A importância da vitamina D para saúde dos idosos/The importance of vitamin D for the health of the elderly

Analisar a efetividade da terapia com vitamina D em idosos com depressão, em comparação ao uso de placebos. Revisão sistemática de literatura. Para seu desenvolvimento, efetuou-se pesquisa em bases de dados para a saúde, seguida da aplicação dos critérios de elegibilidade, considerando textos completos em inglês, português e Ensaios Clínicos Randomizados publicados entre 2008-2020. Em sequência, mediante leitura dos títulos e resumos aos pares, seis publicações compuseram a amostragem final. Os achados indicaram, majoritariamente, inexistir diferenças significativas entre os sintomas depressivos em idosos suplementados com a vitamina D em comparação ao uso do placebo. Os achados não mostraram evidências significativas, atestando que a suplementação da vitamina D não refletiu melhores resultados para a depressão em idosos. Contudo, importante mencionar que uma publicação registrou melhorias em pacientes dialíticos com depressão vascular, melhorando o funcionamento cardiovascular desses pacientes após a suplementação.Descritores: Vitamina D, Depressão, Idosos. Effectiveness of vitamin d therapy in elderly people with depressionAbstract: To analyze the effectiveness of vitamin D therapy in elderly people with depression, compared to the use of placebos. Systematic literature review. For the development of the study, a search was performed in the health’s databases, followed by the application of the eligibility criteria, considering the complete texts in English and Portuguese; Randomized Clinical Trials published between the 2008-2020. In sequence, through the reading of the titles and abstracts in pairs, six publications made up the final sample. The selected articles stated that there were no significant differences between depressive symptoms in the elderly related to vitamin D supplementation compared to the use of placebo. The findings showed no significant evidence, attesting that vitamin D supplementation did not reflect better results for depression in the elderly. However, it is important to mention that one publication recorded improvements in dialysis patients with vascular depression, improving the cardiovascular functioning of these patients after supplementation.Descriptors: Vitamin D, Depression, Seniors. Efectividad de la terapia con vitamina d en ancianos con depresiónResumen: Analizar la efectividad de la terapia con vitamina D en ancianos con depresión, en comparación con el uso de placebos. Revisión sistemática de la literatura. Para el desarrollo del estudio se realizó una búsqueda en las bases de datos de salud, seguida de la aplicación de los criterios de elegibilidad, considerando los textos completos en inglés y portugués; ensayos clínicos aleatorizados publicados entre 2008-2020. En secuencia, mediante la lectura de títulos y resúmenes por parejas, seis publicaciones conformaron la muestra final. Los artículos seleccionados indicaron que no hubo diferencias significativas entre los síntomas depresivos en los ancianos relacionados con la suplementación con vitamina D en comparación con el uso de placebo. Los hallazgos no mostraron evidencia significativa, lo que atestigua que la suplementación con vitamina D no reflejaba mejores resultados para la depresión en los ancianos. Sin embargo, es importante mencionar que una publicación registró mejoras en pacientes de diálisis con depresión vascular, mejorando el funcionamiento cardiovascular de estos pacientes después de la suplementación.Descriptores: Vitamina D, Depresión, Mayores.

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A cost-effective preventative approach to potentially save lives in the coronavirus pandemic, jointly using Vitamin D, Curcumin, and Vitamin C. Authors Bakare T A and Soar J S

10.31232/osf.io/jgf6e ◽

2020 ◽

Author(s):

Jagjit S Soar

Keyword(s):

Vitamin D ◽

Vitamin C ◽

Cost Effective ◽

Risk Groups ◽

The Elderly ◽

Pharmaceutical Drugs ◽

Over The Counter ◽

Literature Searches ◽

Pharmaceutical Agents ◽

And Control

he current COVID-19 pandemic now believed to be based on the mutation of the SARS-CoV virus (first reported in 2002) to SARS-CoV-2 emerging in 2019, is naturally causing extreme worry and concern around the world with sometimes mixed and incoherent messages on how to deal with it. There is a plethora of information from previous epidemics caused by other coronaviruses such as severe acute respiratory syndrome, SARS (2002) and Middle East respiratory syndrome MERS (2012) from which we can extrapolate guidance on how to deal with the current pandemic. In the current absence of specific pharmaceutical agents, we propose assessing the extended tools that we already possess in our biological armoury to combat, prevent and control the spread of this virus. Using a set of precise criteria to locate such possible contenders, we conducted literature searches to find compounds that met these criteria. We have now reduced this to a shortlist of three agents that may be the best candidates. We propose vitamin C, vitamin D and Curcumin fit our criteria well. These compounds are widely available to the general public. They are available online and over-the-counter as supplements. Otherwise healthy individuals are safely able to self-administer these agents as a prophylactic to protect themselves and to enhance their immune response. This would be especially desirable for the elderly and at risk groups. These agents can also be used as adjunct therapy, particularly for those who may have early symptoms. This preventative therapy could be implemented whilst awaiting specific pharmaceutical drugs to emerge as a treatment for COVID-19. Our suggested compounds are a highly cost-effective way to potentially reduce the mortality that is regretfully mounting as a result of COVID-19 infection. The biological mode of action and the dosing of these compounds are summarised.

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Calcium and vitamin D reduced non-vertebral fractures and bone loss in the elderly

Evidence-Based Nursing ◽

10.1136/ebn.1.2.48 ◽

1998 ◽

Vol 1 (2) ◽

pp. 48-48

Author(s):

J. Dewing

Keyword(s):

Vitamin D ◽

Bone Loss ◽

Vertebral Fractures ◽

The Elderly

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The role of vitamin D and related compounds in the treatment of bone disease in the elderly

Bone ◽

10.1016/8756-3282(94)90329-8 ◽

1994 ◽

Vol 15 (6) ◽

pp. 727-728 ◽

Cited By ~ 3

Author(s):

J.A. Kanis ◽

C. Cooper ◽

R. Francis ◽

N. Hamdy ◽

P. Selby ◽

...

Keyword(s):

Vitamin D ◽

Bone Disease ◽

The Elderly ◽

Related Compounds

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Tratamento complementar da esclerose múltipla com vitamina D / Complementary treatment of multiple sclerosis with vitamin D

Brazilian Journal of Development ◽

10.34117/bjdv7n4-527 ◽

2021 ◽

Vol 7 (4) ◽

pp. 41066-41086

Author(s):

Vitor Taveira Takahashi ◽

Samantha Hosokawa Dias de Novoa Rocha ◽

João Vitor Romeu Bello Taveira ◽

Hugo Cardoso Pena

Keyword(s):

Multiple Sclerosis ◽

Vitamin D ◽

Complementary Treatment ◽

Vitamina D

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Low vitamin D status is associated with hearing loss in the elderly: a cross-sectional study

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqaa310 ◽

2020 ◽

Author(s):

Betsy Szeto ◽

Chris Valentini ◽

Anil K Lalwani

Keyword(s):

Vitamin D ◽

Hearing Loss ◽

Low Frequency ◽

The Elderly ◽

Vitamin D Status ◽

Total Calcium ◽

Mineral Density ◽

Cross Sectional ◽

Age Related ◽

Increased Risk

ABSTRACT Background The elderly are at increased risk of both hearing loss (HL) and osteoporosis. Bone mineral density (BMD) has been putatively linked to HL. However, the roles of serum calcium concentrations and vitamin D status have yet to be elucidated. Objectives The purpose of this study was to examine the relation between vitamin D status, parathyroid hormone (PTH), total calcium, BMD, and HL in a nationally representative sample of elderly adults. Methods Using the NHANES (2005–2010), audiometry and BMD data of 1123 participants aged ≥70 y were analyzed in a cross-sectional manner. HL was defined as pure tone averages >25 dB HL at 500, 1000, and 2000 Hz (low frequency); 500, 1000, 2000, and 4000 Hz (speech frequency); and 3000, 4000, 6000, and 8000 Hz (high frequency) in either ear. Multivariable logistic regression was used to examine the relation between HL and total 25-hydroxyvitamin D [25(OH)D], PTH, total calcium, and BMD, adjusting for covariates. Results In multivariable analyses, total 25(OH)D < 20 ng/mL was found to be associated with greater odds of low-frequency HL (OR: 2.02; 95% CI: 1.28, 3.19) and speech-frequency HL (OR: 1.96; 95% CI: 1.12, 3.44). A 1-unit decrease in femoral neck BMD (OR: 4.55; 95% CI: 1.28, 16.67) and a 1-unit decrease in total spine BMD (OR: 6.25; 95% CI: 1.33, 33.33) were found to be associated with greater odds of low-frequency HL. Serum PTH and total calcium were not found to be associated with HL. Conclusions In the elderly, low vitamin D status was associated with low-frequency and speech-frequency HL. Low vitamin D status may be a potential risk factor for age-related HL.

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Serum levels of 25(OH)D are not associated with venous thromboembolism in the elderly population

Thrombosis and Haemostasis ◽

10.1160/th15-02-0148 ◽

2016 ◽

Vol 115 (01) ◽

pp. 169-175 ◽

Cited By ~ 1

Author(s):

Aurélien Delluc ◽

Marie-Pierre Moineau ◽

Cécile Tromeur ◽

Maelenn Gouillou ◽

Karine Lacut ◽

...

Keyword(s):

Vitamin D ◽

Venous Thromboembolism ◽

Seasonal Variations ◽

Elderly Population ◽

Serum Levels ◽

The Elderly ◽

Vitamin D Status ◽

Increased Risk ◽

Vitamin D Levels ◽

Walking Capacity

SummaryThe prevalence of both vitamin D deficiency and venous thromboembolism (VTE) is important in the elderly. Previous studies have provided evidence for a possible association between vitamin D status and the risk of VTE. Thus, we aimed to investigate the association between vitamin D levels and VTE in the population aged 75 and over included in the EDITH case-control study. The association between vitamin D status and VTE was analysed. We also analysed the monthly and seasonal variations of VTE and vitamin D. Between May 2000 and December 2009, 340 elderly patients (mean age 81.5 years, 32 % men) with unprovoked VTE and their controls were included. The univariate and multivariate analysis found no significant association between serum levels of vitamin D and the risk of unprovoked VTE. In the unadjusted analysis, a higher BMI was statistically associated with an increased risk of VTE (OR 1.09; 95 % CI 1.05–1.13) whereas a better walking capacity and living at home were associated with a decreased rate of VTE: OR 0.57; 95 % CI 0.36–0.90 and 0.40; 95 % CI 0.25–0.66, respectively. Although not significant, more VTE events occurred during winter (p=0.09). No seasonal variations of vitamin D levels were found (p=0.11). In conclusion, in contrast with previous reports our findings suggest that vitamin D is not associated with VTE in the elderly population.

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