scholarly journals Bee Venom Acupuncture Effects on Pain and Its Mechanisms: An Updated Review

Toxins ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 608
Author(s):  
Soo-Hyun Sung ◽  
Gihyun Lee
Keyword(s):  
Inflammatory Pain ◽  
Detrimental Effect ◽  
Acupuncture Point ◽  
Pharmaceutical Compounds ◽  
Bee Venom ◽  
Clinical Use ◽  
Analgesic Effects ◽  
The Past ◽  
Bee Venom Acupuncture ◽  
Acupuncture Effects

Bee venom (BV) is a complex natural toxin that contains various pharmaceutical compounds. Bee venom acupuncture (BVA), involving a BV injection into a certain acupuncture point, has been utilized to relieve a range of pain conditions. Regardless of whether pain is caused by disease or injury, if not effectively treated, pain can exert a detrimental effect on all aspects of life. In the past decade, many researchers have investigated the anti-nociceptive effects of BVA through clinical use and experimental evaluation. This report reviews the existing knowledge on the analgesic effects of BVA, focusing on musculoskeletal pain, inflammatory pain and neuropathic pain, and its analgesic mechanisms. Although further clinical trials are needed to clinical application of experimental results, this review will contribute to the standardization and generalization of BVA.

scholarly journals Clinical Applications of Bee Venom Acupoint Injection

Toxins ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 618
Author(s):  
Ting-Yen Lin ◽  
Ching-Liang Hsieh
Keyword(s):  
Bee Venom ◽  
Cochrane Library ◽  
Clinical Settings ◽  
Disc Disease ◽  
Analgesic Effects ◽  
Bee Venom Acupuncture ◽  
Cord Injury ◽  
Clinical Disorders ◽  
Natural Mixture ◽  
Pharmaceutical Properties

Bee venom is a complex natural mixture with various pharmaceutical properties. Among these properties, its peptides and enzymes have potential medical therapy for pain relief and inflammation. In clinical settings, this therapy has been used widely to treat diseases by injecting into acupoints. In this article, we have conducted various research from PubMed, Cochrane Library, and Clinical Key from inception of July 2020. The results revealed that bee venom therapy has been reported effective in anti-inflammatory, antiapoptosis, and analgesic effects. Moreover, bee venom acupuncture has been commonly used for clinical disorders such as Parkinson disease, neuropathic pain, Alzheimer disease, intervertebral disc disease, spinal cord injury, musculoskeletal pain, arthritis, multiple sclerosis, skin disease and cancer.

scholarly journals Anti-inflammatory effects of the bee venom in experimental arthritis rats

2016 ◽  
Vol 19 (2) ◽  
pp. 64-70
Author(s):  
Mao Van Can ◽  
Hoa Thi Nguyen ◽  
Tho Huu Le ◽  
Nhan Trung Nguyen ◽  
Truong Van Nhat Do ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Inflammatory Pain ◽  
Hind Limb ◽  
Acupuncture Point ◽  
Joint Inflammation ◽  
Bee Venom ◽  
Control Group ◽  
Experimental Animals ◽  
The World ◽  
Anti Inflammatory

Study on anti-inflammatory, pain reduction effects of bee venom have been executed by many scientists in the world. On the experimental animals, bee venom has shown anti-inflammatory capabilities and using bee venom in point accupunture got more efficiency than other methods. Our study conducted on 60 rats divided into 5 groups: control group, arthritis group (with complete adjuvant solution) plus saline treatment, arthritis group plus bee venom treatment (doses: 0.5 mg/kg, 1 mg/kg and 1.5 mg/kg) and arthritis group plus Mobic treatment (1 mg/kg), bee venom and Mobic were administered in zusalin acupuncture point in rat’s hind limb. Results showed: complete adjuvant solution (the only dose of 50 μL injected at rat’s hind limb) induced the joint inflammation, temperature increase, pain in rat’s hind limb, leukocytosis and erythrocyte reduction in peripheral blood. Bee venom (1 mg/kg and 1.5 mg/kg) induced the analgesic effect, temperature reduction in on rat’s hind limb and slight leukocytosis in peripheral blood in 21 days after adjuvant injection. The anti-inflamatory effect of bee venom (1.5 mg/kg) is similar to Mobic (1 mg/kg) on rats.

scholarly journals Long-Lasting and Additive Analgesic Effects of Combined Treatment of Bee Venom Acupuncture and Venlafaxine on Paclitaxel-Induced Allodynia in Mice

Toxins ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 620 ◽  
Author(s):  
Daxian Li ◽  
Ju Hyuk Yoo ◽  
Sun Kwang Kim
Keyword(s):  
Receptor Antagonist ◽  
Combined Treatment ◽  
Bee Venom ◽  
Combination Strategy ◽  
Beneficial Effects ◽  
Analgesic Effects ◽  
Bee Venom Acupuncture ◽  
Solid Malignancies ◽  
Medium Dose ◽  
Clinical Strategy

Paclitaxel, a primary chemotherapeutic agent used to treat numerous solid malignancies, is commonly associated with debilitating peripheral neuropathy. However, a satisfactory gold-standard monotherapy for this neuropathic pain is not currently available. A combination strategy of two or more medications with different properties may achieve more beneficial effects than monotherapy. Thus, we investigated the analgesic efficacies and spinal mechanisms of the combination strategy, including bee venom acupuncture (BVA) and venlafaxine (VLX) against paclitaxel-induced allodynia in mice. Four intraperitoneal infusions of paclitaxel on alternating days (2 mg/kg/day) induced cold and mechanical allodynia for at least 1 week as assessed using acetone and the von Frey hair test, respectively. Co-treatment of BVA (1.0 mg/kg, s.c., ST36) with VLX (40 mg/kg, i.p.) at the medium dose produced a longer-lasting and additive effect than each monotherapy at the highest dose (BVA, 2.5 mg/kg; VLX, 60 mg/kg). Spinal pre-administration of idazoxan (α2-adrenergic receptor antagonist, 10 μg), methysergide (mixed 5-HT1/5-HT2 receptor antagonist, 10 μg), or MDL-72222 (5-HT3 receptor antagonist, 10 μg) abolished this analgesia. These results suggest that the combination therapy with BVA and VLX produces long-lasting and additive analgesic effects on paclitaxel-induced allodynia, via the spinal noradrenergic and serotonergic mechanism, providing a promising clinical strategy.

Click Reactions in Chemistry of Triterpenes - Advances Towards Development of Potential Therapeutics

2018 ◽  
Vol 25 (5) ◽  
pp. 636-658 ◽  
Author(s):  
Jan Pokorny ◽  
Lucie Borkova ◽  
Milan Urban
Keyword(s):  
Biological Activities ◽  
Synthetic Approach ◽  
Clinical Use ◽  
New Approach ◽  
Click Reactions ◽  
Drug Candidates ◽  
The Past ◽  
Low Toxicity ◽  
New Compounds ◽  
Potential Therapeutics

Triterpenoids are natural compounds with a large variety of biological activities such as anticancer, antiviral, antibacterial, antifungal, antiparazitic, antiinflammatory and others. Despite their low toxicity and simple availability from the natural resources, their clinical use is still severely limited by their higher IC50 and worse pharmacological properties than in the currently used therapeutics. This fact encouraged a number of researchers to develop new terpenic derivatives more suitable for the potential clinical use. This review summarizes a new approach to improve both, the activity and ADME-Tox properties by connecting active terpenes to another modifying molecules using click reactions. Within the past few years, this synthetic approach was well explored yielding a lot of great improvements of the parent compounds along with some less successful attempts. A large quantity of the new compounds presented here are superior in both activity and ADME-Tox properties to their parents. This review should serve the researchers who need to promote their hit triterpenic structures towards their clinical use and it is intended as a guide for the chemical synthesis of better drug candidates.

Pupil with Obsessive-Compulsive Disorder

2017 ◽  
Vol 7 (2) ◽  
pp. 7-25
Author(s):  
Karolina Diallo
Keyword(s):  
Obsessive Compulsive Disorder ◽  
School Performance ◽  
School Environment ◽  
Detrimental Effect ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Past ◽  
And Performance ◽  
The Impact

Pupil with Obsessive-Compulsive Disorder. Over the past twenty years childhood OCD has received more attention than any other anxiety disorder that occurs in the childhood. The increasing interest and research in this area have led to increasing number of diagnoses of OCD in children and adolescents, which affects both specialists and teachers. Depending on the severity of symptoms OCD has a detrimental effect upon child's school performance, which can lead almost to the impossibility to concentrate on school and associated duties. This article is devoted to the obsessive-compulsive disorder and its specifics in children, focusing on the impact of this disorder on behaviour, experience and performance of the child in the school environment. It mentions how important is the role of the teacher in whose class the pupil with this diagnosis is and it points out that it is necessary to increase teachers' competence to identify children with OCD symptoms, to take the disease into the account, to adapt the course of teaching and to introduce such measures that could help children reduce the anxiety and maintain (or increase) the school performance within and in accordance with the school regulations and curriculum.

Bee Venom Acupuncture for Musculoskeletal Pain: A Review

2008 ◽  
Vol 9 (4) ◽  
pp. 289-297 ◽  
Author(s):  
Myeong Soo Lee ◽  
Max H. Pittler ◽  
Byung-Cheul Shin ◽  
Jae Cheol Kong ◽  
Edzard Ernst
Keyword(s):  
Musculoskeletal Pain ◽  
Bee Venom ◽  
Bee Venom Acupuncture

scholarly journals Clinical Progress in Proton Radiotherapy: Biological Unknowns

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 604
Author(s):  
Laura Vanderwaeren ◽  
Rüveyda Dok ◽  
Kevin Verstrepen ◽  
Sandra Nuyts
Keyword(s):  
Proton Irradiation ◽  
Current Knowledge ◽  
Clinical Use ◽  
Proton Radiation ◽  
Photon Irradiation ◽  
Normal Tissues ◽  
The Past ◽  
Depth Dose ◽  
Damage Response ◽  
Depth Dose Distribution

Clinical use of proton radiation has massively increased over the past years. The main reason for this is the beneficial depth-dose distribution of protons that allows to reduce toxicity to normal tissues surrounding the tumor. Despite the experience in the clinical use of protons, the radiobiology after proton irradiation compared to photon irradiation remains to be completely elucidated. Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance.

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