Karakteristik pasien ocular surface squamous neoplasia di Pusat Mata Nasional RS Mata Cicendo periode Januari 2012- Juni 2014

2019 ◽  
Vol 43 (1) ◽  
pp. 40
Author(s):  
Sandraningrum Sandraningrum ◽  
M Rinaldy Dahlan
Keyword(s):  
Ocular Surface ◽  
Wide Excision ◽  
Invasive Squamous Cell Carcinoma ◽  
Ocular Surface Squamous Neoplasia ◽  
Surface Mass ◽  
Broad Term ◽  
The Mean ◽  
Excisional Surgery ◽  
Histopathology Examination

Background: Ocular surface squamous neoplasia (OSSN) is a broad term encompassing conjunctival intraepithelial neoplastic lesions (CIN) and invasive squamous cell carcinoma (SCC) of conjunctiva and cornea. The purpose of this study is to describe the demographic, clinical, therapy and histopathology characteristics of OSSNs patients in Cicendo Eye Center within period of January 2012 – June 2014. Methods: Patient medical records were reviewed. Fourty patients of biopsy-proven OSSN at Cicendo Eye Centre from January 2012 until June 2014 were reviewed. Results: Data was collected from 40 patients (41 eyes), OSSN was more frequent in men (62.5%) and had unilateral presentation (97.5%). The mean patient age was 45.9±14.7 years. The most common complaint was lump on the ocular surface (50%). The size of lesion was mostly less than 2 mm (62.5%). All of the patients were managed with surgery using wide excision and histopathology examination, of whom 46.4% cases were managed with wide excision only, 41.4% cases were managed with wide excision and application of topical mitomycin C (MMC), 12.2% cases were managed with wide excision, application of topical MMC, and cryotherapy. Histopathology examination revealed that 41.5% cases were CIN, 19.5% cases were carcinoma in situ, and 39% cases were invasive SCC. Conclusions: Patients with OSSN who came to Cicendo Eye Center were mostly male and had unilateral presentation. The most common clinical sign and symptom were ocular surface mass with size of the lesion less than 2 mm. Management of patient with OSSN is mostly excisional surgery only. Majority of histopathology examination showed CIN.

scholarly journals An Unusual Case of Wart-like Presentation of Ocular Surface Squamous Neoplasia

2019 ◽  
Vol 2 (2) ◽  
pp. 270-271
Author(s):  
Nirsara Shrestha ◽  
Sangeeta Shrestha ◽  
Arjun Shrestha
Keyword(s):  
Ocular Surface ◽  
Carcinoma In Situ ◽  
Unusual Case ◽  
Intraepithelial Neoplasia ◽  
Excisional Biopsy ◽  
Invasive Squamous Cell Carcinoma ◽  
Severe Dysplasia ◽  
High Grade ◽  
Ocular Surface Squamous Neoplasia

The ocular surface squamous neoplasia refers to the entire spectrum ranging from mild to severe dysplasia to carcinoma in situ and invasive squamous cell carcinoma. Ocular surface squamous neoplasia may present clinically in various ways: gelatinous, velvety or papilliform or leukoplakic. This case report describes a 50-year-old male who presented with a filiform wart-like appearance of conjunctival mass unlike described earlier. Excisional biopsy was done and histopathology revealed intraepithelial neoplasia with high-grade dysplasia.

scholarly journals Clinico-Pathological Study of Ocular Surface Squamous Neoplasia in a Tertiary Care Centre of Western Region of Nepal

2019 ◽  
Vol 7 (1) ◽  
pp. 9-13
Author(s):  
Sushila Patel ◽  
Binita Bhattarai Pokharel ◽  
Anita Shah ◽  
Manita Sunam Goda ◽  
Saraswati Khadka Thapa
Keyword(s):  
Ocular Surface ◽  
Histopathological Examination ◽  
Tertiary Care ◽  
Western Region ◽  
Invasive Squamous Cell Carcinoma ◽  
Care Centre ◽  
Ocular Surface Squamous Neoplasia ◽  
Tertiary Care Centre ◽  
Male Predominance ◽  
Wide Range

INTRODUCTION: Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjunctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. In recent times, the incidence of OSSN seems to be on the rise, especially in developing countries. The present study was aimed to analyse demographic pattern, clinical characteristics, and histopathology findings of OSSN in a tertiary care centre of western region of Nepal.  MATERIAL AND METHODS: It was a retrospective study. We analyzed 94 cases of OSSN who presented to cornea department of Lumbini Eye Institute, Bhairahawa, Nepal over a period 1.5 years from 1st July 2017 to 31st December 2018. All the patients with OSSN, detailed clinical history and examination were recorded. Lesions were excised with a 3 mm margin clearance and sent for histopathological examination.  RESULTS: Mean age of our patients with OSSN was 48.89±17.955 years ranging from 17 to 85 years. There were 52 (55.32%) male and 42 (44.68%) female. Mean duration of presentation was 6.34±6.17 months. A solitary nodule at the limbus was the commonest presentation. Right eyes were involved more than left eyes. Lesions were found most commonly on temporal site 52 (55.32%) followed by nasal 36 (38.30%). On histopathological examination benign lesions were found in 31 (32.98%) eyes, preinvasive lesion in 50 (53.19%) eyes and invasive lesions in 13 (13.83%) eyes.  CONCLUSION: OSSN were seen more commonly in young adults with male predominance. Benign and pre invasive lesions are found more commonly than invasive lesions.

scholarly journals Role of Conjunctival Ultraviolet Autofluorescence in Ocular Surface Squamous Neoplasia

2020 ◽  
Vol 6 (6) ◽  
pp. 422-429
Author(s):  
Saumya Yadav ◽  
Noopur Gupta ◽  
Rashmi Singh ◽  
Mukesh Patil ◽  
Rachna Meel ◽  
...  
Keyword(s):  
Clinical Diagnosis ◽  
Outcome Measures ◽  
Ocular Surface ◽  
Surgical Intervention ◽  
Morphological Characteristics ◽  
Impression Cytology ◽  
Ocular Surface Squamous Neoplasia ◽  
Non Invasive ◽  
The Mean

<b><i>Objective:</i></b> To evaluate the adjunctive role of conjunctival autofluorescence in the management of ocular surface squamous neoplasia (OSSN). <b><i>Materials and Methods:</i></b> Seventeen patients with clinically diagnosed OSSN were included. Morphological characteristics, type of OSSN, and autofluorescence photographs of the lesion were captured. Presence and area of conjunctival ultraviolet autofluorescence (CUVAF) were the main outcome measures. <b><i>Results:</i></b> Overall, 17 patients with 15 (88%) primary and 2 (12%) recurrent OSSN were included. Common locations were temporal (<i>n</i> = 10), nasal (<i>n</i> = 5), and diffuse variety (<i>n</i> = 2). Morphologically, there were 4 (22.2%) nodular, 4 (22.2%) leucoplakic, 3 (16.7%) gelatinous, and 1 (5.5%) each of papillary, nodulo-ulcerative, and diffuse variety. Mixed morphology was present in 4 eyes (22.2%). Sixteen of 18 eyes (88.9%) with OSSN displayed autofluorescence on CUVAF images. The mean area of CUVAF was 15.82 mm<sup>2</sup> (10.77–19.59 mm<sup>2</sup>). Autofluorescence was reported in 8 eyes (44.4%) which had negative reports on impression cytology. <b><i>Conclusions:</i></b> Conjunctival autofluorescence was seen in the majority of cases with OSSN, in spite of negative cytology reports. Our study demonstrates that CUVAF may serve as an effective ancillary, non-invasive, and resource-friendly tool for supplementing the clinical diagnosis of OSSN, especially in diffuse and recurrent lesions that are not amenable to surgical intervention.

Spontaneous regression of presumed ocular surface squamous neoplasia: A report of 8 cases

2021 ◽  
pp. 112067212110573
Author(s):  
Vijitha S Vempuluru ◽  
Neha Ghose ◽  
Nidhi Mahendra Vithalani ◽  
Shahenaz Sultana ◽  
Swathi Kaliki
Keyword(s):  
Ocular Surface ◽  
Spontaneous Regression ◽  
Tumor Regression ◽  
Anterior Segment ◽  
Retrospective Chart Review ◽  
Tumor Diameter ◽  
Ocular Surface Squamous Neoplasia ◽  
Duration Of Symptoms ◽  
The Mean

Purpose To report the phenomenon of spontaneous regression in presumed ocular surface squamous neoplasia (OSSN) Methods Retrospective chart review of clinically diagnosed cases of OSSN during 2016 to 2019 Results Of the 449 OSSN lesions, spontaneous regression was seen in 8 lesions (2%). The mean age at diagnosis of OSSN was 37 years (median, 36 years; range, 21 to 59 years). All were males with unilateral, treatment-naïve tumors. Mean duration of symptoms was 3 months (median, 2 months; range, 1 to 12 months). All tumors arose within the interpalpebral region, located in the nasal quadrant in 88% (n = 7) and in temporal quadrant in 12% (n = 1). The mean tumor diameter was 4 mm (median, 4 mm; range, 3 to 5 mm). Lesions showed nodular (n = 4; 50%) or placoid (n = 4; 50%) morphology. The other features included keratin production and intrinsic vascularity (n = 8; 100%), feeder vessels (n = 4; 50%), and intratumoral pigmentation (n = 4; 50%). The diagnosis of OSSN was confirmed by classic anterior segment optical coherence tomography (AS-OCT) features. Tumors regressed after a mean period of 5 months (median, 4 months; range, <1 to 17 months) from presumed onset and a mean period of 2 months (median, 1 month; range, <1 to 6 months) from presentation to the clinic. No recurrences were noted at a mean follow up of 37 months (median, 35 months; range, 17 to 52 months) after spontaneous regression of tumors. Conclusion OSSN can spontaneously regress in 2% of cases. Immune-mediated reversal of dysplastic changes may explain this phenomenon. Précis In this study, spontaneous regression of presumed ocular surface squamous neoplasia was noted in 2% patients. Tumor regression resulted in restoration of normal epithelial architecture and no recurrences were observed during the follow-up period.

scholarly journals Szemfelszíni laphám-neoplasia

2017 ◽  
Vol 158 (51) ◽  
pp. 2011-2022 ◽  
Author(s):  
Gábor Tóth ◽  
Gábor László Sándor ◽  
Andrea Gyenes ◽  
Jeannette Tóth ◽  
Berthold Seitz ◽  
...  
Keyword(s):  
Ocular Surface ◽  
Treatment Options ◽  
Intraepithelial Neoplasia ◽  
Invasive Squamous Cell Carcinoma ◽  
Ocular Surface Squamous Neoplasia ◽  
Adequate Treatment ◽  
Regular Control ◽  
Low Malignant Potential ◽  
Life Threatening ◽  
Advanced Stages

Abstract: To summarize actual knowledge on epidemiology, etiology, pathology, clinical apparence and treatment of ocular surface squamous neoplasias. We summarize up-to-date literature on conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma and present some own cases. Ocular surface squamous neoplasia is the most common malignant ocular surface tumor and the third most common ocular malignancy following malignant melanoma and lymphoma. In spite of its low malignant potential, in advanced stages it may reduce visual acuity significantly or even the eye globe has to be removed. In case of metastasis it may also be life-threatening. As local recurrences of ocular surface squamous neoplasias may occur, knowledge of intra- and postoperative adjuvant treatment options are indispensable and regular control examinations are necessary. Identification and adequate treatment of ocular surface squamous neoplasias are necessary in order to avoid its progression and to prevent recurrences. Orv Hetil. 2017; 158(51): 2011–2022.

scholarly journals CLINICAL PROFILE OF OCULAR SURFACE SQUAMOUS NEOPLASIA (OSSN).

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Dr. Rishi Gupta
Keyword(s):  
Ocular Surface ◽  
Clinical Profile ◽  
Hiv Positive ◽  
Age Group ◽  
Care Centre ◽  
Ocular Surface Squamous Neoplasia ◽  
Eye Care ◽  
Younger Age ◽  
Centre Hospital

Aim: To Study the Clinical profile of Ocular Surface Squamous Neoplasia (OSSN). Design: Retrospective study. Materials and Methods: We analysed 28 cases of OSSN who presented to the out-patient department of tertiary eye care centre Hospital, over a period of 1 year from January 2017 to January 2018. Results: In patients, who presented with OSSN age ranged from 24 to 70 years, mean age being 44.80 years. Males were predominantly affected accounting for 64.28%. A nodule at the libus is the commonest presentation. About 25% of the patients were positive for HIV with mean age of presentation 32 years. Among HIV positive patients 5 cases had SCC. Conclusion: OSSN was observed more common in males. Nodular type of lesion is the commonest variety. HIV positive individuals have an increased incidence of OSSN with invasive characteristics. Hence, ophthalmologists need to be aware of this association and a thorough workup is warranted for all patients presenting with OSSN, especially in the younger age group. Keywords:   Ocular surface squamous neoplasia, Carcinoma in-situ(CIS), Squamous cell carcinoma (SCC)

scholarly journals Management of Ocular Surface Squamous Neoplasia with Topical and Intralesional Interferon Alpha 2B in Mexicans

2018 ◽  
Vol 10 (2) ◽  
pp. 143-150 ◽  
Author(s):  
Ángel Nava-Castañeda ◽  
Joaquín Hernández-Orgaz ◽  
Lilia Garnica-Hayashi ◽  
Alberto Ansart ◽  
Gonzalo Matus ◽  
...  
Keyword(s):  
Interferon Alpha ◽  
Ocular Surface ◽  
Treatment Time ◽  
Case Series ◽  
Demographic Variables ◽  
Histopathological Diagnosis ◽  
Ocular Surface Squamous Neoplasia ◽  
Interferon Alpha 2B ◽  
The Mean

Introduction: Ocular surface squamous neoplasia (OSSN) is the most common nonpigmented ocular surface neoplasm and it can originate from the conjunctiva and/ or corneal epithelium. Since the rate of recurrence after surgical excision is high, chemotherapeutic and immunotherapeutic agents such as interferon alpha-2b (IFN α-2b) have been used for its treatment. Objective: Our objective is to describe the demographic variables of patients with OSSN treated with IFN α-2b and to describe the outcomes of its use in Mexican patients, treated between 2011 and 2017 at Instituto de Oftalmología Fundación Conde de Valenciana. Materials and Methods: This is a non-randomized retrospective interventional case series. We reviewed the files of patients older than 18 years, with clinical and/or histopathological diagnosis of OSSN, treated with IFN α-2b alone or in combination with surgery, with a minimum of 6 months follow-up. We studied demographic variables, such as gender, age, eye affected and associated risks factors; we also studied the type of therapy with interferon (topical, intralesional and/or associated with surgery), time of treatment, time of follow up, recurrences and complications. Results: A total of 39 patients were included. The mean age of diagnosis was 61 ± 16 years and OSSN was more frequent in males (64.1% of cases). Most of the cases (43.6%) had no identifiable risk factors. The mean time of IFN α-2b treatment was 5 ± 2 months, being higher in the intralesional group (6.5 months) than in the topical group (4.2 months). The clinical resolution with the use of IFN α-2b was evidenced between 0.5 and 10 months, being achieved in 87.1% of the patients. Conclusions: The use of IFN α-2b is effective for the treatment of OSSN with a high success rate (87.1%) and a low incidence of relapse (5 cases), with no reported complications during follow up.  

scholarly journals Clinicopathological Characteristics of Ocular Surface Squamous Neoplasia: A 10-Year Review form a Referral Tertiary Centre in Nigeria

2021 ◽  
Author(s):  
Dauda Eneyamire Suleiman ◽  
Almustapha Aliyu Liman ◽  
Garba Dahiru Waziri ◽  
Yawale Iliyasu ◽  
Saad Aliyu Ahmed
Keyword(s):  
Ocular Surface ◽  
Clinicopathological Characteristics ◽  
Invasive Squamous Cell Carcinoma ◽  
Age Group ◽  
Ocular Surface Squamous Neoplasia ◽  
Tertiary Referral Centre ◽  
Duration Of Symptoms ◽  
North West ◽  
Tertiary Centre ◽  
Heterogenous Group

Abstract Background: Ocular surface squamous neoplasia is a heterogenous group of proliferative squamous lesions on the ocular surface with varying biologic behaviours. This study aims to report the clinical profile and pathologic characteristics of cases of OSSN seen at a tertiary referral centre in North West NigeriaMethods: A retrospective review of all cases of OSSN diagnosed over a 10-year period was doneResults: OSSN accounted for 68 out of 91 ocular surface lesions affecting twice as many males as females and a peak incidence in the 30-39 years age group. They frequently presented as higher grade and higher stage lesions with invasive squamous cell carcinoma being the most frequently diagnosed OSSN. They also frequently show association with HIV infection and a relatively long duration of symptoms before presentationConclusion: OSSN occur in a relatively young age group in our environment. Certain clinical and epidemiological features appear to [predict the occurrence of higher grade lesions and this may help in the clinical prediction of likely pathologic grade and/or biologic behaviour of these lesions.

scholarly journals To Evaluate Efficacy And Safety Of Mmc After Excision Of Ocular Surface Squamous Neoplasia With Conjunctival Autograft

2020 ◽  
Vol 7 (06) ◽  
pp. 4854-4859
Author(s):  
Kamal Mohan Verma ◽  
Dr. Manoj Govila
Keyword(s):  
Mitomycin C ◽  
Ocular Surface ◽  
Eye Drops ◽  
Ocular Surface Squamous Neoplasia ◽  
Conjunctival Autograft ◽  
Kaplan Meier ◽  
Systemic Side Effects ◽  
The Mean ◽  
Disease Free

Purpose:  This study was conducted to determine the treatment of histologically confirmed ocular surface squamous neoplasia by excision with conjunctival auto graft, and Mitomycin C. Methods: A clinical study of 19 eyes of 19 patients in which excision with conjunctival autograft of ocular surface squamous neoplasia was done and treated with Mitomycin C 0.04% eye drop daily for two to three alternate seven day courses according to the protocol. All patients had weekly follow-up visits till the end of the treatment course, then biweekly visits for three months, and finally monthly visits thereafter. Results: The mean ± SD follow-up period was 39.4±15.3 months (range 06-56 months). Four patients (21.05%) experienced recurrence after the initial treatment; three of them responded to re-treatment and were disease-free, thereafter, till the end of follow-up. Survival analysis with Kaplan-Meier was 94.74%, non-recurrence for 36 months (mean 37.83 months with S.D of 14.73) of follow-up. All patients reported mild to moderate redness and irritation which were controlled with lubricants and mild corticosteroid eye drops. No serious ocular or systemic side effects were seen. Conclusion: Mitomycin C (0.04%) drops used daily for two to three alternate seven day courses were found to be safe and effective with lower recurrence rate for ocular surface squamous neoplasia (OSSN).

Histopathology-guided management of ocular surface squamous neoplasia with corneal stromal or scleral invasion using ruthenium-106 plaque brachytherapy

2021 ◽  
pp. bjophthalmol-2021-319201
Author(s):  
Raksha Rao ◽  
Santosh G Honavar ◽  
Sumeet Lahane ◽  
Kaustubh Mulay ◽  
Vijayanand Palkonda Reddy
Keyword(s):  
Visual Acuity ◽  
Ocular Surface ◽  
Case Series ◽  
Prior Treatment ◽  
Tumour Regression ◽  
Excision Biopsy ◽  
Invasive Squamous Cell Carcinoma ◽  
Ocular Surface Squamous Neoplasia ◽  
Basal Diameter ◽  
Plaque Brachytherapy

Background/aimTo evaluate the safety and efficacy of ruthenium-106 (Ru-106) plaque brachytherapy in managing invasive ocular surface squamous neoplasia (OSSN).MethodsThis is a retrospective, non-comparative, interventional case series of 42 eyes with OSSN with histopathologically-proven corneal stromal and/or scleral invasion that underwent Ru-106 plaque brachytherapy. Main outcome measures were tumour regression, eye salvage, final visual acuity, treatment complications and metastasis.ResultsAt presentation, the mean tumour basal diameter was 9.3 mm (range 5–26 mm) and thickness 3.1 mm (range 1.5–11 mm). Prior treatment included excision biopsy in two patients (5%), incision biopsy and topical interferon in one each (2%). Following excision with 4 mm clinically clear margins, corneal stromal and/or scleral invasion of OSSN was confirmed in all 42 cases, with the excised base showing invasive squamous cell carcinoma. A total dose of 5000 cGy over a mean duration of 19.7 hours (range 7–41 hours) was provided to an axial depth of 2 mm using Ru-106 surface plaque. Over a mean follow-up of 36.9 months (range 22.3–72 months), complete tumour regression was achieved in all eyes (100%). Two eyes (5%) showed conjunctival tumour growth remote from the site of prior treatment. Visual acuity was maintained at ≥20/200 in 35 eyes (83%), with a loss of >2 Snellen lines in 1 eye (2%). There was no evidence of regional lymph node or systemic metastasis.ConclusionHistopathology-guided use of Ru-106 surface plaque brachytherapy is a safe and an effective adjuvant therapy in the management of corneal stromal and/or scleral invasion of OSSN.

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