Effect of vitamin D on sleep quality in hemodialysis patients

Introduction: Quality of sleep is among the factors that affect the improvement of life quality. The previous studies showed that 50%-80% of hemodialysis patients experience sleeping disturbances. Additionally, dialysis patients commonly experience vitamin D deficiency. Objectives: We aimed to determine the impact of vitamin D deficiency therapy on sleep quality of hemodialysis patients. Patients and Methods: Thirty hemodialysis patients with 25-hydroxy vitamin D deficiency and Pittsburgh Sleep Quality Index (PSQI) ≥5 were enrolled in this clinical trial. Patients were treated with 50000-unit vitamin D per week for 12 weeks. After treatment, the PSQI score was recalculated for each patient. Results: Nineteen out of 30 patients (63.3%) were men and 11(36.7%) were women, with a mean age of 56.7 ± 14.3 years. The mean of vitamin D level was 18.61 ± 6.32 ng/mL before treatment and 41.14 ± 9.62 ng/mL after the treatment. The mean of PSQI score at the start of study was 9.97 and after treatment with vitamin D3, it was 9.47 (P > 0.05). Conclusion: Treatment of vitamin D deficiency did not have any effect on the sleep quality according to the PSQI score in hemodialysis patients. Trial registration: This randomized controlled trial was registered in the Iranian Registry of Clinical Trials (identifier: IRCT20200223046593N1; https://en.irct.ir/trial/46126, ethical code; IR.SBMU.RETECH.REC.1397.1277).

Download Full-text

Vitamin D assessment in perioperative medicine and critical care

Wiener klinische Wochenschrift ◽

10.1007/s00508-019-01584-x ◽

2019 ◽

Cited By ~ 1

Author(s):

Paul Zajic ◽

Stefan Heschl ◽

Michael Schörghuber ◽

Petra Srekl-Filzmaier ◽

Tatjana Stojakovic ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Deficiency ◽

False Positive Rate ◽

Fluid Loading ◽

Vitamin D Levels ◽

Positive Rate ◽

25 Hydroxy Vitamin D ◽

The Mean ◽

Clinical Trials Registry ◽

The Impact

Summary Background There is controversy about the impact of acute illness on vitamin D levels. This study was carried out to assess the influence of perioperative fluid loading on 25-hydroxy-vitamin D [25(OH)D] levels. The study evaluated the clinical utility of a commonly available chemiluminescence assay (ECLIA, IDS-iSYS) and liquid chromatography/mass spectrometry (LC-MS/MS) in the diagnosis of vitamin D deficiency in this setting. Methods In this prospective observational pilot study in adult patients undergoing cardiovascular surgery on cardiopulmonary bypass (CPB), blood samples drawn at preoperative baseline (t1), after weaning from CPB (t2), on intensive care unit (ICU) admission (t3) and on the first (t4) and second (t5) postoperative days were analyzed. Results A total of 26 patients (130 samples) were included in this study. Fluid loading by CPB led to a median reduction of 25(OH)D by −22.6% (range −54.5% to −19.5%) between t1 and t2. Cohen’s kappa (κ) for method agreement for vitamin D deficiency (tested cut-off values 20 ng/ml and 12 ng/ml), was κ = 0.291 (p < 0.001) and κ = 0.469 (p < 0.001), respectively. The mean difference between measurements by ECLIA and LC-MS/MS was 4.8 ng/ml (±5.7), Pearson’s r for correlation was 0.73 (p < 0.001). The biologically inactive C3-epimer did not contribute to 25(OH)D levels assessed by LC-MS/MS. Conclusion The 25(OH)D measurements by chemiluminescence assays can noticeably deviate from those measured by LC-MS/MS, which can be considered the unequivocal gold standard. These assays may still be acceptably reliable in the screening for vitamin D deficiency, especially in the setting of low vitamin D levels. Stricter definitions, e.g. serum 25(OH)D levels lower than 12 ng/ml, may be used to diagnose deficiency with low false positive rate. Trial Registration DRKS00009216, German Clinical Trials Registry (www.drks.de)

Download Full-text

Correlation between quality of life and adherence to treatment in hemodialysis patients

Journal of Renal Injury Prevention ◽

10.15171/jrip.2019.05 ◽

2018 ◽

Vol 8 (1) ◽

pp. 22-27 ◽

Cited By ~ 1

Author(s):

Mahin Naderifar ◽

Mansoureh Zagheri Tafreshi ◽

Mahnaz Ilkhani ◽

Magid Reza Akbarizadeh ◽

Fereshteh Ghaljaei

Keyword(s):

Quality Of Life ◽

Healthcare Providers ◽

Life Quality ◽

Well Being ◽

Sample Volume ◽

Hemodialysis Patients ◽

Adherence To Treatment ◽

Medical Sciences ◽

The Mean

Introduction: Institutionalizing adherence to treatment in hemodialysis patients is one of the important nursing goals for improving quality of life in these patients. Adherence to treatment approach in these patients can play a pivotal role in improving the health level and feeling of well-being. Objectives: This study aimed at determining the quality of life in hemodialysis patients presenting to hemodialysis centers affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran, on the basis of adherence to treatment. Patients and Methods: This is a correlational descriptive-analytic study. The study population consisted of hemodialysis patients in five hospitals affiliated to Shahid Beheshti University of Medical Sciences, Tehran, in 2017. The data were collected during 8 months from October 2016 to May 2017 in Tehran. A sample volume of 200 patients was determined in this study. Demographic information questionnaire, KDQOL-SF, and ESRD-AQ were applied in data collection. Availability sampling method was used to select the samples on the basis of inclusion criteria. The data were analyzed with SPSS version 18 using descriptive and inferential statistics. Results: Our findings showed that 50% of the patients were male. Most of the respondents of the study (23%) were 51-60 years old. The results indicated that the mean score of quality of life of patients was 50.42±22.81. The mean total score of adherence to treatment was 901.13±85.30. Also, the correlation coefficient in this study revealed a significant correlation between total score of quality of life and adherence to treatment (r=0.218, P<0.01). Conclusion: Considering the significant correlation between adherence to treatment and life quality of patients, healthcare providers can promote the life quality of these patients via focusing on planning programs for emphasizing the role of education and interventions that improve adherence to treatment in these patients.

Download Full-text

The Impact of COVID-19 Infection on the Quality of Life of Health Care Workers

10.21203/rs.3.rs-1009194/v1 ◽

2021 ◽

Author(s):

Sadeel Shanshal ◽

Harith Kh. Al-Qazaz

Keyword(s):

Quality Of Life ◽

Sleep Quality ◽

Psychological Health ◽

World Health ◽

World Health Organization Quality ◽

Significant Difference ◽

Males And Females ◽

The Mean ◽

The Impact

Abstract Background: COVID-19 pandemic has negatively affected the entire world and one of its impacts was the increased level of stress and anxiety, especially among healthcare workers. Therefore, this study aims at evaluating the quality of life (QoL) and sleep quality of healthcare professionals in Iraq.Methods: This study assessed the QoL and sleep quality by using World Health Organization Quality of Life Instruments (WHOQOL-BREF) and the Insomnia Severity Index (ISI) respectively. The questionnaires were administered through an online cross-sectional survey targeted at workers in medical fields in Iraq from 1st to 20th of August 2021. Results: Three hundred medical health workers participated, and females constituted 75.3%. The two questionnaires had very good internal consistency. The highest scoring domain was the social relationships, followed by physical health. Significant difference was found in the mean scores of psychological health domain between males and females, with higher scores observed in males. The mean of the total ISI score was 11.58 ± 6.88 with a range between 0 and 27. Severe insomnia was observed in only 9.7% of the participants. A significant negative correlation (r = -0.118) was found between age and ISI scores of the participants. Significant differences were found between males and females with higher ISI mean score observed among males. Conclusion: The quality of life and sleep pattern can be impacted by COVID-19 infection with the psychological aspect of QoL being the most affected and some degrees of insomnia being observed in many participants.

Download Full-text

Chronic Urticaria and Its Impact on the Quality of Life of Nepalese Patients

Dermatology Research and Practice ◽

10.1155/2020/6694191 ◽

2020 ◽

Vol 2020 ◽

pp. 1-5

Author(s):

Sushil Paudel ◽

Niraj Parajuli ◽

Rabindra Prasad Sharma ◽

Sudip Dahal ◽

Sudarshan Paudel

Keyword(s):

Quality Of Life ◽

Chronic Urticaria ◽

Demographic Data ◽

Life Quality ◽

Well Being ◽

Female Ratio ◽

Principle Component ◽

The Mean ◽

The Impact

Chronic urticaria (CU) is a skin condition characterized by sudden and recurrent episodes of wheals, angioedema, or both and commonly associated with itching for a duration of more than six weeks. The available data indicate that urticaria markedly affects both objective functioning and subjective well-being of patients. A review of patients’ records with chronic urticaria attending Civil Service Hospital from January 2018 to December 2019 was done. A detailed demographic data of all patients with chronic urticaria was also retrieved. Dermatology Life Quality Index questionnaire (DLQI) Nepalese version was used for the assessment of the impact of disease on life quality. Mann–Whitney U-test was applied to compare means, and principle component analysis for factor analysis was used. A total of 149 patients were included, with a male-to-female ratio of 1 : 1.9. The mean age of the study population was 32.86 ± 12.837 years. The mean DLQI score was 8.30 ± 6.73 with men having a significantly greater score than women ( p < 0.02 ). DLQI scores negatively correlated with age ( p < 0.01 ). There was a high internal consistency among items (Cronbach’s alpha 0.89), and all items had satisfactory correlation with each other as well. Principle component extraction revealed that there were two underlying factors in the DLQI questionnaire on measuring quality of life in chronic urticaria. Males had a greater impairment in quality of life than females due to chronic urticaria. Most severe impairment was seen in symptoms/feelings subdomain. It also revealed that there were two different underlying factors in DLQI questionnaire.

Download Full-text

AB0139 RHEUMATOID ARTHRITIS AND SLEEP QUALITY

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.3310 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1097.1-1097

Author(s):

S. Rekik ◽

L. Ben Ammar ◽

S. Boussaid ◽

S. Jemmali ◽

E. Cheour ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Sleep Quality ◽

Sleep Problem ◽

Sleep Problems ◽

Symptomatic Treatment ◽

Cross Sectional Study ◽

Cross Sectional ◽

The Mean ◽

The Impact

Background:Consequences of rheumatoid arthritis (RA) are many and varied: physical, psycho-affective and financial.Objectives:The objective of our study is to evaluate the impact of RA on sleep quality.Methods:We conducted a cross-sectional study including 49 RA patients. An evaluation of sleep quality using the MOS-Sleep Scale was performed.Results:The mean age of patients was 54.1 years, with a female predominance (89.8%). The mean duration of RA was 11.43 ± 7.32 years with a mean time to diagnosis of 2.35 years. Rheumatoid factor was positive in 77.6% of cases. A atlanto-axial dislocation was found in 4.1% of cases and coxitis in 8.2% of cases. All patients were on symptomatic treatment, 57.1% of whom were on corticosteroid therapy. 83.67% of patients were on cs-DMARDs and 14.2% were on biologics. At inclusion, sleep was optimal in 63.2% of cases and the mean Sleep Problem Index was 26.19 ± 22.77.The index of sleep problems was higher in older subjects and in those with long diagnostic delays. The presence of co-morbidities and atlanto-axial dislocation and/or coxitis was associated with impaired sleep quality. Also, VAS pain and EGP were associated with an increase in the sleep problem index. In the multivariate study, EGP, the presence of co-morbidities and atlanto-axial dislocation and/or coxitis were the independent factors affecting sleep quality.Conclusion:The impact of RA on the patient’s quality of life and especially the quality of sleep is confirmed by several studies in the literature. A global management of the patient is necessary in order to adapt well to his disease.Disclosure of Interests:None declared

Download Full-text

MO888QUALITY OF LIFE AND QUALITY OF SLEEP IN MAINTENANCE HEMODIALYSIS PATIENTS: REPORTS FROM TWO HEMODIALYSIS CENTERS IN IRAN

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfab100.0013 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

Samaneh Hashemi ◽

Roya Rezaee ◽

AmirHossein Saeedi ◽

Hazhir Hojati ◽

Reza Yahyavi Sahzabi ◽

...

Keyword(s):

Quality Of Life ◽

Kidney Disease ◽

Sleep Quality ◽

Hemodialysis Patients ◽

Maintenance Hemodialysis ◽

Quality Of Sleep ◽

Dialysis Adequacy ◽

The Mean ◽

Phosphorus Levels

Abstract Background and Aims Patients with End Stage Kidney Disease (ESKD) usually tend to have lower Quality of Life (QoL) compared to the general population. The purpose of this study was to determine the QoL and quality of sleep in patients on maintenance hemodialysis (MHD) and its relation with medical factors. Method This descriptive-analytical study was performed on 145 patients on MHD in two hospitals affiliated to Abadan University of Medical Sciences. Patients' QoL was assessed via KDQOL-SF questionnaire. For sleep quality, Pittsburgh Sleep Quality Questionnaire (PSQI) was used. Demographic information of patients, type of vascular access, history of dialysis, and frequency and duration of each dialysis session were collected. The average results of related laboratory tests in the last six months, were also recorded for each patient. Results Of 145 MHD patients, 81 (55%) were men and 64 were women. Most patients (53%) were between 30 and 60 years old. Illiteracy was present in 48 (33%) patients. Unemployed patients accounted for 70% of patients (99) and most of the participants (83.44%) lived in the city. Of 145 patients, 102 (70.34%) were married, 20 (13.79%) were single, and the rest were widows. The mean dialysis adequacy of patients was 1.14, and 53% had dialysis adequacy less than 1.2. The average quality of life score was 66.00 ±13, suggesting a high QoL in this group of patients. literacy was significantly associated with QoL score (P<0.001). Likewise, there was significant association between QoL score and income level (p <.001), the effect of Kidney disease on life (p <.001), working status (p <.009), social functioning (p <.046), and marital status (p <.001). The quality of social interactions was significantly associated with residence location (p <.001). On the other hand, the presence of Kidney disease burden, sexual dysfunction, unemployment, role emotional and role physical, was associated with low QoL scores. We found a significant relationship between hemoglobin level and cognitive function (p <.001, r= .075). In addition, significant relationships between phosphorus levels and physical function (p=.021) and role emotional (P:0.04) were observed. Seemingly, phosphorus levels were inversely related with sexual function in our patients (p <0.001, r= - .013). Our data also suggested that serum calcium levels may have an impact on the patients’ social function (p=.038). The mean score of sleep quality was 7.00±4.00. Most of the patients (61%) had a PSQI>5, indicating a poor sleep quality. High sleep quality (PSQI<5) is significantly associated with low age and high-income level. There was also a significant relationship between the average sleep quality and general health (p <0.001, r= -0.206), social function (p= 0.018, r=-0.208), and energy fatigue (p <0.001, r= -0.309). Conclusion Our study showed that a wide range of determinants, including demographic, socioeconomic and disease-related factors can significantly influence the QoL and sleep quality in ESKD patients undergoing hemodialysis. Among them, modifiable factors including laboratory test results, socioeconomic determinants and psychosocial status should be addressed and accordingly treated and solved. Hence, an improvement in both the QoL and sleep quality of maintenance hemodialysis patients will be expected. Keywords Hemodialysis, Quality of life, Sleep quality, Sociodemographic characteristics.

Download Full-text

Cost of depression: effect of adherence and treatment response

European Psychiatry ◽

10.1016/j.eurpsy.2006.04.005 ◽

2006 ◽

Vol 21 (6) ◽

pp. 349-354 ◽

Cited By ~ 24

Author(s):

L. von Knorring ◽

A.-C. Åkerblad ◽

F. Bengtsson ◽

Å. Carlsson ◽

L. Ekselius

Keyword(s):

Quality Of Life ◽

Major Depression ◽

Treatment Response ◽

Controlled Trial ◽

Indirect Costs ◽

The Mean ◽

Cost Of Drugs ◽

The Cost ◽

The Impact

AbstractObjectives:The purpose of the present study has been to assess the societal cost of major depression and the distribution into different cost components. The impact of adherence and treatment response was also explored.Method:Data were collected from a randomized controlled trial of patients with major depressive disorder who were treated in a naturalistic primary care setting. Resource use and quality of life were followed during the two-year trial.Results:The mean total cost per patient during two years was KSEK 363 (EUR 38 953). Indirect costs were the most important component (87%), whereas the cost of drugs was minor (4.5%). No significant differences in costs or quality of life between treatment arms or between adherent and non-adherent patients were demonstrated. However, treatment responders had 39% lower total costs per patient and experienced a larger increase in quality of life compared to non-responders.Conclusions:Major depression has high costs for society, primarily due to indirect costs. Treatment responders have considerably lower costs per patient and higher quality of life than non-responders. This indicates that measures to increase response rates are also important from an economic perspective.

Download Full-text

Serum 25-hydroxy vitamin D and nutritional status: Implications for vitamin D assessment and dietary supplementation in oncology

Journal of Clinical Oncology ◽

10.1200/jco.2009.27.15_suppl.9638 ◽

2009 ◽

Vol 27 (15_suppl) ◽

pp. 9638-9638

Author(s):

K. Trukova ◽

D. Gupta ◽

P. G. Vashi ◽

A. Adams ◽

G. M. Lambert ◽

...

Keyword(s):

Vitamin D ◽

Nutritional Status ◽

Serum Albumin ◽

Vitamin D Deficiency ◽

Cancer Survival ◽

Case Series ◽

Vitamin D Levels ◽

Significant Difference ◽

25 Hydroxy Vitamin D ◽

The Mean

9638 Background: There is emerging evidence in the literature to suggest a protective role of vitamin D in cancer survival. Vitamin D status is not routinely assessed, despite the high prevalence of malnutrition in this population. We hypothesized that malnutrition could contribute to vitamin D deficiency, and therefore expected mean serum 25-hydroxy-vitamin D [25(OH)D] levels to be significantly lower in malnourished oncology patients. Methods: A consecutive case series of 737 cancer patients seen at Cancer Treatment Centers of America between Jan-June 08. Nutritional status was assessed using Subjective Global Assessment (SGA) and serum albumin. SGA categorizes patients into 3 distinct classes of nutritional status; well nourished (SGA-A), moderately malnourished (SGA-B) and severely malnourished (SGA-C). Serum albumin was divided into 2 groups: >=3.6 g/dl and <=3.5 g/dl. Mean serum 25(OH)D was compared across 3 categories of SGA using ANOVA and across 2 categories of serum albumin using 2 sample t test. Results: Of 737 patients, 302 were males and 435 females. The mean age at presentation was 55.7 years (SD = 10.2). The most common cancer types were lung (133, 18%), breast (131, 17.8%), colorectal (97, 13.2%), pancreas (86, 11.7%), prostate (44, 6%) and ovarian (38, 5.2%). The mean serum albumin and serum 25(OH)D was 3.5g/dl (SD = 0.6) and 21.9 ng/ml (SD = 13.5) respectively. There was no significant difference in the mean vitamin D levels across serum albumin (p = 0.76). The mean vitamin D levels across the 3 classes of SGA also showed no statistically significant difference ( Table ). Conclusions: Contrary to what we expected, vitamin D deficiency was found to be prevalent in cancer regardless of nutritional status. No significant differences were found across the 3 classes of SGA. Based on these results, screening for vitamin D deficiency and aggressive vitamin D repletion should be considered for all people with cancer. [Table: see text] No significant financial relationships to disclose.

Download Full-text

Effect of Prenatal Vitamin D Supplementation on Placental Angiogenic Factors in Bangladesh (FS08-07-19)

Current Developments in Nutrition ◽

10.1093/cdn/nzz044.fs08-07-19 ◽

2019 ◽

Vol 3 (Supplement_1) ◽

Author(s):

Anita Subramanian ◽

Casey Carr ◽

Eszter Papp ◽

Kellie Murphy ◽

Abdullah Al Mahmud ◽

...

Keyword(s):

Vitamin D ◽

Growth Factor ◽

Controlled Trial ◽

Secondary Analysis ◽

Vitamin D Supplementation ◽

Angiogenic Factors ◽

Fetal Sex ◽

Maternal Vitamin ◽

The Mean ◽

The Impact

Abstract Objectives To determine the effect of prenatal vitamin D supplementation on expression of angiogenic factors in the placenta. Methods This is a secondary analysis of the Maternal Vitamin D for Infant Growth trial, a randomized controlled trial of maternal vitamin D supplementation in Dhaka, Bangladesh. We examined the expression of angiogenic factors in placental tissues. Women (n = 1300) were enrolled at 17–24 weeks gestation and randomized to receive: placebo, 4200 IU/week, 16,800 IU/week or 28,000 IU/week until delivery. We examined a subset of randomly selected placentas (n = 80) collected at birth, which included 20 tissues (10 male & 10 female offspring) from each treatment group in maternal/fetal pairs. A full thickness placental core was collected; fixed in formalin and embedded in paraffin. Tissue sections were stained for vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) using immunofluorescence. ImageJ was used to quantify intensity and % area of expression. T-tests were used to estimate the effects of each vitamin D dose on expression of angiogenic factors, compared to placebo. Interactions by fetal sex were also examined. Results The mean (SD) for % area of expression was 17.0 (4.0) for VEGF and 14.8 (1.9) for PlGF. The mean (SD) for intensity was 6520 (1549) for VEGF and 5716 (734) for PlGF. There were no significant differences in VEGF and PlGF between any vitamin D treatment groups versus placebo for % area or intensity of expression (Table 1). The effect of vitamin D treatment was not modified by fetal sex. Conclusions Vitamin D supplementation starting from mid-pregnancy until delivery did not effect expression of two key angiogenic factors in the placenta at term. The impact of periconception vitamin D supplementation on expression of angiogenic factors in the placenta remains unknown. Funding Sources Bill and Melinda Gates Foundation. Supporting Tables, Images and/or Graphs

Download Full-text

Effects of Aromatherapy with Lavender and Peppermint Essential Oils on the Sleep Quality of Cancer Patients: A Randomized Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2020/7480204 ◽

2020 ◽

Vol 2020 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Sahar Hamzeh ◽

Roya Safari-Faramani ◽

Alireza Khatony

Keyword(s):

Sleep Quality ◽

Essential Oils ◽

Cancer Patients ◽

Controlled Trial ◽

Control Group ◽

Significant Difference ◽

The Mean ◽

The Difference ◽

And Control

One of the problems of cancer patients is sleep disorder. Given the absence of studies on comparing the effect of inhalation aromatherapy with lavender and peppermint on the sleep quality of the cancer patients, this study was performed to compare the effect of inhalation aromatherapy with lavender and peppermint essential oils on the sleep quality of cancer patients. For this purpose, 120 patients were randomly allocated to three groups of lavender, peppermint, and control. The intervention groups received three drops of the essential oil for 7 days. In the control group, aromatic distilled water was used instead. Pittsburgh Sleep Quality Inventory (PSQI) was used. Before the intervention, no significant difference was observed between the mean PSQI scores of three groups, while the difference was statistically significant after the intervention. The mean PSQI scores were lower in lavender and peppermint groups than in the control group. Aromatherapy can improve the sleep quality of cancer patients. To confirm the findings, more studies should be done.

Download Full-text