scholarly journals Putting Biomedical Ontologies to Work

2010 ◽  
Vol 49 (02) ◽  
pp. 135-140 ◽  
Author(s):  
M. Brochhausen ◽  
B. Smith
Keyword(s):  
Experimental Data ◽  
General Trend ◽  
Information Resources ◽  
The Other ◽  
Ontology Development ◽  
Biomedical Ontologies ◽  
Snomed Ct ◽  
User Friendliness ◽  
Cross Domain ◽  
The One

Summary Objectives: Biomedical ontologies exist to serve integration of clinical and experimental data, and it is critical to their success that they be put to widespread use in the annotation of data. How, then, can ontologies achieve the sort of user-friendliness, reliability, cost-effectiveness, and breadth of coverage that is necessary to ensure extensive usage? Methods: Our focus here is on two different sets of answers to these questions that have been proposed, on the one hand in medicine, by the SNOMED CT community, and on the other hand in biology, by the OBO Foundry. We address more specifically the issue as to how adherence to certain development principles can advance the usability and effectiveness of an ontology or terminology resource, for example by allowing more accurate maintenance, more reliable application, and more efficient interoperation with other ontologies and information resources. Results: SNOMED CT and the OBO Foundry differ considerably in their general approach. Nevertheless, a general trend towards more formal rigor and cross-domain interoperability can be seen in both and we argue that this trend should be accepted by all similar initiatives in the future. Conclusions: Future efforts in ontology development have to address the need for harmonization and integration of ontologies across disciplinary borders, and for this, coherent formalization of ontologies is a prerequisite.

scholarly journals CULTURAL REPRESENTATION OF POWER AND THE COURT DURING THE PERSONAL REIGN OF CHARLES I STUART

2020 ◽  
Vol 30 (1) ◽  
pp. 104-110
Author(s):  
L. I. Ivonina
Keyword(s):  
Social Context ◽  
General Trend ◽  
Daily Life ◽  
Cultural Representation ◽  
The Other ◽  
Charles I ◽  
The World ◽  
King Charles I ◽  
History Of ◽  
The One

The article analyzes the main features of the Caroline era in the history of Britain, which were reflected in the cultural representation of the power of King Charles I Stuart and the court’s daily life in the 1630s. The author shows that, on the one hand, the cult of peace and the greatness of the monarch were the cultural product of the Caroline court against the background of the Thirty Years' War in continental Europe. On the other hand, there was a spread of various forms of escapism, the departure into the world of illusions. On the whole, the representation of the power of Charles Stuart and the court’s daily life were in line with the general trend of the time. At the same time, the court of Charles I reflected his personality. Thinly sensing and even determining the artistic tastes of his era, the English king abstracted from its political and social context.

The Interaction of Carbon Black with Sulfur, MBT and TMTD in Vulcanization

1961 ◽  
Vol 34 (2) ◽  
pp. 588-599 ◽  
Author(s):  
G. A. Blokh ◽  
Ch. L. Melamed
Keyword(s):  
Experimental Data ◽  
Carbon Black ◽  
Chemical Reactions ◽  
The Other ◽  
Considerable Importance ◽  
Physical Aspect ◽  
Active Centers ◽  
Other Hand ◽  
The One

Abstract The experimental data collected on the interaction of active centers of carbon black with the rubber on the one hand and of the active centers of carbon black with the sulfur and accelerators, and also with the antioxidants, on the other hand, provide a sound basis for belief that the problem of reinforcement of rubber by active fillers in the process of vulcanization cannot be explained from the physical aspect alone. The facts indicate the considerable importance of the chemical reactions between the active groups of carbon black and the compounding ingredients in the course of vulcanization.

Case and φ-feature agreement in advanced L2 Spanish grammars

2002 ◽  
Vol 2 ◽  
pp. 71-86 ◽  
Author(s):  
Florencia Franceschina
Keyword(s):  
Experimental Data ◽  
The Other ◽  
Gender Agreement ◽  
Advanced Learners ◽  
Number Agreement ◽  
Functional Features ◽  
L2 Spanish ◽  
And Gender ◽  
The One ◽  
Case Number

One account of divergence in advanced L2 grammars is that speakers fail to acquire functional features in the L2 that are not part of the L1 inventory, and that this leads to non-native representations. Since this idea was first proposed by Hawkins and Chan (1997), few studies have provided the type of data which would allow for it to be adequately tested. This paper presents experimental data from two studies of the acquisition of Case, number and gender agreement in a group of advanced learners of Spanish who are L1 speakers of English, French, German, Greek, Italian and Portuguese. Differences were found between accuracy on Case and number agreement on the one hand, and gender agreement on the other, in ways predicted by the Failed Functional Features hypothesis.

scholarly journals St. Lucian Kwéyòl on St. Croix: How gender and education affect language choice and attitudes in a multilingual context

2011 ◽  
pp. 0
Author(s):  
Edward S. Mitchell ◽  
Diana Ursulin Mopsus
Keyword(s):  
General Trend ◽  
Language Choice ◽  
Virgin Islands ◽  
The Other ◽  
Social Variables ◽  
Gender And Education ◽  
Crucian Creole ◽  
The Many ◽  
The One ◽  
The Right

Based on interviews conducted within a community of St. Lucian Creole (Kwéyòl) speakers on the island of St. Croix, U.S. Virgin Islands, the authors investigated the use of and attitudes towards Kwéyòl, English, Spanish, and Crucian Creole, the four most widely-spoken languages on St. Croix. The article examines the roles of two social variables, namely gender and education, in questions of language choice and attitudes in this bilingual creolophone community. Some of the more remarkable revelations of this study were found in the many apparently conflicting responses. On the one hand, we observed a general trend towards the loss of Kwéyòl, yet on the other, pride in the language is exceedingly high. We observed a strong tendency pointing towards a taboo against speaking Kwéyòl in public on St. Croix, while at the same time, a significant number proclaimed the right to speak Kwéyòl in public.

Assessing Applicability of Ontological Principles to Different Types of Biomedical Vocabularies

2009 ◽  
Vol 48 (05) ◽  
pp. 459-467 ◽  
Author(s):  
R. Linder ◽  
J. Ingenerf
Keyword(s):  
The Other ◽  
Snomed Ct ◽  
Other Hand ◽  
Intended Purpose ◽  
Different Types ◽  
The One ◽  
Logical Formalism ◽  
Aggregation Level

Summary Objectives: Recently, ontological principles have been applied to numerous biomedical vocabularies, with the intention to identify mistakes and poor modeling decisions. No doubt, such applications are useful and necessary for terminological systems like SNOMED CT based on an axiomatic logical formalism. Methods: In the following review, ontology is dealt with by focussing on particularly two aspects: the problem of ISA-overloading and the intrusion of epistemology-loaded terms in biomedical vocabularies. Both aspects are considered with respect to three types of biomedical vocabularies. Results: Opposed to concept-oriented terminological systems, the purpose-specific organization of descriptors in thesauri and classes in statistical classifications on an extra aggregation level make it impossible to apply ontological principles. On the contrary, their intended purpose presupposes specific mechanisms that are in conflict with those principles. Conclusions: Interestingly, for thesauri and classifications there are rather similar initiatives linking the extra level of descriptors and classes on the one hand and an intermediate concept level on the other hand. Such an approach proved beneficial for maintaining and translating thesauri and classifications.

Study of Electromagnetic Multipole Transition Half-Lives of One-Hole 15O–15N and One-Particle 17O–17F Mirror Nuclei

2013 ◽  
Vol 68 (10-11) ◽  
pp. 709-714 ◽  
Author(s):  
Mohammadreza Pahlavani ◽  
Behnam Firoozi
Keyword(s):  
Experimental Data ◽  
Wave Functions ◽  
The Other ◽  
Spin Orbit Coupling ◽  
Spin Orbit ◽  
Matrix Elements ◽  
Saxon Potential ◽  
N Isotopes ◽  
The One ◽  
Theoretical Results

Energy spectrum and wave functions are obtained numerically with a potential consisting of Woods-Saxon, Coulomb, and spin-orbit coupling parts for the nuclei 15O, 15N, 17O, and 17F. The radial parts of the wave functions are used to calculate some matrix elements of electromagnetic transitions. These results are applied to calculate half-lives of low-lying exited states in the one-particle 17O and 17F as well as in the one-hole 15O and 15N isotopes. The calculated half-lives are compared with available experimental and theoretical results based on harmonic oscillator wave functions and Weisskopf units. In comparison with the results calculated from the other methods, our results based on the Woods-Saxon potential indicate a satisfactory agreement with accessible experimental data.

The search for the active base operating in alkoxide promoted E2 reactions in low polar solvents: A kinetic analysis of the elusive problem

1981 ◽  
Vol 46 (13) ◽  
pp. 3247-3263 ◽  
Author(s):  
Jiří Závada ◽  
Magdalena Pánková ◽  
Antonín Vítek
Keyword(s):  
Experimental Data ◽  
Kinetic Analysis ◽  
Kinetic Models ◽  
The Other ◽  
Polar Solvents ◽  
Tert Butanol ◽  
Isomer Distribution ◽  
Single Substrate ◽  
The One ◽  
Active Base

Partial kinetic orders in base for 1-decene, cis-2-decene and trans-2-decene formation from the reaction of 2-decyl bromide with t-C4H9OK in tetrahydrofuran and in tert-butanol and with t-C4H9ONa in tert-butanol have been determined and their significance for assessment of active base has been probed. It has been ascertained that assessment of active base in alkoxide promoted E2 reactions is model-dependent. An unambiguous evidence has been provided by a kinetic analysis of the effect of base concentration on olefin-isomer distribution in the reaction. Two alternative kinetic models of this effect have been devised, the one assuming a competition of several active base species for a single substrate and the other a competition between an uncomplexed and alkoxide-complexed substrate for a single active base. Compatibility of both kinetic models with experimental data has been demonstrated.

A few practical remarks on the user-friendliness of online systems

1980 ◽  
Vol 2 (6) ◽  
pp. 277-283 ◽  
Author(s):  
V. Stibic
Keyword(s):  
Natural Language ◽  
Input Data ◽  
Free Choice ◽  
The Other ◽  
User Friendliness ◽  
Output Data ◽  
Online Systems ◽  
Input And Output ◽  
The One ◽  
User Friendly

A list of general properties of a user-friendly online sys tem is presented. Unfortunately, the requirements of experi enced users on the one hand, and of the beginners or inci dental users on the other hand, are contradictory. Synonymous commands, less strictly formalized input data transformed to standardized formats by intelligent input programs, explicit as well as implicit input data, free choice between default or user's own parameters and procedures or macrocommands, can make any system more friendly even for heterogeneous user population. Similarly, flexibility of output (e.g. elo quent natural-language messages for non-experienced users and concise coded and abbreviated output for experts) im proves acceptance of the system by all users. Examples of flexible, free forms of commands, input and output data are given.

Modeling the Combined Effect of pH and Temperature on the Heat Resistance of Bacillus stearothermophilus Spores Heated in a Multicomponent Food Extract

2001 ◽  
Vol 64 (10) ◽  
pp. 1631-1635 ◽  
Author(s):  
W. TEJEDOR ◽  
M. RODRIGO ◽  
A. MARTÍNEZ
Keyword(s):  
Experimental Data ◽  
Heat Resistance ◽  
Mathematical Models ◽  
Bacillus Stearothermophilus ◽  
Combined Effect ◽  
The Other ◽  
Distilled Water ◽  
Effect Of Ph ◽  
Food Extract ◽  
The One

The combined effect of pH and temperature on the heat resistance of Bacillus stearothermophilus spores heated in an extract of complex food was studied. The results showed that, in general, reducing the pH reduced the heat resistance of the spores. Similarly, the value for the D parameter in the nonacidified extract was between 30 and 70% lower than the one obtained with double-distilled water. This result once again shows the importance of the substrate in inactivation studies of microorganisms. The experimental data were used to carry out a comparison of two predictive mathematical models of inactivation, one based on a multiparametric regression obtained in this study and the other obtained from the bibliography and based on a linear-Bigelow equation. Both models predict reasonably well, although the multiparametric model presented a slightly better accuracy factor (1.11) than the one obtained with the linear-Bigelow equation (1.13).

The Recognition of Foreign Divorces in Ireland: The Return of Travers v. Holley

2001 ◽  
Vol 50 (1) ◽  
pp. 144-157 ◽  
Author(s):  
Jonathan Hill
Keyword(s):  
General Trend ◽  
The Other ◽  
European Countries ◽  
The Law ◽  
Western European ◽  
The One ◽  
The Right

Over the course of the last hundred and fifty years or so the general trend in the laws of Western European countries has been, first, to make provision for judicial divorce and, second, to make it easier for parties to a marriage which has broken down to obtain such a divorce. This coupled with increased mobility has added to the significance of the law relating to the recognition of foreign divorces. The law's essential task is to strike the right balance between, on the one hand, being too restrictive, thereby creating “limping” marriages (i.e., marriages which are valid in one or more countries, but not others) and, on the other, being too generous, thereby sanctioning “quickie” divorces or divorces of convenience.1

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