scholarly journals Microencapsulation of Purple Cactus Pear Fruit (Opuntia ficus indica) Extract by the Combined Method W/O/W Double Emulsion-Spray Drying and Conventional Spray Drying: A Comparative Study

Processes ◽  
2018 ◽  
Vol 6 (10) ◽  
pp. 189 ◽  
Author(s):  
Keren Toledo-Madrid ◽  
Tzayhrí Gallardo-Velázquez ◽  
Guillermo Osorio-Revilla
Keyword(s):  
Spray Drying ◽  
Desirability Function ◽  
Double Emulsion ◽  
Dry Weight ◽  
Antioxidant Compounds ◽  
Pear Fruit ◽  
Cactus Pear ◽  
Opuntia Ficus Indica ◽  
Globule Size ◽  
Oil In Water

The aim of this study was to microencapsulate an optimized extract of purple cactus pear fruit (Opuntia ficus indica), rich in phenolic compounds (PC), betacyanins (BC), and betaxanthins (BX), with antioxidant capacity (AC), by two methodologies: combined water-in-oil-in water double emulsions-spray drying (W/O/W-SP) and conventional spray drying, studying the effect of spray drying (SP) on PC and AC. Optimal extraction conditions for bioactive compounds were: 52 °C, for 30 min, using aqueous ethanol (40%) as the solvent, with a 0.85 desirability function, obtaining 17.39 ± 0.11 mg GAE/gdw (gallic acid equivalents per gram of dry weight) for PC, 0.35 mg BE/gdw (betanin equivalents per gram of dry weight) for BC, and 0.26 mg IE/gdw (indicaxanthin equivalents per gram of dry weight) for BX. The best combination of temperatures for conventional SP and W/O/W-SP was 160–80 °C obtaining the highest retention and encapsulation efficiencies for PC. For conventional SP, results were: 107% and 100% PC and AC retention efficiencies (RE-PC and RE-AC), respectively, with 97% of PC encapsulation efficiency (EE-PC), meanwhile for the W/O/W-SP results were: 78% and 103% RE-PC and RE-AC, respectively, with 70% of EE-PC. Microcapsules obtained with W/O/W-SP maintained their structure and integrity and showed a considerable reduction in globule size in the reconstituted W/O/W emulsions due to the spray drying stress. Despite having lower EE-PC than conventional SP, spray dried W/O/W emulsions seems to be a promising controlled-delivery vehicle for antioxidant compounds.

Effect of soluble fiber on the physicochemical properties of cactus pear (Opuntia ficus indica) encapsulated using spray drying

2014 ◽  
Vol 23 (3) ◽  
pp. 755-763 ◽  
Author(s):  
Martha Graciela Ruiz-Gutiérrez ◽  
Carlos Abel Amaya-Guerra ◽  
Armando Quintero-Ramos ◽  
Teresita de Jesús Ruiz-Anchondo ◽  
Janeth Alejandra Gutiérrez-Uribe ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Spray Drying ◽  
Soluble Fiber ◽  
Cactus Pear ◽  
Opuntia Ficus Indica

scholarly journals Spray drying microencapsulation of purple cactus pear (Opuntia ficus indica) peel extract and storage stability of bioactive compounds

2020 ◽  
pp. 958 ◽  
Author(s):  
Toledo-Madrid Keren Ileana ◽  
Gallardo-Velázquez Tzayhrí Guadalupe ◽  
Terrazas-Valencia Francisco ◽  
Osorio-Revilla Guillermo Ismael
Keyword(s):  
Spray Drying ◽  
Bioactive Compounds ◽  
Storage Stability ◽  
Waste Product ◽  
Outlet Temperature ◽  
Cactus Pear ◽  
Opuntia Ficus Indica ◽  
Weight Percentage ◽  
Drying Conditions ◽  
Peel Extract

Purple cactus pear (Opuntia ficus indica) is a fruit found in Mexico that is mainly consumed fresh. The fruit has a peel, which is a non-usable by-product that can represent up to 52% of the fruit´s total weight. This peel is rich in phenolic compounds (PC) and betalain pigments (betacyanins (BC) and betaxanthins (BX)), with important antioxidant capacity (AC), making this waste product an interesting source to obtain extracts rich in bioactive compounds that can be utilized by food industry. Since extracts are liable to degradation, they require protection through techniques such as spray drying microencapsulation. Therefore, this study evaluated the retention of bioactive compounds during spray drying microencapsulation of purple cactus pear peel extract using 10, 15, and 20%w (weight percentage) of maltodextrin (MDX) and Gum Arabic (GA) solutions as encapsulating agents, under different drying conditions. Storage stability during 90 days was also studied for powders obtained at the best drying conditions with both encapsulating agents. The best drying conditions were 170-80 °C (inlet-outlet temperature), in which retention efficiencies for MDX were: 95.5 % (PC), 100.5% (BC), 103.5% (BX) using 20%w MDX, and 117.9% (AC) using 15%w MDX; for GA retentions were 92.4% (PC) and 107% (AC) with 20%w GA and 103.4% (BC) and 93.4% (BX) with 10%w GA. Under storage for 90 days at 22-25 °C, 10%w of encapsulating agent protected microcapsules in presence or absence of light, having the advantage of containing higher concentration of bioactive compounds per gram of dry solid.

Application of 32 Full Factorial Design and Desirability Function for Optimizing The Manufacturing Process for Directly Compressible Multi-Functional Co-Processed Excipient

2020 ◽  
Vol 17 (6) ◽  
pp. 523-539
Author(s):  
Jalpa Patel ◽  
Dhaval Mori
Keyword(s):  
Factorial Design ◽  
Spray Drying ◽  
Desirability Function ◽  
Full Factorial Design ◽  
Angle Of Repose ◽  
P Value ◽  
Independent Variables ◽  
Full Factorial ◽  
32 Full Factorial Design ◽  
Response Variables

Background: Developing a new excipient and obtaining its market approval is an expensive, time-consuming and complex process. Compared to that, the co-processing of already approved excipients has emerged as a more attractive option for bringing better characteristic excipients to the market. The application of the Design of Experiments (DoE) approach for developing co-processed excipient can make the entire process cost-effective and rapid. Objective: The aim of the present investigation was to demonstrate the applicability of the DoE approach, especially 32 full factorial design, to develop a multi-functional co-processed excipient for the direct compression of model drug - cefixime trihydrate using spray drying technique. Methods: The preliminary studies proved the significant effect of atomization pressure (X1) and polymer ratio (microcrystalline cellulose: mannitol - X2) on critical product characteristics, so they were selected as independent variables. The angle of repose, Carr’s index, Hausner’s ratio, tensile strength and Kuno’s constant were selected as response variables. Result: The statistical analysis proved a significant effect of both independent variables on all response variables with a significant p-value < 0.05. The desirability function available in Design Expert 11® software was used to prepare and select the optimized batch. The prepared co-processed excipient had better compressibility than individual excipients and their physical mixture and was able to accommodate more than 40 percent drug without compromising the flow property and compressibility. Conclusion: The present investigation successfully proved the applicability of 32 full factorial design as an effective tool for optimizing the spray drying process to prepare a multi-functional co-processed excipient.

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