Faculty Opinions recommendation of The impact of rheumatological evaluation in the management of patients with interstitial lung disease.

2010 ◽  
Author(s):  
Imre Noth ◽  
Nathan Sandbo
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
The Impact

scholarly journals Translation and cultural adaptation of the King’s Brief Interstitial Lung Disease health status questionnaire for use in Brazil

2019 ◽  
Vol 45 (5) ◽  
Author(s):  
Karoline Silveira ◽  
Leila John Marques Steidle ◽  
Darlan Laurício Matte ◽  
Pedro Heliodoro Tavares ◽  
Mariangela Pimentel Pincelli ◽  
...  
Keyword(s):  
Health Status ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
English Language ◽  
Target Population ◽  
Cognitive Debriefing ◽  
Language Version ◽  
Back Translation ◽  
The Impact ◽  
Translation And Cultural Adaptation

ABSTRACT Objective: To translate the King’s Brief Interstitial Lung Disease (K-BILD) questionnaire to Portuguese and culturally adapt it for use in Brazil. The K-BILD quantifies the health status of patients with ILD. Methods: The process involved the following steps: authorization from the author of the original (English-language) questionnaire; translation of the questionnaire to Portuguese by three translators, working independently; merging of the translations by a committee of specialists; back-translation of the questionnaire to English; revision and readjustment of the back-translation by the committee of specialists; evaluation by the original author; revision of the back-translation; cognitive debriefing (verification of the clarity and acceptability of the Portuguese-language version in the target population-i.e., patients with ILD); and finalization of the Portuguese-language version. Results: In the cognitive debriefing step, 20 patients with ILD were interviewed. After the interviews, the clarity and acceptability index of each question was ≥ 0.8, which is considered acceptable. Conclusions: The Portuguese-language version of K-BILD appears to be easily administered to and understood by patients with ILD in Brazil. To our knowledge, this is the only instrument in Brazilian Portuguese that is designed to evaluate the impact that ILD has on the various aspects of the lives of those it affects.

THE IMPACT OF ADVANCE CARE PLANNING IN INTERSTITIAL LUNG DISEASE (ILD)

CHEST Journal ◽  
2018 ◽  
Vol 154 (4) ◽  
pp. 802A
Author(s):  
ALIA DAOUD ◽  
JANICE RICHMAN-EISENSTAT ◽  
MEENA KALLURI
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Advance Care Planning ◽  
Care Planning ◽  
Advance Care ◽  
The Impact

scholarly journals A cluster-based analysis evaluating the impact of comorbidities in fibrotic interstitial lung disease

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Alyson W. Wong ◽  
Tae Yoon Lee ◽  
Kerri A. Johannson ◽  
Deborah Assayag ◽  
Julie Morisset ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Function ◽  
Pulmonary Fibrosis ◽  
Lung Disease ◽  
Disease Progression ◽  
Rapid Decline ◽  
Agglomerative Clustering ◽  
Lung Function Decline ◽  
Obstructive Sleep ◽  
The Impact

Abstract Background Comorbidities are frequent and have been associated with poor quality of life, increased hospitalizations, and mortality in patients with interstitial lung disease (ILD). However, it is unclear how comorbidities lead to these negative outcomes and whether they could influence ILD disease progression. The goal of this study was to identify clusters of patients based on similar comorbidity profiles and to determine whether these clusters were associated with rate of lung function decline and/or mortality. Methods Patients with a major fibrotic ILD (idiopathic pulmonary fibrosis (IPF), fibrotic hypersensitivity pneumonitis, connective tissue disease-associated ILD, and unclassifiable ILD) from the CAnadian REgistry for Pulmonary Fibrosis (CARE-PF) were included. Hierarchical agglomerative clustering of comorbidities, age, sex, and smoking pack-years was conducted for each ILD subtype to identify combinations of these features that frequently occurred together in patients. The association between clusters and change in lung function over time was determined using linear mixed effects modeling, with adjustment for age, sex, and smoking pack-years. Kaplan Meier curves were used to assess differences in survival between the clusters. Results Discrete clusters were identified within each fibrotic ILD. In IPF, males with obstructive sleep apnea (OSA) had more rapid decline in FVC %-predicted (− 11.9% per year [95% CI − 15.3, − 8.5]) compared to females without any comorbidities (− 8.1% per year [95% CI − 13.6, − 2.7]; p = 0.03). Females without comorbidities also had significantly longer survival compared to all other IPF clusters. There were no significant differences in rate of lung function decline or survival between clusters in the other fibrotic ILD subtypes. Conclusions The combination of male sex and OSA may portend worse outcomes in IPF. Further research is required to elucidate the interplay between sex and comorbidities in ILD, as well as the role of OSA in ILD disease progression.

scholarly journals Monocyte count and the risk for acute exacerbation of fibrosing interstitial lung disease: A retrospective cohort study

2020 ◽  
Vol 17 ◽  
pp. 147997312090984 ◽  
Author(s):  
Kodai Kawamura ◽  
Kazuya Ichikado ◽  
Keisuke Anan ◽  
Yuko Yasuda ◽  
Yuko Sekido ◽  
...  
Keyword(s):  
Cohort Study ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Retrospective Cohort Study ◽  
Scoring System ◽  
Retrospective Cohort ◽  
Significant Risk ◽  
Monocyte Count ◽  
Peripheral Monocyte ◽  
The Impact

Recent studies have suggested that an increased peripheral monocyte count predicts a poor outcome in fibrosing interstitial lung disease (ILD). However, the association between an increased monocyte count and acute exacerbations (AEs) of fibrosing ILD remains to be elucidated. Our retrospective cohort study aimed to assess the impact of peripheral monocyte count on AEs of fibrosing ILD. We analyzed the electronic medical records of 122 consecutive patients with fibrosing ILD and no prior history of an AE, who were treated with anti-fibrotic agents from August 2015 to December 2018. We determined their peripheral monocyte counts at anti-fibrotic agent initiation and performed univariate and multivariate Cox regression analyses of time-to-first AE after anti-fibrotic agent initiation to assess the impact of monocyte count on AEs of fibrosing ILD. Twenty-six patients developed an AE during the follow-up period, and there was an increased monocyte count at anti-fibrotic agent initiation in these patients compared to those who did not develop an AE. There was also a significantly shorter time-to-first AE of fibrosing ILD in patients with a higher absolute monocyte count. Subgroup analyses indicated similar results regardless of the idiopathic pulmonary fibrosis diagnoses. This association was independently significant after adjusting for the severity of the fibrosing ILD. Using our results, we developed a simple scoring system consisting of two factors—monocyte count (<>380 µL−1) and ILD-gender, age, physiology score (<>4 points). Our findings suggest that the absolute monocyte count is an independent significant risk factor for AE in patients with fibrosing ILD. Our simple scoring system may be a predictor for AEs of fibrosing ILD, although further studies are needed to verify our findings.

scholarly journals Morphologic Aspects of Interstitial Pneumonia With Autoimmune Features

2018 ◽  
Vol 142 (9) ◽  
pp. 1080-1089 ◽  
Author(s):  
Ellen Caroline Toledo do Nascimento ◽  
Bruno Guedes Baldi ◽  
Marcio Valente Yamada Sawamura ◽  
Marisa Dolhnikoff
Keyword(s):  
Interstitial Lung Disease ◽  
Connective Tissue ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Connective Tissue Disease ◽  
Usual Interstitial Pneumonia ◽  
Connective Tissue Diseases ◽  
Distinct Subgroup ◽  
Management Protocol ◽  
The Impact

Context.— Interstitial lung disease, a common complication observed in several connective tissue diseases, causes significant morbidity and mortality. Similar to individuals with connective tissue diseases, a significant subgroup of patients with clinical and serologic characteristics suggestive of autoimmunity but without confirmed specific connective tissue disease presents with associated interstitial lung disease. These patients have been classified using different controversial nomenclatures, such as undifferentiated connective tissue disease–associated interstitial lung disease, lung-dominant connective tissue disease, and autoimmune featured interstitial lung disease. The need for a better understanding and standardization of this entity, interstitial lung disease with autoimmune features, and the need for an adequate management protocol for patients resulted in the introduction of a new terminology in 2015: interstitial pneumonia with autoimmune features. This new classification requires a better comprehension of its diagnostic impact and the influence of its morphologic aspects on the prognosis of patients. Objective.— To review the diagnostic criteria for interstitial pneumonia with autoimmune features, with an emphasis on morphologic aspects. Data Sources.— The review is based on the available literature, and on pathologic, radiologic, and clinical experience. Conclusions.— The interstitial pneumonia with autoimmune features classification seems to identify a distinct subgroup of patients with different prognoses. Studies show that nonspecific interstitial pneumonia and usual interstitial pneumonia are the most prevalent morphologic patterns and show discrepant results on the impact of the usual interstitial pneumonia pattern on survival. Prospective investigations are necessary to better define this subgroup and to determine the prognosis and appropriate clinical management of these patients.

scholarly journals Impact of supervised exercise training on pulmonary function parameters, exercise capacity and Irisin Biomarker in Interstitial lung disease patients

2020 ◽  
Vol 36 (5) ◽  
Author(s):  
Rahma Mohammad Alyami ◽  
Abdulrahman Mohammed Alhwaikan ◽  
Abdullah Rashed Alharbi ◽  
Ghada AL-Nafisah
Keyword(s):  
Interstitial Lung Disease ◽  
Exercise Training ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Exercise Capacity ◽  
University Hospital ◽  
Enzyme Linked Immunosorbent Assay ◽  
Supervised Exercise ◽  
Before And After ◽  
The Impact

Objectives: To assess the impact of supervised exercise training (SET) on pulmonary function Parameters, exercise capacity and Irisin biomarker in Interstitial Lung Disease (ILD) patients. Methods: Ten (10) patients with ILD and 18 healthy controls of age between 30-40+ years were selected for 8-weekSET program. Before and after SET all subjects performedexercise capacity six minutes’ walk test (6MWT), heart rate (HR) changes were recorded, shortness of Breath Respiratory Questionnaire (SOBQ) was obtained and Irisin levels were measuredby Enzyme-Linked Immunosorbent Assay (ELISA).This interventional study was carried out atDepartment of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2018 to February 2019. Results: Mean six minutes’ walk distance (6MWD) was 395±68.4 m at 1st visit increased significantly (p=0.001) to 458.8±87.1 mat 15 visit. However, 6MWD values found significantly higher in controls (517.4±84.1 m; 561.7±81.6 m; p=0.013) thanILD patients. Overall change (difference between post and pre exercise) in HRvalue was recorded lower in ILD patients (30-35 bpm) as compared to controls (40-45 bpm). Moreover, ILD patients had overall higher SOBQ score than controls. Pre SET Irisin levelsofILD patients (4.24 ± 1.73 pg/ml) and controls (3.43±1.04pg/ml) werefound unchangedafter SET (4.48±2.02pg/ml, 3.39 ±1.41pg/ml,p=0.677, p=0.093) respectively. However, patients Irisin values were foundhigher as compared to controls before and after SET. Conclusion: Exercise capacity and Dyspneain patients with ILD were improved after 8-week of SET program. No major changes in Irisin levels among patients with ILD and controls were observed. Additional research requires to be carried out on large number of subjects to deterMinutese the advantages of exercise in ILD. doi: https://doi.org/10.12669/pjms.36.5.1795 How to cite this:Alyami RM, Alhwaikan AM, Alharbi AR, AL-Nafisah G. Impact of supervised exercise training on pulmonary function parameters, exercise capacity and Irisin Biomarker in Interstitial lung disease patients. Pak J Med Sci. 2020;36(5):1089-1095.  doi: https://doi.org/10.12669/pjms.36.5.1795 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

scholarly journals Outcome of hospitalisation for COVID-19 in patients with Interstitial Lung Disease: An international multicentre study.

2020 ◽  
Author(s):  
Gisli Jenkins ◽  
Tom Drake ◽  
Annemarie B Docherty ◽  
Ewan Harrison ◽  
Jennifer Quint ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Function ◽  
Lung Disease ◽  
Primary Outcome ◽  
Secondary Analysis ◽  
Risk Of Death ◽  
Increased Risk ◽  
Co Morbidity ◽  
The Impact ◽  
Overall Mortality

Rationale: The impact of COVID-19 on patients with Interstitial Lung Disease (ILD) has not been established. Objectives: To assess outcomes following COVID-19 in patients with ILD versus those without in a contemporaneous age, sex and comorbidity matched population. Methods: An international multicentre audit of patients with a prior diagnosis of ILD admitted to hospital with COVID-19 between 1 March and 1 May 2020 was undertaken and compared with patients, without ILD obtained from the ISARIC 4C cohort, admitted with COVID-19 over the same period. The primary outcome was survival. Secondary analysis distinguished IPF from non-IPF ILD and used lung function to determine the greatest risks of death. Measurements and Main Results: Data from 349 patients with ILD across Europe were included, of whom 161 were admitted to hospital with laboratory or clinical evidence of COVID-19 and eligible for propensity-score matching. Overall mortality was 49% (79/161) in patients with ILD with COVID-19. After matching ILD patients with COVID-19 had higher mortality (HR 1.60, Confidence Intervals 1.17-2.18 p=0.003) compared with age, sex and co-morbidity matched controls without ILD. Patients with a Forced Vital Capacity (FVC) of <80% had an increased risk of death versus patients with FVC ≥80% (HR 1.72, 1.05-2.83). Furthermore, obese patients with ILD had an elevated risk of death (HR 1.98, 1.13−3.46). Conclusions: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity. Stringent precautions should be taken to avoid COVID-19 in patients with ILD.

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