scholarly journals No Evidence of Reduced Contrast Sensitivity in Migraine-with-Aura for Large, Narrowband, Centrally Presented Noise-Masked Stimuli

Vision ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 32
Author(s):  
Jordi M. Asher ◽  
Louise O’Hare ◽  
Paul B. Hibbard
Keyword(s):  
Contrast Sensitivity ◽  
Migraine With Aura ◽  
Gaussian White Noise ◽  
Alternative Methods ◽  
Migraine Aura ◽  
Contributing Factors ◽  
Control Groups ◽  
Neural Noise ◽  
Masking Noise ◽  
And Control

Individuals with migraine aura show differences in visual perception compared to control groups. Measures of contrast sensitivity have suggested that people with migraine aura are less able to exclude external visual noise, and that this relates to higher variability in neural processing. The current study compared contrast sensitivity in migraine with aura and control groups for narrow-band grating stimuli at 2 and 8 cycles/degree, masked by Gaussian white noise. We predicted that contrast sensitivity would be lower in the migraine with aura group at high noise levels. Contrast sensitivity was higher for the low spatial frequency stimuli, and decreased with the strength of the masking noise. We did not, however, find any evidence of reduced contrast sensitivity associated with migraine with aura. We propose alternative methods as a more targeted assessment of the role of neural noise and excitability as contributing factors to migraine aura.

scholarly journals A Study of Factors Contributing to Denture Stomatitis in a North Indian Community

2011 ◽  
Vol 2011 ◽  
pp. 1-4 ◽  
Author(s):  
Amit Vinayak Naik ◽  
Ranjana C. Pai
Keyword(s):  
Candida Albicans ◽  
Test Group ◽  
Control Group ◽  
Clinical Tests ◽  
Contributing Factors ◽  
Control Groups ◽  
Denture Stomatitis ◽  
And Control ◽  
Salivary Measurements ◽  
Microscopic Investigations

Factors like oral and denture hygiene, presence of saliva, age of the denture, and degree of colonization withCandida albicansare to be evaluated as local contributing factors for causing denture stomatitis. 100 patients aged 30 to 70 years were selected for the study. Among these, 70 patients were labeled test group showing signs of stomatitis and 30 patients as control group as they showed no inflammatory signs. Clinical tests included oral and denture hygiene evaluation, salivary measurements, and age of the dentures, and microscopic investigations were done. Results showed no significant differences between the two groups in terms of saliva, oral and denture hygiene habits, and denture age. Test group showed stomatitis in patients who were wearing dentures for 5 to 10 years compared to control group who were wearing dentures for 10 years and above. Denture age was proportional toCandidacolonization and not to degree of inflammation. Significant differences were found inCandidacolonization of the fitting surface of the denture between stomatitis and control groups. Poor denture hygiene habits are the most prominent contributing factor for denture stomatitis and colonization.

Effects of blunt trauma of eye on retinal nerve fibre layer

2021 ◽  
Vol 2 (4) ◽  
pp. 228-232
Author(s):  
Kumar Aalok ◽  
Keyword(s):  
Visual Acuity ◽  
Contrast Sensitivity ◽  
Blunt Trauma ◽  
Color Vision ◽  
Control Groups ◽  
Rnfl Thickness ◽  
Department Of Ophthalmology ◽  
Significant Difference ◽  
And Control

AIM: To study the effects of blunt trauma of eye on visual acuity and retinal nerve fiber layer (RNFL). METHODS: A prospective observational study was done on the patients of a road traffic accident (RTA) having blunt trauma injury of the eye from august 2018 to July 2019 at the Department of Ophthalmology, Hind Institute of Medical Sciences, Barabanki. Patients between the age group of 20 to 65 years undergoing RTA with ocular complaints were included in this study. Colour vision, contrast sensitivity, and best-corrected visual acuity (BCVA) were recorded, RNFL analysis was done through OCT. RESULTS: A total of 108 patients were enrolled in this study and were grouped as 54 cases and 54 controls. The mean age was 43±2.3 years with 11 (20.37%) females and 43 (79.6%) males in the case group. At initial visit after RTA, the difference between color vision, contrast sensitivity and BCVA between right and left eyes of cases and controls were significant. After a follow up of 3mo only significant difference was noted in contrast sensitivity between cases and control groups. Change in color vision and BCVA after 3mo was insignificant. Similarly, an initial significant difference was noted in mean RNFL thickness between cases and control groups, but after follow up of 3mo mean RNFL thickness difference was significant only in superior and temporal quadrants. CONCLUSION: RTA or blunt trauma of eye can lead to persistent RNFL thinning and decreased visual function.

scholarly journals Chromatic Induction in Migraine

Vision ◽  
2021 ◽  
Vol 5 (3) ◽  
pp. 37
Author(s):  
Xim Cerda-Company ◽  
Olivier Penacchio ◽  
Xavier Otazu
Keyword(s):  
Migraine With Aura ◽  
Migraine Without Aura ◽  
Lateral Interactions ◽  
Control Groups ◽  
Central Neuron ◽  
Inhibitory Mechanisms ◽  
Classical Receptive Field ◽  
Visual Phenomena ◽  
The Difference ◽  
And Control

The human visual system is not a colorimeter. The perceived colour of a region does not only depend on its colour spectrum, but also on the colour spectra and geometric arrangement of neighbouring regions, a phenomenon called chromatic induction. Chromatic induction is thought to be driven by lateral interactions: the activity of a central neuron is modified by stimuli outside its classical receptive field through excitatory–inhibitory mechanisms. As there is growing evidence of an excitation/inhibition imbalance in migraine, we compared chromatic induction in migraine and control groups. As hypothesised, we found a difference in the strength of induction between the two groups, with stronger induction effects in migraine. On the other hand, given the increased prevalence of visual phenomena in migraine with aura, we also hypothesised that the difference between migraine and control would be more important in migraine with aura than in migraine without aura. Our experiments did not support this hypothesis. Taken together, our results suggest a link between excitation/inhibition imbalance and increased induction effects.

scholarly journals PENGARUH PERMAINAN TRADISIONAL ANJANG-ANJANGAN TERHADAP KARAKTER TANGGUNG JAWAB ANAK USIA DINI

Edukid ◽  
2019 ◽  
Vol 13 (2) ◽  
Author(s):  
Mia Kusmiati ◽  
Euis Kurniati ◽  
I Gusti Komang Aryaprasetya
Keyword(s):  
Character Trait ◽  
Alternative Methods ◽  
Control Group ◽  
Control Groups ◽  
Control Group Design ◽  
Number Of Children ◽  
Significant Difference ◽  
And Control ◽  
Traditional Game ◽  
Experimental Group

The  Influence  Of  Anjang-anjangan  Traditional  Game  On  Young Children’s  Character  Trait  Of  Responsibility.  The  research  intends  to  find  the influence  of  anjang-anjangan  traditional  game  on  young  children’s  character  trait  of responsibility. It adopted quasi-experimental method with nonequivalent control group design.  The  research  was  conducted  to  Group  B  of  State  Kindergarten  Centeh, Bandung City, with a number of 14 and 17 children as the sample for the experimental and control groups, respectively. Data were collected using a research instrument in the form of observation guidelines. The results of the pretest show that 25% of the children in the experimental group had shown an emerging character trait of responsibility and the  rest  75%  had  not;  meanwhile,  36%  of  the  children  in  the  control  group  had demonstrated  an  emerging  character  trait  of  responsibility,  and  the  rest  64%  had  not. After  treatment,  results  of  the  posttest  show  that  the  number  of  children  in  the experimental  group  showing  the  emergence  of  responsibility  character trait  was 73%, and those who did not 27%, whereas in the control group the percentages of children who  showed  and  did  not  show  emerging  responsibility  character  trait  were  61%  and 39%,  respectively.  With  the  result  of  t-test  showing  that  p  (0.038)  <  0.05,  Ha  was accepted,  meaning  that  there  was  a  significant  difference  in  the  character  trait  of responsibility between the experimental and control groups. Based these findings, it is recommended  that  teachers  of  young  children  employ  anjang-anjangan  traditional game  as  one  of  the  alternative  methods  to  develop  young  children’s  responsibility character trait.    Abstrak: Pengaruh Permainan Tradisional Anjang-anjangan Terhadap Karakter Tanggung  Jawab  Anak  Usia  Dini.  Penelitian  ini  bertujuan  untuk  mengetahui pengaruh  permainan  tradisional  anjang-anjangan  terhadap  karakter  tanggung  jawab anak  usia  dini.  Metode  penelitian  yang  digunakan  adalah  kuasi  eksperimen  dengan desain  penelitian  nonequivalent  control  group  desain.  Penelitian  ini  dilakukan  pada kelompok  B  di  Taman  Kanak-kanak  Negeri  Centeh  Kota  Bandung,  dengan  jumlah sampel kelompok eksperimen sebanyak 14 orang dan kontrol sebanyak 17 orang. Data penelitian  diperoleh  menggunakan  instrumen  penenlitian  berupa  pedoman  observasi. Berdasarkan  hasil  penelitian  bahwa  data  pretest  pada  kelompok  eksperimen menunjukkan anak yang muncul karakter tanggung jawabnya sebanyak 25% dan yang belum muncul sebanyak 75%, pada kelompok kontrol  menunjukkan anak yang muncul karakter  tanggung  jawabnya  sebanyak  36%  dan  yang  belum  muncul  sebanyak  64%. Setelah  dilakukan  treatment  hasil  akhir  pada  data  posttest  kelompok  eksperimen menunjukkan anak yang muncul karakter tanggung jawabnya sebanyak 73% dan yang belum muncul sebanyak 27%, pada kelompok kontrol menunjukkan anak yang muncul karakter  tanggung  jawabnya  sebanyak  49%  dan  yang  belum  muncul  sebanyak  51%, dengan  perolehan  akhir    uji  t  menunjukkan  P  (0,038)  <  0,05  maka  Ha  diterima,  yang artinya  terdapat  perbedaan  yang  signifikan  karakter  tanggung  jawab  antara  kelompok eksperimen  dengan  kelompok  kontrol.  Berdasarkan  hasil  penelitian  tersebut  peneliti merekomendasikan  kepada  pendidik  anak  usia  dini  supaya  permainan  tradisional anjang-anjangan  dijadikan  sebagai  metode  alternative  mengembangkan  karakter tanggung jawab pada anak usia dini.   

Biomonitoring of Buccal Mucosa Cells in Chronic Smokers and Nonsmokers

2016 ◽  
Vol 7 (4) ◽  
pp. 189-194 ◽  
Author(s):  
Neeraj Taneja ◽  
Ruhi S Sarpal ◽  
Navdeep K Shergill ◽  
SV Ravindra
Keyword(s):  
Buccal Mucosa ◽  
Tobacco Consumption ◽  
Contributing Factors ◽  
Control Groups ◽  
Significant Relation ◽  
Related Factors ◽  
Buccal Mucosa Cells ◽  
Study Case ◽  
And Control ◽  
Male Subjects

ABSTRACT Background Despite the well-known presence of carcinogens in tobacco smoke, results in the scientific literature linking smoking habits to micronuclei frequency are rather controversial. Aim The study was conducted to compare and evaluate the frequency of micronuclei in chronic smokers and nonsmokers in relation to habit history, personal history, and other related factors like occupation, exposure to radiation, etc. Materials and methods A total of 50 randomly selected male subjects were included in the study. Case and control groups (smokers and nonsmokers respectively) comprised 25 subjects each (mean age in controls = 38.24 ± 2.7; mean age in smokers = 39.32 ± 3.8). Results and conclusion There was a significant relation between tobacco consumption and frequency of micronucleated cells (p = 0.05) and between radiation exposure and presence of micronuclei (p = 0.05) in controls and subjects. Within the smokers group, left cheek scrapings showed higher count (p = 0.05; significant) for the micronucleated cells as compared with right cheek scrapings. Clinical significance In this study, an attempt was made to estimate the cytogenetic damage in oral mucosa in people habituated to smoking beedi. Though tobacco plays an important role in micronuclei generation, other factors like ionizing radiation and personal habits also contribute to micronuclei frequency. Site of smear, sample size, nuclear specific stain usage are some of the contributing factors. In addition, cytogenetic alterations like karyolysis, pyknosis, etc., can be included in future studies to increase the specificity. How to cite this article Sarpal RS, Taneja N, Shergill NK, Ravindra SV. Biomonitoring of Buccal Mucosa Cells in Chronic Smokers and Nonsmokers. World J Dent 2016;7(4):189-194.

scholarly journals Assessing the usefulness of mineral licks containing herbal extracts with anti-parasitic properties for the control of gastrointestinal helminths in grazing sheep – a field trial

2016 ◽  
Vol 53 (2) ◽  
pp. 180-185 ◽  
Author(s):  
P. Nosal ◽  
M. Murawski ◽  
P. M. Bartlewski ◽  
J. Kowal ◽  
M. Skalska ◽  
...  
Keyword(s):  
Field Trial ◽  
Alternative Methods ◽  
Herbal Extracts ◽  
Parasite Control ◽  
Control Groups ◽  
Gastrointestinal Helminths ◽  
Helminth Infections ◽  
Mineral Licks ◽  
Ad Libitum ◽  
And Control

SummaryOne of the alternative methods of parasite control, of particular importance in sustainable farming, is the use of medicinal plants. The specific aim of the present field trial was to assess the anti-parasitic effects of herbal extracts contained in a commercially available lick formulation for sheep. At the outset of this study conducted during the grazing season, all animals were de-wormed and then randomly assigned to one of the two separately kept groups (treatment and control), each consisting of 25 animals (11 ewes and 14 lambs). The treatment group received mineral licks containing the extracts of the plants with anti-parasitic properties, while control animals received standard mineral licks ad libitum. Rectal fecal samples were collected monthly from all animals for the McMaster analyses. There were no significant differences in the prevalence and intensity of helminth infections between the treatment and control groups. Thus, we were not able to ascertain the efficacy of the commercial herbal de-wormer tested for the control of gastrointestinal helminths in grazing ewes and their lambs.

scholarly journals Migraine Visual Aura and Cortical Spreading Depression—Linking Mathematical Models to Empirical Evidence

Vision ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 30
Author(s):  
Louise O’Hare ◽  
Jordi M. Asher ◽  
Paul B. Hibbard
Keyword(s):  
Experimental Evidence ◽  
Migraine With Aura ◽  
Visual Processing ◽  
Subjective Experience ◽  
Reaction Diffusion ◽  
Diffusion Models ◽  
Oscillatory Activity ◽  
Migraine Aura ◽  
Visual Aura ◽  
Neural Noise

This review describes the subjective experience of visual aura in migraine, outlines theoretical models of this phenomenon, and explores how these may be linked to neurochemical, electrophysiological, and psychophysical differences in sensory processing that have been reported in migraine with aura. Reaction–diffusion models have been used to model the hallucinations thought to arise from cortical spreading depolarisation and depression in migraine aura. One aim of this review is to make the underlying principles of these models accessible to a general readership. Cortical spreading depolarisation and depression in these models depends on the balance of the diffusion rate between excitation and inhibition and the occurrence of a large spike in activity to initiate spontaneous pattern formation. We review experimental evidence, including recordings of brain activity made during the aura and attack phase, self-reported triggers of migraine, and psychophysical studies of visual processing in migraine with aura, and how these might relate to mechanisms of excitability that make some people susceptible to aura. Increased cortical excitability, increased neural noise, and fluctuations in oscillatory activity across the migraine cycle are all factors that are likely to contribute to the occurrence of migraine aura. There remain many outstanding questions relating to the current limitations of both models and experimental evidence. Nevertheless, reaction–diffusion models, by providing an integrative theoretical framework, support the generation of testable experimental hypotheses to guide future research.

Conjugated Linoleic Acid Causes a Marked Increase in Liver α-Tocopherol and Liver α-Tocopherol Transfer Protein in C57BL/6 J Mice

2010 ◽  
Vol 80 (1) ◽  
pp. 65-73 ◽  
Author(s):  
Pei-Min Chao ◽  
Wan-Hsuan Chen ◽  
Chun-Huei Liao ◽  
Huey-Mei Shaw
Keyword(s):  
Antioxidant Enzymes ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Thiobarbituric Acid ◽  
Control Group ◽  
Thiobarbituric Acid Reactive Substances ◽  
Control Groups ◽  
Protein Levels ◽  
Transfer Protein ◽  
And Control

Conjugated linoleic acid (CLA) is a collective term for the positional and geometric isomers of a conjugated diene of linoleic acid (C18:2, n-6). The aims of the present study were to evaluate whether levels of hepatic α-tocopherol, α-tocopherol transfer protein (α-TTP), and antioxidant enzymes in mice were affected by a CLA-supplemented diet. C57BL/6 J mice were divided into the CLA and control groups, which were fed, respectively, a 5 % fat diet with or without 1 g/100 g of CLA (1:1 mixture of cis-9, trans-11 and trans-10, cis-12) for four weeks. α-Tocopherol levels in plasma and liver were significantly higher in the CLA group than in the control group. Liver α-TTP levels were also significantly increased in the CLA group, the α-TTP/β-actin ratio being 2.5-fold higher than that in control mice (p<0.01). Thiobarbituric acid-reactive substances were significantly decreased in the CLA group (p<0.01). There were no significant differences between the two groups in levels of three antioxidant enzymes (superoxide dismutase, glutathione peroxidase, and catalase). The accumulation of liver α-tocopherol seen with the CLA diet can be attributed to the antioxidant potential of CLA and the ability of α-TTP induction. The lack of changes in antioxidant enzyme protein levels and the reduced lipid peroxidation in the liver of CLA mice are due to α-tocopherol accumulation.

The Prospects and Risks Connected with Increasing the Level of Self-Organisation in Students

2020 ◽  
pp. 75-81
Author(s):  
Svetlana Alexandrovna Kosareva ◽  
Keyword(s):  
Higher Education ◽  
Professional Competence ◽  
Initial Level ◽  
Education Institution ◽  
Diagnostic Methods ◽  
Study Guide ◽  
Learning Approaches ◽  
Control Groups ◽  
Self Organisation ◽  
And Control

The paper describes the method for increasing the level of self-organisation in students which has been developed by the author. It also contains the method testing results and presents the prospects and risks teachers could face while applying the method in a higher education institution. The purpose of this study is to find out the prospects and risks of applying the method for increasing the level of self-organisation in students and to determine the ways of reducing the risks. Methodology. The author points out the learning approaches which were the basis of developing the method and describes diagnostic methods for determining students’ self-organisation levels. The work focused on increasing each student’s initial level consists of a theoretical and a practical part and includes project activities on creating a study guide. The results of the study. The method developed proved to be effective. It was established by diagnosing the final level of self-organisation in students in the experimental and control groups. The paper considers the advantages of the method among which there is universal character, flexibility, improvements to teacher’s and students’ professional competence, etc. At the same time it is necessary to be aware of the risks due to the increased amount of teacher’s work and the fact that students’ work within the project tends to be monotonous. In conclusion, the prospects of the method for increasing the level of self-organisation in students are related to its advantages and the final results of the work. The risks of its use can be reduced with the help of the measures proposed in the paper.

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