scholarly journals ESTIMULAÇÃO CRÔNICA DO SISTEMA IMUNOLÓGICO EM PACIENTES COM CÂNCER GINECOLÓGICO E MAMA E LINFÓCITOS T AUXILIARES PERIFÉRICOS PRODUTORES DE IL-12/ CHRONIC STIMULATION OF THE IMMUNE SYSTEM IN PATIENTS WITH GYNECOLOGICAL CANCER AND IL-12-PRODUCING PERIPHERAL HELPER T LYMPHOCYTES

2020 ◽  
Vol 6 (11) ◽  
pp. 87994-88005
Author(s):  
Jéssica Ferreira Vieira ◽  
Eddie Fernando Cândido Murta ◽  
Rosekeila Simões Nomelini ◽  
Márcia Antoniazi Michelin
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Gynecological Cancer ◽  
Chronic Stimulation ◽  
Helper T Lymphocytes ◽  
Stimulation Of

scholarly journals A reasonable Approach for the Treatment of HIV Infection in the Early Phase with Ozonetherapy (Autohaemotherapy). How ‘Inflammatory’ Cytokines may have A therapeutic Role

1994 ◽  
Vol 3 (5) ◽  
pp. 315-321 ◽  
Author(s):  
V. Bocci
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Hiv Infection ◽  
Inflammatory Cytokines ◽  
Early Phase ◽  
Mechanisms Of Action ◽  
Therapeutic Role ◽  
Immunoregulatory Cytokines ◽  
Reasonable Approach ◽  
Stimulation Of

Immunoregulatory cytokines produced by the TH1 subset and by CD8+T lymphocytes appear to brake naturally and sometimes arrest the progress of HIV infection in the early phase. It appears reasonable to assume that a mild and equilibrated stimulation of the immune system may prevent or delay the fatal transition towards the prevalent production of TH2-type cytokines. The problem is how to stimulate the immune system in a physiological fashion. In the last 7 years we have clarified the main mechanisms of action of an unorthodox immunotherapeutic method first used 40 years ago. Optimized autohaemotherapy after a brief exposure ofblood to ozone may today afford the trick of reprogramming the immune system to keep HIV at bay. The autohaemotherapeutic procedure is simple, safe, inexpensive and most likely is more effective than conventional approaches.

scholarly journals The influence of thiotriazoline on the change of immune system in the blood of guinea-pigs under the conditions of development of experimental bronchial asthma

2015 ◽  
Vol 17 (2) ◽  
Author(s):  
M. S. Reheda ◽  
М. А. Kolishetska ◽  
V. R. Yurevych
Keyword(s):  
Immune System ◽  
T Lymphocytes ◽  
Blood Plasma ◽  
B Lymphocytes ◽  
Bronchial Asthma ◽  
Functional State ◽  
Immune Complexes ◽  
Guinea Pigs ◽  
Stimulation Of ◽  
Plasma Activity

<p>The aim of our research was to determine the character of the role and functional state of separate indexes<br />of the immune system in blood of guinea-pigs under the conditions of the development of experimental bronchial<br />asthma (BA ) and estimation of thiotriazoline influence on them. Decreasing of T-lymphocytes, stimulation of humoral<br />link of immunity, namely increasing of B-lymphocytes and immunoglobulins of A, M and G, elevation of circulatory<br />immune complexes and slump of complement blood plasma activity had been determined in this research. Immune<br />correcting action of thiotriazoline upon the pointed out indices in case of BA is revealed.</p>

Interferons: role in cancer therapy

Immunotherapy ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 833-855 ◽  
Author(s):  
Mohadeseh Haji Abdolvahab ◽  
Behrad Darvishi ◽  
Mohammad Zarei ◽  
Keivan Majidzadeh-A ◽  
Leila Farahmand
Keyword(s):  
Immune System ◽  
Cancer Therapy ◽  
Immune Cells ◽  
Biological Function ◽  
Host Cells ◽  
Combination Therapies ◽  
Chronic Stimulation ◽  
Induce Resistance ◽  
Extreme Responses ◽  
Stimulation Of

Interferons (IFNs) are a group of signaling cytokines, secreted by host cells to induce protection against various disorders. IFNs can directly impact on tumor cells or indirectly induce the immune system to protect host cells. The expression levels of IFNs and its functions of are excellently modulated in a way to protect host cells from probable toxicities caused by extreme responses. The efficacy of anticancer therapies is correlated to IFNs signaling. Although IFN signaling is involved in induction of antitumor responses, chronic stimulation of the IFN signaling pathway can induce resistance to various antineoplasm therapies. Hence, IFNs are expressed by both cancer and immune cells, and modulate their biological function. Understanding this mechanism of action might be a key target of combination therapies.

scholarly journals Pathogenesis of Bone Alterations in Gaucher Disease: The Role of Immune System

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Juan Marcos Mucci ◽  
Paula Rozenfeld
Keyword(s):  
Immune System ◽  
Gaucher Disease ◽  
Autosomal Recessive ◽  
Bone Pathology ◽  
Chronic Stimulation ◽  
Osteolytic Lesions ◽  
Lysosomal Disorder ◽  
Skeletal Bone ◽  
Stimulation Of

Gaucher, the most prevalent lysosomal disorder, is an autosomal recessive inherited disorder due to a deficiency of glucocerebrosidase. Glucocerebrosidase deficiency leads to the accumulation of glucosylceramide primarily in cells of mononuclear-macrophage lineage. Clinical alterations are visceral, hematological, and skeletal. Bone disorder in Gaucher disease produces defects on bone metabolism and structure and patients suffer from bone pain and crisis. Skeletal problems include osteopenia, osteoporosis, osteolytic lesions, and osteonecrosis. On the other hand a chronic stimulation of the immune system is a well-accepted hallmark in this disease. In this review we summarize the latest findings in the mechanisms leading to the bone pathology in Gaucher disease in relationship with the proinflammatory state.

The role of bacterial super antigens in the immune response: From biology to cancer treatment

2020 ◽  
Vol 16 ◽  
Author(s):  
Behnam Emamgolizadeh Gurt Tapeh ◽  
Mohammad Sadegh Hashemzadeh ◽  
Ali Mir Hoseini
Keyword(s):  
Immune Response ◽  
Immune System ◽  
T Lymphocytes ◽  
Cancer Treatment ◽  
Tumor Cells ◽  
Vector Systems ◽  
Bacterial Vector ◽  
Antigen Presenting ◽  
Stimulation Of

Aims: Encouraging results have been indicated preclinically and in patients using the bacterial super antigen. This review article intends to summarize the role of the super antigens that have been recently used in the treatment of cancer. In addition, the vector systems including lentiviral vectors, adeno-associated vector systems and retroviral vectors that are increasingly being used in basic and applied research were discussed. Most importantly, the new CRISPR technique has also been discussed in this literature review. Discussion: More successful therapies can be achieved by manipulating bacterial vector systems through incorporating genes related to the super antigens and cytokines. The products of SAg and cytokine genes contributes to the strong stimulation of immune system against tumor cells. They bind to MHC II molecules as well as the V beta regions of TCR and lead to the production of IL2 and other cytokines, the activation of antigen-presenting cells and T lymphocytes. Additionally, super antigens can be used to eradicate tumor cells. Better results in cancer treatment can be achieved by transferring super antigen genes and subsequent strong immune stimulation along with other cancer immunotherapy agents. Conclusion: Super antigens induce the proliferation of T lymphocytes and antigen-presenting cells by binding to MHCII molecules and V beta regions in T cell receptors. Therefore, the presentation of tumor cell antigens is increased. Additionally, the production of important cytokines by T cells and APCs contributes to the stimulation of immune response against tumor cells. The manipulation of bacterial vector systems through incorporating genes related to SAgs and other immune response factors is a good strategy for immune system stimulating and eradicating of tumor cells along with other immunotherapy agents.

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