scholarly journals Sorption and Degradation Potential of Pharmaceuticals in Sediments from a Stormwater Retention Pond

Water ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 526 ◽  
Author(s):  
Fan Liu ◽  
Asbjørn Nielsen ◽  
Jes Vollertsen
Keyword(s):  
Half Life ◽  
Pond Water ◽  
Organic Micropollutants ◽  
Partitioning Coefficient ◽  
Retention Pond ◽  
Retention Ponds ◽  
Water Partitioning ◽  
Stormwater Retention ◽  
Sorption Potential

Stormwater retention ponds commonly receive some wastewater through misconnections, sewer leaks, and sewer overloads, all of which leads to unintended loads of organic micropollutants, including pharmaceuticals. This study explores the role of pond sediment in removing pharmaceuticals (naproxen, carbamazepine, sulfamethoxazole, furosemide, and fenofibrate). It quantifies their sorption potential to the sediments and how it depends on pH. Then it addresses the degradability of the pharmaceuticals in microcosms holding sediment beds and pond water. The sediment-water partitioning coefficient of fenofibrate varied little with pH and was the highest (average log Kd: 4.42 L kg−1). Sulfamethoxazole had the lowest (average log Kd: 0.80 L kg−1), varying unsystematically with pH. The coefficients of naproxen, furosemide and carbamazepine were in between. The degradation by the sediments was most pronounced for sulfamethoxazole, followed by naproxen, fenofibrate, furosemide, and carbamazepine. The first three were all removed from the water phase with half-life of 2–8 days. Over the 38 days the experiment lasted, they were all degraded to near completion. The latter two were more resistant, with half-lives between 1 and 2 months. Overall, the study indicated that stormwater retention ponds have the potential to remove some but not all pharmaceuticals contained in wastewater contributions.

Sulfide production kinetics and model of stormwater retention ponds

2018 ◽  
Vol 77 (10) ◽  
pp. 2377-2387 ◽  
Author(s):  
P. M. D'Aoust ◽  
F. R. Pick ◽  
R. Wang ◽  
A. Poulain ◽  
C. Rennie ◽  
...  
Keyword(s):  
Critical Role ◽  
Oxygen Demand ◽  
Pond Water ◽  
Sediment Oxygen Demand ◽  
Sulfide Concentration ◽  
Retention Ponds ◽  
Production Of Hydrogen ◽  
Sulfide Production ◽  
Stormwater Retention

Abstract Stormwater retention ponds can play a critical role in mitigating the detrimental effects of urbanization on receiving waters that result from increases in polluted runoff. However, the benthic oxygen demand of stormwater facilities may cause significant hypoxia and trigger the production of hydrogen sulfide (H2S). This process is not well-documented and further research is needed to characterize benthic processes in stormwater retention ponds in order to improve their design and operation. In this study, sediment oxygen demand (SOD), sediment ammonia release (SAR) and sediment sulfide production (SSP) kinetics were characterized in situ and in the laboratory. In situ SOD and SSP data were utilized to develop a stormwater retention pond water sulfide concentration model which demonstrates strong correlation with sulfide concentrations observed in situ (r = 0.724, N = 91, p < 0.001) and in laboratory experiments (r = 0.691, N = 38, p < 0.001). At 4 °C, in situ rates of SOD, SAR and SSP were higher than those measured in laboratory. Sulfate-reducing bacteria (SRB) represented 4.99% of the bacteria present in the top 30 cm of the pond sediment, with Desulfobulbaceae spp., Desulfobacteraceae spp. and Desulfococcus spp. being the dominant SRB taxa identified.

scholarly journals Sea Level Rise Effect on Groundwater Rise and Stormwater Retention Pond Reliability

Water ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1129 ◽  
Author(s):  
Rahman Davtalab ◽  
Ali Mirchi ◽  
Rebecca J. Harris ◽  
Mark X. Troilo ◽  
Kaveh Madani
Keyword(s):  
Sea Level Rise ◽  
Sea Level ◽  
Peak Flow ◽  
Coastal Areas ◽  
Groundwater Table ◽  
Retention Pond ◽  
Retention Ponds ◽  
Increased Risk ◽  
Study Results ◽  
Stormwater Retention

The coastal areas of Florida, United States, are exposed to increasing risk of flooding due to sea level rise as well as severe hurricanes. Florida regulations suggest constructing stormwater retention ponds as an option to retain excess runoff generated by the increased impervious area and to protect the environment by reducing pollutants from new developments. Groundwater level rise can significantly lower the soil storage capacity and infiltration at retention ponds, in turn, reducing the pond’s capacity to capture consecutive storms due to longer pond volume recovery time. Partial groundwater inundation can affect retention ponds’ ability to decrease peak flow rates and keep the post-development outflow lower than or equal to pre-development conditions. In this paper, the reliability and performance of a retention pond near Tampa Bay, Florida, was evaluated under sea level rise conditions. An integrated surface water and groundwater model was developed, and the groundwater table was projected for future conditions as a function of sea level rise. The results showed that sea level rise could increase the seasonal high water elevation of the retention pond up to 40 cm by mid-21st century. This increase lowered the reliability of the retention pond by about 45%. The pond failed to recover the designed treatment volume within required 72 h because of the high groundwater table, increasing the risk of pollutant discharge. Furthermore, the peak flow and volume of runoff significantly increased under sea level rise and associated groundwater table rise conditions. The study results suggest that it is imperative to consider future sea level rise conditions in stormwater design in low-lying coastal areas of Florida and around the world to prevent poor pond performance and increased risk of flooding in the future.

scholarly journals Hydraulic investigation of the impact of retrofitting floating treatment wetlands in retention ponds

2019 ◽  
Vol 80 (8) ◽  
pp. 1476-1484 ◽  
Author(s):  
Sher Khan ◽  
Muhammad Shoaib ◽  
Mudasser Muneer Khan ◽  
Bruce W. Melville ◽  
Asaad Y. Shamseldin
Keyword(s):  
Root Length ◽  
Longitudinal Axis ◽  
Hydraulic Performance ◽  
Treatment Wetlands ◽  
Experimental Investigations ◽  
Retention Pond ◽  
Retention Ponds ◽  
Floating Treatment Wetlands ◽  
The Impact ◽  
Stormwater Retention

Abstract This paper describes the laboratory experimental investigations undertaken to analyse the influence of floating treatment wetlands (FTWs) on the hydraulic performance of a stormwater retention pond. Two experimental series were conducted, each focussed on investigating the influence of placing an FTW in a pond with firstly the inflow entering the retention pond from an inlet positioned 0.25 m offset from the longitudinal axis of the pond, and secondly the inlet positioned at the longitudinal axis of the pond. For both series of experiments, tests were undertaken at 1 l/s and 1.5 l/s, and with and without an artificial FTW installed. This study is the first to investigate the hydraulic impact of FTWs and their root systems on the performance of stormwater retention ponds. The results presented in this study suggest that FTWs are a viable method to minimise hydraulic inefficiencies, thereby increasing retention time and optimising hydraulic performance of stormwater retention ponds. The results highlight the importance of plant root characteristics. The optimal arrangement of root length is LR/DP = 0.5, where LR = root length and DP = pond depth. The results also indicate that the spatial variability of vegetation has a significant impact on the hydraulic performance of the pond.

Retrofitting a stormwater retention pond using a deflector island

2011 ◽  
Vol 63 (12) ◽  
pp. 2867-2872 ◽  
Author(s):  
S. Khan ◽  
B. W. Melville ◽  
A. Y. Shamseldin
Keyword(s):  
Physical Model ◽  
Residence Time ◽  
Time Distribution ◽  
Residence Time Distribution ◽  
Stormwater Runoff ◽  
Sediment Removal ◽  
Retention Pond ◽  
Retention Ponds ◽  
Runoff Analysis ◽  
Stormwater Retention

Stormwater retention ponds are one of the principal methods to treat stormwater runoff. Analysis of residence time distribution (RTD) curves can be used to evaluate the capability of these ponds for sediment removal. Deflector islands have been suggested as a means of improving the performance of retention ponds, due to their diffusing the inlet jet. In this study, the effect of an island on retention pond performance was investigated using a physical model of an existing stormwater retention pond. The physical model is a trapezoidal pond having top dimensions 4.1 × 1.5 × 0.23 m and side slopes of 2:1 (h:v). Three different arrangements were studied. The results show that placing an island to deflect the influent to a stormwater retention pond does not improve pond performance, rather it stimulates short-circuiting. This unexpected behaviour, in relation to previous studies, is considered to be a consequence of the model pond incorporating sloping walls; which is a novel aspect of this paper.

scholarly journals Half-Life Systematics across theN=126Shell Closure: Role of First-Forbidden Transitions in theβDecay of Heavy Neutron-Rich Nuclei

2014 ◽  
Vol 113 (2) ◽  
Author(s):  
A. I. Morales ◽  
J. Benlliure ◽  
T. Kurtukián-Nieto ◽  
K.-H Schmidt ◽  
S. Verma ◽  
...  
Keyword(s):  
Half Life ◽  
Forbidden Transitions

Prophylaxis for Hemophilia in the Era of Extended Half-Life Factor VIII/Factor IX Products

2016 ◽  
Vol 42 (05) ◽  
pp. 518-525 ◽  
Author(s):  
Erik Berntorp ◽  
Nadine Andersson
Keyword(s):  
Half Life ◽  
Safety Margin ◽  
Clinical Development ◽  
Factor Ix ◽  
Life Extension ◽  
Bleeding Events ◽  
Treatment And Prevention ◽  
Trough Levels ◽  
Life Factor

There are two main bioengineering approaches to extending the half-life of factor (F)VIII or FIX products used for hemophilia replacement therapy. These are fusion to Fc-immunoglobulin G (FVIII and FIX) or to albumin (FIX) or pegylation/glycopegylation (FVIII and FIX). Four FVIII and three FIX products are in clinical development or have recently been licensed in regions of the world. The reported half-life extension is approximately 1.5-fold for FVIII and 2.5-fold, or even longer, for FIX. Clinical trials have shown promising results with respect to extension of dose intervals and efficacy in the treatment and prevention of bleeding events. The role of these products in clinical practice has been discussed in terms of either improving convenience and adherence through prolongation of the interval between infusions or maintaining current intervals thereby increasing trough levels and the safety margin against bleeds. This review of extended half-life products addresses the possibilities and problems of their introduction in hemophilia treatment.

scholarly journals Evaluation of antibiotics as a methodological procedure to inhibit free-living and biofilm bacteria in marine zooplankton culture

2016 ◽  
Vol 88 (suppl 1) ◽  
pp. 733-746 ◽  
Author(s):  
Vanessa O. Agostini ◽  
Alexandre J. Macedo ◽  
Erik Muxagata
Keyword(s):  
Half Life ◽  
Culture Medium ◽  
Metabolic Inhibitors ◽  
Penicillin G ◽  
Streptomycin Sulphate ◽  
Free Living ◽  
Marine Zooplankton ◽  
Scientific Experiments ◽  
Biofilm Bacteria

There is a problem with keeping culture medium completely or partially free from bacteria. The use of prokaryotic metabolic inhibitors, such as antibiotics, is suggested as an alternative solution, although such substances should not harm non-target organisms. Thus, the aim of this study was to assess the effectiveness of antibiotic treatments in inhibiting free-living and biofilm bacteria and their half-life in artificial marine environment using the copepod Acartia tonsa as bioindicador of non-harmful antibiotic combinations. Regarding to results, the application of 0.025 g L-1 penicillin G potassium + 0.08 g L-1 streptomycin sulphate + 0.04 g L-1 neomycin sulphate showed great potential for use in marine cultures and scientific experiments without lethal effects to non-target organisms. The effect of this combination starts within the first six hours of exposure and reduces up to 93 % the bacterial density, but the half-life is short, requiring replacement. No adverse changes in water quality were observed within 168 hours of exposure. As a conclusion, we can infer that this treatment was an effective procedure for zooplankton cultures and scientific experiments with the aim of measuring the role of free-living and biofilm in the marine community.

scholarly journals FOXO3a is stabilized by USP18-mediated de-ISGylation and inhibits TGF-β1-induced fibronectin expression

2019 ◽  
Vol 68 (3) ◽  
pp. 786-791 ◽  
Author(s):  
Ban Wang ◽  
Yanhui Li ◽  
Heather Wang ◽  
Jing Zhao ◽  
Yutong Zhao ◽  
...  
Keyword(s):  
Half Life ◽  
Transforming Growth Factor ◽  
Fibroblast Cells ◽  
Post Translational Modification ◽  
Human Lung Fibroblast ◽  
Post Translational Modifications ◽  
Cellular Processes ◽  
Fibronectin Expression ◽  
Tgf Β1

FOXO3a belongs to a family of transcription factors characterized by a conserved forkhead box DNA-binding domain. It has been known to regulate various cellular processes including cell proliferation, apoptosis and differentiation. Post-translational modifications of FOXO3a and their roles in the regulation of FOXO3a activity have been well-documented. FOXO3a can be phosphorylated, acetylated and ubiquitinated, however, the ISGylation of FOXO3a has not been reported. Protein overexpression, ISGylation and half-life were measured to determine the post-translational modification of FOXO3a. Human fibroblast cells were treated with transforming growth factor (TGF)-β1 to determine the role of FOXO3a ISGylation in TGF-β1 signaling. FOXO3a’s half-life is around 3.7 hours. Inhibition of the proteasome, not lysosome, extends its half-life. ISGylation, but not ubiquitination of FOXO3a, is increased in the presence of the proteasome inhibitor. Overexpression of ISG15 increases FOXO3a degradation, while overexpression of USP18 stabilizes FOXO3a through de-ISGylation. These results suggest that FOXO3a is degraded in the ISGylation and proteasome system, which can be reversed by USP18, an ISG15-specific deubiquitinase. This study reveals a new molecular mechanism by which ISGylation regulates FOXO3a degradation. Furthermore, we show that the overexpression of FOXO3a attenuated TGF-β1-induced fibronectin expression in human lung fibroblast cells without altering Smad2/3 expression and activation. FOXO3a can be ISGylated, which can regulate FOXO3a stability. USP18/FOXO3a pathway is a potential target for treating TGF-β1-mediated fibrotic diseases such as idiopathic pulmonary fibrosis.

Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation

Science ◽  
2018 ◽  
Vol 361 (6403) ◽  
pp. 701-704 ◽  
Author(s):  
Jaechul Lim ◽  
Dongwan Kim ◽  
Young-suk Lee ◽  
Minju Ha ◽  
Mihye Lee ◽  
...  
Keyword(s):  
Gene Regulation ◽  
Half Life ◽  
Messenger Rna ◽  
Mrna Translation ◽  
Posttranscriptional Gene Regulation ◽  
And Function ◽  
Mrna Half Life ◽  
In Cells

RNA tails play integral roles in the regulation of messenger RNA (mRNA) translation and decay. Guanylation of the poly(A) tail was discovered recently, yet the enzymology and function remain obscure. Here we identify TENT4A (PAPD7) and TENT4B (PAPD5) as the enzymes responsible for mRNA guanylation. Purified TENT4 proteins generate a mixed poly(A) tail with intermittent non-adenosine residues, the most common of which is guanosine. A single guanosine residue is sufficient to impede the deadenylase CCR4-NOT complex, which trims the tail and exposes guanosine at the 3′ end. Consistently, depletion of TENT4A and TENT4B leads to a decrease in mRNA half-life and abundance in cells. Thus, TENT4A and TENT4B produce a mixed tail that shields mRNA from rapid deadenylation. Our study unveils the role of mixed tailing and expands the complexity of posttranscriptional gene regulation.

Role of enhanced half-life factor VIII and IX in the treatment of haemophilia

2015 ◽  
Vol 169 (6) ◽  
pp. 768-776 ◽  
Author(s):  
Ali J. Mahdi ◽  
Samya G. Obaji ◽  
Peter W. Collins
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Viii And Ix ◽  
Life Factor
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