Diagnostischer Stellenwert der multiparametrischen MRT mit gezielter Fusionsbiopsie der Prostata bei Patienten mit PSA-Anstieg und negativer Stanzbiopsie zur Detektion klinisch signifikanter Prostatakarzinome

2017 ◽  
Vol 56 (04) ◽  
pp. 147-155 ◽  
Author(s):  
Helmut J. Wieler ◽  
Frank M. Jakobs ◽  
Kasra Taymoorian ◽  
Arnd Gerhards ◽  
Matthias Miederer ◽  
...  
Keyword(s):  
Gleason Score ◽  
Low Grade ◽  
High Grade ◽  
Prädiktiver Wert ◽  
Fand Sich ◽  
Psma Pet ◽  
Pet Ct ◽  
Multiparametrische Mrt

ZusammenfassungZiel: Die multiparametrische MRT (mpMRT) in Verbindung mit einer perinealen gezielten Ultraschall (US)-Fusionsbiopsie soll die diagnostische Präzision bei der Diagnose des klinisch signifikanten Prostatakarzinoms steigern und die Überdiagnose niedrigmaligner Karzinome reduzieren.Methoden: Bei 99 Männern mit vorherigen negativen Standardbiopsien und erhöhtem PSA wurde eine mpMRT durchgeführt und anschließend ul traschallgestützte gezielte perineale Fusionsbiopsien entnommen. Die mittels mpMRT gewonnenen PI-RADS-Daten (PS) und der histopathologisch erhobene Gleason Score (GS) wurden miteinander verglichen.Ergebnisse: Bei der mpMRT wurden bei 72/99 Patienten (73 %) Läsionen des PS 4 oder 5 gefunden. Histopathologisch zeigte sich bei 33/99 Patienten (33 %) kein Anhaltspunkt für Malignität. Bei 66 Patienten wurde trotz vorheriger negativer konventioneller Stanzbiopsien in 42 Fällen (64 %) ein low-grade- (GS 6, ≤ 7a) und in 24 Fällen (36 %) ein High-grade-Karzinom (GS ≥ 7b) entdeckt. Bei 21/24 high-grade-Karzinomen (88 %) war auch bei der mpMRT ein Karzinom detektiert worden (PS 4-5). Bei einer Sensitivität von 88 % fand sich ein negativer prädiktiver Wert (NPV) von 85 % (p=0,002). Darüber hinaus wurde bei 35 von 42 low-grade-Karzinomen (83 %) in der mpMRT ein Karzinom-Befund (PS 4-5) erhoben (p < 0,001). Die Sensitivität für eine Differenzierung zwischen low- und high- grade-Karzinomen (GS ≤ 7a vs. ≥ 7b) mittels PS betrug 88 % bei einem NPV von 70 % (p=0,74).Schlussfolgerung: Die Ergebnisse der vorliegenden Studie weisen darauf hin, dass die mpMRT-gestützte US-Fusionsbiop- sie erheblich höhere Detektionsraten zum Nachweis klinisch signifikanter Prostatakarzinome aufweist als die bislang gebräuchlichen Diagnoseverfahren. Jedoch konnte keine statistische Signifikanz bezüglich der Differenzierung zwischen high- und low-gra- de-Karzinomen gezeigt werden. Es ist zu hoffen, dass die Hybridverfahren PSMA- PET/CT bzw. PSMA-PET/MRT in der bis jetzt nicht befriedigenden Signifikanz bei der Differenzierung zwischen high- und low-gra- de-Karzinomen den nächsten Optimierungsschritt herbeiführen werden.

68Ga-PSMA-11-PET/mpMRT zur Lokaldetektion des primären Prostatakarzinoms bei Männern mit negativer Vorbiopsie

2021 ◽  
Vol 42 (06) ◽  
pp. 440-445
Author(s):  
Tobias Maurer ◽  
Hannah Gesterkamp ◽  
Noemi Nguyen ◽  
Kay Westenfelder ◽  
Jürgen E. Gschwend ◽  
...  
Keyword(s):  
Gleason Score ◽  
Bildgebende Diagnostik ◽  
Eine Hohe ◽  
Retrospektive Analyse ◽  
Psma Pet ◽  
Multiparametrische Mrt

Zusammenfassung Hintergrund Die multiparametrische MRT (mpMRT) stellt den Goldstandard der bildgebenden Diagnostik zur Detektion eines primären Prostatakarzinoms (PC) nach negativer Biopsie dar. Die PSMA-PET weist eine hohe Genauigkeit auf, wird aber derzeit vor allem in der Rezidivsituation eingesetzt. Das Ziel der vorliegenden Arbeit war nun, die Effektivität einer kombinierten 68Ga-PSMA-11-PET/mpMRT-Bildgebung zur Detektion eines PC nach vorheriger negativer Prostatabiopsie zu untersuchen. Material und Methoden Es wurden 57 Patienten in die retrospektive Analyse eingeschlossen, bei denen zuvor mindestens eine negative Prostatabiopsie erfolgt war. Alle Patienten erhielten eine 68Ga-PSMA-11-PET/mpMRT-Bildgebung der Prostata. Die mpMRT wurde anhand der PI-RADS-Klassifikation, die 68Ga-PSMA-11-PET durch eine 5-stufige Likert-Skala ausgewertet (1: PC sehr unwahrscheinlich; 2: PC unwahrscheinlich; 3: unklarer Befund; 4: PC wahrscheinlich; 5: PC sehr wahrscheinlich). Alle Patienten erhielten sowohl eine systematische randomisierte als auch eine gezielte transrektale Biopsie auffälliger Läsionen in der Bildgebung. Ergebnisse der Bildgebung und der histologischen Untersuchung der Prostatabiopsate wurden auf Patientenebene korreliert. Ergebnisse In der histologischen Untersuchung zeigten sich bei 35/57 (61,4 %) der Patienten Prostatakarzinominfiltrate. Bei Patienten mit histologisch gesichertem PC zeigte sich bei 21/35 (60,0 %) eine PI-RADS-4- oder -5-Läsion im mpMRT bzw. bei 28/35 (80,0 %) ein PET-Rating von 4 oder 5. Die kombinierte 68Ga-PSMA-11-PET/mpMRT übersah nur einen Patienten mit PC-Gleason-Score (GS) 7a (Beurteilung mit 1 oder 2 in sowohl PET als auch mpMRT). Als Limitationen sind sowohl die retrospektive Analyse als auch negative Resultate trotz gezielter Biopsieentnahme anzuführen. Schlussfolgerung In dieser ersten Analyse zeigte sich die kombinierte 68Ga-PSMA-11-PET/mpMRT als zuverlässige bildgebende Diagnostik für die Prostatabiopsie zur Detektion eines PC bei Patienten nach vorheriger negativer Biopsie. Dabei lieferten die 68Ga-PSMA-11-PET und die mpMRT teilweise komplementäre Ergebnisse, die die Detektion eines PC erhöhten.

PET–CT for the diagnosis and treatment of primary musculoskeletal tumors in Chinese patients - experience from 255 patients in a single center

2021 ◽  
Author(s):  
Aikeremujiang Muheremu ◽  
Tianlin Wen ◽  
Xiaohui Niu
Keyword(s):  
Soft Tissue ◽  
Case Series ◽  
Soft Tissue Sarcomas ◽  
Standardized Uptake Value ◽  
Chinese Patients ◽  
Histopathological Study ◽  
Low Grade ◽  
High Grade ◽  
Musculoskeletal Tumors ◽  
Pet Ct

Objective: The current study was carried out to assess the value of positron emission tomography (PET)/CT on the diagnosis and staging of primary musculoskeletal tumors. Methods: PET–CT test results and histopathological study reports of all the patients with primary musculoskeletal tumors in our department from January 2006 to July 2015 were retrospectively reviewed. Maximum standardized uptake value (SUVmax) in these PET–CT reports were recorded and analyzed respectively for each type of sarcoma. Results: A total of 255 patients were included in the final analysis. Sensitivity of SUVmax based diagnosis was 96.6% for primary malignant osseous sarcomas and 91.2% for soft tissue sarcomas. SUVmax of high-grade osseous sarcomas (average 8.4 ± 5.5) was significantly higher (p < 0.001) than low-grade osseous sarcomas (average 3.9 ± 1.8); based on current case series, SUVmax of high-grade soft tissue sarcomas (7.5 ± 5.1) was not significantly different (p = 0.229) from that of low-grade soft tissue sarcomas (5.3 ± 3.7). Significant decrease of SUVmax value after chemotherapy was associated with favorable prognosis in patients with osteosarcoma. Conclusion: Results of the current study indicate that, the SUVmax based application of PET–CT can be a valuable supplementary method to histopathological tests regarding the diagnosis and staging of primary musculoskeletal sarcomas. Advances in knowledge: SUVmax based application of PET–CT is a highly sensitive method in diagnosis of primary osseous and soft tissue sarcomas in Chinese patients.

scholarly journals Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 537 ◽  
Author(s):  
Renuka Sriram ◽  
Mark Van Criekinge ◽  
Justin DeLos Santos ◽  
Fayyaz Ahamed ◽  
Hecong Qin ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Gleason Score ◽  
Prostate Tissue ◽  
Resonance Spectroscopy ◽  
Low Grade ◽  
High Grade ◽  
Metabolic Alterations ◽  
Ldh Activity ◽  
Benign Prostate

Non-invasive assessment of the biological aggressiveness of prostate cancer (PCa) is needed for men with localized disease. Hyperpolarized (HP) 13C magnetic resonance (MR) spectroscopy is a powerful approach to image metabolism, specifically the conversion of HP [1-13C]pyruvate to [1-13C]lactate, catalyzed by lactate dehydrogenase (LDH). Significant increase in tumor lactate was measured in high-grade PCa relative to benign and low-grade cancer, suggesting that HP 13C MR could distinguish low-risk (Gleason score ≤3 + 4) from high-risk (Gleason score ≥4 + 3) PCa. To test this and the ability of HP 13C MR to detect these metabolic changes, we cultured prostate tissues in an MR-compatible bioreactor under continuous perfusion. 31P spectra demonstrated good viability and dynamic HP 13C-pyruvate MR demonstrated that high-grade PCa had significantly increased lactate efflux compared to low-grade PCa and benign prostate tissue. These metabolic differences are attributed to significantly increased LDHA expression and LDH activity, as well as significantly increased monocarboxylate transporter 4 (MCT4) expression in high- versus low- grade PCa. Moreover, lactate efflux, LDH activity, and MCT4 expression were not different between low-grade PCa and benign prostate tissues, indicating that these metabolic alterations are specific for high-grade disease. These distinctive metabolic alterations can be used to differentiate high-grade PCa from low-grade PCa and benign prostate tissues using clinically translatable HP [1-13C]pyruvate MR.

Interim Positron Emission Tomography-Computed Tomography (PET-CT) Is Predictive of Post-Therapy Outcome in High Grade Transformation of Low Grade Lymphoproliferative Disorders

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 5038-5038
Author(s):  
Louise Imlay-Gillespie ◽  
David Simon Kliman ◽  
Kelly Wong ◽  
Christopher Arthur ◽  
Luke Coyle ◽  
...  
Keyword(s):  
Research Funding ◽  
Metabolic Response ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
High Grade ◽  
Interim Pet ◽  
Pet Ct ◽  
High Grade Transformation ◽  
Post Therapy ◽  
Initial Staging

Abstract Background PET-CT has become an essential tool in the management of Lymphoma. PET-CT is utilized in both the initial staging of lymphoma as well as assessing treatment-response. High grade transformation of a low grade lymphoproliferative disorder (LPD) is associated with a poor prognosis. Patients (pts) are usually treated with standard of care for Diffuse Large B-Cell Lymphoma (DLBCL) with R-CHOP but generally have poorer outcomes and can experience relapse of either low or high grade disease. To our knowledge, PET-CT has not been evaluated as a prognostic tool for the subgroup of transformed DLBCL. Methods A retrospective audit was performed of patients treated at Royal North Shore Hospital in Sydney, Australia between 2003-2012. Pts were included if they were treated with Rituximab for DLBCL during the study period and if this occurred on a background of low-grade LPD. Clinical data including LPD type, initial staging, treatment and outcomes were also collected. Treatments were stratified into standard R-CHOP-like versus more intensive regimens including Hyper-CVAD and dose-adjusted R-EPOCH. PET-CT reports were reviewed at staging, interim and post-therapy time points and outcomes stratified to complete metabolic response (CR), partial metabolic response (PR) and progressive disease (PD),based on the nuclear medicine physician's report. Results 64 pts were identified in the study period with median follow up 4.4 yrs (range, 50d-11yrs)Male:female ratio was 1:1. Median age was 65 yrs (range 30-89). LPD diagnosis included Follicular Lymphoma (FL) (75%), Chronic Lymphocytic Leukemia (CLL) (6%) and others (19%) that included Mucosa Associated Lymphoid Tissue and Marginal Zone Lymphomas. 39 pts (61%) had PET-CT reports available for review. 45 pts (70%) were treated with R-CHOP with the remainder having more intensive regimes. 26% of pts received consolidation radiotherapy. 13 pts (20%) underwent autologous and 6 (9%) proceeded to an had an allogeneic transplant. 3 yr OS and EFS was 89% and 73% respectively. Univariate analysis demonstrated both interim and post therapy PET-CT to be significant for both OS and EFS (p<0.01) with three groups identified; CR, PR and PD with 3 year OS for negative interim PET of 100%, 91% and 0% accordingly. CR on end of therapy CT was associated with improved OS (p<0.05) but not interim CT (p=0.967). On multivariate analysis interim PET-CT was the strongest independent predictor for EFS but not OS (p < 0.05). Discussion PET-CT is an invaluable tool in the management of LPD. This retrospective review demonstrates the utility of interim PET-CT in the prognostication of pts with transformed LPD. Larger prospective studies should be considered using PET-CT to more accurately stratify treatment for pts with transformed LPD. Figure 1. Figure 1. Disclosures Imlay-Gillespie: Novartis: Honoraria. Arthur:Amgen: Honoraria; Amgen: Honoraria; BMS: Honoraria. Mackinlay:Sanofi Aventis: Research Funding; Roche: Research Funding. Mulligan:Celgene: Consultancy, Honoraria; Janssen: Consultancy, Honoraria, Speakers Bureau; Sanofi Aventis: Research Funding; Roche: Consultancy, Honoraria, Research Funding, Speakers Bureau.

scholarly journals Qualitative analysis of spinal intramedullary lesions using PET/CT

2015 ◽  
Vol 23 (5) ◽  
pp. 613-619 ◽  
Author(s):  
Kentaro Naito ◽  
Toru Yamagata ◽  
Hironori Arima ◽  
Junya Abe ◽  
Naohiro Tsuyuguchi ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Proliferation Index ◽  
Low Grade ◽  
Tumor Proliferation ◽  
High Grade ◽  
Pet Ct ◽  
Grade Malignancy ◽  
High Grade Malignancy ◽  
Met Pet ◽  
Mib 1

OBJECT Although the usefulness of PET for brain lesions has been established, few reports have examined the use of PET for spinal intramedullary lesions. This study investigated the diagnostic utility of PET/CT for spinal intramedullary lesions. METHODS l-[methyl-11C]-methionine (MET)- or [18F]-fluorodeoxyglucose (FDG)-PET/CT was performed in 26 patients with spinal intramedullary lesions. The region of interest (ROI) within the spinal cord parenchyma was placed manually in the axial plane. Maximum pixel counts in the ROIs were normalized to the maximum standardized uptake value (SUVmax) using subject body weight. For FDG-PET the SUVmax was corrected for lean body mass (SULmax) to exclude any influence of the patient’s body shape. Each SUV was analyzed based on histopathological results after surgery. The diagnostic validity of the SUV was further compared with the tumor proliferation index using the MIB-1 monoclonal antibody (MIB-1 index). RESULTS A total of 16 patients underwent both FDG-PET and MET-PET, and the remaining 10 patients underwent either FDG-PET or MET-PET. Pathological diagnoses included high-grade malignancy such as glioblastoma multiforme, anaplastic astrocytoma, or anaplastic ependymoma in 5 patients; low-grade malignancy such as hemangioblastoma, diffuse astrocytoma, or ependymoma in 12 patients; and nonneoplastic lesion including cavernous malformation in 9 patients. Both FDG and MET accumulated significantly in high-grade malignancy, and the SULmax and SUVmax correlated with the tumor proliferation index. Therapeutic response after chemotherapy or radiation in high-grade malignancy was well monitored. However, a significant difference in SULmax and SUVmax for FDG-PET and MET-PET was not evident between low-grade malignancy and nonneoplastic lesions. CONCLUSIONS Spinal PET/CT using FDG or MET for spinal intramedullary lesions appears useful and practical, particularly for tumors with high-grade malignancy. Differentiation of tumors with low-grade malignancy from nonneoplastic lesions may still prove difficult. Further technological refinement, including the selection of radiotracer or analysis evaluation methods, is needed.

68Ga-PSMA-11 PET/mpMRT zur Lokaldetektion des primären Prostatakarzinom bei Männern mit negativer Vorbiopsie

2020 ◽  
Author(s):  
Tobias Maurer ◽  
Hannah Gesterkamp ◽  
Noemi Nguyen ◽  
Kay Westenfelder ◽  
Jürgen E. Gschwend ◽  
...  
Keyword(s):  
Gleason Score ◽  
Bildgebende Diagnostik ◽  
Eine Hohe ◽  
Retrospektive Analyse ◽  
Psma Pet ◽  
Multiparametrische Mrt

Zusammenfassung Hintergrund Die multiparametrische MRT (mpMRT) stellt den Goldstandard der bildgebenden Diagnostik zur Detektion eines primären Prostatakarzinoms (PC) nach negativer Biopsie dar. Die PSMA PET weist eine hohe Genauigkeit auf, wird aber derzeit vor allem in der Rezidivsituation eingesetzt. Das Ziel der vorliegenden Arbeit war nun die Effektivität einer kombinierten 68Ga-PSMA-11 PET/mpMRT Bildgebung zur Detektion eines PC nach vorheriger negativer Prostatabiopsie zu untersuchen. Material und Methoden Es wurden 57 Patienten in die retrospektive Analyse eingeschlossen, bei denen zuvor mindestens eine negative Prostatabiopsie erfolgt war. Alle Patienten erhielten eine 68Ga-PSMA-11 PET/mpMRT Bildgebung der Prostata. Die mpMRT wurde anhand der PI-RADS Klassifikation, die 68Ga-PSMA-11 PET durch eine 5-stufige Likert-Skala ausgewertet (1: PC sehr unwahrscheinlich; 2: PC unwahrscheinlich; 3: unklarer Befund; 4: PC wahrscheinlich; 5: PC sehr wahrscheinlich). Alle Patienten erhielten sowohl eine systematische randomisierte als auch eine gezielte transrektale Biopsie auffälliger Läsionen in der Bildgebung. Ergebnisse der Bildgebung und der histologischen Untersuchung der Prostatabiopsate wurden auf Patientenebene korreliert. Ergebnisse In der histologischen Untersuchung zeigten sich bei 35 /57 (61,4 %) der Patienten Prostatakarzinominfiltrate. Bei Patienten mit histologisch gesichertem PC zeigte sich bei 21 /35 (60,0 %) eine PI-RADS 4 oder 5 Läsion im mpMRT bzw. bei 28 /35 (80,0 %) ein PET-Rating von 4 oder 5. Die kombinierte 68Ga-PSMA-11 PET/mpMRT übersah nur einen Patienten mit PC Gleason-Score (GS) 7a (Beurteilung mit 1 oder 2 in sowohl PET als auch mpMRT). Als Limitationen sind die retrospektive Analyse als auch negative Resultate trotz gezielter Biopsieentnahme anzuführen. Schlussfolgerung In dieser ersten Analyse zeigte sich die kombinierte 68Ga-PSMA-11 PET/mpMRT als zuverlässige bildgebende Diagnostik für die Prostatabiopsie zur Detektion eines PC bei Patienten nach vorheriger negativer Biopsie. Dabei lieferte die 68Ga-PSMA-11 PET und die mpMRT teilweise komplementäre Ergebnisse, die die Detektion eines PC erhöhen.

Use of FDG-PET Imaging for Patients with Disseminated Cancer of the Appendix

2010 ◽  
Vol 76 (12) ◽  
pp. 1338-1344 ◽  
Author(s):  
Payam Rohani ◽  
Stephen D. Scotti ◽  
Perry Shen ◽  
John H. Stewart ◽  
Gregory B. Russell ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Fdg Pet ◽  
Peritoneal Dissemination ◽  
Low Grade ◽  
High Grade ◽  
Positron Emission ◽  
Pet Ct ◽  
The Mean ◽  
Ct Data ◽  
Abdominal Quadrant

The goal of this study is to evaluate the use of positron emission tomography (PET) in evaluation of patients with peritoneal dissemination of carcinoma of appendiceal origin (PDA). Thirty-three patients with PDA, who had preoperative PET or PET/CT imaging, were analyzed. Using operative, pathology, and PET ± CT data, presence or absence of disease in each abdominal quadrant was noted and the use of 18fluoro-deoxy-glucose (FDG) PET for each quadrant was evaluated. The mean age was 52, and there were 17 males; 58 per cent had low-grade lesions. PET was positive in only 35 per cent of cases overall (30 and 41% sensitivity for low-grade and high-grade, respectively). PET without CT sensitivity for low-grade and high-grade lesions was 21 and 8 per cent, respectively. PET imaging has limited use for patients with PDA. We do not recommend the use of FDG-PET for patients with PDA from cancer of the appendix.

scholarly journals 3D Mueller matrix mapping of layered distributions of depolarisation degree for analysis of prostate adenoma and carcinoma diffuse tissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Volodymyr A. Ushenko ◽  
Benjamin T. Hogan ◽  
Alexander Dubolazov ◽  
Gennadii Piavchenko ◽  
Sergey L. Kuznetsov ◽  
...  
Keyword(s):  
Gleason Score ◽  
Mueller Matrix ◽  
Low Grade ◽  
High Grade ◽  
Tissue Samples ◽  
Prostate Tumour ◽  
Carcinoma Tissue ◽  
Matrix Mapping ◽  
Prostate Adenoma ◽  
Malignant Prostate

AbstractProstate cancer is the second most common cancer globally in men, and in some countries is now the most diagnosed form of cancer. It is necessary to differentiate between benign and malignant prostate conditions to give accurate diagnoses. We aim to demonstrate the use of a 3D Mueller matrix method to allow quick and easy clinical differentiation between prostate adenoma and carcinoma tissues with different grades and Gleason scores. Histological sections of benign and malignant prostate tumours, obtained by radical prostatectomy, were investigated. We map the degree of depolarisation in the different prostate tumour tissues using a Mueller matrix polarimeter set-up, based on the superposition of a reference laser beam with the interference pattern of the sample in the image plane. The depolarisation distributions can be directly related to the morphology of the biological tissues. The dependences of the magnitude of the 1st to 4th order statistical moments of the depolarisation distribution are determined, which characterise the distributions of the depolarisation values. To determine the diagnostic potential of the method three groups of histological sections of prostate tumour biopsies were formed. The first group contained 36 adenoma tissue samples, while the second contained 36 carcinoma tissue samples of a high grade (grade 4: poorly differentiated—4 + 4 Gleason score), and the third group contained 36 carcinoma tissue samples of a low grade (grade 1: moderately differentiated—3 + 3 Gleason score). Using the calculated values of the statistical moments, tumour tissues are categorised as either adenoma or carcinoma. A high level (> 90%) accuracy of differentiation between adenoma and carcinoma samples was achieved for each group. Differentiation between the high-grade and low-grade carcinoma samples was achieved with an accuracy of 87.5%. The results demonstrate that Mueller matrix mapping of the depolarisation distribution of prostate tumour tissues can accurately differentiate between adenoma and carcinoma, and between different grades of carcinoma. This represents a first step towards the implementation of 3D Mueller matrix mapping for clinical analysis and diagnosis of prostate tumours.

Ga-68 PSMA PET/CT in recurrent high-grade gliomas: evaluating PSMA expression in vivo

2021 ◽  
Author(s):  
Arunav Kumar ◽  
Sreedharan Thankarajan ArunRaj ◽  
Khush Bhullar ◽  
K. P. Haresh ◽  
Subhash Gupta ◽  
...  
Keyword(s):  
High Grade ◽  
Psma Pet ◽  
Pet Ct ◽  
High Grade Gliomas ◽  
Psma Expression
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