scholarly journals Evaluation of Non-Invasive Measurement of Haemoglobin using PPG in Clinically Ill Pediatric Patients

2019 ◽  
Vol 8 (12) ◽  
pp. 4618-4621
Keyword(s):  
Pediatric Patients ◽  
Pediatric Population ◽  
Linear Regression Analysis ◽  
Venous Blood ◽  
Primary Objective ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Characteristic Features ◽  
Invasive Measurement

Non-invasive haemoglobin (SpHb) estimation using Photoplethysmograph signal has gained enormous attention among researches in order to provide an earlydiagnosis to polycythemia, anaemia, various cardiovascular diseases, etc. The primary objective of this work is to evaluate the performance efficiency of SpHb monitoring using PPG in clinically ill pediatric population. PPG signal was obtained from the pediatric patients, and SpHb was calculated from the characteristic features of PPG. Haemoglobin value obtained through venous blood sample was compared with SpHb. Theabsolute mean difference between the SpHb and Hbref was 0.78g/dL (SD 0.99; 0.1 to 4.1).For a statistical analysis of the correlation between SpHb and Hblab, IBM SPSS statistics software was used. Bland-Altman analysis, T-test and Linear regression analysis were further used for finding the agreeability limits. Overestimation of SpHb value was observed for lower Hblab values, and SpHb failed to detect anaemic subject

scholarly journals Accuracy and precision of non-invasive continuous haemoglobin concentration monitoring in diabetic patients

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Rosanna Carmela De Rosa ◽  
Antonio Romanelli
Keyword(s):  
Linear Regression Analysis ◽  
Haemoglobin Concentration ◽  
Diabetic Patients ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Accuracy And Precision ◽  
Size Population ◽  
Diabetic Population ◽  
First Time

Abstract Background Accuracy and precision of non-invasive continuous haemoglobin concentration (SpHb) provided by Masimo device in diabetic patients is poorly studied. This retrospective analysis aimed to provide data on SpHb accuracy and precision in diabetic patients. Results The sample size population consisted of 14 patients, with 56 SpHb/Lab data pairs. Lab value showed a mean ± standard deviation (SD) of 13.2 ± 1.2 g/dL, whilst SpHb showed a mean ± SD of 11.8 ± 1.1 g/dL. Linear regression analysis between Lab/SpHb data pairs showed a r of 0.8960 (CI95% 0.8281-0.9379, p value < 0.0001). SpHb underestimated the real Hb values provided by Lab. Bland-Altman analysis showed that SpHb accuracy was −1.37 g/dL (CI95% −1.51 to −1.22 g/dL, p value < 0.0001), precision of 0.55 g/dL, lower LOA −2.45 g/dL (CI95% −2.71 to −2.20 g/dL) and upper LOA −0.28 g/dL (CI95% −0.53 to −0.02 g/dL). Conclusions For the first time, we provided data on SpHb accuracy and precision in the diabetic population. SpHb showed a high correlation coefficient when compared with Lab values, but the wide LOA limits its accuracy.

scholarly journals Evidence for the use of the Alere Afinion™ AS100 for measuring the levels of C-reactive protein in an elderly South African population

2020 ◽  
pp. 71-76
Author(s):  
I Mpofana ◽  
M Nyirenda ◽  
N Abbai
Keyword(s):  
Linear Regression Analysis ◽  
Reference Method ◽  
Altman Analysis ◽  
Concordance Correlation ◽  
Excellent Correlation ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Cvd Risk ◽  
Bland Altman Analysis ◽  
Reactive Protein

Introduction: This study evaluated the performance of the Alere Afinion™ AS100 analyser for the measurement of C-reactive protein (CRP) levels in a population of older adults from South Africa. Methods: This study was a sub-study of the Sexual Health, HIV infection and comorbidity with non-communicable diseases among Older Persons (SHIOP) study. The median age of SHIOP participants was 61 years (interquartile range 12). Serum samples collected through SHIOP were used to measure CRP levels on the Alere Afinion™ AS100 (Point-of-care) and ABX Pentra 400 (reference method), respectively. Bland–Altman analysis and Lin’s concordance correlation coefficients were used to assess the agreement between the two analysers. Results: A total of 183 serum samples were tested in the study. The Alere Afinion™ AS100 median values for CRP were 9.5 mg/L and 11.5 mg/L in women and men respectively (p = 0.275). The ABX Pentra 400 median levels were lower with 5.6 mg/L and 3.6 mg/L for women and men (p = 0.027), respectively. Bland–Altman analysis and linear regression analysis showed an excellent correlation between the Pentra and Afinion analysers, with a Lin’s concordance correlation coefficient of 0.971. The Alere Afinion™ AS100 was able to correctly classify > 90% (165/183) of the CRP results when compared to the ABX Pentra 400. Conclusion: This study showed that the Alere Afinion™ AS100 had an excellent correlation with a standard laboratory method. However, the Afinion™ AS100 did not correlate well at elevated CRP levels. This may not be clinically significant since the cut-points for CVD risk are at much lower levels.

scholarly journals The accuracy of ultrasound to predict endotracheal tube size for pediatric patients with congenital scoliosis

2020 ◽  
Author(s):  
Jianhong Hao ◽  
Jie Zhang ◽  
Buhuai Dong ◽  
Zhenguo Luo
Keyword(s):  
Endotracheal Tube ◽  
Pediatric Patients ◽  
Cricoid Cartilage ◽  
Congenital Scoliosis ◽  
Transverse Diameter ◽  
Scoliosis Surgery ◽  
Altman Analysis ◽  
Lateral Bending ◽  
Bland Altman Analysis ◽  
Lumbar Scoliosis

Abstract Background: Ultrasonography has been used to predict the necessary endotracheal tube (ETT) size by measuring the cricoid cartilage diameter. The aim of this study was to determine the accuracy of ultrasound to predict ETT size for pediatric patients with congenital scoliosis. Methods: Fifty pediatric patients who underwent scoliosis surgery were included in the study. According to the position of the scoliosis, patients were divided into three groups: Group C (cervical lateral bending), Group T (thoracic scoliosis), and Group L (lumbar scoliosis). For all participants, the transverse diameter of the cricoid cartilage was measured with ultrasonography. The initial ETT size was chosen according to the measurements, then the leak test was used to determine the bestfit ETT size. The ETT size predicted by ultrasound and the bestfit ETT size were compared using Bland-Altman analysis. Results: There was a strong correlation between the bestfit ETT size and the ETT size predicted by ultrasound in Group T (r = 0.93, p < 0.001) and Group L (r = 0.94, p < 0.001) and a moderate correlation in Group C (r = 0.83, p < 0.001). Bland-Altman analysis showed that the ETT size was overestimated by ultrasound in pediatric patients with cervical lateral bending (bias = 0.73 mm, precision = 0.42 mm, limit of agreement = 0.08 to 1.38 mm). Conclusion: Ultrasound is a reliable tool to predict ETT size for pediatric patients with thoracic or lumbar scoliosis. However, pediatric patients with cervical lateral bending will need an ETT smaller than the size predicted by ultrasonography. Trial Registration: Chinese Clinical Trial Registry, TRN: ChiCTR1900023408, date of registration: 05.26.2019, 'retrospectively registered'.

scholarly journals A method comparison study of a point-of-care blood gas analyser with a laboratory auto-analyser for the determination of potassium concentrations during hyperkalaemia in patients with kidney disease

2020 ◽  
Vol 30 (3) ◽  
pp. 432-438
Author(s):  
Mogamat-Yazied Chothia ◽  
Patricia Kassum ◽  
Annalise Zemlin
Keyword(s):  
Regression Analysis ◽  
Systematic Error ◽  
Potassium Concentration ◽  
Point Of Care ◽  
Venous Blood ◽  
Mean Difference ◽  
Renal Unit ◽  
Blood Gas ◽  
Altman Analysis ◽  
Bland Altman Analysis

Introduction: Hyperkalaemia is a common electrolyte disorder that may cause life-threatening cardiac arrythmias. We aimed to determine the agreement of potassium concentrations between GEM premier 3500 point-of-care blood gas analyser (POC-BGA) and Roche Cobas 6000 c501 autoanalyser in patients with hyperkalaemia. Methods: A prospective, cross-sectional study of all consecutive adult patients referred to the Renal Unit with a serum potassium concentration ≥ 5.5 mmol/L was performed. A total of 59 paired venous blood samples were included in the final statistical analysis. Passing-Bablok regression and Bland Altman analysis were used to compare the two methods. Results: The median laboratory auto-analyser potassium concentration was 6.1 (5.9-7.1) mmol/L as compared to the POC-BGA potassium concentration of 5.7 (5.5-6.8) mmol/L with a mean difference of - 0.43 mmol/L and 95% upper and lower limits of agreement of 0.35 mmol/L and - 1.21 mmol/L, respectively. Regression analysis revealed proportional systematic error. Test for linearity did not indicate significant deviation (P = 0.297). Conclusion: Although regression analysis indicated proportional systematic error, on Bland Altman analysis, the mean difference appeared to remain relatively constant across the potassium range that was evaluated. Therefore, in patients presenting to the emergency department with a clinical suspicion of hyperkalaemia, POC-BGA potassium concentrations may be considered a surrogate for laboratory auto-analyser measurements once clinicians have been cautioned about this difference.

Non-invasive measurement of azygos venous blood flow using magnetic resonance

1995 ◽  
Vol 22 (4) ◽  
pp. 399-403 ◽  
Author(s):  
David J. Lomas ◽  
Michael P. Hayball ◽  
David Parry Jones ◽  
Clare Sims ◽  
Michael E.D. Allison ◽  
...  
Keyword(s):  
Blood Flow ◽  
Magnetic Resonance ◽  
Venous Blood ◽  
Venous Blood Flow ◽  
Non Invasive ◽  
Invasive Measurement

scholarly journals Use of Vacuum-suction in Depressed Skull Fractures – Case Report and Technical Nuances of Nonoperative Treatment

2020 ◽  
Author(s):  
Rodrigo Moreira Faleiro ◽  
Sérgio Cavalheiro ◽  
João Tiago Alves Belo ◽  
Vítor Vieira de Souza Moraes ◽  
Aieska Kellen Dantas dos Santos ◽  
...  
Keyword(s):  
Case Report ◽  
Pediatric Patients ◽  
Surgical Repair ◽  
Pediatric Population ◽  
Skull Fracture ◽  
Invasive Procedure ◽  
Nonoperative Treatment ◽  
Skull Fractures ◽  
Vacuum Suction ◽  
Non Invasive

AbstractUp to 20% of victims from skull fractures are represented by the pediatric population, and 50% of these lesions are depressed skull fractures. The treatment is multimodal in nature, ranging from conservative treatment to open surgical repair. The last one is associated, although in a small proportion, to complications, such as infections, hematomas and even death, besides the risks of the anesthetic procedure itself. The authors of the present article present a case report of the successful treatment of a depressed skull fracture in a newborn patient, using the vacuum-suction technique. The use of vacuum-suction may be beneficial for the pediatric patients, as it is a quick, non-invasive procedure, without the need for general anesthesia.

scholarly journals Multicenter comparison of the Cobas 6800 system with the RealStar RT-PCR kit for the detection of SARS-CoV-2

2020 ◽  
Author(s):  
Marc Wirden ◽  
Linda Feghoul ◽  
Mélanie Bertine ◽  
Marie-Laure Nere ◽  
Quentin Le Hingrat ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Regression Line ◽  
Clinical Samples ◽  
Altman Analysis ◽  
Rt Pcr ◽  
Bland Altman Analysis ◽  
Deming Regression ◽  
The Mean ◽  
Pcr Assays

ABSTRACTBackgroundRT-PCR testing is crucial in the diagnostic of SARS-CoV-2 infection. The use of reliable and comparable PCR assays is a cornerstone to allow use of different PCR assays depending on the local equipment. In this work, we provide a comparison of the Cobas® (Roche) and the RealStar® assay (Altona).MethodsAssessment of the two assays was performed prospectively in three reference Parisians hospitals, using 170 clinical samples. They were tested with the Cobas® assay, selected to obtain a distribution of cycle threshold (Ct) as large as possible, and tested with the RealStar assay with three largely available extraction platforms: QIAsymphony (Qiagen), MagNAPure (Roche) and NucliSENS-easyMag (BioMérieux).ResultsOverall, the agreement (positive for at least one gene) was 76%. This rate differed considerably depending on the Cobas Ct values for gene E: below 35 (n = 91), the concordance was 99%. Regarding the positive Ct values, linear regression analysis showed a determination correlation (R2) of 0.88 and the Deming regression line revealed a strong correlation with a slope of 1.023 and an intercept of -3.9. Bland-Altman analysis showed that the mean difference (Cobas® minus RealStar®) was + 3.3 Ct, with a SD of + 2.3 Ct.ConclusionsIn this comparison, both RealStar® and Cobas® assays provided comparable qualitative results and a high correlation when both tests were positive. Discrepancies exist after 35 Ct and varied depending on the extraction system used for the RealStar® assay, probably due to a low viral load close to the detection limit of both assays.

scholarly journals The accuracy of ultrasound to predict endotracheal tube size for pediatric patients with congenital scoliosis

2020 ◽  
Author(s):  
Jianhong Hao ◽  
Jie Zhang ◽  
Buhuai Dong ◽  
Zhenguo Luo
Keyword(s):  
Endotracheal Tube ◽  
Pediatric Patients ◽  
Cricoid Cartilage ◽  
Congenital Scoliosis ◽  
Altman Analysis ◽  
Lateral Bending ◽  
Bland Altman Analysis ◽  
Thoracic Scoliosis ◽  
Lumbar Scoliosis ◽  
Best Fit

Abstract Background: Ultrasonography has been used for prediction the endotracheal tube(ETT) size through measuring the cricoid cartilage diameter. The aim of this study was to determine the accuracy of ultrasound to predict ETT size for pediatric patients with congenital scoliosis.Methods:Fifty pediatric patients underwent scoliosis surgery were included in the study. According to the position of scoliosis, patients were divided into three groups: Group C (cervical lateral bending); Group T ( thoracic scoliosis); and Group L (lumbar scoliosis). For all participants, the transverse diameter of the cricoid cartilage was measured with ultrasonography and the initial ETT size was chosen according to the measurements, then the leak test was used to determine the best‑fit ETT size. In each group, the ETT size measured by ultrasound and the best‑fit ETT size were compared using Bland-Altman analysis and linear regression analysis.Results: There was a strong correlation between the best‑fit ETT size and the ETT size predicted by ultrasound in Group T (r=0.93, p<0.001) and Group L(r=0.95, p<0.001) and a moderate correlation in Group C(r=0.83, p<0.001). Bland-Altman analysis show that the ETT size was over estimated by ultrasound in pediatric patients with cervical lateral bending.Conclusion: Ultrasound is a reliable tool to predict ETT size for pediatric patients with thoracic scoliosis and lumbar scoliosis. However, compared to what was predicted by ultrasonography, pediatric patients with cervical lateral bending need a smaller sized ETT.

scholarly journals The TRUTH confirmed: validation of an intraindividual comparison of gadobutrol and gadoteridol for imaging of glioblastoma using quantitative enhancement analysis

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Matthew J. Kuhn ◽  
Julia W. Patriarche ◽  
Douglas Patriarche ◽  
Miles A. Kirchin ◽  
Massimo Bona ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Region Of Interest ◽  
Mean Difference ◽  
Altman Analysis ◽  
Double Blind ◽  
Bland Altman Analysis ◽  
Intraindividual Comparison ◽  
Contrast Enhanced ◽  
Magnetic Resonance Imaging Mri

Abstract Background Previous intraindividual comparative studies evaluating gadobutrol and gadoteridol for contrast-enhanced magnetic resonance imaging (MRI) of brain tumours have relied on subjective image assessment, potentially leading to misleading conclusions. We used artificial intelligence algorithms to objectively compare the enhancement achieved with these contrast agents in glioblastoma patients. Methods Twenty-seven patients from a prior study who received identical doses of 0.1 mmol/kg gadobutrol and gadoteridol (with appropriate washout in between) were evaluated. Quantitative enhancement (QE) maps of the normalised enhancement of voxels, derived from computations based on the comparison of contrast-enhanced T1-weighted images relative to the harmonised intensity on unenhanced T1-weighted images, were compared. Bland-Altman analysis, linear regression analysis and Pearson correlation coefficient (r) determination were performed to compare net QE and per-region of interest (per-ROI) average QE (net QE divided by the number of voxels). Results No significant differences were observed for comparisons performed on net QE (mean difference -24.37 ± 620.8, p = 0.840, r = 0.989) or per-ROI average QE (0.0043 ± 0.0218, p = 0.313, r = 0.958). Bland-Altman analysis revealed better per-ROI average QE for gadoteridol-enhanced MRI in 19/27 (70.4%) patients although the mean difference (0.0043) was close to zero indicating high concordance and the absence of fixed bias. Conclusions The enhancement of glioblastoma achieved with gadoteridol and gadobutrol at 0.1 mmol/kg bodyweight is similar indicating that these agents have similar contrast efficacy and can be used interchangeably, confirming the results of a prior double-blind, randomised, intraindividual, crossover study.

scholarly journals Vascular Access Flow during Dialysis: Does Needle Orientation Matter?

2021 ◽  
Vol 1 (2) ◽  
pp. 138-146
Author(s):  
Georgios Tsangalis ◽  
Valérie Loizon
Keyword(s):  
Linear Regression ◽  
Vascular Access ◽  
Linear Regression Analysis ◽  
Dilution Method ◽  
Altman Analysis ◽  
Dialysis Adequacy ◽  
Flow Measurements ◽  
Bland Altman Analysis ◽  
The Impact

Background: Monitoring of vascular access outflow (VAO) in dialysis is based on the indicator dilution method by ultrasound (UD). The role of arterial needle orientation in VAO measurement is not clear. We compared the impact of the retrograde (RET) versus the antegrade orientation (ANT) in terms of (a) VAO (UD) and (b) dialysis adequacy. Moreover, we compared VAO (UD ANT and RET orientation) with VAO measured by Doppler ultrasound. Methods: 22 patients participated in the study. Inclusion criteria: Dialysis > 6 months with a functioning AVF, no stenosis, no active infection, EF > 45% and informed consent. 4 flow measurements were taken on the same dialysis day (4 consecutive weeks). To account for blood pressure variation, we “corrected” VAO for a mean arterial pressure of 100 mmHg. Doppler VAO was measured just before dialysis. Means were compared by the paired t-test. For correlation and agreement, linear regression and Bland-Altman analysis were performed respectively. Results: Mean VAO (UD) was higher in the (ANT) versus the (RET) orientation: 1286.17 mL/min (SD = 455.78, 95%CI = 1084–1488) versus 1189.96 mL/min (SD = 401.05, 95%CI = 1012–1368) (p = 0.013) with a mean difference of 96.21 mL/min (5.66%). Mean Kt/V (RET orientation) was 1.57 (SD = 0.10, 95%CI = 1.52–1.61) versus 1,55 (SD = 0.10, 95%CI = 1.50–1.60) (ANT) orientation (p = 0.062). Recirculation was always 0%. The mean VAO (Doppler) was 1079.54 mL/min (SD = 356.04, 95%CI = 922–1237), 16% lower than VAO measured by UD with (ANT) orientation (p = 0.009) and 9.3% lower than the VAO in the (RET) orientation (p = 0.113). Linear regression analysis showed that VA flows (ANT versus RET) orientation of the needle correlates well between them (r = 0.93, p < 0.001) but show poor agreement (Bland–Altman analysis). Conclusion: VAO (UD) in the RET orientation was significantly lower than VAO in the ANT orientation and more consistent with VAO assessed by Doppler without influencing dialysis adequacy. Therefore, when using UD for VAO surveillance, the RET orientation should be used.

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