scholarly journals A Recurrent Inflammatory Myofibroblastic Tumor-like Lesion of the Splenic Capsule in a Kitten: Clinical, Microscopic and Ultrastructural Description

2021 ◽  
Vol 8 (11) ◽  
pp. 275
Author(s):  
Silvia Ferro ◽  
David Chiavegato ◽  
Piergiorgio Fiorentin ◽  
Valentina Zappulli ◽  
Stefano Di Palma
Keyword(s):  
Clinical Relevance ◽  
Inflammatory Myofibroblastic Tumor ◽  
Clinical Course ◽  
Present Report ◽  
Surgical Excision ◽  
Tumor Treatment ◽  
Splenic Tumor ◽  
Orbital Region ◽  
Over Time

Objective: To describe the findings of an unusual splenic tumor in a kitten. Methods: A grossly multinodular mass arising from the splenic capsule of a 7-month-old male Havana kitten was echographically detected and surgically removed by splenectomy, then analyzed microscopically and ultrastructurally. Results: The mass showed features of an inflammatory myofibroblastic tumor. Treatment and Outcome: Two months after surgical excision, the mass recurred in the same intra-abdominal area but disappeared after 2 months of anti-inflammatory therapy. Follow-up at 18 months after surgery revealed resolution of the disease. Clinical Relevance: Inflammatory myofibroblastic tumor in cats have been rarely reported and are usually in the orbital region. In the present report, an unusual multinodular gross presentation, a recurrence over time, and a favorable clinical course, are described.

Six-year longitudinal course and outcomes of subtypes of depression

2016 ◽  
Vol 208 (1) ◽  
pp. 62-68 ◽  
Author(s):  
F. Lamers ◽  
A. T. F. Beekman ◽  
A. M. van Hemert ◽  
R. A. Schoevers ◽  
B. W. J. H. Penninx
Keyword(s):  
Latent Class ◽  
Clinical Course ◽  
Depression And Anxiety ◽  
Major Depressive ◽  
Longitudinal Course ◽  
Baseline Severity ◽  
Depressive Subtypes ◽  
Depression Subtypes ◽  
Over Time

BackgroundClinical and aetiological heterogeneity have impeded our understanding of depression.AimsTo evaluate differences in psychiatric and somatic course between people with depression subtypes that differed clinically (severity) and aetiologically (melancholic v. atypical).MethodData from baseline, 2-, 4- and 6-year follow-up of The Netherlands Study of Depression and Anxiety were used, and included 600 controls and 648 people with major depressive disorder (subtypes: severe melancholic n = 308; severe atypical n = 167; moderate n = 173, established using latent class analysis).ResultsThose with the moderate subtype had a significantly better psychiatric clinical course than the severe melancholic and atypical subtype groups. Suicidal thoughts and anxiety persisted longer in those with the melancholic subtype. The atypical subtype group continued to have the highest body mass index and highest prevalence of metabolic syndrome during follow-up, although differences between groups became less pronounced over time.ConclusionsCourse trajectories of depressive subtypes mostly ran parallel to each other, with baseline severity being the most important differentiator in course between groups.

Perianal Granular Cell Tumor: Report of a Case and Review of the Literature

2009 ◽  
Vol 95 (4) ◽  
pp. 538-541 ◽  
Author(s):  
Massimiliano Mistrangelo ◽  
Paola Cassoni ◽  
Gitana Scozzari ◽  
Isabella Castellano ◽  
Giorgia Gavello ◽  
...  
Keyword(s):  
Literature Search ◽  
Granular Cell Tumor ◽  
Clinical Course ◽  
Granular Cell ◽  
Surgical Excision ◽  
Cell Tumor ◽  
Pathological Examination ◽  
Perianal Region ◽  
Therapeutic Procedures

Introduction Granular cell tumor was first described by Abrikossoff in 1926. Over the years several cases of this neoplasm have been reported, with a variety of localizations. We here report a case of perianal granular cell tumor and discuss its histogenesis and its relevance to clinical practice. Methods The clinical course and histopathology of the case are reviewed, and a literature search for other reported cases has been performed. Results A 46-year-old woman presented with a perianal nodular lesion. Pathological examination revealed a granular cell tumor. A literature search produced only 25 other cases of anal and perianal granular cell tumors. Conclusions Granular cell tumors are rarely observed in the perianal region. Their existence must always be borne in mind in the differential diagnosis of perianal neoplasms. In most cases surgical excision is curative, but potential malignant transformation must be considered during therapeutic procedures and follow-up.

Baló's disease showing benign clinical course and co-existence with multiple sclerosis-like lesions in Chinese

2008 ◽  
Vol 14 (3) ◽  
pp. 418-424 ◽  
Author(s):  
Chaodong Wang ◽  
Kun-Nan Zhang ◽  
Xiao-Mu Wu ◽  
Gang Huang ◽  
Xu-Fang Xie ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetic Resonance ◽  
Clinical Features ◽  
Clinical Course ◽  
Demyelinating Disorder ◽  
Baló’S Concentric Sclerosis ◽  
Chinese Subjects ◽  
Over Time

Baló's concentric sclerosis (BCS) is a rare demyelinating disorder usually considered a variant of multiple sclerosis (MS). However, its pathogenesis and its correlation with MS remains unclear and controversial. This report presents seven Hans Chinese subjects diagnosed as BCS on the basis of the pathognomonic MR (magnetic resonance) findings. Upon diagnosis, all the cases displayed good responses to corticosteroids and showed an overall benign prognosis during a follow-up period of 4—13.5 years, although three relapsed later. MR findings suggest that the characteristic concentric lesions of BCS frequently (5/7) coexist with multiple sclerosis-like lesions. During follow-up, the Baló-like lesions may either dissolve over time or transform into an MS-like lesion. Moreover, the Balóand MS-like lesions occurred one after another at the onset and relapse phases of the same patient in two cases. These clinical features suggest that Baló's disease showing benign clinical course and co-existence of multiple sclerosis (MS)-like lesion is not rare among the Chinese, and strengthens the notion that BCS correlates intrinsically with MS. Multiple Sclerosis 2008; 14: 418—424. http://msj.sagepub.com

Duration and severity of depression predict mortality in older adults in the community

2002 ◽  
Vol 32 (4) ◽  
pp. 609-618 ◽  
Author(s):  
S. W. GEERLINGS ◽  
A. T. F. BEEKMAN ◽  
D. J. H. DEEG ◽  
J. W. R. TWISK ◽  
W. VAN TILBURG
Keyword(s):  
Clinical Course ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Treatment Of Depression ◽  
Mortality Effect ◽  
Severity Of Depression ◽  
High Degree ◽  
Over Time ◽  
Course Of Depression

Background. The association between depression and mortality has become a topic of interest. Little is known about the association between the course of depression and mortality.Methods. In an initially non-depressed cohort (N = 325) and a depressed cohort (N = 327), depression was measured using the Center for Epidemiologic Studies Depression scale (CES-D) at eight successive waves over a period of 3 years. Both cohorts were then followed with respect to mortality status for up to 3·5 additional years. Clinical course types as well as theoretical course type parameters (basic symptom levels, increases in symptoms and instability over time) were distinguished to study the effect of the course of depression on mortality.Results. Contrary to transient states of depression, both chronic depression and chronic intermittent depression predicted mortality at follow-up. Additionally, evidence was found that the effect on mortality is related to severity of depression; high basic symptom levels and increases in symptoms over time were predictive of mortality. A high degree of instability over time was not associated with mortality.Conclusions. Since the mortality effect of depression is a function of both exposure time and symptom severity, more attention should be paid to the treatment of depression in order to prevent severe longstanding depression.

scholarly journals Venous Myxoma of the Distal Femoral Vein: A Rare Case of Leg Pain and Swelling

2021 ◽  
pp. 1-3
Author(s):  
Hervé Probst ◽  
Hervé Probst ◽  
Sébastien Vedani ◽  
Louis Guillou ◽  
Cédric Bron ◽  
...  
Keyword(s):  
Rare Case ◽  
Present Report ◽  
Femoral Vein ◽  
Surgical Excision ◽  
Leg Pain ◽  
Vein Wall ◽  
Complete Surgical Excision ◽  
Precise Diagnosis ◽  
One Year

Background: Myxoma is a rare tumor most frequently discovered in cardiac locations. The present report describes a rare case of extracardiac origin in the femoral vein, initially presenting as leg pain and swelling. Case Presentation: A 40-year-old woman was admitted to our regional hospital with unilateral left leg swelling and pain. She underwent a Duplex scan and CT scan, which revealed a 21 x 25 mm diameter mass in contact with the distal femoral vein, initially diagnosed as a thrombosed sacciform aneurysm. The patient underwent surgical excision of a bulging mass in the vein wall, which was directly closed by running suture. The anatomopathological report concluded with a myxoma. One-year follow-up showed a patent vein without evidence of recurrence of the tumor. Conclusion: Although very rare, peripheral venous myxoma may manifest with common symptoms as leg pain and swelling. Current vascular imaging and complete surgical excision should be performed without delay to allow a precise diagnosis and prevent further complications.

scholarly journals True cervicothoracic meningocele: a rare and benign condition

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Bruno L. Pessoa ◽  
Yara Lima ◽  
Marco Orsini
Keyword(s):  
Magnetic Resonance Imaging ◽  
Clinical Course ◽  
Spinal Dysraphism ◽  
Surgical Excision ◽  
Female Child ◽  
Illustrative Case ◽  
Resonance Imaging ◽  
Benign Condition ◽  
The Times

Cervical meningoceles are rare spinal dysraphism, accounting for approximately 7% of all cystic spinal dysraphism. In spite of the rarity, the clinical course is most of the times benign. The surgical treatment includes resection of the lesion and untethering, when presented. We present a 14-day-old female child with true meningoceles who underwent to surgical excision and dura-mater repair. Retrospect analysis of the literature concerning true cervical meningocele is performed. By reporting this illustrative case, we focus on its classification and its differentiation from other types of cervical spinal dysraphism, such as myelocystocele and myelomeningocele. Although its course is benign, it is mandatory a continuum follow up with periodic magnetic resonance imaging of spinal cord, since late neurological deterioration has been described.

Inflammatory myofibroblastic lung tumor with dysphagia in a 4-year-old child

2017 ◽  
Vol 25 (9) ◽  
pp. 653-655 ◽  
Author(s):  
Vinitha V Nair ◽  
Kunal Krishna Singh ◽  
Joseph Thomas Kathayanat ◽  
Ratish Radhakrishnan ◽  
Akash Babu ◽  
...  
Keyword(s):  
Weight Loss ◽  
Respiratory Symptoms ◽  
Inflammatory Myofibroblastic Tumor ◽  
Lung Tumor ◽  
Gastroesophageal Junction ◽  
Surgical Excision ◽  
Pulmonary Vasculature ◽  
Rare Presentation ◽  
Inflammatory Myofibroblastic Tumors

Inflammatory myofibroblastic tumors of the lung are rare in adults but common among pediatric lung tumors. A 4-year-old girl was evaluated for respiratory symptoms, dysphagia, and weight loss. Radiology revealed a right hilar mass that persisted despite antibiotic treatment. On exploration, a hilar mass involving the pulmonary vasculature, diaphragm and gastroesophageal junction was found. Aggressive surgical excision including a right pneumonectomy was performed. Histopathology confirmed an inflammatory myofibroblastic tumor with no features of malignancy. At the 2-year follow-up, the child was clinically stable with no recurrence. Dysphagia is a very rare presentation of such tumors.

scholarly journals Squamous Cell Carcinoma Arising from Linear Porokeratosis - a case report and review of the literature

2017 ◽  
Vol 9 (4) ◽  
pp. 163-167
Author(s):  
Snežana Radoš ◽  
Milena Milovanović ◽  
Milica Rajović ◽  
Kristina Kostić ◽  
Ivana Tufegdžić ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Course ◽  
Surgical Excision ◽  
Healing Ulcer ◽  
Cornoid Lamella ◽  
Clinical Surveillance ◽  
Malignant Lesions

Abstract Porokeratosis belongs to a group of disorders of keratinization that are characterized by the histopathological feature of the cornoid lamella, a column of tightly fitted parakeratotic cells. The etiology of porokeratosis is still unclear. Different variants of porokeratosis (PK) have been subsequently recognized, each with its own specific properties in terms of morphology, distribution and clinical course. Linear porokeratosis is one of the variants of porokeratosis, a rare disorder of keratinization that may develop into several epidermal malignancies, squamous cell carcinoma being the most frequent among all of them. Thus, a clinical surveillance for malignancy is an imperative. We present a case of a 54-year-old man with non-healing ulcer of the lower leg caused by squamous cell carcinoma arising on long-standing linear porokeratosis. The treatment included wide excision of tumor with the reconstruction of the area. Acitretin was prescribed for linear porokeratosis treatment. The follow-up of our patient so far has shown that he does not have new malignant lesions after surgical excision.

Infantile haemangiopericytoma: a rare congenital cervical tumour

2014 ◽  
Vol 128 (2) ◽  
pp. 212-215 ◽  
Author(s):  
E M Farrar ◽  
J E H Bates ◽  
S Bitetti ◽  
I A Bruce
Keyword(s):  
Histological Analysis ◽  
Clinical Course ◽  
Surgical Excision ◽  
Neck Mass ◽  
Diagnostic Challenge ◽  
Adults And Children ◽  
Posterior Neck ◽  
Borderline Malignancy ◽  
One Year

AbstractObjective:Infantile haemangiopericytoma is a rare childhood vascular tumour of borderline malignancy and unpredictable clinical course. It can present a diagnostic challenge due to indeterminate clinical, radiological and pathological features. This report presents the case of a large congenital haemangiopericytoma of the neck in a neonate, and discusses diagnosis, imaging, pathology and surgical management.Clinical presentation:A full-term neonate presented with a large posterior neck mass at birth. Pre-operative radiological appearances were suggestive of teratoma, but following surgical excision the diagnosis of infantile haemangiopericytoma was confirmed on histological analysis. There were no signs of recurrence at 12-month follow up.Conclusion:Haemangiopericytoma can follow an aggressive course in adults, including local recurrence and metastasis. The infantile variant is rare but typically follows a distinct clinical course, and is associated with more benign behaviour compared with similar tumours in adults and children over one year. Congenital haemangiopericytoma can be effectively treated with surgery, without requiring adjuvant therapy.

scholarly journals Nonoperative management of solitary eosinophilic granulomas of the calvaria

2013 ◽  
Vol 12 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Guillermo De Angulo ◽  
Sushmita Nair ◽  
Vivian Lee ◽  
Ziad Khatib ◽  
John Ragheb ◽  
...  
Keyword(s):  
Complete Resolution ◽  
Nonoperative Management ◽  
Clinical Course ◽  
Eosinophilic Granuloma ◽  
Surgical Excision ◽  
The Other ◽  
Surgical Interventions ◽  
Imaging Results ◽  
Reasonable Approach

Object Solitary eosinophilic granuloma (EG) of the calvaria is most commonly treated with surgical excision. The authors hypothesize that many solitary EGs will resolve without intervention, and observation may be a reasonable option. This study was undertaken to investigate that hypothesis. Methods The authors reviewed their institutional records and identified 14 cases of solitary calvarial EG. In 6 cases the patients underwent resection based on family and/or neurosurgeon preferences. A strategy of nonoperative management (purposeful observation) was chosen for the other 8 cases. The authors report the clinical course and imaging results in these 8 cases. Results One of the 8 patients underwent surgery 2 months after presentation because of slight enlargement of the lesion and increasing pain. After a median follow-up period of 1 year (range 6–19 months), none of the other patients had required surgery. Five of these 7 patients had pain at presentation. Pain resolved completely in all 5. The remaining 2 remained asymptomatic. Complete resolution of pain was reported in the 5 patients who had pain at presentation. There was complete clinical resolution of the palpable soft-tissue lesion in all 7 cases. Complete radiographic resolution of the lesion was observed in 5 cases and near-complete resolution in the remaining 2. Conclusions Observation is a safe and reasonable approach in the management of solitary calvarial EG and may prevent unnecessary surgical interventions.

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