scholarly journals Studi Interaksi Obat Antihiperlipidemia Pada Pasien Rawat Jalan RSUD Dr. M.M. Dunda Limboto

2021 ◽  
Vol 3 (1) ◽  
pp. 15-22
Author(s):  
Rahma Hasan
Keyword(s):  
Drug Interaction ◽  
Data Analysis ◽  
Survey Research ◽  
Univariate Analysis ◽  
Blood Lipid ◽  
Inclusion Criteria ◽  
Moderate Severity

Hyperlipidemia is an abnormal lipid condition of metabolism which is characterized by increasing the level of blood lipid. Hyperlipidemia is often followed by other diseases. Therefore, the treatment of hyperlipidemia is often combined with other drugs and potentially increases the occurrence of drugsinteractions. This study aimed to identify the severity of antihyperlipidemic drugsinteractions to the outpatients at Dr. M.M Dunda Limboto Regional PublicHospital on January to March 2018.This research was included in the observation (survey) research, the type of research was the analytic survey and the data was obtained retrospectively. The type of data analysis was univariate analysis and the data was managed theoretically using the guidelines of Stockley Drug Interactionand drugs.com application review. Of the 170 prescription sheets that met the inclusion criteria, 67.65 % were potentially triggered the drugs interactions and 32.35 % had no drugs interactions. One of Antihyperlipidemic drug was often prescribed and mostly generated the interactions was simvastatin (64.12 %). Of the 170 prescriptions, 209 cases of severity of drugs interactions were found, with minor severity of 27.27 %, moderate severity of 47.85 % and major severity of 24.88 %. Hiperlipidemia merupakan suatu keadaan ketidaknormalan metabolisme lipid yang ditandai dengan adanya peningkatan kadar lipid dalam darah. Hiperlipidemiasering diikuti dengan penyakit lain. Sehingga pengobatan hiperlipidemia seringdikombinasikan bersama obat lain dan berpotensi meningkatkan terjadinyainteraksi obat. Penelitian ini bertujuan untuk mengidentifikasi tingkat keparahaninteraksi obat antihiperlipidemia pada pasien rawat jalan RSUD Dr. M.M DundaLimboto periode Januari sampai Maret 2018. Penelitian ini termasuk penelitian observasi (survei), jenis penelitian survei analitik dan data diambil secara retrospektif. Jenis analisis data adalah analisis univariat dan data dikelola secara teoritik menggunakan Stockley Drug Interaction dan review aplikasi drugs.com. Dari 170 lembar resep yang memenuhi kriteria inklusi, diperoleh 67,65 % berpotensi mengalami interaksi obat dan 32,35 % tidak mengalami interaksi obat. Antihiperlipidemia yang sering diresepkan dan paling besar menimbulkan interaksi obat adalah simvastatin (64,12 %). Dari 170 lembar resep, ditemukan 209 kasus tingkat keparahan interaksi obat, dengan tingkat keparahan minor sebesar 27,27 %, tingkat keparahan moderat sebesar 47,85% dan tingkat keparahan mayor sebesar 24,88 %.

HUBUNGAN LAMA WAKTU MENDERITA STROKE DENGAN TINGKAT KEMANDIRIAN KLIEN DALAM MELAKUKAN AKTIVITAS PEMENUHAN KEBUTUHAN SEHARI-HARI

2018 ◽  
Vol 1 (2) ◽  
pp. 58
Author(s):  
Setia Budi ◽  
Ria Dila Syahfitri
Keyword(s):  
Data Analysis ◽  
Univariate Analysis ◽  
Sampling Technique ◽  
P Value ◽  
Cross Sectional ◽  
Stroke Incidence ◽  
Bivariate Data ◽  
Cross Sectional Design ◽  
Interviewing Techniques ◽  
Need For Rehabilitation

The rate of stroke incidence is about 200 per 100,000 people throughout the world. This study aims to determine the Relation Suffer Stroke With Independence Level In Neurology Polyclinic TK II DR Ak Gani Palembang Year Hospital 2017. The research method used is descriptive quantitative with cross sectional design that is done by interviewing techniques with questionnaires on 42 respondents with Accidental sampling technique. This research was conducted in August 2017. Data analysis used is univariate data analysis and bivariate data analysis with one way anova test result. The results of univariate analysis showed that the duration of the respondents suffering from stroke was between 2.10 years to 3.38 years. Also found that most respondents were at the level of independence f; independent, except bathing, dressing, moving, and one other function with a total of 12 respondents. The results showed that there was a significant relationship between the long suffering stroke with the level of independence with the value of p value 0.025. For that the need for rehabilitation to patients and families of patients in order to help improve the independence of stroke patients in doing their daily activities. Keywords : Long Suffer Stroke, Level of Independence

Kajian Interaksi Obat Metformin pada Pasien Diabetes Mellitus

2019 ◽  
Vol 8 (2) ◽  
pp. 55-58
Author(s):  
Havizur Rahman ◽  
Teresia Anggi Octavia
Keyword(s):  
Diabetes Mellitus ◽  
Drug Interaction ◽  
Data Collection ◽  
Drug Interactions ◽  
Degenerative Disease ◽  
Moderate Severity ◽  
Purposive Sampling ◽  
Chronic Degenerative Disease ◽  
Over Time ◽  
Diabetes Melitus

Diabetes melitus merupakan penyakit degeneratif kronis yang apabila tidak ditangani dengan tepat, lama kelamaan bisa timbul berbagai komplikasi, ini cenderung menyebabkan pasien mendapatkan banyak obat dalam satu resep yang dapat menimbulkan interaksi antar obat. Tujuan dari penelitian ini adalah mengetahui persentase terjadinya interaksi obat metformin secara teori serta mengkaji efek yang mungkin timbul dan solusinya. Teknik pengambilan data dengan purpossive sampling, yaitu resep pasien rujuk balik yang menderita diabetes mellitus yang menggunakan metformin. Data yang diperoleh ditemukan bahwa obat yang berinteraksi dengan metformin dengan tingkat keparahan minor ialah sebesar 60%. Kemudian untuk tingkat keparahan moderat ialah sebesar 20%. Sedangkan untuk tingkat keparahan mayor tidak ditemukan. Dari tabel diatas juga dapat diketahui bahwa terdapat 4 obat yang saling berinteraksi dengan metformin, sedangkan untuk obat yang tidak saling berinteraksi dengan metformin terdapat 9 obat. Jumlah obat yang berinteraksi secara teori sebesar 6,85% dan yang tidak berinteraksi 93,15%. Terdapat interaksi obat metformin dengan beberapa obat yaitu furosemid, lisinopril, acarbose dan ramipril.   Kata kunci: interaksi obat, metformin, diabetes mellitus   STUDY OF METFORMIN INTERACTION IN MELLITUS DIABETES PATIENTS   ABSTRACT Mellitus is a chronic degenerative disease which if not handled properly, over time can arise various complications, this tends to cause patients to get many drugs in one recipe that can cause interactions between drugs. The purpose of this study is to determine percentage of metformin drug interactions in theory and examine the effects that may arise and solutions. Data collection techniques using purposive sampling, which is a recipe for reconciliation patients who suffer from diabetes mellitus using metformin. The data obtained it was found that drugs that interact with metformin with minor severity were 60%. Then for moderate severity is 20%. Whereas the major severity was not found. From the table above it can also be seen that there are 4 drugs that interact with metformin, while for drugs that do not interact with metformin there are 9 drugs. The number of drugs that interacted theoretically was 6.85% and 93.15% did not interact. An interaction of the drug metformin with several drugs namely furosemide, lisinopril, acarbose and ramipril.   Keywords: drug interaction, metformin, diabetes mellitus

scholarly journals SIKAP KERJA ADVOKAT PADA ORGANISASI PROFESIONAL

2020 ◽  
Vol 15 (2) ◽  
pp. 353-368
Author(s):  
Tukinu Tukinu ◽  
Istiatin Istiatin ◽  
Supawi Pawenang
Keyword(s):  
Job Satisfaction ◽  
Regression Analysis ◽  
Data Analysis ◽  
Organizational Commitment ◽  
Data Collection ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Survey Research ◽  
Job Attitudes ◽  
Data Collection Technique

The objective of the research is to analyze the effect of professionalism, job satisfaction, and organizational commitment on job attitudes among members of Indonesian Advocate Congress (Kongres Advokat Indonesia/ KAI) in Solo Raya. The type of the research is survey research. The sample of the research uses non-probability census sampling. The data collection technique was done using questionnaire. The data analysis is done using multiple regression analysis. The research concluded that professionalism, job satisfaction, and organizational commitment affect the job attitudes among advocates both simultaneously and partially

scholarly journals Comparison of Three Methods of Predictive Postoperative FEV1 and DLCO Calculations in Relation to Their Observed Postoperative Values in Lung Resection

2020 ◽  
Keyword(s):  
Risk Assessment ◽  
Data Analysis ◽  
Lung Carcinoma ◽  
Calculation Method ◽  
Lung Resection ◽  
Univariate Analysis ◽  
Lung Lobectomy ◽  
Postoperative Fev1 ◽  
Better Than

Introduction: Three ways of simple calculations (segmental based on 18 segments method, segmental based on 19 segments method and subsegmental method) of predictive postoperative values of FEV1 and DLCO are in use during the preoperative survey for patients planned for lung resection as treatment of lung carcinoma as a part of risk assessment. Hypothesis: Segmental calculation method based on 19 segments is better than subsegmental method and segmental calculation method based on 18 segments in prediction of postoperative values of both FEV1 and DLCO one month after lung lobectomy. Materials and methods: Expected postoperative calculated values of FEV1 and DLCO (two segmental and one subsegmental method) of 52 patients undergone lobectomy are related to real postoperative values for same patients one month after surgery. Results: According to univariate analysis, real values of postoperative DLCO correlate most significantly with ppoDLCO calculated by segmental method (18 segments), but real values of postoperative FEV1 correlate most significantly with ppoFEV1 calculated by 19 overall segments segmental method. Data analysis as well showed that preoperative calculated PpoFEV1 and PpoDLCO underestimate real postoperative values of FEV1 and DLCO one month after lobectomy, but it is not statistically significant. Discussion: Same as contemporary guidelines suggest, ppoFEV1 calculation by 19 segments segmental method seems to be the best choice. PpoDLCO is maybe better to calculate by 18 segments segmental method.

scholarly journals Review of Emotional Intelligence: A Preliminary Map Across Latin America

2019 ◽  
Vol 34 (7) ◽  
pp. 1271-1271
Author(s):  
H Patino-Carvajal ◽  
L Tibiriçá ◽  
Y Garcia ◽  
A Maresco ◽  
I Tourgeman
Keyword(s):  
Emotional Intelligence ◽  
Data Analysis ◽  
Latin American ◽  
Life Science ◽  
Life Sciences ◽  
Inclusion Criteria ◽  
Related Subject ◽  
The Mean ◽  
Latin American Countries ◽  
Total Life

Abstract Objective The purpose of this study was to investigate the prevalence of Emotional Intelligence (EI) research among 19 Latin American countries. Participants and Method Respective to each country, Total Life Science publications and Psychology publications were gathered from “UNESCO Science Report Towards 2030.” Population and GDP statistics pertaining to each country were derived from CIA Factbook. Mean education and percentage of GDP allocated for education were gathered from UNESCO Institute for Statistics. The databases SciELO and Redalyc were used to exhume the number of published Emotional Intelligence articles. The term “inteligencia emocional” was used. Findings were filtered to meet inclusion criteria: peer-reviewed, published between 2008-2018, corresponding to a Psychology related subject. Duplicate articles, those that did not contain the term “inteligencia emocional” in the abstract and articles that were not listed under the Psychology category were excluded. Results Data analysis of 19 countries from 2008-2014 revealed the mean number of Emotional Intelligence published articles to be 2.65 (SD = 5.54) articles per country - with a maximum of 22 and a minimum of 0. The percent of articles featuring EI in relation to Total Psychology articles published had a mean of 7% - with Minimum of 0% and Maximum of 60%. Bolivia has the highest percentage of articles on EI (60%), whereas Colombia the highest total number of articles published (n = 41). Population was significantly correlated with Total Articles Published and Total Psychology Articles Published. Conclusions Emotional Intelligence in Latin American countries is not widely investigated. Findings revealed 12 out of 19 Latin American countries had one or more publications related to Emotional Intelligence. While population was shown to be related to the number of articles published in Life Sciences and Psychology, it did not reveal a correlation with the publication of studies regarding EI. Furthermore, education and GDP were not related to the overall publication of articles.

Development and validation of a yoga module for Parkinson disease

2017 ◽  
Vol 14 (3) ◽  
Author(s):  
Noopur Kakde ◽  
Kashinath G. Metri ◽  
Shivarama Varambally ◽  
Raghuram Nagaratna ◽  
H.R. Nagendra
Keyword(s):  
Quality Of Life ◽  
Data Analysis ◽  
Parkinson Disease ◽  
Content Validity ◽  
Poor Quality ◽  
Inclusion Criteria ◽  
Future Studies ◽  
Development And Validation

AbstractBackgroundParkinson’s disease (PD), a progressive neurodegenerative disease, affects motor and nonmotor functions, leading to severe debility and poor quality of life. Studies have reported the beneficial role of yoga in alleviating the symptoms of PD; however, a validated yoga module for PD is unavailable. This study developed and validated an integrated yoga module(IYM) for PD.MethodsThe IYM was prepared after a thorough review of classical yoga texts and previous findings. Twenty experienced yoga experts, who fulfilled the inclusion criteria, were selected validating the content of the IYM. A total of 28 practices were included in the IYM, and each practice was discussed and rated as (i) not essential, (ii) useful but not essential, and (iii) essential; the content validity ratio (CVR) was calculated using Lawshe’s formula.ResultsData analysis revealed that of the 28 IYM practices, 21 exhibited significant content validity (cut-off value: 0.42, as calculated by applying Lawshe’s formula for the CVR).ConclusionsThe IYM is valid for PD, with good content validity. However, future studies must determine the feasibility and efficacy of the developed module.

Biological Parameters Predictive Of Percent Dense Red Blood Cell Decrease Under Hydroxyurea Therapy

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 990-990
Author(s):  
Marie Georgine Rakotoson ◽  
Gaetana Di Liberto ◽  
Anoosha Habibi ◽  
Christine Fauroux ◽  
Sanam Khorgami ◽  
...  
Keyword(s):  
Blood Cell ◽  
Univariate Analysis ◽  
Acute Chest Syndrome ◽  
Mean Corpuscular Hemoglobin ◽  
Therapeutic Effects ◽  
Biological Parameters ◽  
Inclusion Criteria ◽  
Corpuscular Hemoglobin ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Abstract Introduction Dehydrated, dense red blood cells (DRBC), a subpopulation of sickle cells, are characterized by density >1.112; their increased mean corpuscular hemoglobin concentration (MCHC) leads to hemoglobin S (HbS) polymerization. The %DRBC is the biological parameter most strongly associated with some sickle-cell–disease (SCD) chronic organ damage, e.g., renal dysfunction, leg ulcers and priapism, also called hemolytic subphenotypes (Bartolucci et al. Blood 2012; Kato et al. Blood Rev 2007). Proven hydroxyurea (HU) efficacy against SCD lowers vaso-occlusive crisis, acute chest syndrome frequencies, and mortality (Charache et al. N Engl J Med 1995). The classical biological parameters indicating HU response are fetal hemoglobin (HbF) and mean corpuscular cell volume (MCV) increases (Steinberg et al. Blood 1997). However, we previously found decreased %DRBC in 33 patients after 6 months of HU (Bartolucci et al. Blood 2012) .We analyzed baseline biological parameters to identify those predictive of %DRBC decline under HU. Patients and methods We conducted a monocenter, prospective, longitudinal study on SCD patients undergoing HU therapy. Data were collected at baseline (day 0) and after 6 months of HU. Inclusion criteria were: SS and S-β0 thalassemia patients, age >18 years. Non-inclusion criteria were pregnancy, chronic blood transfusion and refused consent. Biological parameters determined were: %DRBC assessed with the phthalate density-distribution technique, D50 (defined as the density at which [(height of cells below phthalate index/sum of those above and below that index) = 0.5]), white blood-cell count (WBC count), MCV, MCHC, mean corpuscular hemoglobin content (MCH), total Hb, reticulocytes (RET), %HbF, platelet count, total bilirubin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase. Results are expressed as means ± SD, numbers or %, as appropriate. Quantitative parameters were compared between groups with Student’s paired t-test. Correlations were established with Pearson’s correlation coefficient. Multiple linear regressions were used to explore models that better predicted DRBC variation under HU. The final models included the variables that remained significantly associated with %DRBC decline after adjustment for the other variables in the models. R-squared (r2) were used as measures of variance explained by the models. P < 0.05 defined significance. This study was approved by the local Institutional Review Board. Results and Discussion Fifty-nine patients, mean age 35 ± 9 years, were included. Their %DRBC fell significantly by 40.7% after 6 months of HU therapy (P = 0.0003) from 10.1 ± 8% to 6 ± 4%. The %HbF rose from 7.2 ± 4% to 17.3 ± 8%. Our univariate analysis identified variables significantly correlated with %DRBC (Table). Multivariate analysis retained a significantly positive correlation between %DRBC decreases under HU and the pretreatment %DRBC on day 0. This statistical model accounted for 71.9% of the variability of %DRBC decline under HU. Pertinently, no correlation was found between %HbF and %DRBC changes, suggesting different mechanisms of action. Conclusion Our results confirmed the HU impact on %DRBC decrease, suggesting new indications to prevent or treat SCD complications associated with high %DRBC. They also showed that the major parameter predictive of DRBC decline under HU was the baseline %DRBC. %HbF and %DRBC changes under HU were not correlated. Prospective studies are needed to analyze the therapeutic effects of HU on chronic complications. Disclosures: No relevant conflicts of interest to declare.

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