scholarly journals Low-Cost Benzene Toluene Xylene Measurement Gas System Based on the Mini Chromatographic Cartridge

Sensors ◽  
2020 ◽  
Vol 21 (1) ◽  
pp. 125
Author(s):  
Emiliano Zampetti ◽  
Paolo Papa ◽  
Joshua Avossa ◽  
Andrea Bearzotti ◽  
Catia Balducci ◽  
...  
Keyword(s):  
Detection System ◽  
Low Cost ◽  
Control Unit ◽  
High Sensitivity ◽  
Reliable Technique ◽  
Qualified Personnel ◽  
Gas System ◽  
Benzene Toluene ◽  
Photo Ionization ◽  
Mini Pump

Benzene, toluene and xylene (BTX) are an important part of the volatile organic compounds (VOCs) to be detected and monitored in the air, due to their toxicity towards human health. One of the most reliable technique used in BTX detection is gas chromatography (GC), which presents a high sensitivity. On the other hand, it has important drawbacks, such as high costs, the need for qualified personnel and frequent maintenance. To overcome these drawbacks, this work reports the development of a low cost and portable BTX gas detection system based on a mini chromatographic cartridge, a photo ionization detector (PID), a simple control unit (based on Arduino architecture) and a mini pump. In order to separate the BTX components, we propose the use of a cartridge 80 mm in length, composed of several commercial chromatographic column sections. To test the system performances, we have injected different amounts (from about 0.3 to 5.3 µg) of benzene, toluene and xylene and two of the most frequent possible interferents (ethanol, acetone). Experimental results have shown different retention time values (i.e., 25 ± 0.5 s, 51 ± 1.2 s and 117 ± 4 s, respectively) for benzene, toluene and xylene.

scholarly journals Sliding wire detection system of electric lock screw tool based on motor characteristics

2021 ◽  
Vol 2137 (1) ◽  
pp. 012009
Author(s):  
Ning Zhang ◽  
Yinxin Yan ◽  
Houcheng Yang ◽  
Zhangsi Yu
Keyword(s):  
Real Time ◽  
Detection System ◽  
Low Cost ◽  
High Sensitivity ◽  
High Accuracy ◽  
Normal Operation ◽  
Automatic Assembly ◽  
The Real ◽  
Current Change ◽  
Real Time Detection

Abstract This paper presents a sliding wire detection system of electric screw locking tool based on the characteristics of motor. The system can judge whether the screw has sliding wire through the current change of motor during normal operation, and realize the real-time detection and alarm of sliding wire. The system has the advantages of high sensitivity, low cost and high accuracy. It can be widely used in automatic assembly and other fields.

Study on Green Gas Data Detection System

2013 ◽  
Vol 722 ◽  
pp. 322-327
Author(s):  
Feng Ying Zhang ◽  
Yun Hua Gao
Keyword(s):  
Indoor Air ◽  
Controller Design ◽  
Detection System ◽  
Low Cost ◽  
High Sensitivity ◽  
Data Detection ◽  
Wireless Data ◽  
Wireless Data Transmission ◽  
Pollution Detection ◽  
Treatment Analysis

This paper describes a wireless gas data detection system, based on CC1010 MCU as the core controller design measurement circuit of indoor air quality. IF in the air pollutants such as smokes and doors, TGS gas sensor sensitive to perceived pollutants transferred to the receiving device through the wireless function after CC1010 MCU treatment analysis. The system has the function of wireless data transmission, small size, high sensitivity, good stability, low cost, long life and other advantages of the peripheral circuits required little devices can be widely used in enclosed spaces such as indoor, automobile air pollution detection.

scholarly journals A MEMS-Based Multi-Parameter Integrated Chip and Its Portable System for Water Quality Detection

Micromachines ◽  
2020 ◽  
Vol 11 (1) ◽  
pp. 63 ◽  
Author(s):  
Ziyue Wu ◽  
Jiaqi Wang ◽  
Chao Bian ◽  
Jianhua Tong ◽  
Shanhong Xia
Keyword(s):  
Water Quality ◽  
Copper Ions ◽  
Detection System ◽  
Low Cost ◽  
Temperature Response ◽  
High Sensitivity ◽  
Integrated Sensor ◽  
Quality Detection ◽  
Portable Detection ◽  
Portable System

As an important means to protect water resources, water quality detection is of great social and economic significance. Water quality detection sensors processed by micro-electro-mechanical system (MEMS) technology have the advantages of low-cost, small size, and high sensitivity. In this paper, a multi-parameter water quality detection integrated sensor chip is further studied, and a portable detection system using this chip is developed. Temperature, pH, oxidation-reduction potential (ORP), conductivity and concentration of copper ions (Cu2+) are selected as typical water quality parameters. Experiments of sensor calibrations using this portable detection system were performed in standard solutions. The sensor has a sensitivity of −57.34 mV/pH in pH detection and 5.95 Ω/°C in temperature response. ORP is directly detected by Pt microelectrode on the chip and the relative error is less than 3%. The electrode constant of the sensor is 1.416 cm−1 and the linearity is 0.9995 in conductivity detection. With the gold nanoparticles deposited on the electrode, the detection peak of Cu2+ appears at 280 mV and the sensor shows good linearity to the concentration of Cu2+ in the range of 0–0.6 mg/L. The detection limit of Cu2+ concentration is 2.33 μg/L. Through measurement and calculation, the accuracy of the portable system is within 4%. This portable multi-parameter water quality detection system with the MEMS-based integrated chip shows great potential in the field and fast detection.

PATH-30. RAPID AND LOW-COST LIQUID BIOPSY-BASED METHOD FOR SCREENING AND MONITORING OF GBM BY MASTER REGULATORY GENE MARKERS IN GBM STEM-LIKE CELLS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi121-vi121
Author(s):  
David Tran ◽  
Tianyi Liu ◽  
Son Le
Keyword(s):  
Detection System ◽  
Low Cost ◽  
Regulatory Gene ◽  
False Negative ◽  
High Sensitivity ◽  
Normal Cells ◽  
Gene Markers ◽  
Master Regulators ◽  
Healthy Donors ◽  
Chromosomal Loci

Abstract BACKGROUND Current liquid-based cancer screening relies on massive deep NGS to detect rare cancer-derived genetic materials - a costly method fraught with high false-negative and false-positive rates. We aim to develop a non-NGS-centered, AI-directed liquid-based detection of GBM stem-like cells (GSCs). METHODS Utilizing a robust AI suite, NETZEN, we defined a common master regulatory gene network (MRGN) of the GBM state in GSCs. Since master regulators (MRs) in MRGN are developmentally restricted, their chromosomal loci are accessible in GSCs but not in normal cells. Downstream factors in MRGN are massively overexpressed in GSCs compared to normal cells. Thus, we measured the following in PBMCs from healthy controls spiked with known quantities of GSCs and patients with GBM: 1) accessibility of MR genes using transposase/transposons carrying unique barcodes to be inserted into the MR’s predetermined accessible locations, and 2) expression of downstream factors using nested qRT-PCR. RESULTS We characterized 10 MRs in GSCs with ≥1 promoter region that is hypomethylated and accessible (by ATACseq) in GBM/GSCs per GSE70175-92460 (19 samples) and GSE67633-96088 (14 samples), or hypermethylated and inaccessible in lymphocytes/PBMCs per GSE98837 (6) and GSE74912 (13). Using barcoded transposons, we specifically disrupted 4 MR’s accessible foci only in GSCs, not in PBMCs. We also identified 50 downstream factors with the top 20 having 3 to 5-orders-of-magnitude higher mean expression in GSCs compared to PBMCs (GSE79362-86884, 451 samples). Currently our method has a detection limit of 0.2-1 GSC per 106 PBMCs. Using the first iteration, we detected MRGN of the GBM state in blood samples of 14 of 14 GBM patients before resection, compared to none of 15 healthy donors. CONCLUSIONS Chromosomal accessibility and signal amplification in MRGN of GSCs provide powerful substrates for a non-NGS, low-cost, liquid-based GBM detection system with high sensitivity and specificity. Further testing and optimization are ongoing.

scholarly journals BIOM-14. METHODS FOR SCREENING AND MONITORING BY GBM MASTER REGULATORY GENE MARKERS IN LIQUID BIOPSY

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii4-ii4
Author(s):  
Tianyi Liu ◽  
Son Le ◽  
David Tran
Keyword(s):  
Detection System ◽  
Low Cost ◽  
Regulatory Gene ◽  
False Negative ◽  
High Sensitivity ◽  
Normal Cells ◽  
Gene Markers ◽  
Master Regulators ◽  
Healthy Donors ◽  
Chromosomal Loci

Abstract BACKGROUND Current liquid-based cancer screening relies on massive deep NGS to detect rare cancer cell-derived genetic materials - a costly method fraught with high false-negative and false-positive rates. We aim to develop a non-NGS-centered, AI-directed liquid-based detection of GBM stem-like cells (GSC). METHODS Utilized a robust AI suite, NETZEN, we defined a common master regulatory gene network (MRGN) in GSC. Since master regulators (MR) in MRGN are developmentally restricted, their chromosomal loci are accessible in GSC but not in normal cells. Downstream factors in MRGN are massively overexpressed in GSC compared to normal cells. Thus, we measured 1) accessibility of MR genes using transposase/transposons carrying unique barcodes that can be detected after insertion into the MR’s predetermined accessible locations, and 2) expression of downstream factors using nested qRT-PCR, in PBMC from healthy controls spiked with known quantities of GSC or patients with GBM. RESULTS We characterized 10 MR genes in GSC with ≥1 GC-rich promoter region that is hypomethylated and accessible (ATACseq) in GBM/GSC per GSE70175/92460/52271 (19 samples) and GSE67633/96088 (14 samples), and hypermethylated and inaccessible in lymphocytes/PBMC per GSE98837 (6) and GSE74912 (13), respectively. Using barcoded transposons, we specifically disrupted 4 MR’s accessible regions only in GSC, not in PBMC. We also characterized 50 upregulated downstream factors with the top 20 having 3 to 5-orders-of-magnitude higher mean expression in GSC compared to PBMC (GSE79362/86884, 451 samples). Currently our method has a detection limit of 0.2–1 GSC in 106 PBMC. Using the first iteration, we detected GSC’s MRGN in blood samples of 14/14 GBM patients before resection, compared to in none of 15 healthy donors. CONCLUSIONS Chromosomal accessibility of MR and signal amplification in MRGN of GSC provide powerful substrates for a non-NGS, low-cost, liquid-based GBM detection system with potentially high sensitivity and specificity. Further testing and optimization are ongoing.

scholarly journals FahamecV1:A Low Cost Automated Metaphase Detection System

2017 ◽  
Vol 7 (6) ◽  
pp. 2160-2166
Author(s):  
H. Yilmaz ◽  
M. Kamil Turan
Keyword(s):  
Detection System ◽  
Electronic Control Unit ◽  
Low Cost ◽  
Control Unit ◽  
Chromosome Analysis ◽  
Active Role ◽  
High Accuracy ◽  
True Negative ◽  
Metaphase Stage ◽  
Microscope Stage

In this study, FahamecV1 is introduced and investigated as a low cost and high accuracy solution for metaphase detection. Chromosome analysis is performed at the metaphase stage and high accuracy and automated detection of the metaphase stage plays an active role in decreasing analysis time. FahamecV1 includes an optic microscope, a motorized microscope stage, an electronic control unit, a camera, a computer and a software application. Printing components of the motorized microscope stage (using a 3D printer) is of the main reasons for cost reduction. Operations such as stepper motor calibration, are detection, focusing, scanning, metaphase detection and saving of coordinates into a database are automatically performed. To detect metaphases, a filter named Metafilter is developed and applied. Average scanning time per preparate is 77 sec/cm2. True positive rate is calculated as 95.1%, true negative rate is calculated as 99.0% and accuracy is calculated as 98.8%.

Design on the Amplifier Circuit of Metal-Oxide Semiconductor Gas-Sensitive Sensor

2012 ◽  
Vol 220-223 ◽  
pp. 1939-1942 ◽  
Author(s):  
Xi Feng Liang ◽  
Li Hao Liu
Keyword(s):  
Metal Oxide ◽  
Detection System ◽  
Low Cost ◽  
High Sensitivity ◽  
Metal Oxide Semiconductor ◽  
Oxide Semiconductor ◽  
Gas Detection ◽  
Amplifier Circuit ◽  
Detection Systems ◽  
System A

Metal-oxide semiconductor gas-sensitive sensors have various advantages as the basic devices of gas detection systems, such as high sensitivity, fast responsibility and low cost, etc. They are widely applied to many fields. Amplifier circuit is an important section of gas detection system. A new type of amplifier circuit including a three-stage operational amplifier was designed in the paper which can effectively eliminate the influence of the follow-up circuit on the sensor output. Theory analysis and experimental simulations were performed. The results show that the output voltage signals have a linear relation with the concentrations of the detected gas.

scholarly journals Investigation on Thermal Resistance and Capacitance Characteristics of a Highly Integrated Power Control Unit Module

Electronics ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 958
Author(s):  
Maosheng Zhang ◽  
Yu Bai ◽  
Shu Yang ◽  
Kuang Sheng
Keyword(s):  
Thermal Resistance ◽  
Power Control ◽  
Electric Vehicles ◽  
Low Cost ◽  
Control Unit ◽  
Underlying Mechanism ◽  
Power Converter ◽  
Liquid Cooling ◽  
Integration Density ◽  
Unit Module

With the increasing integration density of power control unit (PCU) modules, more functional power converter units are integrated into a single module for applications in electric vehicles or hybrid electric vehicles (EVs/HEVs). Different types of power dies with different footprints are usually placed closely together. Due to the constraints from the placement of power dies and liquid cooling schemes, heat-flow paths from the junction to coolant are possibly inconsistent for power dies, resulting in different thermal resistance and capacitance (RC) characteristics of power dies. This presents a critical challenge for optimal liquid cooling at a low cost. In this paper, a highly integrated PCU module is developed for application in EVs/HEVs. The underlying mechanism of the inconsistent RC characteristics of power dies for the developed PCU module is revealed by experiments and simulations. It is found that the matching placement design of power dies with a heat sink structure and liquid cooler, as well as a liquid cooling scheme, can alleviate the inconsistent RC characteristics of power dies in highly integrated PCU modules. The findings in this paper provide valuable guidance for the design of highly integrated PCU modules.

scholarly journals Integrating high-performing electrochemical transducers in lateral flow assay

2021 ◽  
Author(s):  
Antonia Perju ◽  
Nongnoot Wongkaew
Keyword(s):  
High Performance ◽  
Point Of Care ◽  
Low Cost ◽  
High Sensitivity ◽  
Lateral Flow ◽  
Analytical Performance ◽  
Label Free ◽  
High Performing ◽  
Lateral Flow Assays ◽  
Electrochemical Transducers

AbstractLateral flow assays (LFAs) are the best-performing and best-known point-of-care tests worldwide. Over the last decade, they have experienced an increasing interest by researchers towards improving their analytical performance while maintaining their robust assay platform. Commercially, visual and optical detection strategies dominate, but it is especially the research on integrating electrochemical (EC) approaches that may have a chance to significantly improve an LFA’s performance that is needed in order to detect analytes reliably at lower concentrations than currently possible. In fact, EC-LFAs offer advantages in terms of quantitative determination, low-cost, high sensitivity, and even simple, label-free strategies. Here, the various configurations of EC-LFAs published are summarized and critically evaluated. In short, most of them rely on applying conventional transducers, e.g., screen-printed electrode, to ensure reliability of the assay, and additional advances are afforded by the beneficial features of nanomaterials. It is predicted that these will be further implemented in EC-LFAs as high-performance transducers. Considering the low cost of point-of-care devices, it becomes even more important to also identify strategies that efficiently integrate nanomaterials into EC-LFAs in a high-throughput manner while maintaining their favorable analytical performance.

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