scholarly journals A Study of Serum Zinc level in Cirrhosis of Liver

2013 ◽  
Vol 5 (2) ◽  
pp. 44-47
Author(s):  
F Atia ◽  
N Sultana ◽  
S Ahmed ◽  
S Ferdousi ◽  
R Sultana ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Medical College ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver ◽  
Zinc Levels ◽  
Age Range

Cirrhosis is a consequence of chronic liver diseases. Zinc is a micronutrient that plays an important role in the function of liver. This cross-sectional study was carried out in the Department of Biochemistry, Dhaka Medical College, from July 2010 to June 2011 to observe the association of serum zinc level with liver cirrhosis. A total of 100 adults, both males and females with age range of 18-60 years, of which 50 were healthy subjects and 50 adult hospitalised cirrhotic patients were selected purposively for the study according to selection crieteria. Fasting serum zinc level was measured with atomic absorption spectrophotometer. Serum zinc level was found to be low in 72% patients. Mean ±SD of serum zinc levels (?g/L) were 610.32 ± 169.60 and 827.66 ± 267.32 in cases and controls respectively. In cirrhotic patients serum zinc level was significantly lower than that of healthy controls (P<0.001). Though, it is difficult to draw any definite conclusion from this study, because of reduced level serum of zinc found in cirrhotics, Zn may be supplemented to them with a hope of better treatment response. DOI: http://dx.doi.org/10.3329/bjmb.v5i2.13340 Bangladesh J Med Biochem 2012; 5(2): 44-47

Serum Zinc Levels in Cirrhotic Patients Attending General and Specialty Hospitals, Yangon

2019 ◽  
Vol 31 (3) ◽  
pp. 251-256
Keyword(s):  
Clinical Practice ◽  
Hepatic Encephalopathy ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Zinc Level ◽  
The Body ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Cirrhotic Patients ◽  
Cirrhosis Of Liver

Cirrhosis of liver is one of the common medical problem in daily clinical practice and one of the leading causes of morbidity and mortality. Zinc is an essential trace elements for human and plays in many biological roles in the body. Among them, zinc deficiency is thought to be involved in metabolism of ammonia and causes hyperammonia that worsen hepatic encephalopathy. This study aimed to find out the severity of cirrhosis of liver was by Child Turcotte Pugh score and to investigate the associations between serum zinc level and severity of cirrhosis. A hospital-based cross-sectional descriptive study was performed on 78 patients with different underlying causes of cirrhosis of liver at the Medical Units of Yangon General Hospital and Yangon Specialty Hospital. Among the study population, Child grade A was found to be 28.21%, Child grade B was 30.77% and Child grade C was 41.03%. Regarding result of serum zinc level, 62.8% were low level, 28.2% were within normal level and 8.9% were high level. Mean value of serum zinc level in grade A was 0.68 mg/l, grade B was 0.54 mg/l and grade C was 0.48 mg/l (p=0.00). It was found out that there was a high prevalence of zinc deficiency in severe cirrhotic patients. The zinc level was significantly lowest among patients with Child-Pugh C as compare to those with Child-Pugh B and C. Severity of zinc deficiency should be requested for supplementation therapy in cirrhotic patients as to prevent complications such as hepatic encephalopathy, hepatocellular carcinoma and liver failure. Screening for zinc deficiency may need in these patients with more advanced cirrhosis because it seems to be a marker of advanced liver disease and it can be deducted that awareness of serum zinc level among cirrhotic patients is very important in clinical practice.

scholarly journals Estimation of serum zinc levels in children with febrile convulsions

2018 ◽  
Vol 5 (4) ◽  
pp. 1518 ◽  
Author(s):  
Ubaidur Rehman H. ◽  
Shamshad Ahmed Khan ◽  
Prakash R. Saldanha
Keyword(s):  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Significant Difference ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: Febrile seizures are the most common form of convulsion in children with the aged between 6 months to 6 years. Different studies have shown that reduction of zinc leads to the incidence of febrile seizures in children. This study was conducted with the goal of examination of the zinc level in the patients with Febrile Seizures.Methods: This cross sectional study was conducted on 50 children in two equal groups of children with febrile seizures, febrile children without seizures. In order to examine the zinc level blood samples were taken of all subjects and the zinc level of these patients was determined. The data was analyzed using the SPSS-16 statistical software and by descriptive statistical tests.Results: 31 males (47.2%) and 19 female children (52.8%) with the average age of 27.23±15.3 months were examined. The two groups had no significant difference in terms of age and sex. The average of zinc level in the patients with Febrile Seizures was 57.4 µg/dL and it was 116 µg/dL in the febrile children without FS there was a significant difference between the two groups in terms of the zinc level (P=0.01).Conclusions: The low serum zinc level in the group of patients with Febrile Seizures compared with children without febrile seizures indicate the existence of a relationship between the serum zinc level and development of FS in children aged between 6 months and 6 years.

scholarly journals A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 722
Author(s):  
Syed Mohamed ◽  
Santosh Kumar ◽  
J. Kumutha
Keyword(s):  
Cord Blood ◽  
Growth Parameters ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Cross Sectional ◽  
Medical College ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

scholarly journals The association between hypozincemia and aortic stenosis prevalence in hemodialysis patients: a single-center cross-sectional study

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Satoshi Matsui ◽  
Tomonaga Ameku ◽  
Daisuke Takada ◽  
Shinji Ono
Keyword(s):  
Aortic Stenosis ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Single Center ◽  
Cross Sectional ◽  
Dialysis Vintage ◽  
Zinc Levels ◽  
Serum Zinc Levels

Abstract Background Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. Methods To investigate the association between hypozincemia and AS prevalence in patients undergoing hemodialysis, we designed a single-center cross-sectional study. Our outcome “AS” was defined as prevalence of moderate or severe AS or surgical history for AS. Depending on serum zinc levels, we divided patients undergoing hemodialysis into deciles. The association between hypozincemia and AS prevalence was analyzed via logistic regression adjusted for age, sex, dialysis vintage, diabetes history, serum albumin, and history of taking calcium-containing phosphate binder. Results Ninety-three patients undergoing hemodialysis were eligible. The mean serum zinc level was 61.3 ± 13.9 μg/dL. Twelve patients who belonged to 1st decile had serum zinc levels ≤ 48 μg/dL. Of these twelve patients, six patients (50 %) had AS. On the other hand, of eighty one patients who belonged to 2nd–10th deciles (serum zinc levels > 48 μg/dL), thirteen patients (16 %) had AS. Hypozincemia (serum zinc levels ≤ 48 μg/dL) was associated with AS prevalence (P = 0.038; odds ratio 4.43; 95% confidence interval 1.09–18.0). Conclusions AS was more prevalent in patients undergoing hemodialysis with severe hypozincemia in our cross-sectional study, although interventional studies are required to elucidate the benefit of zinc supplementation for AS progression.

scholarly journals Association of Serum Zinc Level with Febrile Seizures in Children

2021 ◽  
pp. 200-203
Author(s):  
Maryum Naveed ◽  
Rimsha Mohsin ◽  
Palwasha Khan
Keyword(s):  
Febrile Seizure ◽  
Serum Zinc ◽  
Febrile Convulsion ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Control Group ◽  
Case Group ◽  
Serum Zinc Level ◽  
Cross Sectional

Introduction: Febrile seizure (FS), previously known as febrile convulsion, is the most common seizure in children. FS usually occurs between six months and five years of age. Aims and objectives: The main objective of the study is to find the association of serum zinc level with febrile seizures in children of Pakistan. Material and methods: This cross sectional study was conducted at Mayo Hospital, Lahore during June 2020 to January 2021. The data was collected from 164 patients of both genders. Results: The data was collected from 164 patients. In the case group, 46 children were male (53.3%), and 36 children (46.7%) were female. In the control group 44 children were male (43.3%) and 38 children were female (56.7%). The age of all participants was between one months and six years. Conclusion: It is concluded that low serum zinc levels are fairly un-sufficient to support the hypothesis that Zinc deficiency could not be a potential risk factor for febrile seizure in children.

scholarly journals Serum Zinc Status During Different Trimesters of Gestation

1970 ◽  
Vol 6 (1) ◽  
pp. 52-57
Author(s):  
Nushrat Noor ◽  
Nasim Jahan ◽  
Nayma Sultana ◽  
Rezina Akter
Keyword(s):  
Pregnant Women ◽  
Rank Correlation ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Mortality And Morbidity ◽  
Micronutrient Status ◽  
Serum Zn

Background: Hypozincemia may be found in different trimesters of pregnancy. Gradual alteration of this micronutrient status during pregnancy is associated with increased maternal and infant mortality and morbidity. Objective: To measure serum zinc level of pregnant women in different trimesters in order to find out their micronutrient status. Method: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January 2010 to 31st December 2010. 90 normal pregnant women, age ranged from 20 to 30 years were included in the study group (Group-B) which was further divided into group B1 consisting of 30 different pregnant women in 1st trimester, group B2 consisting of 30 different pregnant women in 2nd trimester and group B3 consisting of 30 different pregnant women in 3rd trimester. Age matched 30 apparently healthy nonpregnant women (Group A) were also selected by for comparison. Serum zinc level was measured by Spectrophotometric method and serum total protein and albumin levels were estimated by standard laboratory technique. Statistical analysis was done by using ANOVA & Spearman rank Correlation as applicable. Result: In this study, serum Zn level was significantly lower in 1st (p<0.01), 2nd and 3rd trimester (p<0.001) of pregnant women in comparison to that of non-pregnant women. Again, this value was significantly (p<0.001) lower in 3rd trimester than those of 1st and 2nd trimesters of pregnant women. Moreover, serum Zn concentration showed negative correlation (r=-0.621) with different trimesters of gestation and this correlation was statistically significant (p< 0.001).  Conclusion: This study reveals that gradual hypozincemia was observed in pregnant women from 1st to 3rd trimester of gestation. Key words: Serum zinc; Trimester; Pregnancy. DOI: http://dx.doi.org/10.3329/jbsp.v6i1.8085 J Bangladesh Soc Physiol. 2011 June; 6(1): 52-57

scholarly journals Is Serum Zinc Level Associated with Prediabetes and Diabetes?: A Cross-Sectional Study from Bangladesh

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e61776 ◽  
Author(s):  
Md. Rafiqul Islam ◽  
Iqbal Arslan ◽  
John Attia ◽  
Mark McEvoy ◽  
Patrick McElduff ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Sectional Study ◽  
Serum Zinc Level ◽  
Cross Sectional

scholarly journals Implication of serum zinc level with duration and clinical type of vitiligo

2016 ◽  
Vol 6 (2) ◽  
pp. 99
Author(s):  
Sohail Mirza ◽  
Mohammad Eakub Ali ◽  
Lubna Khondker ◽  
Md. Shirajul Islam Khan ◽  
Nadia Islam ◽  
...  
Keyword(s):  
Large Scale ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
The Mean ◽  
The Difference ◽  
Medical University ◽  
The Relationship

<p><strong>Background:</strong> Vitiligo is a common dermatological disorder characterized by acquired, idiopathic, progressive, hypomelanosis of the skin and hair, with total absence of melanocytes microscopically. <strong></strong></p><p><strong>Objective:</strong> The study was conducted to find out the relationship between serum zinc level and clinical spectrum of vitiligo. <strong></strong></p><p><strong>Methods:</strong> A cross sectional study conducted in the departmenl of Dermatology and Venereology and department of Biochemistry, Bang­abandbu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh and the period of study was from May 2010 to October 2011. <strong></strong></p><p><strong>Results:</strong> The mean difference of sernm zinc level in male and female of both groups were significant (p&lt;0.05) but the mean serum zinc level was not significantly different (p&gt;0.05) among various clinical types ofvitiligo. ln case oflocalized vitiligo mean serum zinc level was 755.3 ± 288.6, in case of acrofacial viriligo mean serum zinc level was 821.4 ± 259.6 and in case of generalized vitiligo mean sernm zinc level was 771.6 ± 222.2. The difference of mean sernm zinc level observed between family history positive and negative group were not statistically significant (p&gt;0.05). The difference of mean senun zinc level was also not statistically significant (p&gt;0.05) among &lt;1 year, 1-10 years and 11-20 years duration groups of vitiligo patients. A negative correlation (r = -0.227) was observed between duration of symptom with senun zinc level in this study.<strong> </strong></p><p><strong>Conclusion:</strong> This study showed low level of serum zinc in vitiligo patients. Large-scale studies are needed to confirm these findings and multicenter study should be carried out to reveal the accurate pattern of zinc status in vitiligo.</p>

scholarly journals Zinc Status and Febrile Seizures: Results from a Cross-sectional Study

2020 ◽  
Vol 11 (04) ◽  
pp. 597-600
Author(s):  
Janani Arul ◽  
Peter Prasanth Kumar Kommu ◽  
Ananthanarayanan Kasinathan ◽  
Lopamudhra Ray ◽  
Lalitha Krishnan
Keyword(s):  
Odds Ratio ◽  
Serum Zinc ◽  
Febrile Seizures ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Demographic Variables ◽  
Sectional Study ◽  
Cross Sectional ◽  
Zinc Levels ◽  
Level Of Significance

Abstract Objective To estimate the serum zinc levels in children under the age of 5 years with febrile seizures and febrile children without seizures Materials and Methods In this cross-sectional study from 2017 to 2018, 40 children with febrile seizures (simple and complex) were taken as cases. Forty age- and sex-matched febrile children without convulsions were recruited as controls. Serum zinc estimates were analyzed using a spectrophotometer (Biolis 50i–Autoanalyzer). Statistical Analysis The demographic variables and serum zinc estimates were analyzed using the Mann–Whitney test. The odds ratio was used to calculate the association of zinc deficiency in febrile seizures; 5% level of significance was considered. Results The mean serum concentrations of zinc in the cases and controls were 83.8 ± 33.1 μg/dL and 116.3 ± 30.3 μg/dL, respectively (p = 0.002). Hypozincemia defined by “a serum zinc level of less than 63 μg/dL” was found in 12 (30%) cases and 2(5%) controls with an odds ratio of 8:1. Conclusion Children with febrile seizures had significantly reduced concentrations of zinc in the serum.

Hair Zinc content and its relation to Serum Zinc level in children with Idiopathic Epilepsy

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Omnia Fathy El Rashidy ◽  
Mariam Fathy Abdel Maksoud ◽  
Raghda Mohamed Hesham Zaitoun ◽  
Nermine Farag Mohamed Abdel Hafez
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Idiopathic Epilepsy ◽  
Hair Zinc ◽  
Serum Zinc Level ◽  
Cross Sectional ◽  
Age And Gender ◽  
Control Subjects ◽  
And Gender ◽  
Zinc Levels

Abstract Objective to measure the level of hair zinc, as well as its level in serum, in patients with epilepsy and compare them to the levels found in non-epileptic age and gender matched children, and to explore any potential correlation between either serum or hair level of magnesium and seizure characteristics in children with idiopathic epilepsy. Methods An observational cross-sectional study including 50 children with idiopathic epilepsy and 100 non-epileptic age and gender matched control subjects. Cases were subjected to full history taking, examination and measurements of serum and hair levels of zinc, control subjects only had their serum and hair level of zinc measured as for the cases. Results The mean serum zinc was 1.13 (0.61 - 1.69) ug/ml for cases and 1.81 (0.75 - 3) ug/ml for controls and the median hair level of zinc was 116.58 ug/g with IQR of 74.97 - 176.58 for cases and 143.64 ug/g with IQR of 95.22 - 178.28 for controls. Serum zinc level was significantly lower in cases compared to controls, but the difference was not statistically significant for hair zinc. No statistically significant correlation was observed between either hair or serum levels of zinc and seizure characteristics. Conclusion Serum zinc levels are reduced in epileptic patients compared to healthy age and gender matched controls. Hair zinc levels do not seem to be affected in idiopathic epilepsy. Studies involving larger numbers of patients are needed to confirm these results.

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