scholarly journals Evaluation of the synergistic effects of antioxidant activity on mixtures of the essential oil from Apium graveolens L., Thymus vulgaris L. and Coriandrum sativum L. using simplex-lattice design

Heliyon ◽  
2019 ◽  
Vol 5 (6) ◽  
pp. e01942 ◽  
Author(s):  
Yasiel Arteaga Crespo ◽  
Luis Ramón Bravo Sánchez ◽  
Yudel García Quintana ◽  
Andrea Silvana Tapuy Cabrera ◽  
Abdel Bermúdez del Sol ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Essential Oil ◽  
Synergistic Effects ◽  
Coriandrum Sativum ◽  
Apium Graveolens ◽  
Thymus Vulgaris ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice

scholarly journals Optimasi Formula Gel Antioksidan Ekstrak Etanol Buah Bligo (Benincasa hispida) dengan Metode Simplex Lattice Design (SLD)

2017 ◽  
Vol 3 (2) ◽  
pp. 150-156
Author(s):  
Suryani Suryani ◽  
Andi Nafisah ◽  
Syahrir Mana'an
Keyword(s):  
Antioxidant Activity ◽  
Laboratory Experiments ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Benincasa Hispida ◽  
Dpph Method ◽  
Simplex Lattice ◽  
Dispersive Power ◽  
Carbomer 940 ◽  
Optimal Formula

Benincasa hispida has many benefits including as antioxidant. This study aims to evaluate the effect of Carbomer 940, HPMC and NaOH concentrations in antioxidant gel formula and to determine Carbomer 940, HPMC and NaOH concentrations that could produce the optimal antioxidant gel formula. Benincasa hispida was extracted by maceration method and antioxidant activity was tested by DPPH method. The antioxidant gels were formulated with variety combinations of Carbomer 940, HPMC and NaOH. The optimal gel formula was obtained by Design Expert 7.1.5 with Simplex Lattice Design method. The physical characteristic of optimal gel formula was retested and compared with the results of Simplex Lattice Design .The results showed that antioxidant activity of Benincasa hispida ethanolic extract has potent activity with the IC50 40,28 μg/mL. The increasing concentration of Carbomer 940, HPMC and NaOH possessed the high coefficients viscosity (cPs) with the value of 4366, 4133 and 3750 respectively. The increasing concentration of NaOH possessed pH and dispersive power of the gel with coefficients of 11,0 and 5,21 respectively. The desirability values suggested by Simplex Lattice Design were 1,000 with component variation of the optimal formula were Carbomer 940 1,5%, HPMC 0,5% and NaOH 0,4%. The significance test of the optimal formula  compared to the results of laboratory experiments showed the significance of viscosity of 0,130, the dispersive power of 0,348 and pH of 0,184 that means there was no significant difference between the prediction values by using Simplex Lattice Design and results of laboratory experiments. It was indicated that significance values of each responses were over 0,05 (p>0.05).

The Optimization of Maltodextrin and Arabic Gum in the Microencapsulation of Aqueous Fraction of Clinacanthus nutans Using Simplex Lattice Design

2018 ◽  
Vol 8 (2) ◽  
Author(s):  
Intan Martha Cahyani ◽  
Ebta Narasukma Anggraeny ◽  
Bekti Nugraheni ◽  
Christiana Retnaningsih ◽  
V Kristina Ananingsih
Keyword(s):  
Antioxidant Activity ◽  
Moisture Content ◽  
Flow Rate ◽  
Aqueous Fraction ◽  
Arabic Gum ◽  
Design Expert ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Clinacanthus Nutans ◽  
Simplex Lattice

The aqueous fraction of Clinacanthus nutans leaf extracts contains flavonoids which known had antioxidative properties. To improve acceptability, this viscous and bitter aqueous fraction was microencapsulated using maltodextrin and Arabic gum. This research aims to discover the effectivity of maltodextrin and Arabic gum and the concentrations for optimum microencapsulation. Optimization design was done using Design Expert with simplex lattice design with ratios of 1:0; 0.75:0.25; 0.5:0.5; 0.25:0.75 and 0:1. The evaluations done to the results were microcapsule yield, moisture content, flow rate, and antioxidant activity. The optimum ratio of maltodextrin and Arabic gum was obtained at 0.806:0.194 with 1.49% moisture content, flow rate 4.375 g/s and antioxidant activity at the value of 842,499 ppm. The result of one-sample T-test showed that the prediction result of Design Expert did not differ significantly from the experiment result. From the data, it was concluded that the resulting equation was valid

scholarly journals Simplex lattice design for optimization of the mass ratio of Curcuma longa L., Curcuma zedoaria (Christm.) Roscoe and Curcuma aromatica Salisb. to maximize curcuminoids content and antioxidant activity

2021 ◽  
Vol 71 (3) ◽  
pp. 445-457
Author(s):  
Chaowalit Monton ◽  
Panupong Chuanchom ◽  
Puwadon Popanit ◽  
Sukanya Settharaksa ◽  
Pathamaporn Pathompak
Keyword(s):  
Antioxidant Activity ◽  
High Performance Liquid Chromatography ◽  
High Performance ◽  
Curcuma Longa ◽  
Mass Ratio ◽  
Curcuma Zedoaria ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
The Individual

AbstractThe aim of this work was to optimize the mass ratio of three Curcuma plants’ rhizomes to obtain the highest curcuminoid content and antioxidant activity using the simplex lattice design. The selected Curcuma plants were C. longa, C. zedoaria and C. aromatica. The simplex lattice design was applied in the work. The individual curcuminoids (curcumin, demethoxycurcumin and bis-demethoxycurcumin) and total curcuminoid content were determined using high-performance liquid chromatography. Curcuma longa alone provided the highest content of bis-demethoxycurcumin and demethoxycurcumin. A mixture of C. longa and C. aromatica in the mass ratio of 72:28 % provided the highest curcumin content. The results showed that C. longa alone exhibited the highest antioxidant activity.

scholarly journals BAYESIAN APPROACH TO THE D-OPTIMAL FOR MIXTURE EXPERIMENTAL DESIGN

2019 ◽  
Vol 3 (2) ◽  
pp. 109
Author(s):  
Uqwatul Alma Wizsa
Keyword(s):  
Optimal Design ◽  
Quadratic Model ◽  
Model Parameters ◽  
Potential Term ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Simplex Lattice ◽  
Mixture Experimental Design ◽  
Special Case ◽  
Experimental Region

A mixture experiment is a special case of response surface methodology in which the value of the components are proportions. In case there are constraints on the proportions, the experimental region can be not a simplex. The classical designs such as a simplex-lattice design or a simplex-centroid design, in some cases, cannot fit to the problem. In this case, optimal design come up as a solution. A D-optimal design is seeking a design in which minimizing the covariance of the model parameter.  Some model parameters are important and some of them are less important. As the priority of the parameters, the prior information of parameters is needed in advance. This brings to a Bayesian D-optimal design. This research was focus on a baking experiment in which consisted of three ingredients with lower bounds on the proportion of the ingredients. The assumption model was a quadratic model. Due to the priority of the model parameters, the Bayesian D-optimal design was used to solve the problem. A point-exchange algorithm was developed to find the optimal design. Nineteen candidates is used to choose twelve design points. It found that the potential term is feasible to the actual model and design points represent overall points in the design area.

OPTIMASI FORMULA EKSTRAK JAHE MERAH (Zingiber officinale) DENGAN METODE KEMPA LANGSUNG MENGGUNAKAN ANALISIS SIMPLEX LATTICE DESIGN

2017 ◽  
Vol 1 (1) ◽  
pp. 47
Author(s):  
Hayatus Sa'adah
Keyword(s):  
Dosage Form ◽  
Ethanol Extract ◽  
Zingiber Officinale ◽  
Disintegration Time ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Optimum Proportion ◽  
Simplex Lattice ◽  
Red Ginger ◽  
Tablet Hardness

Processing of medicinal plants into the appropriate dosage form can ensure security during use. It is a motivation in making acceptable dosage form which is easy and convenient to use, especially the manufacture of ethanol extract red ginger tablets using a combination of starch 1500 and amprotab.The study begins with the manufacture of dry extract of red ginger. Optimization of making tablets using a combination of starch 1500 and disintegrator with simplex lattice design using three formulas is done by direct compaction method. Further testing on the tablet hardness, friability and disintegration time.The results showed starch 1500 has a greater influence increase hardness and disintegration time of tablets, as well as lowering the fragility of the tablet. While the interaction of starch 1500 and disintegrator has no effect on the physical tablet. The optimum proportion of the combination of starch 1500 and disintegrator meet the physical requirements of tablets with a ratio of 4: 6 with 7.99 kg hardness, the friability of 0.32% and disintegration time of 2.42 minutes

Application of Simplex Lattice Design in Formulation Development of Lozenges Containing Vernonia cinerea Extract for Smoking Cessation

2019 ◽  
Vol 819 ◽  
pp. 227-232
Author(s):  
Chaowalit Monton ◽  
Thanaporn Sangprapai ◽  
Narathip Mekwimonmas ◽  
Tinnapas Sawangsang ◽  
Natawat Chankana ◽  
...  
Keyword(s):  
Milk Powder ◽  
Angle Of Repose ◽  
Formulation Development ◽  
Disintegration Time ◽  
Powder Mixtures ◽  
Lattice Design ◽  
Simplex Lattice Design ◽  
Weight Variation ◽  
Simplex Lattice ◽  
Vernonia Cinerea

The aim of this work was to apply the simplex lattice design in the formulation development of lozenges containing Vernonia cinerea extract. The different ratios of three diluents; milk powder, xylitol, and inulin were investigated. The preformulation parameters of powder mixtures were evaluated. The compressed lozenges were evaluated for their weight variation, thickness, hardness, friability, and disintegration time. Results showed that the ratios of the three diluents affected the preformulation parameters. The angle of repose data revealed that all 12 powder mixtures had excellent flow property. The formulation containing milk powder had the highest values of Carr’s index and Hausner ratio, indicating the poor compressibility. While formulation containing inulin had the best compressibility. A formulation containing xylitol had the lowest moisture content. The compressed lozenges had a weight variation of less than 5%, a diameter of 1.5 mm, a thickness of 5-6 mm, and a hardness of 2-12 kP. The 8 of 12 formulations had friability of less than 1%. Use of milk powder provided the longest disintegration time. The desired properties of developed lozenge achieved when the medium amount of xylitol and inulin and low amount of milk powder were used. The optimal diluent ratio providing the weight variation not more than 5%, the hardness of 5-8 kP, friability not more than 1%, and disintegration time not more than 30 min was an equal weight ratio of milk powder, xylitol, and inulin.

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