Effects of tobacco smoking on pulmonary function indices among undergraduate students

Author(s):  
Babatunde O. A. Adegoke ◽  
Ayodele Akintunde AKINREMI ◽  
Adekemi E Akintobi

Background: Tobacco smoking is a risk factor for chronic respiratory disorders. The tobacco epidemic is driven by adolescents and young adults. Tobacco-related morbidity rises with increasing years of smoking, and the increasing number of young smokers may have considerable future public health implications.Objective: This study investigated the effect of tobacco smoking on pulmonary function indices among undergraduate students. Methods: This is a cross sectional study involving 104 male undergraduate students between 18 and 30 years of age. They were recruited by snowball sampling and were grouped based on their smoking status (current smoker 52: non-smoker 52). Participants with signs of respiratory disease, thoracic spine deformity, or contraindication to spirometry were excluded from the study. Participants’ forced vital capacity (FVC), forced expiratory volume in first second (FEV1), both in litres, and forced expiratory ratio (FER) in percentage were assessed using standard protocols. Data were analyzed using mean, standard deviation, independent t-test and chi-square test with alpha level set at 0.05.Results: The two groups were not significantly different in age, height and body mass index (BMI). Smokers had significantly reduced FVC (3.42±0.42 vs 3.87±0.4 litres) p=0.03; FEV1 (2.39±0.37 vs 3.22±0.38 litres) p=0.001 and FER (%) (70.7±7.58vs82.3±4.05) p=0.01. Among the smokers, a relationship was observed between years and numbers of cigarettes smoked and lung function. The proportion of participants with FER below the age-matched reference was significantly higher among smokers than non-smokers (40.4%vs6.7%) at p=0.021. Conclusion: Smoking reduced pulmonary function among undergraduate students. This may have important public health implications since continued smoking may accelerate lung function deterioration and consequently increase the future risk of developing lung disease.

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e022638 ◽  
Author(s):  
Maciej Polak ◽  
Krystyna Szafraniec ◽  
Magdalena Kozela ◽  
Renata Wolfshaut-Wolak ◽  
Martin Bobak ◽  
...  

ObjectivePrevious studies have reported inverse associations between socioeconomic status (SES) and lung function, but less is known about whether pulmonary function is affected by SES changes. We aimed to describe the relationship of changes of SES between childhood and adulthood with pulmonary function.DesignCross-sectional study.ParticipantsThe study sample included 4104 men and women, aged 45–69 years, residents of Krakow, participating in the Polish part of the Health, Alcohol and Psychosocial Factors in Eastern Europe Project.Main outcomeForced expiratory volume (FEV1) and forced vital capacity (FVC) were assessed by the standardised spirometry procedure. Participants were classified into three categories of SES (low, moderate or high) based on information on parent’s education, housing standard during childhood, own education, employment status, household amenities and financial status.ResultsThe adjusted difference in mean FVC between persons with low and high adulthood SES was 100 mL (p=0.005) in men and 100 mL (p<0.001) in women; the differences in mean FEV1were 103 mL (p<0.001) and 80 mL (p<0.001), respectively. Upward social mobility and moderate or high SES at both childhood and adulthood were related to significantly higher FEV1and FVC compared with low SES at both childhood and adulthood or downward social mobility.ConclusionsLow SES over a life course was associated with the lowest lung function. Downward social mobility was associated with a poorer pulmonary function, while upward mobility or life course and moderate or high SES were associated with a better pulmonary function.


2020 ◽  
Vol 20 (4) ◽  
pp. 151-155
Author(s):  
Jisu Choi ◽  
Eunju Park ◽  
Jae Woong Sull

Background: Smoking is a known risk factor for decreasing pulmonary function. The objective of this study was to investigate the relationship between smoking and lung function considering obesity and age group.Methods: This study was based on the data collected during the 2016 Korean National Health and Nutrition Examination Surveys (KNHANES VII). A total of 3,411 adults were retrieved from KNHANES VII. Among 3,411 adults, we studied 1,411 male subjects. Impaired lung function was measured by spirometry at least twice. Data were analyzed using one way analysis of variance.Results: In this study, forced expiratory volume in the first second was associated with smoking status (P=0.024). The association was stronger in old subjects (P=0.008). Also, in the obese group, the association of lung function with smoking status was not significant, but the association was significant in the non-obese group (P=0.019).Conclusions: In this study, Smoking was significantly associated with impaired lung function. The association was stronger in old men and obese men. In order to obtain an accurate assessment of the association between smoking and pulmonary function values, further prospective cohort study in the future is necessary.


Author(s):  
Olena Ivanova ◽  
Celso Khosa ◽  
Abhishek Bakuli ◽  
Nilesh Bhatt ◽  
Isabel Massango ◽  
...  

Background: Local spirometric prediction equations are of great importance for interpreting lung function results and deciding on the management strategies for respiratory patients, yet available data from African countries are scarce. The aim of this study was to collect lung function data using spirometry in healthy adults living in Maputo, Mozambique and to derive first spirometric prediction equations for this population. Methods: We applied a cross-sectional study design. Participants, who met the inclusion criteria, underwent a short interview, anthropometric measurements, and lung function testing. Different modelling approaches were followed for generating new, Mozambican, prediction equations and for comparison with the Global Lung Initiative (GLI) and South African equations. The pulmonary function performance of participants was assessed against the different reference standards. Results: A total of 212 males and females were recruited, from whom 155 usable spirometry results were obtained. The mean age of participants was 35.20 years (SD 10.99) and 93 of 155 (59.35%) were females. The predicted values for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and the FEV1/FVC ratio based on the Mozambican equations were lower than the South African—and the GLI-based predictions. Conclusions: This study provides first data on pulmonary function in healthy Mozambican adults and describes how they compare to GLI and South African reference values for spirometry.


Author(s):  
Joon-Sung Joh ◽  
Mo-Yeol Kang ◽  
Jun-Pyo Myong

Nickel is a well-known skin allergen; however, few studies to date have investigated the association between nickel exposure and lung function impairment. The present study, therefore, evaluated the relationship between blood nickel concentrations and lung function profiles in the Korean general population (n = 1,098). Dose–response relationships between blood nickel quartiles and pulmonary function were assessed by sex in multivariate models, after adjustment for potentially confounding factors such as age, height, and smoking status. Quartiles of blood nickel concentrations were significantly associated with markers of pulmonary function in Korean men, such as forced expiratory volume in 1 second (FEV1) and forced expiratory flow 25–75% (FEF25–75%). Relative to the first quartile, the estimated coefficients (standard error (SE)) of blood nickel levels for FEV1 in the third and fourth quartiles of Korean men were −126.6 mL (59.1) and −138.5 mL (59.8), respectively (p < 0.05). Relative to the first quartile, the estimated coefficients (SE) of blood nickel levels for FEF25–75% in the second and fourth quartiles were −244.9 mL (109.5) and −266.8 mL (111.5), respectively (p < 0.05). Dose–response relationships were observed between quartiles of blood nickel concentrations and the pulmonary function markers FEV1 and FEF25–75% in Korean men aged 40 or older.


2021 ◽  
Vol 10 (3) ◽  
pp. e32410313455
Author(s):  
Danilo Sobral da Silva Fernandes ◽  
Manoel Pereira Guimarães ◽  
Einstein Zeus Alves de Brito ◽  
João Diego Cabral Lima ◽  
Mateus de Sousa Rodrigues ◽  
...  

Introduction: Obstructive sleep apnea is a condition characterized by frequent respiratory pauses lasting ≥ 10 seconds, accompanied by desaturation/reoxygenation cycles and repetitive arousals triggered by complete (apnea) or partial (hypopnea) cessation of airflow during sleep. Objective: To determine the prevalence and to assess the respiratory and anthropometric parameters of patients with obstructive sleep apnea in Vale do São Francisco area. Methods: This is a descriptive, cross-sectional study using secondary data collected from 466 patients between June 2015 and June 2017. Patients who underwent home polysomnography were included while those who did not perform the lung function test and/or failed to present a medical report were excluded. Results: Obstructive sleep apnea was observed in 79.2% (n = 126) of the patients enrolled. Cases with greater severity were observed in males and were more prevalent among those aged 60 years or above. Forced expiratory volume in 1 second (P = 0.006) and forced vital capacity (P = 0.001) decreased with increased obstructive sleep apnea severity. Significant correlations were observed between the severity of obstructive sleep apnea and age, body mass index and Apnea-Hypopnea Index, while pulmonary function variables presented a low negative correlation with obstructive sleep apnea severity. Conclusion: Greater severity of obstructive sleep apnea was more prevalent in males and the involvement of the pulmonary function was more pronounced in the groups with severe obstructive sleep apnea. Reductions in lung function were also found in this population, with negative linear correlations between ventilatory parameters and obstructive sleep apnea severity.


Author(s):  
Vasann Saranya ◽  
Saranya Kuppusamy ◽  
Pravati Pal ◽  
Munisamy Malathi ◽  
Medha Rajappa ◽  
...  

AbstractBackgroundInterleukin-23 (IL-23), a key inflammatory regulator in the pathogenesis of psoriasis, is suspected to play a role in the onset of pulmonary dysfunction (chronic obstructive pulmonary disease) in psoriasis. Despite that, pulmonary function tests are rarely studied in these subjects. This study aims to seek a possible relation between pulmonary function in psoriasis patients serum IL-23.MethodsFor this analytical cross-sectional study, male psoriasis patients in the age group of 25–45 years were recruited from dermatology out patient department (n = 40). Age and BMI matched apparently healthy individuals were recruited as control group (n = 40). After obtaining demographic and personal details, anthropometric parameters and blood pressure were recorded. The severity of psoriasis was assessed using Psoriasis Area and Severity Index score. Pulmonary function was assessed using computerized spirometry, and serum IL-23 was measured using ELISA.ResultsForced vital capacity, forced expiratory volume in 1 s, peak expiratory flow rate, and forced expiratory flow at 25%–75% of the pulmonary volume (FEF25%–75%) were significantly reduced in psoriasis. Based on the percentage of predicted values FEF25%–75% was significantly reduced in psoriasis. Serum IL-23 (pg/mL) was significantly higher in psoriasis. The increase in IL-23 in psoriasis subjects does not correlate with their pulmonary function.ConclusionsPsoriasis may be associated with a reduced lung function even when the disease is in the mild stage. Increased IL-23 found in these subjects is suggestive of systemic inflammation, which indirectly lowers lung function.


2014 ◽  
Vol 59 (1) ◽  
Author(s):  
Michael Walsh ◽  
M. Haseeb

AbstractToxocariasis has been highlighted as a potentially important neglected infection of poverty in developed countries that experience substantive health disparities such as the United States. An association between Toxocara infection and lung function, in concert with a relatively high prevalence of infection, may mark an important mechanism by which this infection could contribute significantly to the differential morbidity across different socioeconomic groups and landscapes. To assess the potential relevance of this infection in a dense urban environment, we measured the association between forced expiratory volume in 1 second (FEV1) and serology diagnosed Toxocara infection in a sample of US-born New York City residents. We identified a significant independent association between Toxocara infection and lung function, wherein those with previous Toxocara infection had a 236.9 mL reduced FEV1 compared to those without Toxocara infection even after adjusting for age, sex, ethnicity, level of education, smoking status, body mass index, and pet ownership. These findings from New York City corroborate similar findings in a national sample and, while the cross-sectional data preclude a direct causal relationship, this study identifies a potentially important neglected infection in a dense urban landscape.


Author(s):  
Angelica Tiotiu ◽  
Iulia Ioan ◽  
Nathalie Wirth ◽  
Rodrigo Romero-Fernandez ◽  
Francisco-Javier González-Barcala

Background: Tobacco smoking is associated with more severe asthma symptoms, an accelerated decline in lung function, and reduced responses to corticosteroids. Our objective was to compare asthma outcomes in terms of disease control, exacerbation rates, and lung function in a population of asthmatic patients according to their smoking status. Methods: We compared patients’ demographics, disease characteristics, and lung-function parameters in current-smokers (CS, n = 48), former-smokers (FS, n = 38), and never-smokers (NS, n = 90), and identified predictive factors for asthma control. Results: CS had a higher prevalence of family asthma/atopy, a lower rate of controlled asthma, impaired perception of dyspnea, an increased number of exacerbations, and poorer lung function compared to NS. The mean asthma control questionnaire’s (ACQ) score was higher in CS vs. NS and FS (1.9 vs. 1.2, p = 0.02). Compared to CS, FS had a lower rate of exacerbations, a better ACQ score (similar to NS), a higher prevalence of dyspnea, and greater lung-diffusion capacity. Non-smoking status, the absence of dyspnea and exacerbations, and a forced expiratory volume in one second ≥80% of predicted were associated with controlled asthma. Conclusions: CS with asthma exhibit worse clinical and functional respiratory outcomes compared to NS and FS, supporting the importance of smoking cessation in this population.


2021 ◽  
Vol 8 (1) ◽  
pp. e000932
Author(s):  
Geir Klepaker ◽  
Paul Keefer Henneberger ◽  
Jens Kristoffer Hertel ◽  
Øystein Lunde Holla ◽  
Johny Kongerud ◽  
...  

BackgroundAlthough asthma and obesity are each associated with adverse respiratory outcomes, a possible interaction between them is less studied. This study assessed the extent to which asthma and overweight/obese status were independently associated with respiratory symptoms, lung function, Work Ability Score (WAS) and sick leave; and whether there was an interaction between asthma and body mass index (BMI) ≥25 kg/m2 regarding these outcomes.MethodsIn a cross-sectional study, 626 participants with physician-diagnosed asthma and 691 without asthma were examined. All participants completed a questionnaire and performed spirometry. The association of outcome variables with asthma and BMI category were assessed using regression models adjusted for age, sex, smoking status and education.ResultsAsthma was associated with reduced WAS (OR=1.9 (95% CI 1.4 to 2.5)), increased sick leave in the last 12 months (OR=1.4 (95% CI 1.1 to 1.8)) and increased symptom score (OR=7.3 (95% CI 5.5 to 9.7)). Obesity was associated with an increased symptom score (OR=1.7 (95% CI 1.2 to 2.4)). Asthma was associated with reduced prebronchodilator and postbronchodilator forced expiratory volume in 1 s (FEV1) (β=−6.6 (95% CI −8.2 to −5.1) and −5.2 (95% CI −6.7 to −3.4), respectively) and prebronchodilator forced vital capacity (FVC) (β=−2.3 (95% CI −3.6 to −0.96)). Obesity was associated with reduced prebronchodilator and postbronchodilator FEV1 (β=−2.9 (95% CI −5.1 to −0.7) and −2.8 (95% CI −4.9 to −0.7), respectively) and FVC (−5.2 (95% CI −7.0 to −3.4) and −4.2 (95% CI −6.1 to −2.3), respectively). The only significant interaction was between asthma and overweight status for prebronchodilator FVC (β=−3.6 (95% CI −6.6 to −0.6)).ConclusionsAsthma and obesity had independent associations with increased symptom scores, reduced prebronchodilator and postbronchodilator FEV1 and reduced prebronchodilator FVC. Reduced WAS and higher odds of sick leave in the last 12 months were associated with asthma, but not with increased BMI. Besides a possible association with reduced FVC, we found no interactions between asthma and increased BMI.


2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Li Li ◽  
Bangchuan Hu ◽  
Shijin Gong ◽  
Yihua Yu ◽  
Haiwen Dai ◽  
...  

Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and FEV1to FVC ratio (FEV1/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV1(r=-0.2987,p<0.0001). Multiple stepwise regression analyses showed that ARB and FEV1 (p<0.0001) were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary.


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