scholarly journals Accuracy and precision of non-invasive continuous haemoglobin concentration monitoring in diabetic patients

2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Rosanna Carmela De Rosa ◽  
Antonio Romanelli
Keyword(s):  
Linear Regression Analysis ◽  
Haemoglobin Concentration ◽  
Diabetic Patients ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Accuracy And Precision ◽  
Size Population ◽  
Diabetic Population ◽  
First Time

Abstract Background Accuracy and precision of non-invasive continuous haemoglobin concentration (SpHb) provided by Masimo device in diabetic patients is poorly studied. This retrospective analysis aimed to provide data on SpHb accuracy and precision in diabetic patients. Results The sample size population consisted of 14 patients, with 56 SpHb/Lab data pairs. Lab value showed a mean ± standard deviation (SD) of 13.2 ± 1.2 g/dL, whilst SpHb showed a mean ± SD of 11.8 ± 1.1 g/dL. Linear regression analysis between Lab/SpHb data pairs showed a r of 0.8960 (CI95% 0.8281-0.9379, p value < 0.0001). SpHb underestimated the real Hb values provided by Lab. Bland-Altman analysis showed that SpHb accuracy was −1.37 g/dL (CI95% −1.51 to −1.22 g/dL, p value < 0.0001), precision of 0.55 g/dL, lower LOA −2.45 g/dL (CI95% −2.71 to −2.20 g/dL) and upper LOA −0.28 g/dL (CI95% −0.53 to −0.02 g/dL). Conclusions For the first time, we provided data on SpHb accuracy and precision in the diabetic population. SpHb showed a high correlation coefficient when compared with Lab values, but the wide LOA limits its accuracy.

scholarly journals Evaluation of Non-Invasive Measurement of Haemoglobin using PPG in Clinically Ill Pediatric Patients

2019 ◽  
Vol 8 (12) ◽  
pp. 4618-4621
Keyword(s):  
Pediatric Patients ◽  
Pediatric Population ◽  
Linear Regression Analysis ◽  
Venous Blood ◽  
Primary Objective ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Characteristic Features ◽  
Invasive Measurement

Non-invasive haemoglobin (SpHb) estimation using Photoplethysmograph signal has gained enormous attention among researches in order to provide an earlydiagnosis to polycythemia, anaemia, various cardiovascular diseases, etc. The primary objective of this work is to evaluate the performance efficiency of SpHb monitoring using PPG in clinically ill pediatric population. PPG signal was obtained from the pediatric patients, and SpHb was calculated from the characteristic features of PPG. Haemoglobin value obtained through venous blood sample was compared with SpHb. Theabsolute mean difference between the SpHb and Hbref was 0.78g/dL (SD 0.99; 0.1 to 4.1).For a statistical analysis of the correlation between SpHb and Hblab, IBM SPSS statistics software was used. Bland-Altman analysis, T-test and Linear regression analysis were further used for finding the agreeability limits. Overestimation of SpHb value was observed for lower Hblab values, and SpHb failed to detect anaemic subject

scholarly journals Evidence for the use of the Alere Afinion™ AS100 for measuring the levels of C-reactive protein in an elderly South African population

2020 ◽  
pp. 71-76
Author(s):  
I Mpofana ◽  
M Nyirenda ◽  
N Abbai
Keyword(s):  
Linear Regression Analysis ◽  
Reference Method ◽  
Altman Analysis ◽  
Concordance Correlation ◽  
Excellent Correlation ◽  
C Reactive Protein ◽  
Serum Samples ◽  
Cvd Risk ◽  
Bland Altman Analysis ◽  
Reactive Protein

Introduction: This study evaluated the performance of the Alere Afinion™ AS100 analyser for the measurement of C-reactive protein (CRP) levels in a population of older adults from South Africa. Methods: This study was a sub-study of the Sexual Health, HIV infection and comorbidity with non-communicable diseases among Older Persons (SHIOP) study. The median age of SHIOP participants was 61 years (interquartile range 12). Serum samples collected through SHIOP were used to measure CRP levels on the Alere Afinion™ AS100 (Point-of-care) and ABX Pentra 400 (reference method), respectively. Bland–Altman analysis and Lin’s concordance correlation coefficients were used to assess the agreement between the two analysers. Results: A total of 183 serum samples were tested in the study. The Alere Afinion™ AS100 median values for CRP were 9.5 mg/L and 11.5 mg/L in women and men respectively (p = 0.275). The ABX Pentra 400 median levels were lower with 5.6 mg/L and 3.6 mg/L for women and men (p = 0.027), respectively. Bland–Altman analysis and linear regression analysis showed an excellent correlation between the Pentra and Afinion analysers, with a Lin’s concordance correlation coefficient of 0.971. The Alere Afinion™ AS100 was able to correctly classify > 90% (165/183) of the CRP results when compared to the ABX Pentra 400. Conclusion: This study showed that the Alere Afinion™ AS100 had an excellent correlation with a standard laboratory method. However, the Afinion™ AS100 did not correlate well at elevated CRP levels. This may not be clinically significant since the cut-points for CVD risk are at much lower levels.

scholarly journals Changes in Salivary Amylase and Glucose in Diabetes: A Scoping Review

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 453
Author(s):  
Pilar Pérez-Ros ◽  
Emmanuel Navarro-Flores ◽  
Ivan Julián-Rochina ◽  
Francisco Miguel Martínez-Arnau ◽  
Omar Cauli
Keyword(s):  
Glycemic Control ◽  
Glucose Concentration ◽  
Diabetic Patients ◽  
Clinical Settings ◽  
Salivary Amylase ◽  
Glucose Levels ◽  
Non Invasive ◽  
Diabetic Population ◽  
Saliva Collection

Background and Objective: Diabetes mellitus (DM) is a common long-term disease which can be related with salivary amylase levels. DM has recently been associated with salivary amylase diagnostics that could further impair diagnoses in the diabetic population, as well as being an interesting alternative to traditional methods of determine glucose levels. The main advantage of this method is related to the fact that it is a fast diagnostic method. The DM population experiences changes to their metabolism which affects their salivary parameters, making this an alternative procedure for diagnosis and follow-up of the illness due to the non-invasive nature of salivary analyzes. The objective of this review is to summarize the evidence regarding the changes in salivary amylase and glucose levels, and their relationship with blood markers of glycemic control used in clinical settings such as blood glucose and glycated hemoglobin. The differences in salivary amylase levels depending on the method of saliva collection under fasting or non-fasting conditions. The changes in salivary amylase depends on the type of diabetes, the type of insulin treatment or the quality of glycemic control. Conclusions: Salivary amylase concentration is increased in diabetic patients in most of the studies and salivary glucose concentration in all studies in both fasting and non-fasting (post-prandial) conditions. Salivary amylase and glucose concentration represent potential non-invasive biomarkers to evaluate glycemic control and clinical management of diabetic patients, although it is necessary to evaluate the influence of potential modulating factors such as age, duration diseases, sex and the effects of pharmacological treatments in these outcomes which remained to be elucidated.

scholarly journals Segmentation Approaches for Diabetic Foot Disorders

Sensors ◽  
2021 ◽  
Vol 21 (3) ◽  
pp. 934
Author(s):  
Natalia Arteaga-Marrero ◽  
Abián Hernández ◽  
Enrique Villa ◽  
Sara González-Pérez ◽  
Carlos Luque ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Spatial Information ◽  
Ground Truth ◽  
Diabetic Patients ◽  
Non Invasive ◽  
Depth Images ◽  
Accuracy And Precision ◽  
Technical Issues ◽  
Monitoring Protocols ◽  
Visual Light

Thermography enables non-invasive, accessible, and easily repeated foot temperature measurements for diabetic patients, promoting early detection and regular monitoring protocols, that limit the incidence of disabling conditions associated with diabetic foot disorders. The establishment of this application into standard diabetic care protocols requires to overcome technical issues, particularly the foot sole segmentation. In this work we implemented and evaluated several segmentation approaches which include conventional and Deep Learning methods. Multimodal images, constituted by registered visual-light, infrared and depth images, were acquired for 37 healthy subjects. The segmentation methods explored were based on both visual-light as well as infrared images, and optimization was achieved using the spatial information provided by the depth images. Furthermore, a ground truth was established from the manual segmentation performed by two independent researchers. Overall, the performance level of all the implemented approaches was satisfactory. Although the best performance, in terms of spatial overlap, accuracy, and precision, was found for the Skin and U-Net approaches optimized by the spatial information. However, the robustness of the U-Net approach is preferred.

scholarly journals Multicenter comparison of the Cobas 6800 system with the RealStar RT-PCR kit for the detection of SARS-CoV-2

2020 ◽  
Author(s):  
Marc Wirden ◽  
Linda Feghoul ◽  
Mélanie Bertine ◽  
Marie-Laure Nere ◽  
Quentin Le Hingrat ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Linear Regression Analysis ◽  
Regression Line ◽  
Clinical Samples ◽  
Altman Analysis ◽  
Rt Pcr ◽  
Bland Altman Analysis ◽  
Deming Regression ◽  
The Mean ◽  
Pcr Assays

ABSTRACTBackgroundRT-PCR testing is crucial in the diagnostic of SARS-CoV-2 infection. The use of reliable and comparable PCR assays is a cornerstone to allow use of different PCR assays depending on the local equipment. In this work, we provide a comparison of the Cobas® (Roche) and the RealStar® assay (Altona).MethodsAssessment of the two assays was performed prospectively in three reference Parisians hospitals, using 170 clinical samples. They were tested with the Cobas® assay, selected to obtain a distribution of cycle threshold (Ct) as large as possible, and tested with the RealStar assay with three largely available extraction platforms: QIAsymphony (Qiagen), MagNAPure (Roche) and NucliSENS-easyMag (BioMérieux).ResultsOverall, the agreement (positive for at least one gene) was 76%. This rate differed considerably depending on the Cobas Ct values for gene E: below 35 (n = 91), the concordance was 99%. Regarding the positive Ct values, linear regression analysis showed a determination correlation (R2) of 0.88 and the Deming regression line revealed a strong correlation with a slope of 1.023 and an intercept of -3.9. Bland-Altman analysis showed that the mean difference (Cobas® minus RealStar®) was + 3.3 Ct, with a SD of + 2.3 Ct.ConclusionsIn this comparison, both RealStar® and Cobas® assays provided comparable qualitative results and a high correlation when both tests were positive. Discrepancies exist after 35 Ct and varied depending on the extraction system used for the RealStar® assay, probably due to a low viral load close to the detection limit of both assays.

scholarly journals The TRUTH confirmed: validation of an intraindividual comparison of gadobutrol and gadoteridol for imaging of glioblastoma using quantitative enhancement analysis

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Matthew J. Kuhn ◽  
Julia W. Patriarche ◽  
Douglas Patriarche ◽  
Miles A. Kirchin ◽  
Massimo Bona ◽  
...  
Keyword(s):  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Region Of Interest ◽  
Mean Difference ◽  
Altman Analysis ◽  
Double Blind ◽  
Bland Altman Analysis ◽  
Intraindividual Comparison ◽  
Contrast Enhanced ◽  
Magnetic Resonance Imaging Mri

Abstract Background Previous intraindividual comparative studies evaluating gadobutrol and gadoteridol for contrast-enhanced magnetic resonance imaging (MRI) of brain tumours have relied on subjective image assessment, potentially leading to misleading conclusions. We used artificial intelligence algorithms to objectively compare the enhancement achieved with these contrast agents in glioblastoma patients. Methods Twenty-seven patients from a prior study who received identical doses of 0.1 mmol/kg gadobutrol and gadoteridol (with appropriate washout in between) were evaluated. Quantitative enhancement (QE) maps of the normalised enhancement of voxels, derived from computations based on the comparison of contrast-enhanced T1-weighted images relative to the harmonised intensity on unenhanced T1-weighted images, were compared. Bland-Altman analysis, linear regression analysis and Pearson correlation coefficient (r) determination were performed to compare net QE and per-region of interest (per-ROI) average QE (net QE divided by the number of voxels). Results No significant differences were observed for comparisons performed on net QE (mean difference -24.37 ± 620.8, p = 0.840, r = 0.989) or per-ROI average QE (0.0043 ± 0.0218, p = 0.313, r = 0.958). Bland-Altman analysis revealed better per-ROI average QE for gadoteridol-enhanced MRI in 19/27 (70.4%) patients although the mean difference (0.0043) was close to zero indicating high concordance and the absence of fixed bias. Conclusions The enhancement of glioblastoma achieved with gadoteridol and gadobutrol at 0.1 mmol/kg bodyweight is similar indicating that these agents have similar contrast efficacy and can be used interchangeably, confirming the results of a prior double-blind, randomised, intraindividual, crossover study.

scholarly journals Vascular Access Flow during Dialysis: Does Needle Orientation Matter?

2021 ◽  
Vol 1 (2) ◽  
pp. 138-146
Author(s):  
Georgios Tsangalis ◽  
Valérie Loizon
Keyword(s):  
Linear Regression ◽  
Vascular Access ◽  
Linear Regression Analysis ◽  
Dilution Method ◽  
Altman Analysis ◽  
Dialysis Adequacy ◽  
Flow Measurements ◽  
Bland Altman Analysis ◽  
The Impact

Background: Monitoring of vascular access outflow (VAO) in dialysis is based on the indicator dilution method by ultrasound (UD). The role of arterial needle orientation in VAO measurement is not clear. We compared the impact of the retrograde (RET) versus the antegrade orientation (ANT) in terms of (a) VAO (UD) and (b) dialysis adequacy. Moreover, we compared VAO (UD ANT and RET orientation) with VAO measured by Doppler ultrasound. Methods: 22 patients participated in the study. Inclusion criteria: Dialysis > 6 months with a functioning AVF, no stenosis, no active infection, EF > 45% and informed consent. 4 flow measurements were taken on the same dialysis day (4 consecutive weeks). To account for blood pressure variation, we “corrected” VAO for a mean arterial pressure of 100 mmHg. Doppler VAO was measured just before dialysis. Means were compared by the paired t-test. For correlation and agreement, linear regression and Bland-Altman analysis were performed respectively. Results: Mean VAO (UD) was higher in the (ANT) versus the (RET) orientation: 1286.17 mL/min (SD = 455.78, 95%CI = 1084–1488) versus 1189.96 mL/min (SD = 401.05, 95%CI = 1012–1368) (p = 0.013) with a mean difference of 96.21 mL/min (5.66%). Mean Kt/V (RET orientation) was 1.57 (SD = 0.10, 95%CI = 1.52–1.61) versus 1,55 (SD = 0.10, 95%CI = 1.50–1.60) (ANT) orientation (p = 0.062). Recirculation was always 0%. The mean VAO (Doppler) was 1079.54 mL/min (SD = 356.04, 95%CI = 922–1237), 16% lower than VAO measured by UD with (ANT) orientation (p = 0.009) and 9.3% lower than the VAO in the (RET) orientation (p = 0.113). Linear regression analysis showed that VA flows (ANT versus RET) orientation of the needle correlates well between them (r = 0.93, p < 0.001) but show poor agreement (Bland–Altman analysis). Conclusion: VAO (UD) in the RET orientation was significantly lower than VAO in the ANT orientation and more consistent with VAO assessed by Doppler without influencing dialysis adequacy. Therefore, when using UD for VAO surveillance, the RET orientation should be used.

scholarly journals Limitations of a non-invasive model of the estimation of pulmonary vascular resistance by magnetic resonance imaging in patients with heart failure

2021 ◽  
Vol 22 (Supplement_2) ◽  
Author(s):  
V Vidal Urrutia ◽  
A Cubillos-Arango ◽  
P Garcia-Gonzalez ◽  
J Gradoli-Palmero ◽  
J Nunez-Villota ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Heart Failure ◽  
Magnetic Resonance ◽  
Pulmonary Vascular Resistance ◽  
Altman Analysis ◽  
Resonance Imaging ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Patients With Heart Failure ◽  
The Mean

Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Pulmonary vascular resistance (PVR) is a hemodynamic parameter with important diagnostic and prognostic implications in patients with heart failure. Currently the gold standard technique for its quantification is right heart catheterization (RHC). However, cardiovascular magnetic resonance imaging (CMR) has been postulated as a non-invasive alternative for its estimation. The aim of this study is to assess the accuracy of a non-invasive model of PVR estimated by CMR in a specific subgroup of patients with acute heart failure (AHF). Methods. Between January 2014 and December 2018, 108 patients with AHF who underwent RHC and CMR on the same day were prospectively included. PVR was assessed by CMR using the model: 19.38 - [4.62 x Ln mean pulmonary artery velocity - 0.08 x right ventricular ejection fraction (RVEF)]. During RHC, PVR were calculated using the ratio between transpulmonary gradient and cardiac output. We evaluated their correlation using the Spearman correlation coefficient, receiver operating characteristic [ROC] curves, and Bland-Altman analysis. Results. The mean age of our cohort was 65 ± 11 years and 64.8% were male. The median PVR (Wood Units, WU) assessed by CMR and RHC were 5.1 WU (3.4 - 6.8) and 3 WU (1.5 - 3.9); p &lt; 0.001, respectively. A weak correlation was observed between the PVR obtained by RHC and those obtained by CMR in our population (r = 0.21; p = 0.02). On Bland-Altman analysis, the mean bias was -1.7, and the 95% limits of agreement ranged from -10.02 to 6.6 WU. The area under the ROC curve for PVR assessed by CMR to detect PVR ³3 WU was 0.57, 95% confidence interval (CI): 0.47-0.68. Conclusions. In patients with AHF, the non-invasive estimation of PVR using CMR shows poor accuracy, as well as a limited capacity to discriminate increased PVR values.

Non-invasive monitoring of carboxyhemoglobin during hyperbaric oxygen therapy

2021 ◽  
pp. 33-42
Author(s):  
Daniel Bidstrup ◽  
Frederikke Ravn ◽  
Isabel Guida Smidt-Nielsen ◽  
Anna Mygind Wahl ◽  
Erik Christian Jansen ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Repeated Measurements ◽  
Co Poisoning ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Non Invasive ◽  
Continuous Measurements ◽  
Multiple Observations ◽  
Hbo2 Therapy ◽  
Hyperbaric Conditions

Introduction: This study aimed to assess the capability of a pulse CO-oximeter to continuously monitor carboxyhemoglobin (COHb) during hyperbaric oxygen (HBO2) therapy. We estimated limits of agreement (LOA) between blood gas analysis and pulse CO-oximeter for COHb during HBO2 therapy in patients suffering from acute CO poisoning. Furthermore, we did a medicotechnical evaluation of the pulse CO-oximeter in hyperbaric conditions. Method: We conducted a prospective, non-clinical, observational study in which we included n=10 patients with acute CO poisoning referred for HBO2 therapy. We did five repeated measurements of COHb for each patient during the HBO2 therapy. Bland-Altman analysis for multiple observations per individual was used to assess the agreement. The a priori LOA was ±6% for COHb. For the medicotechnical evaluation continuous measurements were obtained throughout each complete HBO2 therapy. The measurements were visually inspected and evaluated. Results: The Bland-Altman analysis showed that the pulse CO-oximeter overestimated COHb by 2.9 % [±1.0%] and the LOA was ±7.3% [±1.8%]. The continuous measurements by pulse CO-oximetry showed fluctuating levels of COHb and summarized saturations reached levels above 100%. Measurements were not affected by changes in pressure. Conclusion: To our knowledge, this study is the first to asses LOA and demonstrate use of a non-invasive method to measure COHb during HBO2 therapy. The pulse CO-oximeter performed within the manufactures reported LOA (±6%) despite hyperbaric conditions and was unaffected by changes in pressure. However, summarized saturations reached levels above 100%.

scholarly journals Comparison of two continuous non-invasive haemodynamic monitoring techniques in the perioperative setting

2019 ◽  
Vol 26 (1) ◽  
pp. 31-37
Author(s):  
Jonė Jackevičiūtė ◽  
Greta Kraujalytė ◽  
Inna Jaremko ◽  
Vilija Stremaitytė ◽  
Jūratė Gudaitytė
Keyword(s):  
Linear Regression ◽  
Quantitative Data ◽  
Haemodynamic Monitoring ◽  
Percentage Error ◽  
Altman Analysis ◽  
Bland Altman Analysis ◽  
Monitoring Techniques ◽  
Non Invasive ◽  
Electrical Bioimpedance ◽  
The Mean

Background. The aim of the study was to identify the accuracy of and agreement between two non-invasive haemodynamic monitoring techniques in the perioperative setting – thoracic electrical bioimpedance (TEB) and Edwards Lifesciences ClearSight system (CS). Materials and methods. The study included ten patients. Parametric quantitative data were expressed as mean ± SD. The ShapiroWilk test was used to test the normality of the distributions. A linear regression model was used to measure the strength of the linear relationship between TEB and CS. Bland-Altman analysis was performed to assess the mean difference, precision, and the limits of agreements (LOA). The Critchley and Critchley method was used to calculate the percentage error (PE), and if

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