Effect of Red Fruit Oil Soap (Pandanus Conoideus Lam.) as Wound Cleansing on Wound Healing and the Number of Bacterial Colonies among Grade II Diabetic Ulcer Patients at Griya Wound Care Clinic Kudus, Indonesia

Background: Diabetic ulcer is an open wound on the skin layer to the dermis due to hyperglycemia and neuropathy. This condition often causes infection and becomes an inhibitor in the wound healing process. Red fruit oil soap can be used as an alternative cleansing to reduce the number of bacterial colonies and accelerate the wound healing process.Aims: This present study aimed to observe the effect of red fruit oil soap in the cleansing process to reduce the number of bacterial colonies and the wound healing process in grade II Diabetic ulcer patientsMethods: This is a quasi-experimental study with the pre-test post-test non-equivalent control group design. Wound cleansing in the intervention group used 0.9% NaCl solution and red fruit oil soap with a pH of 5.74, while the wound cleansing in the control group used 0.9% NaCl solution. Bacterial colonies were assessed and the type of bacteria was observed by the swab method. The wound healing was assessed with Bates-Jensen Wound Assessment Tool (BWAT) instrument for 14 days with observations every 3 days. Analysis test used Mann Whitney and Repeated Measure ANOVA.Results: There was no difference in the mean of the number of bacterial colonies between the wounds that were cleansed with 0.9% NaCl solution and red fruit oil soap and the wounds which were cleansed by using 0.9% NaCl solution (p> 0.05). The mean of the number of colonies in the intervention group until the 14th day reduced by 3.14x106 and in the control group was reduced h 1.40x106. There was a significant decrease in the wound healing scores in each group, in each assessment for 14 days.Conclusion: This study found that the wound cleansing using red fruit oil soap and 0.9% NaCl solution could reduce the number of bacterial colonies on the wound surface and accelerate the wound healing process among patients with grade II diabetic ulcer.

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The Effect of the Verbascum Thapsus on Episiotomy Wound Healing in Nulliparous Women: A Randomized Controlled Trial

10.21203/rs.3.rs-144204/v1 ◽

2021 ◽

Author(s):

Sahar Taleb ◽

Maryam Saeedi

Keyword(s):

Wound Healing ◽

Healing Process ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Wound Healing Process ◽

Verbascum Thapsus ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean

Abstract Background: The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it has been used since ancient times to treat wounds. Therefore, the aim of this study was to evaluate the effect of Verbascum Thapsus on episiotomy wound healing. Methods: The study was designed as a randomized, double-blind, controlled clinical trial. Ninety-three primiparous women who referred to Fatemeh Zahra Hospital in Saveh in 2015 were randomly divided into two groups of intervention (Verbascum Thapsus) and control (placebo). Both groups covered the episiotomy wound twice a day for 10 days with 2 cm of prescribed creams. Wound healing was assessed using the REEDA scale before the intervention and on days 1,3 and 10 after the intervention.Results: Before the intervention, there was no statistically significant difference in terms of demographic characteristics, obstetrics and REEDA scores between the two groups (p <0.05). The mean scores of REEDA on days 1 and 3 in the intervention group was better than the control group but was not statistically significant. However, on the tenth day after the intervention, the mean scores of REEDA were significantly better in the Verbascum group than the placebo (p = 0.01). Conclusions: According to the results of this study, it seems that Verbascum Thapsus is effective in repairing episiotomy wounds. The researchers hope that the results of this study can provide the clinical evidence for the use of this herbal medicine in the wound healing process. Trial registration: this study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT201404073106N15” on 02/12/2015

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The effect of the Verbascum Thapsus on episiotomy wound healing in nulliparous women: a randomized controlled trial

BMC Complementary Medicine and Therapies ◽

10.1186/s12906-021-03339-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Sahar Taleb ◽

Maryam Saeedi

Keyword(s):

Wound Healing ◽

Healing Process ◽

Intervention Group ◽

Control Group ◽

Controlled Clinical Trial ◽

Wound Healing Process ◽

Verbascum Thapsus ◽

Nulliparous Women ◽

Significant Difference ◽

The Mean

Abstract Background The pain and discomfort caused by episiotomy affect the quality of life of the mothers, so rapid and complete repair of the episiotomy is very important. Due to the effective ingredients of Verbascum Thapsus, it has been used since ancient times to treat wounds. Therefore, this study aimed to evaluate the effect of Verbascum Thapsus on episiotomy wound healing. Methods The study was designed as a randomized, double-blind, controlled clinical trial. Ninety-three primiparous women who were referred to Fatemeh Zahra Hospital in Saveh in 2015 were randomly divided into two groups of intervention (Verbascum Thapsus) and control (placebo). Both groups covered the episiotomy wound twice a day for 10 days with 2 cm of prescribed creams. Wound healing was assessed using the REEDA scale before the intervention and on days 1,3 and 10 after the intervention. Results Before the intervention, there was no statistically significant difference in terms of demographic characteristics, obstetrics, and REEDA scores between the two groups (p < 0.05). The mean scores of REEDA on days 1 and 3 in the intervention group were better than the control group but were not statistically significant. However, on the tenth day after the intervention, the mean scores of REEDA were significantly better in the Verbascum group than the placebo (p = 0.01). Conclusions According to the results of this study, it seems that Verbascum Thapsus is effective in repairing episiotomy wounds. The researchers hope that the results of this study can provide clinical evidence for the use of this herbal medicine in the wound healing process. Trial registration This study was registered in the Iranian Registry of Clinical Trials (IRCT) with the code “IRCT201404073106N15” on 02/12/2015.

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Comparison of the effect of collagen (amino acid) and amnion (proteinase inhibitor) on the wound healing of soft tissues

Padjadjaran Journal of Dentistry ◽

10.24198/pjd.vol22no1.14067 ◽

2010 ◽

Vol 22 (1) ◽

Author(s):

Weko Adhiarto ◽

Sunardhi Mangundjaja ◽

Makmuri Yusuf ◽

Bambang Pontjo

Keyword(s):

Wound Healing ◽

Amino Acid ◽

Soft Tissue ◽

Collagen Synthesis ◽

Soft Tissues ◽

Proteinase Inhibitors ◽

Healing Process ◽

Control Group ◽

Wound Healing Process ◽

The Mean

The wound healing process of the soft tissue aims to accelerate the closing of the wound by recurring, restoring the function, and minimizing the scar tissue. This process has to occur in the surgery process to obtain better-wound healing. The aim of this study was to know the stimulation effect of the wound dressing to accelerate the wound healing process of the soft tissue using Collagen (amino acid) and Amnion (proteinase inhibitors). This true experimental study was done to 36 mice (Sprague Dawley) that were divided into three different groups, two groups were the treatment groups and one group was the control group. Each group was adapted in Pathology Laboratory of Faculty of Veterinary Medicine Bogor Agricultural University. All of the mice were injured on the skin by incising the right side of the back for 2 cm in length and 4 mm in depth and then cleaned with 0.9% NaCl solution. To the first group of treatment, the wound was applicated by Amnion, and the second group was applicated by Collagen. Each 4 mice of all group were a termination by ether and encryption on the wounded tissue was conducted on day 3rd, 7th, and 14th. Assessment for a number of fibroblast and collagen synthesis on the wound of back tissue was conducted with the histological examination by painted using hematoxylin-eosin. The results concluded that Collagen application was influencing the mean of fibroblast higher than Amnion, and the lowest was controlled with statistically significant. The mean of collagen used Collagen lower than Amnion, and the lowest was control with statistically significant. It could be concluded that collagen application was preeminent in increasing the productivity of the fibroblast, as well as in developing forms of the collagen synthesis compared with Amnion and control.

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Pengaruh Program Ambulasi Dini Terhadap Proses Penyembuhan Luka Pasien Post Operasi Di RSUD dr Adjidarmo Rangkasbitung

Jurnal Smart Keperawatan ◽

10.34310/jskp.v7i2.378 ◽

2020 ◽

Vol 7 (2) ◽

pp. 85

Author(s):

Rodi Widiantoro

Keyword(s):

Wound Healing ◽

Healing Process ◽

Intervention Group ◽

Sampling Technique ◽

Major Surgery ◽

Control Group ◽

Wound Healing Process ◽

Early Ambulation ◽

Postoperative Wound ◽

Surgical Wounds

Luka dan nyeri akibat dari pembedahan membuat pasien tidak mau bergerak sehingga banyak luka operasi yang mengalami gangguan proses penyembuhan luka, untuk membantu dalam proses penyembuhan luka operasi dapat dilakukan teknik ambulasi. Ambulasi dini adalah salah satu faktor yang dapat mempengaruhi penyembuhan luka pasca Operasi serta dapat mengurangi risiko komplikasi. Tujuan untuk melihat pengaruh program ambulasi dini terhadap perubahan proses penyembuhan luka pada pasien paska operasi. Rancangan penelitian quasi-eksperimental dengan jumlah sampel 99 responden, 75 responden (kelompok intervensi) dan 24 responden (kelompok control), yang diambil secara purposive sampling technique. Data dikumpulkan melalui kuesioner dan lembar observasi, kemudian dianalisis dengan uji regresi logistik ordinal. Hasil menunjukkan rata-rata usia 31 tahun (kontrol), 45 tahun (intervensi), jumlah pasien operasi pada laki-laki (58%), operasi mayor (78%), HB normal: (73,7%). Penyembuhan luka yang adekuat kelompok intervensi sebanyak 50 responden (66,7%) sedangkan pada kelompok kontrol sembuh dengan adekuat 6 responden (25%). Uji beda independen pasien ambulasi dini dengan proses penyembuhan luka post operasi nilai (p=0,000). Disimpulkan bahwa program ambulasi dini berpengaruh terhadap penyembuhan luka post operasi. Penelitian ini merekomendasikan penelitian lebih lanjut dan penggunaan latihan ini sebagai salah satu intervensi mandiri perawat dalam memberikan asuhan keperawatan pada pasien paska operasi. Kata kunci: ambulasi dini; proses penyembuhan luka; operasiINFLUENCE OF EARLY AMBULATION PROGRAM IN WOUND HEALING OF POST OPERATIVE PATIENTS IN RSUD dr. ADJIDARMO RANGKASBITUNG ABSTRACT The wounds and pain resulting from surgery make the patient unable to move so that many surgical wounds experience interference with the wound healing process, to assist in the healing process of surgical wounds an ambulation technique can be used. Early ambulation is one of the factors that can affect postoperative wound healing and can reduce the risk of complications. The aim of the sudy was to determine the effect of early ambulation programs in the wound healing process of postoperative patients. A quasy-experimental research design was used with a sample size of 99 respondents, 75 respondents (intervention group) and 24 respondents (control group), which were taken by purposive technique sampling. The data were collected through questionnaires and observation sheets, and then analyzed using ordinal logistic regression test. The results showed that the mean age was 31 years (control), 45 years (intervention), the number of male patients with surgery is 58%, major surgery is 78%, and normal HB is (73.7%). The adequate wound healing in the intervention group is 50 respondents (66.7%) while the control group healed adequately for 6 respondents (25%). Independent difference test of early ambulation patients with postoperative wound healing process value (p = 0.000). It was concluded that the early ambulation program had an effect on postoperative wound healing. This study recommends further research and the use of this exercise as one of the nurses' independent interventions in providing nursing care to postoperative patients.Keywords: early ambulation; wound healing process; of surgery

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EFFECT OF WOUND CARE ON WOUND HEALING PROCESS OF POST OPERATION IN PATIENTS APENDEKTOMY IN RS DUSTIRA CIMAHI

Jurnal Persatuan Perawat Nasional Indonesia (JPPNI) ◽

10.32419/jppni.v4i1.60 ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Marlin Sutrisna ◽

Vega M Tusyanawati

Keyword(s):

Wound Healing ◽

Wound Care ◽

Healing Process ◽

Intervention Group ◽

Lower Abdominal Pain ◽

Control Group ◽

Wound Healing Process ◽

P Value ◽

Ablative Surgery ◽

Significant Difference

ABSTRACTVega M. Tusyanawati1, Marlin Sutrisna2, Tonika Tohri3 Sekolah Tinggi Ilmu Kesehatan Rajawali Bandung IndonesiaEmail : [email protected]: Appendicitis is one of the emergency cases in the abdominal area with a major complaint of persistent lower abdominal pain that develops and increased pain. An appendectomy is a surgical intervention that has the purpose of ablative surgery or removal of body parts that contain problems or have disease. One of the postoperative treatments of apendectomy is with wound care. The current wound care treatment is modern and conventional wound care. Objective: This study was to investigate the effect of treatment of postoperative wound healing apendectomy. Methodology: The design used in this research is Quasi Experiment, with posttest-only design approach. The number of samples taken is 18 respondent. Taking sampling with accidental sampling technique. Result: The result shows that p-value 0.001, with mean value in intervention group was 5.50 and in control group 13.50. Conclusion: There is a significant difference in the wound healing process using conventional and modern wound care.Keywords : type of wound care, post operative apendectomy

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Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF, and CD34 in diabetic ulcer mouse model of wound healing

F1000Research ◽

10.12688/f1000research.22525.3 ◽

2021 ◽

Vol 9 ◽

pp. 580

Author(s):

Renni Yuniati ◽

Prasetyowati Subchan ◽

Wibi Riawan ◽

Matthew Brian Khrisna ◽

Maryam Restiwijaya ◽

...

Keyword(s):

Wound Healing ◽

Mouse Model ◽

Healing Process ◽

Coconut Oil ◽

Control Group ◽

Wound Healing Process ◽

Virgin Coconut Oil ◽

Diabetic Ulcer ◽

Macroscopic Appearance ◽

Wound Length

Background: Diabetes is a disease that affects people worldwide, including in Indonesia. The prevalence of diabetes in Indonesia is increasing from year to year. One of the most devastating complications of diabetes mellitus is diabetic ulcers, which is a limb-threatening complication. Over the past few decades, ozone generated using plasma medical technology has been investigated as an agent that helps wound healing. This study aims to evaluate the effects of topical ozonated virgin coconut oil (VCO) in a diabetic wound mouse model. Methods: This study was an experimental study with a post-test control design. An ulcer wound model was made in 50 diabetic male Wistar mice, divided into five groups, and a control group of 10 non-diabetic mice. The control groups were given conventional therapy only and the treatment groups were also given topical ozonated VCO with different flow durations (0 min, 90 min, 7 h, 14 h). Macroscopic appearance and wound contraction were observed. HSP90β, VEGF-A, EGF, bFGF, and CD34 levels were measured from the immunostained slices of wound margins. Results: The reduction of wound length was proportionally related to the duration of ozone flow. Ozonated VCO with a longer duration of ozone flow healed the wound more quickly and had the shortest wound length. VCO with ozone flow for 14 hours (16837.10 µm) had the biggest reduction in wound length compared to other groups. The wounds treated with ozonated VCO showed an increase in HSP90β, VEGF-A, EGF, bFGF, and CD34 levels that correlated to improved wound healing. A longer period of treatment resulted in higher levels of wound healing biomarkers compared to shorter therapeutic durations. Conclusions: Topical ozonated VCO improved the wound healing process in a diabetic ulcer mouse model by improving macroscopic wound appearance and increasing levels of wound healing biomarkers.

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27. The Effectiveness Of High Protein Nutrient To The Post Sectio Caesarea Healing Process

Jurnal Medika Veterinaria ◽

10.21157/j.med.vet..v13i2.14090 ◽

2019 ◽

Vol 13 (2) ◽

Author(s):

Darmawati Darmawati ◽

Cut Husna ◽

Aida Fitri ◽

Dahrul Munira

Keyword(s):

Wound Healing ◽

Cesarean Section ◽

Treatment Time ◽

Healing Process ◽

Intervention Group ◽

High Protein ◽

Sectio Caesarea ◽

Control Group ◽

Wound Healing Process ◽

Significant Difference

The prevalence of cesarean section (SC) continues to increase along with the quality of technical facilities improvement. Failure to recover the surgical wounds after cesarean section is one of the possible SC complications that should be taken seriously. Proper nutrition greatly affect to wound healing. This study aims to found the effectiveness of high protein nutrients intake for post SC wound healing process at dr. Zainoel Abidin Hospital Banda Aceh. Design: This study is an experimental research with post test for intervention and control group design and using purposive sampling with the observation format as the measuring instrument. A total of 30 mother with post sectio caesarea participated in this study. There was a significant difference between post-SC wound healing in the intervention group (46.7%) compare to the control group (6.7%) (0.000). The mean of wound healing in the proliferation phase in the intervention group was faster than the control group respectively (10.47; 7.93). The hospital should provide information and evaluate high protein intake especially in post-SC patients during the treatment time, so that the patient is able to apply the information until they are going back home.

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Topical ozonated virgin coconut oil improves wound healing and increases HSP90α, VEGF-A, EGF, bFGF and CD34 in diabetic ulcer mouse model of wound healing

F1000Research ◽

10.12688/f1000research.22525.1 ◽

2020 ◽

Vol 9 ◽

pp. 580

Author(s):

Renni Yuniati ◽

Prasetyowati Subchan ◽

Wibi Riawan ◽

Matthew Brian Khrisna ◽

Maryam Restiwijaya ◽

...

Keyword(s):

Wound Healing ◽

Mouse Model ◽

Healing Process ◽

Coconut Oil ◽

Control Group ◽

Wound Healing Process ◽

Virgin Coconut Oil ◽

Diabetic Ulcer ◽

Macroscopic Appearance ◽

Wound Length

Background: Diabetes is a disease that affects people worldwide, including in Indonesia. The prevalence of diabetes in Indonesia is increasing from year to year. One of the most devastating complications of diabetes mellitus is diabetic ulcers, which is a limb-threatening complication. Over the past few decades, ozone generated using plasma medical technology has been investigated as an agent that helps wound healing. This study aims to evaluate the effects of topical ozonated virgin coconut oil (VCO) in a diabetic wound mouse model. Methods: This study was an experimental study with a post-test control design. An ulcer wound model was made in 50 diabetic male Wistar mice, divided into five groups, and a control group of 10 non-diabetic mice. The control groups were given conventional therapy only and the treatment groups were also given topical ozonated VCO with different flow durations (0 min, 90 min, 7 h, 14 h). Macroscopic appearance and wound contraction were observed. HSP90β, VEGF-A, EGF, bFGF and CD34 levels were measured from the immunostained slices of wound margins. Results: The reduction of wound length was proportionally related to the duration of ozone flow. Ozonated VCO with a longer duration of ozone flow healed the wound more quickly and had the shortest wound length. VCO with ozone flow for 14 hours (16837.10 µm) had the biggest reduction in wound length compared to other groups. The wounds treated with ozonated VCO showed an increase in HSP90β, VEGF-A, EGF, bFGF and CD34 levels that correlated to improved wound healing. A longer period of treatment resulted in higher levels of wound healing biomarkers compared to shorter therapeutic durations. Conclusions: Topical ozonated VCO improved the wound healing process in a diabetic ulcer mouse model by improving macroscopic wound appearance and increasing levels of wound healing biomarkers.

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Effect of Family Empowerment on HbA1c Levels and Healing of Diabetic Foot Ulcers

The International Journal of Lower Extremity Wounds ◽

10.1177/1534734620930120 ◽

2020 ◽

pp. 153473462093012

Author(s):

Rasnah Appil ◽

Elly Lilianty Sjattar ◽

Saldy Yusuf ◽

Kasmawati Kadir

Keyword(s):

Wound Healing ◽

Diabetic Foot ◽

Healing Process ◽

Intervention Group ◽

Foot Ulcers ◽

Control Group ◽

Wound Healing Process ◽

Diabetic Foot Ulcers ◽

Family Empowerment ◽

Hba1c Levels

Objective. To evaluate the effectiveness of family empowerment through educational interventions against HbA1c level and healing progress of diabetic foot ulcers. Method. A quasi-experimental design was employed involving 33 participants from 4 wound care clinics in Makassar, eastern Indonesia. The intervention group consisted of 17 participants and their families; the control group was composed of 16 participants who received nonstructural education. Family empowerment was measured by the Indonesian version of the Family Empowerment Scale instrument. Glycemic control was evaluated with HbA1c levels, and the wound healing process was evaluated on the Diabetic Foot Ulcers Assessment Scale. Result. After 3 months, Family Empowerment Scale scores improved, particularly in the subdomain of family knowledge (16.59 ± 3.92 vs 13.38 ± 1.26; P = .005) and attitude (3.65 ± 0.93 vs 2.75 ± 0.45; P = .002). After 3 months of intervention, HbA1c decreased (from 10.47 ± 2.44% to 8.81 ± 1.83%), compared with the control group ( P = .048). Meanwhile, an independent t test further revealed that the wound healing process tended to be better with the intervention group (4.71 ± 7.74) compared with the control group (17.25 ± 17.06), with P = .010 at the third month. Conclusion. Family-based education intervention creates family empowerment to control HbA1c levels and accelerate wound healing of diabetic foot ulcer.

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Perbandingan Penyembuhan Luka Terbuka Menggunakan Balutan Madu atau Balutan Normal Salin-Povidone Iodine

Jurnal Keperawatan Indonesia ◽

10.7454/jki.v12i1.197 ◽

2008 ◽

Vol 12 (1) ◽

pp. 34-39 ◽

Cited By ~ 1

Author(s):

Zulfa Zulfa ◽

Elly Nurachmah ◽

Dewi Gayatri

Keyword(s):

Wound Healing ◽

Normal Saline ◽

Povidone Iodine ◽

Healing Process ◽

Intervention Group ◽

Control Group ◽

Wound Healing Process ◽

Open Wound ◽

Significant Difference ◽

Equivalent Control

AbstrakPenelitian ini bertujuan mengidentifikasi perbedaan keefektifan penyembuhan luka menggunakan balutan madu dan balutan normal salin-povidone iodine pada pasien trauma dengan luka terbuka yang dirawat di salah satu RS di Bukittinggi. Desain penelitian ini adalah kuasi eksperimen, non-equivalent control group dengan pre dan post-test. Sampel berjumlah 6 responden (3 responden untuk masing-masing kelompok intervensi madu serta normal salin-povidone iodine). Hasil penelitian menunjukkan tidak ada perbedaan bermakna pada rerata skor perkembangan proses penyembuhan luka antara sebelum dan sesudah intervensi perawatan luka dengan madu (P = 0.076) dan dengan normal salin-povidone iodine (P = 0,057). Rerata skor perkembangan penyembuhan luka terbuka setelah intervensi tidak berbeda secara signifikan (P = 0,797) antara kelompok intervensi dengan madu dengan kelompok kontrol. Namun, penurunan skor perkembangan proses penyembuhan luka pada balutan madu (11,52%) lebih besar 6,67% dibandingkan balutan normal salin-povidone iodine (4,85%). Perawatan luka dengan madu membuat responden tidak merasa nyeri, tidak terjadi perlengketan serta perdarahan saat membuka balutan ketika dibersihkan, sedangkan dengan normal salin-povidone iodine, responden merasakan sebaliknya. Hasil penelitian ini merekomendasikan penggunaan balutan madu untuk pasien dengan luka terbuka. AbstractThe aim of this study was to compare the effectiveness of honey dressing and normal salin-povidone iodine dressing in the open wound healing process at a hospital in Bukittinggi. This was a non-equivalent control group quasi experimental study with pre & post test. The samples of this study were 6 respondents (3 respondents in each intervention and control group). The finding from this study showed that there was no significant difference on the mean score of wound healing process before and after wound care intervention using honey dressing (P = 0.076), and normal saline-povidone iodine dressing (P = 0.057). There was also no significant difference on the mean score of wound healing process on traumatic open wound patient after intervention on the control group using normal saline-povidone iodine dressing and intervention group using honey dressing (P = 0,797) However, the wound healing score on the honey intervention group was 6,67% higher (11,52%) than on the wound using normal saline-povidone iodine dressing (4,85%). Unlike patients in the control group, patients using honey dressing were not complaining about pain and bleeding when change dressing. Therefore, the study recommended the honey application for open wound.

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