FEATURES OF RESPIRATORY PATHOLOGY IN CHILDREN LIVING IN THE CONDITIONS OF AEROGENIC EXPOSURE TO ACROLEIN AND FORMALDEHYDE

2018 ◽  
pp. 27-30
Author(s):  
О.А. Maklakova ◽  
I.P. Korotaeva ◽  
O.Yu. Ustinova
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Respiratory Diseases ◽  
Chronic Inflammatory Disease ◽  
Blood Levels ◽  
Nasal Breathing ◽  
Second Child ◽  
Low Level ◽  
Respiratory Pathology

A survey of 158 children aged 4-7 years living in a chronic aerogenic low-level exposition to acrolein and formaldehyde was carried out. 82.3 % of children with high blood levels of acrolein and formaldehyde are diagnosed with respiratory diseases. Every second child has a chronic inflammatory disease of the nasal mucosa, including 29.1 % of allergic rhinitis, which are manifested by complaints of nasal breathing, not related to seasonality, nasal eosinophilia and the presence of nasal obstruction. In 6.3 % of children living in a chronic low-level exposition to acrolein and formaldehyde, the presence of bronchial asthma, manifested by signs of peripheral obstruction, was revealed.

ОЦЕНКА ЦИТОКИНОВОГО ПРОФИЛЯ СЫВОРОТКИ КРОВИ И СУБПОПУЛЯЦИЙ Т-ЛИМФОЦИТОВ У ДЕТЕЙ С АЛЛЕРГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ ОРГАНОВ ДЫХАНИЯ

2019 ◽  
pp. 52-60
Author(s):  
E.V. Prosekova ◽  
A.I. Turyanskaya ◽  
N.G. Plekhova ◽  
M.S. Dolgopolov ◽  
V.A. Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Bronchial Asthma ◽  
Allergic Inflammation ◽  
Allergic Diseases ◽  
Control Group ◽  
Healthy Children ◽  
Serum Cytokine ◽  
Immunological Parameters ◽  
Low Level ◽  
Level Of Significance

Расширение спектра изучаемых клонов Тхелперов определило более сложные иммунные механизмы реализации аллергического воспаления. Цель. Характеристика показателей и взаимосвязей цитокинового профиля сыворотки и субпопуляционного состава Тлимфоцитов периферической крови у детей с бронхиальной астмой и аллергическим ринитом. Материалы и методы. Проведено комплексное обследование 150 детей в возрасте 311 лет с верифицированным диагнозом бронхиальной астмы, аллергического ринита и 30 здоровых сверстников. Иммунологические параметры крови оценивали методом проточной цитометрии, концентрации интерлейкинов и IgE в сыворотке крови определяли методом твердофазного иммуноферментного анализа. При статистической обработке использовали программы Statistica 10 с критическим уровнем значимости р0,05. Результаты. У детей с аллергическими заболеваниями в сыворотке крови определены высокие уровни содержания интерлейкинов4, 8, 13, 17А, сопоставимый с показателями группы контроля уровень IL17F и низкое содержание IFNy. При бронхиальной астме и аллергическом рините у детей выявлено увеличение количества CD3CD8CD45RO, CD3CD8CD45RACD45RO Тлимфоцитов и CD3CD4 Тхелперов и повышение количество Th17 при снижении CD3CD4CD45RO клеток памяти. В группе здоровых детей популяция Th17 составляла 9,491,6, у детей с аллергическими заболеваниями количество данных клеток было значимо выше 14,50,77 (р0,001). Анализ сывороточного содержания цитокинов у детей с изолированным течением БА и в сочетании с аллергическим ринитом выявил разнонаправленные корреляции, отличающиеся по силе и направленности от таковых в группе здоровых детей. Заключение. У детей при изолированном течении бронхиальной астмы и в сочетании с аллергическим ринитом выявлены: сопоставимое с показателями здоровых детей количество CD3CD4 Тклеток, дисбаланс в субпопуляционном составе Тхелперов за счет преобладания Th2 и Th17, активация синтеза IL17A, IL4, IL8, IL13, низкий уровень сывороточного IFNy, изменения силы и направленности взаимосвязей цитокинового профиля и спектра субпопуляций Тлимфоцитов.Expansion of the range of examined Thelper clones has determined more complex immune mechanisms for the implementation of allergic inflammation. Objective. To characterize the parameters and relationships between the serum cytokine profile and Tlymphocyte subpopulation in peripheral blood of children with bronchial asthma and allergic rhinitis. Materials and methods. 150 children aged between 311 years old with bronchial asthma, and allergic rhinitis and 30 healthy volunteers were examined. Immunological parameters were assessed by flow cytometry, the concentration of serum interleukins and IgE were determined by means of enzymelinked immunosorbent assay. Statistical analysis was performed with Statistica 10 program with a critical level of significance p0.05. Results. High levels of interleukins 4, 8, 13, 17A were determined, IL7F level was not significantly different from that in control group and low level of IFNy was found in the serum of children with allergic diseases. The number of CD3CD8CD45RO, CD3CD8CD45RACD45RO Tlymphocytes, CD3CD4 Thelper cells and Th17 were increased and at the same time CD3CD4CD45RO memory cells were decreased In bronchial asthma and allergic rhinitis children. Number of Th17 cells in healthy children was 9.491.6, in allergic children it was significantly higher 14.50.77 (p0.001). Analyses of serum cytokine count in children with isolated BA and in association with allergic rhinitis revealed multidirectional correlations differing in strength and direction from those in the group of healthy children. Conclusion. In children with isolated bronchial asthma and associated with allergic rhinitis the following parameters were found: CD3CD4 Tcells count was comparable to that in healthy children, the imbalance of Thelper subpopulation: prevalence of Th2 and Th17, activation of IL17A, IL4, IL8, IL13 synthesis and low level of serum IFNy.

A Critical Review on Tamaka Shwasa (Bronchial Asthma) - An Ayurvedic View

2017 ◽  
Vol 2 (3) ◽  
Author(s):  
Sandip R. Baheti ◽  
Deepa Sharma ◽  
Saroj Devi ◽  
Amit Rai
Keyword(s):  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Critical Review ◽  
Modern Science ◽  
Modern Medicine ◽  
Chronic Inflammatory Disease ◽  
The Body ◽  
Natural Immunity ◽  
Shortness Of Breath ◽  
Asthma Symptoms

Difficulty in breathing or shortness of breath may be simply termed as Shwasa (Asthma), As per Ayurveda, Shwasa is mainly caused by the Vata and Kapha Doshas. Shwasa is broadly classified into five types in Maha Shwasa (Dyspnoea major), Urdhawa Shwasa (Expiratory Dyspnoea), Chinna Shwasa (Chyne-stroke respiration), Kshudra Shwasa (Dyspnoea minor), Tamaka Shwasa (Bronchial Asthma). In modern science Tamaka Shwasa can be correlated with Asthma, Asthma which is a chronic inflammatory disease of airway. In modern medicine there is no cure for Asthma, symptoms can typically be improved. In Ayurveda, Asthma can be effectively and safely manage the condition without inducing any drug dependency where Pachakarma procedures and use of internal medication detoxifies the body, provides nutrition and increases the elasticity of lung tissue it also develops natural immunity of the body thus decreasing episodic recurrence of the disease.

scholarly journals A CRITICAL REVIEW: TAMAKA SHWASA (BRONCHIAL ASTHMA)

2019 ◽  
Vol 7 (8) ◽  
pp. 258-264
Author(s):  
Vaishnavi Narhari Saka
Keyword(s):  
Bronchial Asthma ◽  
Health Problem ◽  
Respiratory Diseases ◽  
Respiratory Infections ◽  
Climatic Changes ◽  
Chronic Inflammatory Disease ◽  
Age Group ◽  
Major Health Problem ◽  
Major Health ◽  
Recurrent Respiratory Infections

Out of most morbid disorders, the disease shwas is also becoming a major health problem of the society. Difficulties in breathing, cough are common health complains which everyone experiences throughout their life with different magnitude. Such complains are found in every age group. Dyspnea due to respiratory diseases comes under ShwasaRoga. Maha- Urdhva-Chinna-Tamaka and Kshudra are the types of ShwasaRoga. Bronchial asthma is a chronic inflammatory disease of airways characterized by cough, difficulty in breathing and wheeze. Exposure to dust, smoke, recurrent respiratory infections and climatic changes are chief triggering factors of this disease. Bronchial asthma and its associated features clinically correspond to the Tamaka Shwasa described in Ayurveda.

scholarly journals CLINICAL STUDY OF KANTKARI AVLEHA AND VASA AVLEHA IN THE MANAGEMENT OF TAMAK SHWASA W.S.R TO BRONCHIAL ASTHMA

2021 ◽  
Vol p5 (02) ◽  
pp. 2705-2713
Author(s):  
Nishu Raina
Keyword(s):  
Clinical Study ◽  
Bronchial Asthma ◽  
Inflammatory Disease ◽  
Signs And Symptoms ◽  
Chronic Inflammatory Disease ◽  
Ayurvedic Medicine ◽  
Dietary Control ◽  
Allergic Disorder ◽  
Effect Of Therapy

Asthma is a chronic inflammatory disease which causes the lining of the airways to become swollen and inflamed, which further leads to production of thick, sticky mucous. These changes further cause the airways to become narrow, making it difficult for the patient to breathe properly. In this study, efficacy of formulations like Vasavaleha and Kantakari Avaleha are studied in the patients of Tamaka Shwasa w.s.r to bronchial asthma. Tamaka Shwasa is a Yapya Vyadhi. The etiopathogenesis, signs, and symptoms of Tamaka Shwasa may be correlated with Bronchial Asthma. Each patient reacts differently to the factors that trigger asthma and are treated symptomatically. Asthma is the most common chronic allergic disorder in childhood and third leading cause of hospitalization under the age of 15 years. As it is a Kapha-Vata predominant disorder, Ayurvedic medicine may help to decrease the recurrence, improve immunity, and check symptoms naturally. With this aim, a clinical study was undertaken on two groups for a duration of 6 weeks. The Kantakari Avaleha and Vasa Avaleha were given orally, separately in both the groups. All the patients were kept under strict dietary control during the treatment. The observation on the effect of therapy was encouraging and showed less recurrence.

scholarly journals Analysis of the genotypes and interleukins 17A, 17F blood levels in children with allergic bronchial asthma and allergic rhinitis

2020 ◽  
Vol 17 (2) ◽  
pp. 61-68
Author(s):  
Elena V. Prosekova ◽  
Alina I. Turyanskaya ◽  
Maxim S. Dolgopolov ◽  
Oksana L. Zhdanova ◽  
Vitaly A. Sabynych
Keyword(s):  
Allergic Rhinitis ◽  
Blood Serum ◽  
Bronchial Asthma ◽  
Allergic Diseases ◽  
Blood Levels ◽  
Frequency Of Occurrence ◽  
Healthy Children ◽  
Gene Markers ◽  
Polymorphic Gene ◽  
Comprehensive Survey

Introduction. The study of genes that control the activity of cytokines is one of the important issues in revealing the pathogenetic mechanisms of allergic diseases. Aims. Determination of the frequency of occurrence of polymorphic gene markers genotypes and characterization of the interleukins 17A, 17F content in blood serum in children with bronchial asthma and allergic rhinitis. Materials and methods. A comprehensive survey of 110 children with allergic diseases of 311 years old and 60 healthy peers. The material for genetic analysis was DNA with the study of mutation points of IL-17A at position 197 (GA) and IL-17F 7488 (TC). The content of IL-17A, IL-17F interleukins was measured by enzymelinked assay. For the statistical analysis we used the Statistica 10, methods for comparing unrelated groups of genotypes distributions to expected values at HardyWeinberg equilibrium with 2. Results. The frequency of occurrence of genotypes in a group of healthy children was as follows: IL-17A (G197A) heterozygous GA (63,333%), homozygous GG (36,667%); IL-17F (T7488C) TT (36,667%), CT (63,333%), genotypes AA and CC werent determined. In children with allergic diseases, all genotypes were determined: IL-17A (G197A), GG (11,818%), AA (19,091%) and GA (69,091%), IL-17F (T7488C), TT (5,454%), CC (35,455%) and CT (59,091%) with the highest specific gravity of the GG genotype and TT. There were no significant differences in IL-17A, IL-17F levels in the blood serum depending on the genotype. Discussion. There were significant differences in the structure of the polymorphisms of the IL-17A, IL-17F genes, blood levels of IL-17A, IL-17F and the risk of the disease in allergic children and healthy peers. The frequency of allergic diseases in children with genotypes AA and TT is statistically higher, but with genotypes GG, CC is statistically lower than with other genotypes.

Eczema

2018 ◽  
Author(s):  
Ben Esdaile
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Atopic Eczema ◽  
Inflammatory Disease ◽  
Chronic Inflammatory Disease ◽  
Descriptive Term ◽  
Symptoms And Signs

Eczema is a descriptive term for a set of symptoms and signs which usually involve itchy inflammation of the skin, and is subcategorized into many different forms. Atopic eczema (atopic dermatitis) is the most common chronic inflammatory disease amongst children. Other types of eczema include seborrhoeic eczema, discoid eczema, asteatotic eczema, contact allergic eczema, contact irritant eczema, pompholyx eczema, venous eczema, juvenile plantar dermatosis, and lichen simplex. This chapter covers atopic eczema, which is referred to as ‘atopic’ due to its association with other atopic disorders such as asthma and allergic rhinitis.

scholarly journals Study of Eosinophil Count in Nasal and Blood Smear in Allergic Respiratory Diseases

2016 ◽  
Vol 3 (1) ◽  
pp. 44 ◽  
Author(s):  
Ravindra Sonawane ◽  
Nilesh Ahire ◽  
Suhas Patil ◽  
Abhijit Korde
Keyword(s):  
Allergic Rhinitis ◽  
Risk Factor ◽  
Bronchial Asthma ◽  
Eosinophil Count ◽  
Respiratory Diseases ◽  
Geographical Area ◽  
Common Risk Factor ◽  
Peripheral Smear ◽  
Health Care Center ◽  
Male Predominance

<strong>Introduction:</strong> Allergic rhinitis and asthma are two very common allergic diseases of respiratory tract in pediatric patients. In this geographical area, where the prevalence of allergens exists, the role of allergens as the etiological factor is higher in allergic respiratory disorders. Confirmation of allergen as etiologic agent is cumbersome in a small setup, where IgE estimation and allergy tests are not accessible. In this study, the simple test of peripheral smear and nasal smear eosinophil count as a reliable diagnosis to solve the above problem and establishing allergy as etiological agent has been tried. <strong>Material and Methods:</strong> For the present study which was conducted over 2 years in children between 2 to 12 years who visited tertiary health care center, Nashik. The allergic respiratory cases based on typical history and clinical features were included in the study and investigated for nasal and blood eosinophilia. Children with TB, recurrent and chronic pneumonia, malnutrition, malignancy, collagen vascular disorders and those who are on steroid therapy were excluded from the study. The clinical profile of allergic rhinitis with or without asthma and nasal and blood eosinophils are studied. <strong>Result:</strong> Out of 100 patients, there was male predominance and incidence was increasing as age increases. Dust is the most common risk factor for allergic rhinitis followed by weather changes, whereas in allergic rhinitis with bronchial asthma, weather change is common risk factor followed by dust and family history. In children with allergic rhinitis with or without bronchial asthma, there is positive relation between nasal and peripheral smear eosinophil count. <strong>Conclusion:</strong> So, nasal eosinophil count which is simple, non-invasive, economical and reliable can be used as an alternative to invasive peripheral smear eosinophil count as both are equally efficacious in diagnosing allergic respiratory diseases.

Atopic dermatitis: new horizons of therapy

2019 ◽  
Vol 1 (7) ◽  
pp. 29-32 ◽  
Author(s):  
L. S. Kruglova ◽  
E. M. Gensler
Keyword(s):  
Blood Pressure ◽  
Immune Response ◽  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Targeted Therapy ◽  
Inflammatory Response ◽  
Bronchial Asthma ◽  
New Horizons ◽  
The Past

Over the past decades, the first breakthrough milestone in the treatment of severe forms of atopic dermatitis (AD) has been targeted therapy aimed at inhibiting IL-4 and IL-13. This was made possible thanks to advances in the understanding of the pathogenesis of AD, the driver of which is the Th2-type immune response, which also underlies such manifestations of atopy as bronchial asthma, allergic rhinitis, and polynosis. In the case of the Th2-type immune response, cytokines IL-4 and IL-13 are secreted, which are the main promoters of the inflammatory response in AD. Inhibition of IL-4 and IL-13 leads to the prevention of inflammation and is an effective approach to therapy. The use of therapy aimed at inhibition of cytokines allows you to effectively cope with the manifestations of severe and moderately severe blood pressure.

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