scholarly journals Ptaquiloside and Pterosin B Levels in Mature Green Fronds and Sprouts of Pteridium arachnoideum

Toxins ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 288 ◽  
Author(s):  
Debora da Silva Freitas Ribeiro ◽  
Kelly Moura Keller ◽  
Benito Soto-Blanco
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
High Frequency ◽  
Species Complex ◽  
Rio Grande ◽  
Pteridium Aquilinum ◽  
Rio Grande Do Sul ◽  
The World ◽  
The Mean

Pteridium arachnoideum, a fern of the Pteridium aquilinum species complex found in South America, is responsible for several different syndromes of poisoning. Cases of bovine enzootic hematuria and upper alimentary squamous cell carcinoma are both frequent occurrences in Brazil, whereas only bovine enzootic hematuria is noted with any frequency around the world. The reason for the high frequency of upper alimentary squamous cell carcinoma in Brazil is not currently known. One possible explanation may be the higher levels of ptaquiloside and pterosin B in Brazilian Pteridium than those present in the plant in other countries. However, these levels have not yet been determined in P. arachnoideum. Thus, the present study aimed to measure and compare ptaquiloside and pterosin B levels in mature green fronds and sprouts of P. arachnoideum collected from different locations in Brazil. Samples of P. arachnoideum were collected from the states of Minas Gerais and Rio Grande do Sul. A total of 28 mature leaf samples and 23 sprout samples were used. The mean concentrations of ptaquiloside and pterosin B present in the mature green fronds of P. arachnoideum ranged from 2.49 to 2.75 mg/g and 0.68 to 0.88 mg/g, respectively; in P. arachnoideum sprouts, mean concentrations of ptaquiloside and pterosin B ranged from 12.47 to 18.81 mg/g, and 4.03 to 10.42 mg/g for ptaquiloside and pterosin B, respectively. Thus, ptaquiloside and pterosin B levels in P. arachnoideum samples collected in Brazil were higher in sprouts than in mature green fronds, as observed in other countries. However, there was no variation in ptaquiloside levels among plants collected from different cities in Brazil. The high frequency of upper alimentary squamous cell carcinoma in Brazilian cattle may not be attributed to greater levels of ptaquiloside and pterosin B in P. arachnoideum than in other Pteridium species in other countries.

Epidemiological profile of esophageal cancer at the Joliot Curie Institute in Dakar in 2018

2021 ◽  
Vol 1 (1) ◽  
pp. 24-25
Author(s):  
Mohammed Ezzet Charfi ◽  
Abdoul Halim Bagué ◽  
Awaleh Ahmed Awaleh ◽  
Sidy Ka ◽  
Ahmadou Dem
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adenosquamous Carcinoma ◽  
Young Patients ◽  
The World ◽  
The Mean ◽  
Epidemiological Profile ◽  
Consultation Time

INTRODUCTION: Esophageal cancer is one of the most common cancers in the world affecting males more often than females and with a poor prognosis. The aim of our work was to describe the epidemiology of patients followed for esophageal cancer at the Joliot-Curie Institute in 2018. MATERIALS AND METHODS: This is a descriptive retrospective study including all patients followed at the institute from January 1, 2018 to December 31, 2018 for esophageal cancer with histological evidence. RESULTS: We collected 93 patients referred to the institute for the management of esophageal cancer, 46 women (49.5%) and 47 men (50.5%). The mean age was 49 years with a median age of 50 and extremes of 22 and 84 years. The notion of smoking was found in 24 patients (25.8%) exclusively men (51%), associated in six cases with a notion of alcoholism. The median consultation time was five months. The main circumstance of discovery remains dysphagia (87.1%), followed by aphagia (4.3%) and odynophagia (4.3%). Squamous cell carcinoma is the most represented histological type with 89 patients (95.7%) distributed as follows: 45 women and 44 men. Adenocarcinoma was found in three cases (two men and one woman) and finally one case of adenosquamous carcinoma. CONCLUSION: Squamous cell carcinoma is the most frequent esophagus cancer. It represents the fifth location in our institute and occurs in young patients without gender predominance.

Primary periocular squamous cell carcinoma in central Spain: Factors related to recurrence

2021 ◽  
pp. 112067212110356
Author(s):  
Alicia Galindo-Ferreiro ◽  
Hortensia Sanchez-Tocino ◽  
Cecilia Diez-Montero ◽  
Minal Belani-Raju ◽  
Raquel García-Sanz ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Predictor ◽  
Type Ii ◽  
Central Spain ◽  
Recurrence Rates ◽  
The World ◽  
The Mean

Purpose: To describe the characteristics and recurrence rates of primary periocular squamous cell carcinoma (SCC) in Spain. Methods: This retrospective study investigates the characteristics of primary periocular SCC at two tertiary centers in Spain from 2000 to 2020. Data were collected on demographics, skin phenotype, location, clinical and histological diagnosis, the commitment of surgical margins, recurrence, and risk factors. Multivariate analysis and risk factors were used to investigate recurrence rates, considering p < 0.05 as statistically significant. Results: Over the 20-year studied period, 107 patients with primary periocular SCC were assessed. The mean age of SCC was 76.8 ± 12.8 years, 55 (50.9%) were females, and 105 (98.1%) had Fitzpatrick skin phenotype type II or III. SCC lesions affected less than 1/3 of the eyelid (56/52.3% cases), mainly the lower lid (42/39.3% lesions). Sixty (56.1%) cases were SCC differentiated, 76 (71%) had clear margins. Clinical diagnosis of SCC corroborated with histological in 84 (78.5%) cases and orbital involvement occurred in 18 (16.8%) cases. Recurrence was observed in 13 (12.1%) cases, occurring more in large tumors and undifferentiated subtype (53.8%), with committed margins (69.2%) ( p = 0.001), being the commitment of margins a significant predictor for recurrence, although thickness was an independent predictor. Conclusion: Periocular SCC in Spain showed a similar pattern as in the world. The risk of recurrence is increased in undifferentiated and large periocular SCC, partially removed with committed margins.

Histopathological spectrum of oral cavity lesions – A tertiary care experience

2021 ◽  
Vol 8 (3) ◽  
pp. 364-368
Author(s):  
Ishani Gupta ◽  
Rekha Rani ◽  
Jyotsna Suri
Keyword(s):  
Squamous Cell Carcinoma ◽  
Retrospective Study ◽  
Oral Cancer ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Proper Management ◽  
The World ◽  
One Year

Oral cancer is one of a major health problem in some parts of the world especially in the developing countries. Oral cancer is the sixth most common cancer in the world whereas in India it is one of the most prevalent cancer. Oral cavity lesions are usually asymptomatic. Accurate diagnosis of the lesion is the first step for the proper management of patients and histopathology is considered as the gold standard. The objective is to study the different patterns of oral cavity lesions seen in a tertiary care hospital of Jammu: One year retrospective study. Post graduate department of pathology.: It was a retrospective study carried out in a tertiary care centre for a period of one year from March 2020 to Feb 2021. 148 cases of oral cavity lesions were included in this study. The parameters that were included in the study were sociodemographic data, site of the lesion, clinical features and histological diagnosis. Data collected was analysed.148 cases of oral lesions were identified during the period of study. The age of patients varied from 5 to 78years and Male to Female ratio was 2.2:1. Buccal mucosa (30%) was the most common site involved which was followed by tonsil (19%). Out of 148 cases 70 cases were malignant, 10 cases pre malignant and 21 cases were benign. Squamous cell carcinoma (33.7%) was the most common lesion present in our study. Oral cavity lesions have a vast spectrum of diseases which range from tumour like lesions to benign and malignant tumours. Our study concluded that squamous cell carcinoma was the most common malignant lesion of oral cavity. Histological typing of the lesion is important for confirmation of malignancy and it is essential for the proper management of the patient.

scholarly journals Characteristic and Interplay of Esophageal Microbiota in Esophageal Squamous Cell Carcinoma

2021 ◽  
Author(s):  
Zheng Lin ◽  
Wenqing Rao ◽  
Zhisheng Xiang ◽  
Qiaoyan Zeng ◽  
Shuang Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cancerous Tissue ◽  
Association Analyses ◽  
The World ◽  
Rrna Sequencing ◽  
Functional Pathways

Abstract Background: Esophageal squamous cell carcinoma(ESCC) is severe cancer in the world. The role of esophageal microbiota for ESCC is still uncertain. In the current study, 120 paired tissues from ESCC patients were collected, and 16s rRNA sequencing was performed to explore the esophageal microbiota. Results: The present investigation shows that the diversity and composition of the microbiota in ESCC cancerous tissues and para-cancerous tissues is significantly different, this variation between subjects beta diversity mainly explained by regions and sampling seasons. Species R.Mucilaginosa, P.Endodontalis, unclassified species in genus Leptotrichia, genus Phyllobacterium, and genus Sphingomonas were enriched in cancerous tissue. On the other hand, class Bacilli, N.Subflava, H.Pylori, A.Parahaemolyticus, A.Rhizosphaerae, unclassified species in genus Campylobacter and genus Haemophilus were increased in para-cancerous tissue. Compared with the co-occurrence network in cancerous tissue, a denser and more complex association network was formed in para-cancerous tissue. Moreover, the above differential taxa also participated in both co-occurrence network but played quite different roles. Finally, the functional association analyses revealed the altered signaling pathways in ESCCs were correlated to esophageal microbiota. Conclusion: Compared with para-cancerous tissues, microbiota in cancerous tissues showed significant differences in diversity and composition. The alterations in microbial co-occurrence network and functional pathways in ESCC tissues may be involved in carcinogenesis and the maintenance of local microenvironment for ESCC. These discoveries of the esophageal microbiota for ESCC patients may contribute to the etiology for ESCC prevention, diagnosis, early intervention, and treatment.

scholarly journals Narrow band imaging under less-air condition improves the visibility of superficial esophageal squamous cell carcinoma

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Taro Iwatsubo ◽  
Ryu Ishihara ◽  
Yasushi Yamasaki ◽  
Yusuke Tonai ◽  
Kenta Hamada ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Color Change ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Endoscopic Observation ◽  
Flat Type ◽  
The Mean ◽  
Visibility Score

Abstract Background The current virtual chromoendoscopy equipment cannot completely detect superficial squamous cell carcinoma (SCC) in the esophagus, despite its development in the recent years. Thus, in this study, we aimed to elucidate the appropriate air volume during endoscopic observation to improve the visibility of esophageal SCC. Methods This retrospective study included a total of 101 flat type esophageal SCCs identified between April 2017 and January 2019 at the Department of Gastrointestinal Oncology, Osaka International Cancer Institute. Video images of narrow band imaging (NBI) under both less-air and standard-air conditions were recorded digitally. Videos were evaluated by five endoscopists. Relative visibility between less-air and standard-air conditions of the brownish area, brownish color change of the epithelium, and dilated intrapapillary capillary loop (IPCL) were graded as 5 (definitely better under less-air condition) to 1 (definitely worse under less-air condition), with 3 indicating average visibility (equivalent to standard-air observation). Results The mean (standard deviation) visibility score of the brownish area, brownish color change of the epithelium, and dilated IPCLs under less-air condition were 3.94 (0.58), 3.73 (0.57), and 4.13 (0.60), respectively, which were significantly better than that under standard-air condition (p < 0.0001). Esophageal SCC evaluated as ≥ 4 in the mean visibility score of the brownish area, brownish color change of the epithelium, and dilated IPCLs accounted for 50% (51/101 lesions), 34% (34/101 lesions), and 67% (68/101 lesions), respectively. Conclusions The present results suggested that NBI with less air might improve the visibility of flat type esophageal SCC compared with NBI with standard air. Less-air NBI observation may facilitate the detection of flat type esophageal SCC. Trial registration The present study is a non-intervention trial.

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