scholarly journals A Preconception Paternal Fish Oil Diet Prevents Toxicant-Driven New Bronchopulmonary Dysplasia in Neonatal Mice

Toxics ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 7
Author(s):  
Jelonia T. Rumph ◽  
Kayla J. Rayford ◽  
Victoria R. Stephens ◽  
Sharareh Ameli ◽  
Pius N. Nde ◽  
...  
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Fish Oil ◽  
Bronchopulmonary Dysplasia ◽  
Toxicant Exposure ◽  
Placental Dysfunction ◽  
Neonatal Mice ◽  
History Of ◽  
Fish Oil Diet

New bronchopulmonary dysplasia is a developmental lung disease associated with placental dysfunction and impaired alveolarization. Risk factors for new BPD include prematurity, delayed postnatal growth, the dysregulation of epithelial-to-mesenchymal transition (EMT), and parental exposure to toxicants. Our group previously reported that a history of paternal toxicant exposure increased the risk of prematurity and low birth weight in offspring. A history of paternal toxicant exposure also increased the offspring’s risk of new BPD and disease severity was increased in offspring who additionally received a supplemental formula diet, which has also been linked to poor lung development. Risk factors associated with new BPD are well-defined, but it is unclear whether the disease can be prevented. Herein, we assessed whether a paternal fish oil diet could attenuate the development of new BPD in the offspring of toxicant exposed mice, with and without neonatal formula feeding. We investigated the impact of a paternal fish oil diet preconception because we previously reported that this intervention reduces the risk of TCDD associated placental dysfunction, prematurity, and low birth weight. We found that a paternal fish oil diet significantly reduced the risk of new BPD in neonatal mice with a history of paternal toxicant exposure regardless of neonatal diet. Furthermore, our evidence suggests that the protective effects of a paternal fish oil diet are mediated in part by the modulation of small molecules involved in EMT.

scholarly journals Faktor Risiko yang Berhubungan dengan Kejadian Pneumonia pada Balita di Kelurahan Air Tawar Barat Padang

2016 ◽  
Vol 5 (2) ◽  
Author(s):  
Yulia Efni ◽  
Rizanda Machmud ◽  
Dian Pertiwi
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Cigarette Smoke ◽  
Exclusive Breastfeeding ◽  
Case Control Study ◽  
Case Control ◽  
Under Five ◽  
History Of ◽  
Control Study

AbstrakAda beberapa faktor risiko yang meningkatkan angka kejadian pneumonia di negara berkembang yaitu: kurangnya pemberian Air Susu Ibu (ASI) eksklusif, gizi buruk, polusi udara dalam ruangan, Bayi Berat Lahir Rendah (BBLR) dan kurangnya imunisasi campak. Tujuan penelitian ini adalah menentukan faktor risiko yang berhubungan dengan kejadian pneumonia pada balita di Kelurahan Air Tawar Barat, Kota Padang. Penelitian ini menggunakan desain case control study, sampel terdiri dari 27 case dan 27 control. Data dikumpulkan dengan wawancara terpimpin serta melihat data rekam medik dan dianalisis dengan uji chi-square. Hasil penelitian  mendapatkan balita pada kelompok kasus yang tidak mendapatkan ASI eksklusif (81,5%), paparan asap rokok (74,1%), riwayat bayi berat lahir rendah (3,7%), tidak mendapatkan imunisasi campak (40,7%) dan gizi kurang (25,9%). Hasil analisis bivariat menunjukkan terdapat hubungan yang bermakna antara status gizi dengan kejadian pneumonia (p=0,022; OR=9,1; 95%CI=1,034-80,089), sedangkan pemberian ASI eksklusif, paparan asap rokok, riwayat bayi berat lahir rendah dan imunisasi campak tidak terdapat hubungan yang bermakna terhadap pneumonia.Kata kunci: balita, faktor risiko, pneumonia AbstractPneumonia in developing countries are associated to the risk factors such as: lack of exclusive breastfeeding, malnutrition, indoor air pollution, low birth weight and lack of measles vaccinations. The objective of this study was to determine the risk factors associated on the occurrence of pneumonia among the children under five years of age in Air Tawar Barat district, Padang City. This study used case control study  to the 27 cases and 27 control. The data were collected by guided interview and the medical records, than was analyzed by chi-square.test. The results of this study obtanined in the group of cases based on the low exclusive breastfeeding rates (81.5%), exposure to cigarette smoke (74.1%), a history of low birth weight (3.7%), did not get measles vaccinations (40.7%) and malnutrition (25.9%). The result of bivariate analysis shows the significant relationship between nutritional status on the occurrence of pneumonia (p=0.022; OR=9.1; 95% CI=1.034-80.089). The exclusive breastfeeding, exposure to cigarette smoke, a history of low birth weight and measles vaccinations are not significantly related to the occurrence of pneumonia. Keywords: children under five years of age, risk factors, pneumonia

scholarly journals NEONATAL HYPOGLYCEMIA

2018 ◽  
Vol 21 (04) ◽  
pp. 745-749
Author(s):  
Sikandar Ali Bhand ◽  
Farzana Sheikh ◽  
Abdul Rehman Siyal ◽  
Muhammad Akber Nizamani ◽  
Muhammad Saeed
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Family History ◽  
Low Birth Weight ◽  
Gestational Age ◽  
Metabolic Disorder ◽  
Maternal Risk Factors ◽  
Diabetic Mellitus ◽  
Maternal Risk ◽  
History Of

… Objective: To determine the presenting features and assessment of the neonateswith hypoglycemia along with maternal and neonatal risk factors for hypoglycemia. Subjects &methods: All consecutive neonates with hypoglycemia admitted were included in the study.Demographic characteristics of the mothers and their babies, past medical history and illnessesduring pregnancy especially that, of diabetes mellitus and duration, details of the management oflabour and place of delivery, birth asphyxia as well as history of feeding prior to admission. All therisk factors and clinical features were documented. Results: From presenting features neonateswere most common temperature instability 32% of the neonates. Maternal risk factors were asMaternal diabetic mellitus, Intrapartum administration of glucose , Maternal drug uses as: (Betablockers, Oral hypoglycemic agents, Valproate), family history of metabolic disorder and withoutany factors with the percentage 13%, 17%, (15%, 08%, 07%) , 27% and 13% respectively.Neonatal risk factors of the patients were found low birth weight 49%, small gestational age 26%,macrosomia 11%, respiratory distress 32%, sepsis 20%, hypothermia 25%, congenital cardiacabnormalities 4%, endocrine disorder 4%, family history of metabolic disorder 7%, inborn errorsof metabolism 4%, rhesus hemolytic disease 5%, erythroblastosis fetalis 1%, inadequate feeding35% and neonates without factors were 6%. Conclusions: The risk factors associate withneonatal hypoglycemia are, low birth weight, small gestational age, macrodome, respiratorydistress, sepsis, hypothermia and inadequate feeding , and maternal risk factors associate toneonatal hypoglycemia was Eclampsia, Maternal diabetic mellitus, and maternal drug uses

scholarly journals Late hyponatremia: its risk factors in preterm infants and short-term outcome

2021 ◽  
Vol 43 (5) ◽  
pp. 434-443
Author(s):  
Manizheh Gharehbaghi ◽  
Sadollah Yegane Dust ◽  
Elmira Naseri
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Gestational Age ◽  
Short Term ◽  
Term Outcome ◽  
Short Term Outcome ◽  
Osteopenia Of Prematurity

Background. Prematurity is one of the major health problems and common causes of neonatal mortality. One of the complications of premature infants is hyponatremia. The effect of hyponatremia on the prognosis of preterm infants has not been well studied. This study aimed to evaluate infants with late hyponatremia, its risk factors, and prognosis. Methods. This descriptive analytical study reviewed preterm infants (<34 weeks) admitted to Al-Zahra or Children’s Hospital in Tabriz for one year (2019). Neonates diagnosed with hyponatremia after the second week were identified and evaluated for risk factors and short-term outcome. Results. A total of 186 neonates were studied. The mean gestational age of the neonates was 30 weeks (first and third quarters = 29-32 weeks). 101 (54.3%) infants were male. The route of delivery was the cesarean section in 60.7% of cases. Late hyponatremia was present in 50 (26.8 %) infants. Gestational age and birth weight were significantly lower in infants with hyponatremia than in the control group. Multivariate analysis showed that low birth weight, the use of prenatal steroids, and inappropriate weight for gestational age status independently predict the incidence of late hyponatremia. There was a significant relationship between the presence of prolonged late hyponatremia (over 7 days) and bronchopulmonary dysplasia and osteopenia of prematurity. However, no significant association was found between the presence of prolonged late hyponatremia in preterm infants with the length of hospital stay and in-hospital mortality. Conclusion. Based on the findings of this study, low birth weight, prenatal steroid use, and lack of appropriate weight for gestational age were risk factors for late hyponatremia in preterm infants. Prolonged hyponatremia is associated with bronchopulmonary dysplasia and osteopenia of prematurity

scholarly journals Risk factors for non-optimal breastfeeding practices in low birth weight infants

2010 ◽  
Vol 50 (2) ◽  
pp. 86 ◽  
Author(s):  
Ekawaty L Haksari ◽  
Setya Wandita ◽  
Yustivani Yustivani
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Low Birthweight ◽  
Multivariate Logistic Regression Analysis ◽  
Low Birth Weight Infants ◽  
Historical Cohort ◽  
Breastfeeding Practices ◽  
History Of ◽  
Or History

Background Low birth weight infants are ongoing problems sincethey are likely to have high risks of morbidity, mortality andfeeding problems. American Academy of Pediatrics recommendsbreastfeeding practice for infants with low birth weight, yet someproblems have occured.Objective To determine risk factors for non-optimal breastfeedingpractices in low birth weight infants.Methods In this historical cohort study we included mothers with6-month-old infants, single birth with weight of2000-2499 gramsand the pregnancy period of 2:: 34 weeks, and excluded motherswith infants who had a major congenital disorder, labioschizis,labiognatopalatoschizis, or history of admission in NICU. Datawere collected using standard longitudinal surveillance form forbreastfeeding mothers. Analyses were performed using chi-squaretest and logistic regression.Results The percentage of low birth weight infants breastfedoptimally were 42.7%. Working mothers presented the highestrisk for non-optimal breastfeeding. The onset of lactation formore than 6 hours was the second factor (81.8%). The resultsof multivariate logistic regression analysis showed that motherswho worked (RR 2.79; 95% CI 1.84 to 4.23) and onset lactationof more than 6 hours (RR 2.34; 95% CI 1.57 to 3.50) were therisk factors for non-optimal breastfeeding practices in low birthweight infants.Conclusion Mother's working status and onset of lactationfor more than 6 hours were the risk factors for non-optimalbreastfeeding in low birth weight infants.

Risk Factors for Low Birth Weight among Neonates Delivered in Public Health Facilities in Adama town, Oromia Regional State, Ethiopia

2019 ◽  
Author(s):  
Nigusse Obse Nebi ◽  
Tolossa Eticha Chaka ◽  
Tilaye Workineh Abebe ◽  
Ephrem Mannekulih M
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Antenatal Care ◽  
Birth Interval ◽  
World Health ◽  
Bivariate Analysis ◽  
Maternal Risk ◽  
Regional State ◽  
History Of

Abstract Back ground: Low birth weight is the major predictor of prenatal mortality and morbidity world wide. It has been defined by the World Health Organization as weight at birth of less than 2,500 grams irrespective of their age. Rate of low birth weight is still high in developing countries like Ethiopia particularly Oromia regional state where adequate primary health care services for maternal and child health are not universally available to all the populations. It is therefore imperative to identify risk factors for low birth weight in various communities in order to come up with feasible intervention strategies to minimize the problem. Methods: Facility based case-control study design was conducted from June-1/2017 to April-30/2018 on 318 mothers with singleton and full term neonates (108 case to 210 control). Semi structured interviewer administered and pretested questionnaire was used by trained data collectors working in delivery ward. The data were entered and analyzed statistical software. Descriptive and bivariate analysis was done. Result The mean maternal age of all study participants was 26.7 years with [SD of 4.8] with mean age for mothers of cases was 25.5 years and for controls was 27.4 years. In bivariet analysis residency being rural (AOR= 1.95 with 95% CI (1.0-3.48), parity ≥2 (AOR= 3.45 (1.89-6.32), number of antenatal care attendance ˂4 visits (AOR= 0.40(0.218-0.73)), birth interval ˂24 moths (AOR= 2.68 (1.45-4.94), history of hypertension (AOR= 0.39(0.18-0.87) and maternal MUAC ˂21cm (AOR=0.38 (0.159-0.91) were found to be statistically significant. Conclusions Variables that were found to have a statically significant relationship with low birth weight were residency being rural, occupation, parity ≥2 & birth interval ≤24months, number of antenatal care attendance ˂4 visits, history of hypertension and maternal MUAC ˂21cm were found to be statistically significant. Key phrases:- Low bith weight, maternal risk factor

scholarly journals Risk factors for gastroesophageal reflux disease in very low birth weight infants with bronchopulmonary dysplasia

2008 ◽  
Vol 84 (2) ◽  
pp. 154-159 ◽  
Author(s):  
Tha&iacute;s B. Mendes ◽  
Maria Aparecida M.S. Mezzacappa ◽  
Adyléia A. D. C. Toro ◽  
José Dirceu Ribeiro
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Gastroesophageal Reflux Disease ◽  
Low Birth Weight ◽  
Gastroesophageal Reflux ◽  
Bronchopulmonary Dysplasia ◽  
Reflux Disease ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants

scholarly journals Risk Factors of Pneumonia in Children– A Community Survey

1970 ◽  
Vol 20 (2) ◽  
pp. 122-126
Author(s):  
MI Bari ◽  
AB Siddiqui ◽  
T Alam ◽  
A Hossain
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Severe Pneumonia ◽  
Smoking Habits ◽  
Living Room ◽  
Recurrent Attack ◽  
Paternal Education ◽  
Male Preponderance ◽  
History Of

Pneumonia was the leading common cause of death in young children in Bangladesh. 351 patients of Pneumonia below five years of age were selected as per WHO guidelines. Out of 351 patients, one patient died due to very severe pneumonia that had history of low birth weight and malnutrition. The following factors were taken into consideration such as age, sex, low birth weight, feeding pattern, malnutrition, housing, paternal education, ventilation of living room and smoking habits of parents. It was found that below 2 months of age, severe pneumonia showed 50% and there was male preponderance in all age group and also 41.6% of male children had recurrent attack of pneumonia. Low birth weight and lack of breast feeding patient had suffered more frequently of Pneumonia. In this study, it was statistically proved that malnutrition (p=.00028), inadequate paternal education (p=.00007), bad ventilated living room (p=.00037) and also smoking habits of parents (p=.04054) had significant important risk factors of recurrent attack of Pneumonia in children. doi: 10.3329/taj.v20i2.3072 TAJ 2007; 20(2): 122-126

scholarly journals Literature Review Bayi Berat Lahir Rendah

2017 ◽  
Vol 11 (2) ◽  
pp. 8-14
Author(s):  
Sujianti Sujianti
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Health Status ◽  
Maternal Health ◽  
Low Birth Weight ◽  
Literature Review ◽  
Family Income ◽  
First Semester ◽  
Pregnancy Status ◽  
History Of

Indonesia is one of the developing countries with the highest maternal mortality and infant. The infant mortality cases in 2015 asmany as 33,278 cases decreased compared to the year 2015 of 32,007 and in 2017 in the first semester as many as 10,294 cases.One of the causes is the incidence of Low Birth Weight (LBW) of 38.85%. LBW is the birth weight less than 2,500 grams. The reviewof LBW is done by literature review from DOAJ, Pubmed, Scholar and Garuda portal. The literature search using several keywords is"Low Birth Weight ", "risk factors" with four literature publications from 2007-2017. LBW incidence is influenced from maternaldemography status, maternal health status, condition of pregnancy and baby. The four journals DOAJ, Pubmed, Scholar andGaruda portal described risk factors of LBW occurrence include sociodemography (maternal age <18 years and> 34 years,education level, occupation type, family income, kin), maternal health status obstetric history, parity, birth spacing, anemia, history ofdiabetes, malaria, baby malpresentation history, Premature Rupture Of The Membrane, maternal nutritional status, infections,diseases and complications of pregnancy), status of ANC (frequency and quality of care, health worker, site of pregnancyexamination, history of unchecked pregnancy, irregular ANC).

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