scholarly journals Uji Daya Hambat Ekstrak Tinta Cumi-cumi (Loligo sp) terhadap Pertumbuhan Bakteri Streptococcus mutans

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Rocky J. Mangindaan ◽  
Christy N. Mintjelungan ◽  
Damajanty H. C. Pangemanan
Keyword(s):  
Streptococcus Mutans ◽  
Inhibitory Effect ◽  
Control Group ◽  
Strong Inhibition ◽  
Control Group Design ◽  
Group Design ◽  
Mean Diameter ◽  
Post Test ◽  
Strong Inhibitory Effect ◽  
The Mean

Abstract: Dental caries is still a health problem in Indonesia. There are several factors that play some important roles in the occurence of caries, as follows: microorganism, host, food, and time. Streptococcus mutans is one of the microorganisms that cause caries. Squid ink contains melanin which has an active compound to inhibit microbial activity. This study was aimed to determine the inhibitory effect of squid ink extract (Loligo sp) on the growth of Streptococcus mutans. This was a laboratory experimental study, with a post test only control group design. The results showed that the mean diameter of the inhibitory zones of the squid ink extract (Loligo sp) was 10.50 mm which was categorized as strong inhibition (Davis and Stout criteria). In conclusion, the squid ink extract (Loligo sp) had a strong inhibitory effect on the growth of Streptococcus mutans bacteria.Keywords: squid ink extract (Loligo sp), Streptococcus mutans, zone of inhibitionAbstrak: Karies gigi merupakan salah satu masalah kesehatan gigi dan mulut di Indonesia. Faktor-faktor penyebab karies gigi yaitu mikroba, pejamu, makanan, dan waktu. Salah satu mikroba penyebab karies ialah bakteri Streptococcus mutans. Tinta cumi-cumi mengandung melanin yang memiliki senyawa aktif untuk menghambat aktivitas mikroba. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak tinta cumi-cumi (Loligo sp) terhadap pertumbuhan bakteri Streptococcus mutans. Jenis penelitian ialah eksperimental laboratorik, dengan post test only control group design. Hasil penelitian menunjukkan diameter rerata zona hambat dari ekstrak tinta cumi-cumi (Loligo sp) sebesar 10,50 mm dan digolongkan dalam kategori kuat (kriteria Davis dan Stout). Simpulan penelitian ini ialah ekstrak tinta cumi-cumi (Loligo sp) memiliki daya hambat yang kuat terhadap pertumbuhan bakteri Streptococcus mutans.Kata kunci: ekstrak tinta cumi-cumi (Loligo Sp), Streptococcus mutans, zona hambat

scholarly journals Uji daya hambat ekstrak biji buah alpukat (Persea americana Mill.) terhadap pertumbuhan Streptococcus mutans

e-GIGI ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Anggriana H. Bujung ◽  
Heriyannis Homenta ◽  
Johanna A. Khoman
Keyword(s):  
Streptococcus Mutans ◽  
Inhibitory Effect ◽  
Seed Extract ◽  
Persea Americana ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Paper Disk ◽  
Post Test ◽  
Avocado Seed

Abstract: In addition to daily consumption, avocado is also used to treat oral diseases. Scientific studies showed that avocado seed contained flavonoids, tannins, and alkaloid which were expected to inhibit bacterial growth. This study was aimed to obtain the bacterial inhibitory effect of avocado seed (Persea americana Mill.) extract on Streptococcus mutans as the primary cause of dental caries. This was a true experimental study with the post test only control group design. This study used a modified Kirby-Bauer method with paper disk. The positive control was erythromycin and the negative control was aquadest. Avocado seeds were extracted by using maceration method with 96% ethanol. The Streptococcus mutans bacteria were obtained from pure stock of Microbiology Laboratory of Pharmacy Study Program University of Sam Ratulangi Manado. The results showed that the mean diameter of inhibition zone of avocado seed extract was 21.8 mm which was classified as very strong inhibition. Conclusion: Persea Americana Mill. seed extract had a very strong inhibitory effect on the growth of Streptococcus mutans.Keywords: avocado seed (Persea americana Mill.), Streptococcus mutans, inhibition effectAbstrak: Selain menjadi bahan konsumsi masyarakat yang lezat, ternyata alpukat telah lama dipercaya dapat mengobati penyakit di dalam rongga mulut. Di dalam buah alpukat terdapat biji yang terbukti melalui penelitian ilmiah mengandung flavonoid, alkaloid, dan tannin yang mampu menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak biji buah alpukat (Persea americana Mill.) terhadap pertumbuhan Streptococcus mutans. Jenis penelitian ialah eksperimental murni dengan post test only control group design. Metode yang digunakan ialah modifikasi Kirby-Bauer dengan paper disk. Kontrol positif menggunakan antibiotik eritromisin dan kontrol negatif menggunakan akuades. Biji buah alpukat diekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Bakteri Streptococcus mutans diambil dari stok bakteri murni Laboratorium Mikrobiologi Program Studi Farmasi Fakultas MIPA Universitas Sam Ratulangi Manado. Hasil penelitian menunjukkan diameter rerata zona hambat dari ekstrak biji buah alpukat yang terbentuk ialah 21,8 mm dan digolongkan sebagai zona hambat sangat kuat. Simpulan: Ekstrak biji buah alpukat memiliki daya hambat sangat kuat terhadap pertumbuhan Streptococcus mutans.Kata kunci: biji buah alpukat (Persea americana Mill.), Streptococcus mutans, daya hambat

scholarly journals Uji Daya Hambat Perasan Daging Buah Alpukat (Persea americana Mill.) terhadap Pertumbuhan Bakteri Staphylococcus aureus

e-GIGI ◽  
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Dwi S.R. Muchyar ◽  
Damajanty H.C. Pangemanan ◽  
Aurelia S.R. Supit
Keyword(s):  
Staphylococcus Aureus ◽  
Inhibitory Effect ◽  
Negative Control ◽  
Persea Americana ◽  
Control Group ◽  
Control Group Design ◽  
Study Program ◽  
Group Design ◽  
Post Test ◽  
Strong Inhibitory Effect

Abstract: To date, Staphylococcus aureus resistance to some antibiotics is still increasing inter alia the methisillin-resistant Staphylococcus aureus (MRSA). Therefore, it is necessary to find other alternative materials that could overcome this bacteria. Avocado (Persea americana Mill.) is a medicinal plant that contains antibacterial compounds such as saponins, glutathiones, flavonoids, and tannins in its fruit flesh. This study was aimed to obtain the inhibitory effect of avocado flesh on the growth of S. aureus. This was a true experimental study with a post test only control group design. We used Kirby-Bauer modification with paper disks. The positive control was ciprofloxacin and the negative control was aquadest. The avocado flesh was refined by using a juicer and then was filtered. Staphylococcus aureus bacteria were obtained from pure bacteria stock at Microbiology Laboratory of Pharmacy Study Program at Faculty of Mathematics and Natural Sciences, Sam Ratulangi University. The result showed that the avocado juice had an inhibitory effect on the growth of S. aureus. The mean diameter of inhibitory zones formed was 15.55 mm which was classified as a strong inhibitory effect. Conclusion: The avocado flesh had a strong inhibitory effect on the growth of Staphylococcus aureus.Keywords: avocado flesh (Persea americana Mill.), S. aureus, inhibitory effect Abstrak: Resistensi bakteri Staphylococcus aureus terhadap beberapa jenis antibiotik sudah cukup tinggi. Sebagai contoh ialah methicillin-resistant Staphylococcus aureus (MRSA). Oleh karena itu perlu dicari bahan alternatif lain yang dapat mengatasi berkembang biaknya bakteri ini. Buah alpukat (Persea americana Mill.) merupakan salah satu tanaman obat yang dikenal berkhasiat sebagai antibakteri karena terdapat kandungan senyawa antibakteri pada daging buah seperti saponin, glutatin, flavonoid, dan tanin. Penelitian ini bertujuan untuk mengetahui daya hambat perasan daging buah alpukat (Persea americana Mill.) terhadap pertumbuhan bakteri S. aureus. Jenis penelitian ini ialah eksperimental murni dengan post test only control group design. Metode yang digunakan yaitu modifikasi Kirby-Bauer dengan kertas saring. Kontrol positif menggunakan antibakteri ciprofloxacin dan kontrol negatif menggunakan akuades. Daging buah alpukat dihaluskan dengan menggunakan juicer dan disaring. Bakteri S. aureus diambil dari stok bakteri murni Laboratorium Mikrobiologi Program Studi Farmasi Fakultas MIPA Universitas Sam Ratulangi. Hasil penelitian menunjukkan bahwa perasan daging buah alpukat memilki daya hambat terhadap pertumbuhan bakteri S. aureus. Diameter rerata zona hambat yang terbentuk yaitu 15,55 mm dan digolongkan sebagai zona hambat yang kuat. Simpulan: Perasan daging buah alpukat (Persea americana Mill.) memiliki daya hambat kuat terhadap pertumbuhan bakteri S. aureus.Kata kunci: daging buah alpukat (Persea americana Mill.), S. aureus, daya hambat

The Effect of Anonymous Peer Assessment on Writing Ability of the Eleventh Grade Students at SMK PGRI 1 Singaraja

2018 ◽  
Vol 2 (1) ◽  
pp. 1
Author(s):  
A.P. Adhiyanti ◽  
A.A.I.N Marhaeni ◽  
I.P.I Kusuma
Keyword(s):  
Peer Assessment ◽  
Lesson Plan ◽  
Control Group ◽  
Control Group Design ◽  
Writing Ability ◽  
Group Design ◽  
Writing Test ◽  
Post Test ◽  
The Mean ◽  
Academic Year

  This study aimed to investigate the effect of anonymous peer assessment on students’ writing ability. Quantitative approach was used in this study. Post-test only control group design was the design used in this experimental study. The post-test only control group design was designed to discover the purpose of this study which was to investigate the significant effect on writing ability between students who obtain feedback from anonymous peer assessment and students who obtain feedback from conventional assessment. The study was conducted at SMK PGRI 1 Singaraja. The eleventh grade students in Academic Year 2017/2018 were chosen as the population. The samples were 44 students from XI AP and XI UPW. The instruments used in this study were lesson plan, anonymous peer checklist, writing scoring rubric, and writing test. Writing scoring rubric and writing test were used to obtain the data through post-test while lesson plan and anonymous peer assessment were used during the treatment. The data then was analyzed by using SPSS 16. The results of the analysis show that (1) the mean score of the experimental group was 77.55 while the mean score of the control group was 68.77. (2) The t-observe was 3.892 and it exceeded the t-critical value which was 2.018. Therefore, based on the aforementioned results, it can be concluded that there was a significant difference on writing ability between the eleventh grade students who obtained feedback from anonymous peer assessment and those who obtained feedback from conventional assessment at SMK PGRI 1 Singaraja in academic year 2017/2018. 

scholarly journals UJI EFEK ANTI BAKTERI EKSTRAK BUNGA CENGKEH TERHADAP BAKTERI Streptococcus mutans SECARA IN VITRO

e-GIGI ◽  
2014 ◽  
Vol 2 (2) ◽  
Author(s):  
Juvensius R. Andries ◽  
Paulina N. Gunawan ◽  
Aurelia Supit
Keyword(s):  
Streptococcus Mutans ◽  
Control Group ◽  
Antibacterial Effects ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Clove Extract ◽  
Post Hoc ◽  
One Way Anova

Abstrak: Minyak cengkeh berguna sebagai antibakteri alami. Minyak esensial dari cengkeh mempunyai fungsi anestetik dan antimikrobial. Zat yang terkandung dalam cengkeh yang bernama eugenol dapat membunuh bakteri termasuk bakteri yang resisten terhadap antibiotika, salah satunya adalah bakteri Streptococcus mutans. Bakteri ini merupakan mikroorganisme penyebab utama terjadinya karies. Tujuan dari penelitian ini yaitu untuk mengetahui efek antibakteri ekstrak cengkeh terhadap bakteri Streptococcus mutans secara in vitro. Penelitian ini merupakan penelitian eksperimental menggunakan post test only control group design. Penelitian ini menggunakan bahan coba ekstrak cengkeh dengan konsentrasi 40%, 60%, dan 80%, Ciprofloxacin, aquades dengan pengulangan sebanyak lima kali. Data dikumpulkan dan dianalisis dengan one-way ANOVA dan post-hoc uji LSD ( = 0,05). Berdasarkan hasil uji statistik penelitian uji efek antibakteri ekstrak cengkeh terhadap bakteri streptococcus mutans secara in vitro, dapat disimpulkaan bahwa ekstrak cengkeh memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans secara in vitro. Hasil uji lanjut post-hoc uji LSD menunjukan daya hambat ekstrak cengkeh 40%, 60%, 80%, lebih kecil (p<0,05) dalam menghambat Streptococcus mutans secara in vitro dibandingkan Ciprofloxacin. Kata Kunci: Ekstrak cengkeh, Streptococcus mutans.   Abstract: Clove oil is useful as a natural antibacterial agent, essential oil of clove has anesthetic and antimicrobial effect. Substances contained in clove called eugenol can kill bacteria including antibiotic resistant bacteria, one of which is the bacteria Streptococcus mutans. This bacteria is a major cause for caries. The purpose of this study was to mengetahui clove extrack antibacterial effects againts Streptococcus mutans bacteria in vitro. This study is an experimental study using a post test only control group design. This research try using clove extract with a concentration of 40%, 60%, and 80%, Ciprofloxacin, aquades repetition five times. Data collected and analyzed by one-way ANOVA and post-hoc LSD test (α = 0.05). Based on the results of the statistical test to test the effects of anti-bacterial research clove extracts against Streptococcus mutans bacteria in vitro, can disimpulkaan that clove extracts have antibacterial effects in inhibiting the growth of Streptococcus mutans bacteria in vitro.further test result post-hoc LSD test shoved its inhibitory clove extract 40%, 60%, 80% smaller (p<0,05)in hibiting Streptococcus mutans in vitro compared Ciprofloxacin. Keywords: clove extract, Streptococcus mutans

scholarly journals EFEKTIVITAS PEMBERIAN EKSTRAK IKAN HARUAN (Channa striata) TERHADAP JUMLAH NEUTROFIL PADA PROSES PENYEMBUHAN ULKUS TRAUMATIKUS

DENTA ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 8
Author(s):  
Isidora Karsini ◽  
Farhana Nur Fadhila ◽  
Nafiah Nafiah
Keyword(s):  
Wound Healing ◽  
Wistar Rats ◽  
Healing Process ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Unsaturated Fat ◽  
Post Test ◽  
Channa Striata ◽  
The Mean

<p><strong><em>Background:</em></strong><em> </em><em>Channa striata contains important compounds in the process of tissue synthesis and important role in wound healing, such as albumin, zinc (Zn), copper (Cu), iron (Fe) and unsaturated fat acids. <strong>Purpose :</strong> To determine the effect of Channa striata extract to the amount of neutrophil in healing process of traumatic ulcer. <strong>Material and Method :</strong> The design of this study used randomized post test only control group design. 18 wistar rats were divided into 6 groups, i.e: K-1 (no treatment for 1 day), K-3 (no treatment for 3 days), K+1 (giving hyaluronic acid 0.2% for 1 day), K+3 (giving hyaluronic acis 0.2% for 3 days), P1 (giving Channa striata extract 100% for 1 day), P3 (giving Channa striata extract 100% for 3 days). <strong>Results :</strong> There was a decrease in the number of neutrophil in the treatment group. The mean and standart deviation of the number of neutrophil in the K-1 group (75,96±3,65), K-3 (50,76±2,04), K+1(72,96±2,97),K+3(45,06±2,83),P1(54,20±1,31),P3(32,50±,85). <strong>Conclusion :</strong> The using of Channa striata extract 100% for 3 days are the most effective in decreasing the amount of neutrophil in healing process of traumatic ulcer of Rattus Novergicus Strain Wistar.</em></p>

scholarly journals THE EFFECTIVENESS OF SELF COLLECTION STRATEGY AND MOTIVATION ON STUDENTS’ ENGLISH VOCABULARY MASTERY

JURNAL BASIS ◽  
2018 ◽  
Vol 5 (1) ◽  
pp. 13
Author(s):  
Selfa Idriani
Keyword(s):  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
Quasi Experimental ◽  
The Mean ◽  
Individual Accountability ◽  
Academic Year ◽  
Cluster Random Sampling ◽  
English Subject

This research purposed to prove whether Self Collection Strategy and Students’ Motivation gives significant effect on the students’ Vocabulary Mastery on English Subject. This research was quasi-experimental research by using the post test-only control group design. The population was the students at Economic Accountant Department Bung Hatta University in the academic year of 2016/2017. The writer used cluster random sampling to select the samples. To collect the data, the researcher used vocabulary test. The data analyzed by using t-test and SPSS 16.0. The findings of this research showed that the mean score of students who were taught by using Self Collection Strategy was 84. The mean score of students who were taught by using memory strategy was 76. It means that Self Collection Strategy gave significant effect toward their vocabulary mastery on English Subject. The elements of Self Collection Strategy such as heterogeneous group, individual accountability, and group reward are considered as the effort for the findings.

scholarly journals Uji Konsentrasi Hambat Minimum Ekstrak Daun Gedi (Abelmoschus manihot L.) terhadap Pertumbuhan Bakteri Streptococcus Mutans

e-GIGI ◽  
2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Helen N. Sekeon ◽  
Heriyannis Homenta ◽  
Michael A. Leman
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Leaf Extract ◽  
Inhibitory Concentration ◽  
Inhibitory Effect ◽  
Tooth Surface ◽  
Control Group ◽  
Control Group Design ◽  
Cariogenic Bacteria ◽  
Group Design

Abstract: Streptococcus mutans is the most common bacterium that causes dental caries due to its ability to ferment carbohydrates into acid resulting in the decreased pH on the tooth surface. Prevention of dental caries could be achieved by inhibiting the growth of cariogenic bacteria. Various efforts to control and prevent the cariogenic bacteria include the usage of herbal ingredients; one of them is gedi leaves (Abelmoschus manihot L.). These gedi leaves contain bioactive compounds such as flavonoids, alkaloids, steroids, and saponins. This study was aimed to prove that gedi leaf extract had inhibitory effect on the growth of S.mutans and to obtain the minimum inhibitory concentration (MIC) of this extract on the growth of S. mutans. This was a true experimental design with a randomized pretest-posttest control group design. Gedi leaf extract was obtained by maceration method in 96% ethanol. The results showed that gedi leaf extract had an antibacterial effect on the growth of S. mutans. We used turbidimetry, UV-Vis spectrophotometer, and two times of treatment to obtain the MIC of gedi leaf extract on Streptococcus mutans which was 6.25%. Conclusion: Gedi leaf extract could inhibit the growth of S. mutans with a MIC of 6.25%.Keywords: dental caries, gedi leaf extract (Abelmoschus manihot L.), Streptococcus mutans Abstrak: Streptococcus mutans merupakan bakteri yang paling banyak menyebabkan karies gigi karena bakteri ini berkemampuan memfermentasi karbohidrat menjadi asam yang berakibat turunnya pH pada permukaan gigi. Pencegahan karies gigi dapat dicapai dengan menghambat pertumbuhan bakteri kariogenik. Berbagai upaya dilakukan untuk mengen-dalikan dan mencegah bakteri kariogenik, antara lain dengan menggunakan bahan herbal; salah satunya yaitu tanaman gedi (Abelmoschus manihot L.). Daun gedi mengandung senyawa bioaktif antara lain flavonoid, alkaloid, steroid, dan saponin. Penelitian ini bertujuan untuk membuktikan efek inhibisi ekstrak daun gedi terhadap pertumbuhan S. mutans dan mendapatkan konsentrasi hambat minimum (KHM) ekstrak daun gedi terhadap pertumbuhan bakteri S. mutans. Jenis penelitian ini ialah eksperimental murni dengan randomized pretest-posttest control group design. Ekstrak daun gedi dibuat dengan metode maserasi dengan menggunakan etanol 96%. Hasil penelitian menunjukkan bahwa ekstrak daun gedi (Abelmoschus manihot L.) memiliki efek antibakteri dalam menghambat pertumbuhan bakteri Streptococcus mutans. Dengan menggunakan metode turbidimetri dan spektrofotometer UV-Vis dalam 2 (dua) kali perlakuan maka diperoleh KHM ekstrak daun gedi (Abelmoschus manihot L.) terhadap bakteri Streptococcus mutans terdapat pada konsentrasi 6,25%. Simpulan: Ekstrak daun gedi dapat meghambat pertumbuhan Streptococcus mutans dengan KHM pada konsentrasi 6,25%.Kata kunci: karies gigi, ekstrak daun gedi (Abelmoschus manihot L.), Streptococcus mutans

scholarly journals PENGARUH JIGSAW BERBANTUAN MEDIA GAMBAR TERHADAP HASIL BELAJAR IPA KELAS V DI SD GUGUS V

2018 ◽  
Vol 1 (2) ◽  
Author(s):  
Luh Juli Utariasih
Keyword(s):  
Random Sampling ◽  
Control Group ◽  
Grade Student ◽  
Control Group Design ◽  
Group Design ◽  
Post Test ◽  
The Mean ◽  
Academic Year ◽  
Choice Method

This study was aimed to know the differentciateof the result study at sains between group of stundents who followed the study with cooperative jigsaw type that combined by picture media and the students who did not used cooperative jigsaw type combined by picture media. This study was belong to quasi exsperiment with Nonequivalent Post-Test Only Control Group Design. The population of this study was all of the five grade student at five troop in Banjar subdistrict. The teknic model defermined by used random sampling. The method  to collected date of resuit study used multipie choice method. The date collected analysis by statistic descriptive and statistic inferensial t-experimen technic with formulas polled varians.the result of the study showed that there are significance differlance on the sains result study between the group of students who was followed study with cooperative jigsaw type that combinated by picture  media and group of students who did not used study model cooperative jigsaw type that combined by picture on five grade students at troop in banjar subdistrict. That all showed by the hipotesis analysis result with t-experimen  t  (3,292732) > t  (2,022). Next the mean of experiment group was (20,64)the result was high more that mean of control group (18,2).it’s mean that the study that used study model cooperative jigsaw type combined by picture gave effect of sains study result gave grade student at five troop in Banjar subdistrict in the academic year 2017/2018.

scholarly journals IMPROVING STUDENTS� VOCABULARY MASTERY THROUGH ELECTRONIC DICTIONARY

2017 ◽  
Vol 2 (2) ◽  
pp. 88
Author(s):  
Sri Yanti
Keyword(s):  
Quantitative Research ◽  
Control Group ◽  
Control Group Design ◽  
Group Design ◽  
Electronic Dictionary ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental ◽  
The Mean ◽  
Level Of Significance

This research is designed to investigate the use of electronic dictionary in improving students� vocabulary mastery. This quantitative research applied quasi-experimental with nonequivalent control group design by involving 65 second-grader of SMAN 1 Garawangi. There were two instruments used in this research, namely test, consisted of pretest and posttest, and questionnaire. As result, the findings showed that the mean score of experimental class on pretest was 53, and the mean score of experimental class achieved 86 after the treatment. The improvement of students� vocabulary mastery can also be seen from the level of significance (two-tailed) in paired t-test that was less than the alpha (0.000<0.05). It indicated that the null hypothesis was rejected and Ha was accepted which means that there was significant difference of means between pre-test and post-test of experimental class. Besides, most students endorsed ten items of questionnaire involving affective, behavioral, and cognitive aspects which means that most students in experimental class agreed that electronic dictionary can help them in improving their vocabulary mastery. Finally, the researcher concludes that the use of electronic dictionary can improve students� vocabulary mastery.Keywords: electronic dictionary, vocabulary mastery, quasi-experimental, nonequivalent control group

scholarly journals The Effect of Co-Administration of Telang Leaves Ethanolic Extract Towards Fluoxetin’s Sedative Effect on Male Balb/C Mice Based on Sleeping Duration Parameter

2017 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
Anif Nur Artanti ◽  
Maria Ulfah
Keyword(s):  
Ethanolic Extract ◽  
Ethanol Extract ◽  
Sedative Effect ◽  
Control Group ◽  
Phytochemical Analysis ◽  
Control Group Design ◽  
Group Design ◽  
Sleep Analysis ◽  
Post Test ◽  
The Mean

One of Telang plant’s advantages is its activity as sedative agent. Previous studies indicate that Telang plant has anticonvulsant activity on mice at certain dose. This study was conducted to find out the sedative effect of Telang plant, particularly its leaf, when being co-administered with fluoxetin. Phytochemical analysis was carried out qualitatively on Telang ethanolic extract leaves (TEE) to find out the content of chemical compound first.This study was an experimental research with post-test only control group design, employing male balb/c mice. The effect of Telang ethanolic extract co-administration with fluoxetin was observed. The parameter being used in the study was the duration of sleep. Analysis was done by comparing mice sleeping duration prior to administration of fluoxetin alone and in combination with Telang ethanolic extract. The data was then analyzed using SPSS 17.0 for Windows.The results showed that TEE contained tannin, saponin, and flavonoid compounds, and co-administration of TEE and fluoxetin at various doses could provide sedative effect on mice. The co-administration of 400 mg/kgBW extract and 15 mg/kgBW fluoxetin could provide the mean sleeping duration 43 minutes longer than positive control.Keywords:  telang leaves ethanol extract, fluoxetin, sleeping duration

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