scholarly journals EVALUASI SIFAT FISIK SEDIAAN SALEP MINYAK CENGKEH (SYZIGIUM AROMATICUM) DALAM BASIS LARUT AIR

2019 ◽  
Vol 10 (2) ◽  
pp. 31-39
Author(s):  
Rani Prabandari
Keyword(s):  
Essential Oil ◽  
Statistical Tests ◽  
Water Soluble ◽  
Syzygium Aromaticum ◽  
Lattice Design ◽  
Smelting Method ◽  
Irritation Test ◽  
Anti Inflammatory ◽  
Simplex Lattice ◽  
Soluble Base

  The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect.   Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

scholarly journals Pengaruh konsentrasi air dalam formula salep minyak cengkeh (syzigium aromaticum)

2019 ◽  
Vol 10 (2) ◽  
pp. 24-30
Author(s):  
Rani Prabandari
Keyword(s):  
Essential Oil ◽  
Statistical Tests ◽  
Water Soluble ◽  
Syzygium Aromaticum ◽  
Lattice Design ◽  
Smelting Method ◽  
Irritation Test ◽  
Anti Inflammatory ◽  
Simplex Lattice ◽  
Soluble Base

Abstract   The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect.   Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

scholarly journals Optimasi sediaan salep minyak cengkeh (syzigium aromaticum) dalam basis larut air

2019 ◽  
Vol 10 (2) ◽  
pp. 160-166
Author(s):  
Rani Prabandari
Keyword(s):  
Essential Oil ◽  
Statistical Tests ◽  
Water Soluble ◽  
Syzygium Aromaticum ◽  
Lattice Design ◽  
Smelting Method ◽  
Irritation Test ◽  
Anti Inflammatory ◽  
Simplex Lattice ◽  
Soluble Base

Abstract   The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect.   Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

REVIEW : KARAKTERISTIK FISIK DAN DAYA IRITASI MINYAK ATSIRI BUNGA CENGKEH (Syzygium aromaticum) DALAM BEBERAPA TIPE BASIS SEBAGAI ANTI-INFLAMASI

2020 ◽  
Vol 5 (2) ◽  
pp. 364-375
Author(s):  
Amraini Amelia ◽  
◽  
Nining Sugihartini ◽  
Hari Susanti ◽  
Keyword(s):  
Essential Oil ◽  
Physical Properties ◽  
Research Method ◽  
Water Soluble ◽  
Syzygium Aromaticum ◽  
Absorption Properties ◽  
Inflammatory Drugs ◽  
Clove Essential Oil ◽  
Soluble Base ◽  
Essential Oil Formulations

This review aims to determine the types of bases that can be used every day, which are effective and efficient as anti-inflammatory drugs. The research method used was to review the development of clove essential oil formulations that have been carried out using various concentrations of various types of bases including M / A type cream, A / M type cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorbents. The recommended formulation is type M / A cream with a concentration of 5% clove flower essential oil. The types of bases studied were M / A cream, type A / M cream, water soluble base, lotion, emulgel, hydrocarbons, hydrogels and absorption properties which had good physical properties and did not irritate the skin of the test animals. This review refers to several national and international journals released in the last ten years, from 2010 to 2020.

scholarly journals The Profile of Anti-inflammatory Activity of Syzigium Aromaticum Volatile Oil in Lotion with Variation Composition of Oleic Acid and Propylene Glycol as Enhancer

2017 ◽  
Vol 22 (2) ◽  
pp. 111 ◽  
Author(s):  
Fitriah Ardiawijianti Iriani ◽  
Nining Sugihartini ◽  
Tedjo Yuwono
Keyword(s):  
Oleic Acid ◽  
Essential Oil ◽  
Propylene Glycol ◽  
Mouse Strain ◽  
Inflammatory Cells ◽  
Volatile Oil ◽  
Inflammatory Activity ◽  
Syzygium Aromaticum ◽  
Cox 2 ◽  
Anti Inflammatory

Essential oil of clove (Syzygium aromaticum) containing eugenol has an anti-inflammatory activity. The study was aimed to develop the formulation of lotion by adding of oleic acid and propylene glycol as penetration enhancer. The effect of enhancer composition was also studied. Lotion was prepared with the composition of oleic acid (AO) and propylene glycol (PG) as follow: 1:0 (FI), 0,5:0,5 (FII), 0:1 (FIII). Capacity an anti-inflammatory of formulation based on parameters of the amount of cells with COX-2 expression, the number of inflammatory cells and the epidermis thickness was evaluated using male mouse strain BALb/C induced by crotton oil as inflammatory agents. The results showed that the increasing composition propylene glycol caused the decreasing of the amount of cells with COX-2 expression (p <0.05), the inflammatory cells (P <0.05) and the epidermis thickness (p <0.05)

scholarly journals Evaluation of the synergistic effects of antioxidant activity on mixtures of the essential oil from Apium graveolens L., Thymus vulgaris L. and Coriandrum sativum L. using simplex-lattice design

Heliyon ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. e01942 ◽  
Author(s):  
Yasiel Arteaga Crespo ◽  
Luis Ramón Bravo Sánchez ◽  
Yudel García Quintana ◽  
Andrea Silvana Tapuy Cabrera ◽  
Abdel Bermúdez del Sol ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Synergistic Effects ◽  
Coriandrum Sativum ◽  
Apium Graveolens ◽  
Thymus Vulgaris ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice

scholarly journals THE ANTI-INFLAMMATORY ACTIVITY OF ESSENTIAL OIL OF CLOVE (Syzygium aromaticum) IN ABSORPTION BASE OINTMENT WITH ADDITION OF OLEIC ACID AND PROPYLENE GLYCOL AS ENHANCER

2019 ◽  
pp. 106-109
Author(s):  
NINING SUGIHARTINI ◽  
RANI PRABANDARI ◽  
TEDJO YUWONO ◽  
DESTY RESTIA RAHMAWATI
Keyword(s):  
Oleic Acid ◽  
Essential Oil ◽  
Propylene Glycol ◽  
Inflammatory Cells ◽  
Optimal Concentration ◽  
Inflammatory Activity ◽  
Syzygium Aromaticum ◽  
Epidermal Thickness ◽  
Cox 2 ◽  
Anti Inflammatory

Background : The optimal concentration of essential oil of clove in absorption base ointment as anti-inflammatory has been studied. The developmentof formulations can be done by adding oleic acid and propylene glycol as enhancers. The purpose of this study was to determine the anti-inflammatoryactivity of the essential oil of clove in absorption base ointment formula by adding a mixture of oleic acid and propylene glycol as enhancers.Methods: In this study, the composition of oleic acid and propylene glycol was 100% oleic acid (FI), 50% oleic acid and propylene glycol (FII), and100% propylene glycol (FIII). The profile of the anti-inflammatory activity essential oil of clove was carried out using male of mice Balb/C strain whichwas induced inflammatory with croton oil on back of skin. After treatment, it was sacrificed and then was taken the back of skin to get histopathologicalpreparation. After that, the epidermal thickness, number of inflammatory cells, and cyclooxygenase (COX)-2 expression can be measured.Results : Based on the results of the test, it shows that FIII has the smallest of the amount of COX-2 expression, the number of inflammatory cells, andthe epidermal thickness so the addition of the composition enhancer provides good anti-inflammatory activity.Conclusion: The increasing concentration of propylene glycol caused the raising activity of essential oil of clove as anti-inflammatory.

scholarly journals Gel Formulation of Lemongrass Essential Oil with HPMC and Carbopol Bases

2019 ◽  
Vol 14 (2) ◽  
pp. 87
Author(s):  
Suryani Tambunan ◽  
Teuku Nanda Saifullah Sulaiman
Keyword(s):  
Essential Oil ◽  
Physical Properties ◽  
Pathogenic Bacteria ◽  
Ph Value ◽  
Physical Stability ◽  
Lattice Design ◽  
Single Use ◽  
Simplex Lattice ◽  
Optimum Formula ◽  
Lemongrass Essential Oil

Lemongrass (Cymbopogon citratus) essential oil is proven to have efficacy as an antibacterial against pathogenic bacteria, such as Staphylococcus aureus. Essential oils was formulate into gel dosage forms with a base combination of HPMC and carbopol. The use of this combination is known to produce a gel with physical properties better than a single use. This research aimed to investigate the effect of variations of HPMC and carbopol to the physical properties of the gel, the concentration of HPMC and carbopol to produce the optimum formula, and the physical stability of essential oil gel of lemongrass during storage. Gel was made by lemongrass essential oil at a concentration of 6% with  base of HPMC and carbopol. Each formula were made and tested the physical properties that include organoleptic, homogenity, pH, viscosity, spreadability and adhesiveness. HPMC and carbopol composition were determined through the process of screening and optimization Simplex Lattice Design methods by Design Expert 7.1.5 software. Experimental results and predictions of SLD were verified by testing one sample t-test with a 95% confidence level. The optimum formula gel of lemongrass essential oil consisting of 4.00% HPMC and 1.00% carbopol. The results test of physical properties of lemongrass essential oil gel obtained homogeneous gel with a pH value of 6.00 ± 0.00, viscosity of 280.00 ± 26.46 dPa.S, spreadability of 9.36 ± 0.47 cm2, and adhesiveness of 2.36 ± 0.10 seconds. Lemongrass essential oil gel was stable for 3 cycles of testing include organoleptic, homogeneity, syneresis, pH, adhesion, and the viscosity of the gel. Spreadability of gel was not stable.

Antifungal and anti-inflammatory claims for wild carrot essential oil

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
J Valente ◽  
R Resende ◽  
M Zuzarte ◽  
MJ Gonçalves ◽  
MC Lopes ◽  
...  
Keyword(s):  
Essential Oil ◽  
Wild Carrot ◽  
Anti Inflammatory
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