser synthesized Au NPs in SERS, SEIRA and electrocatalysis, while TiN nanoparticles are considered as promising agents for photothermal therapy and photoacoustic imaging.

scholarly journals Glycerol Oxidation over Supported Gold Catalysts: The Combined Effect of Au Particle Size and Basicity of Support

Processes ◽  
2020 ◽  
Vol 8 (9) ◽  
pp. 1016 ◽  
Author(s):  
Ekaterina Pakrieva ◽  
Ekaterina Kolobova ◽  
Dmitrii German ◽  
Marta Stucchi ◽  
Alberto Villa ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Alkaline Earth ◽  
Supported Catalysts ◽  
Combined Effect ◽  
Supported Gold Catalysts ◽  
Au Particle Size ◽  
Supported Gold ◽  
Determining Factor ◽  
Full Conversion

Gold nanoparticles supported on various oxides (CeO2, CeO2/TiO2, MgO, MgO/TiO2, La2O3, La2O3/TiO2) (with 4 wt.% Au loading) were investigated in the liquid (aqueous) phase oxidation of glycerol by molecular oxygen under mild conditions, in the presence of alkaline earth (CaO, SrO and MgO) or alkaline (NaOH) bases. Full conversion and selectivity between 38 and 68% to sodium glycerate were observed on different Au supported catalysts (Au/MgO/TiO2, Au/La2O3/TiO2, Au/CeO2 and Au/CeO2/TiO2). The combined effect of Au particle size and basicity of the support was suggested as the determining factor of the activity. Agglomeration of gold nanoparticles, found after the reaction, led to the deactivation of the catalysts, which prevents the further oxidation of sodium glycerate into sodium tartronate. Promising results were obtained with the use of alkaline earth bases (CaO, SrO, MgO), leading to the formation of free carboxylic acids instead of salts, which are formed in the presence of the more usual base, NaOH.

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