scholarly journals Multifunctional Properties of Binary Polyrhodanine Manganese Ferrite Nanohybrids—From the Energy Converters to Biological Activity

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 2934
Author(s):  
Emilia Zachanowicz ◽  
Magdalena Kulpa-Greszta ◽  
Anna Tomaszewska ◽  
Małgorzata Gazińska ◽  
Monika Marędziak ◽  
...  

The PRHD@MnFe2O4 binary hybrids have shown a potential for applications in the biomedical field. The polymer cover/shell provides sufficient surface protection of magnetic nanoparticles against adverse effects on the biological systems, e.g., it protects against Fenton’s reactions and the generation of highly toxic radicals. The heating ability of the PRHD@MnFe2O4 was measured as a laser optical density (LOD) dependence either for powders as well as nanohybrid dispersions. Dry hybrids exposed to the action of NIR radiation (808 nm) can effectively convert energy into heat that led to the enormous temperature increase ΔT 170 °C (>190 °C). High concentrated colloidal suspensions (5 mg/mL) can generate ΔT of 42 °C (65 °C). Further optimization of the nanohybrids amount and laser parameters provides the possibility of temperature control within a biologically relevant range. Biological interactions of PRHD@MnFe2O4 hybrids were tested using three specific cell lines: macrophages (RAW 264.7), osteosarcoma cells line (UMR-106), and stromal progenitor cells of adipose tissue (ASCs). It was shown that the cell response was strongly dependent on hybrid concentration. Antimicrobial activity of the proposed composites against Escherichia coli and Staphylococcus aureus was confirmed, showing potential in the exploitation of the fabricated materials in this field.

2000 ◽  
Vol 78 (3) ◽  
pp. 243-251 ◽  
Author(s):  
D A Beysens ◽  
G Forgacs ◽  
J A Glazier

Early embryonic development is characterized by spectacular morphogenetic processes such as sorting or spreading of tissues. Analogy between viscoelastic fluids and certain properties of embryonic tissues turned out to be useful in interpreting some aspects of these morphogenetic phenomena. In accordance with the differential adhesion hypothesis, the values of tissue-specific surface tensions have been shown to be consistent with the equilibrium configurations such tissues reach in the course of sorting and spreading. A method to measure tissue surface tension and viscoelastic properties is described. Notions like the Laplace's equation relating surface tension to radii of curvature, or the Kelvin model of viscoelasticity are used to analyze the results of these measurements. The fluid analogy is extended to time-dependent phenomena, in particular, to the analysis of cellular pattern evolution in the course of spreading. On the basis of recent experimental findings, we demonstrate that the kinetics of spreading and nucleation in binary fluids can be analyzed using the same formalism. We illustrate how our results can be used to obtain biologically relevant information on the strength of binding between specific cell adhesion molecules under near physiological conditions. We also suggest a diagnostic application of our method to monitor the metastatic potential of tumors. PACS No.: 03.65Ge


PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e87769 ◽  
Author(s):  
María Claudia Sandoval-Usme ◽  
Adriana Umaña-Pérez ◽  
Borja Guerra ◽  
Orlando Hernández-Perera ◽  
José Manuel García-Castellano ◽  
...  

1985 ◽  
Vol 232 (2) ◽  
pp. 599-603 ◽  
Author(s):  
R O Oreffo ◽  
J A Francis ◽  
J T Triffitt

Retinol and retinoic acid at 20 microM altered cell morphology and inhibited cell proliferation of UMR 106 osteosarcoma cells in culture. No specific cytosolic binding proteins for retinol could be detected.


1989 ◽  
Vol 45 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Eloy A. Ituarte ◽  
Linda R. Halstead ◽  
Akiko Iida-Klein ◽  
Hector G. Ituarte ◽  
Theodore J. Hahn

2020 ◽  
Author(s):  
Jezreel Pantaleón García ◽  
Vikram V. Kulkarni ◽  
Tanner C. Reese ◽  
Shradha Wali ◽  
Saima J. Wase ◽  
...  

AbstractBioactive molecule library screening strategies may empirically identify effective combination therapies. However, without a systems theory to interrogate synergistic responses, the molecular mechanisms underlying favorable drug-drug interactions remain unclear, precluding rational design of combination therapies. Here, we introduce Omics-Based Interaction Framework (OBIF) to reveal molecular drivers of synergy through integration of statistical and biological interactions in supra-additive biological responses. OBIF performs full factorial analysis of feature expression data from single vs. dual factor exposures to identify molecular clusters that reveal synergy-mediating pathways, functions and regulators. As a practical demonstration, OBIF analyzed a therapeutic dyad of immunostimulatory small molecules that induces synergistic protection against influenza A pneumonia. OBIF analysis of transcriptomic and proteomic data identified biologically relevant, unanticipated cooperation between RelA and cJun that we subsequently confirmed to be required for the synergistic antiviral protection. To demonstrate generalizability, OBIF was applied to data from a diverse array of Omics platforms and experimental conditions, successfully identifying the molecular clusters driving their synergistic responses. Hence, OBIF is a phenotype-driven systems model that supports multiplatform exploration of synergy mechanisms.


Endocrinology ◽  
1991 ◽  
Vol 129 (5) ◽  
pp. 2547-2554 ◽  
Author(s):  
A.B. ABOU-SAMRA ◽  
J.D. ZAJAC ◽  
D. SCHIFFER-ALBERTS ◽  
R. SKURAT ◽  
A. KEARNS ◽  
...  

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