scholarly journals EFFECTIVENESS OF TARA DARA (Catharanthus roseus L.) BOILED WATER TOWARD UREUM LEVELS AND CREATININ RATS OF WISTAR GALUR WALL STRAPS

2019 ◽  
Vol 7 (1) ◽  
pp. 768-779
Author(s):  
Rani Meinora Situmeang ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Catharanthus Roseus ◽  
Kidney Failure ◽  
Positive Control ◽  
Male Rats ◽  
Acute Kidney Failure ◽  
Positive Control Group ◽  
Control Group ◽  
Wistar Strain ◽  
Boiled Water

Acute kidney failure is a disorder that occurs suddenly in the ability of the kidneys to infiltrate blood, which is characterized by increased levels of ureum and creatinine within a few days or weeks. This study aims to determine the effectiveness of the tread (Catharanthus roseus L.) on the levels of ureum and creatinine in male wistar strain models of acute kidney failure. The object of the study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams per rat. The study was divided into three groups, namely the treatment group, positive control group, and negative control group. Each group consisted of 10 male rats. Tread leaves taken as much as 5.2 grams are boiled in 300 cc of water until the remaining 100 cc of boiled water. The treatment group and positive control group induced gentamicin 12 mg intra peritoneal / rat / day for the second 7 days. The treatment group was given boiled water for as much as 3.6 cc / day orally for 7 days. Giving a gentamicin injection to damage the kidneys. Data collection on urea and creatinine levels was calculated using the SPSS program version 24 One Way ANOVA test to compare creatinine urea levels. The results showed that there were significant differences in creatinine urea levels between the treatment group and the positive control group (p <0.05). This study concludes that the boiled water of the tread (Catharanthus roseus L.) is effective in reducing the level of ureum and creatinine of male rats in the Wistar strain model of acute kidney failure.

scholarly journals The Effectiveness of Boiled Rosy Periwinkle (Catharanthus roseus) and Cherry (Muntingia calabura L.) on SGOT and SGPT Serum of Male Wistar Strain Rats of Acute Hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 792-803
Author(s):  
Angela Gracelia ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Acute Hepatitis ◽  
Catharanthus Roseus ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Wistar Strain ◽  
Boiled Water ◽  
Muntingia Calabura

Acute hepatitis is inflammation that occurs in the liver caused by infection, drugs, autoimmune, or alcohol consumption and causes an increase in SGOT and SGPT levels. This study aims to determine the effectiveness of boiled Rosy Periwinkle (Catharanthus roseus) and Cherry (Muntingia calabura L.) on decreasing serum levels of SGOT and SGPT. The objects in this study were 30 male Wistar Strain rats aged 2-3 months with a weight of 180-200 grams. Rats were randomly divided into 3 groups: the treatment group, positive control, and negative control. All rats were adapted for 7 days. The liver of treatment group and the positive control group were induced Paracetamol 120 mg/day orally for 7 days. Boiled water of 2.6 grams of Rosy Periwinkle (Catharanthus roseus) and 5 grams of Cherry (Muntingia calabura L.) as much as 3.6 cc/day orally for 7 days was given to the treatment group. The Data were analyzed with SPSS version 24, One Way ANOVA test was performed to compare SGOT SGPT levels. The results showed a significant difference in SGOT levels between the treatment group, positive control group and negative control group (p<0.05) and there were significant differences in SGPT levels between the treatment group and positive control group (p<0.05). The conclusion of this study is that the boiled water of Rosy Periwinkle (Catharanthus roseus) and Cherry (Muntingia calabura L.) have an effect on decreasing SGOT and SGPT serum in male Wistar Strain rats of acute hepatitis model.

scholarly journals Effectiveness of Boiled Figs (Ficus carica L), Rosy Periwinkle (Catharanthus roseus) and Cherry (Muntingia Calabura L.) on Decreasing SGOT and SGPT Serum in Male Wistar Strain Rats with Acute Hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 744-755
Author(s):  
Grace Arni Yunita Hutajulu ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Acute Hepatitis ◽  
Catharanthus Roseus ◽  
Positive Control ◽  
Negative Control ◽  
Ficus Carica ◽  
Positive Control Group ◽  
Control Group ◽  
Wistar Strain ◽  
Muntingia Calabura

Acute hepatitis is inflammation of the liver. This disorder is usually caused by a virus or exposure to alcohol, drugs, toxic, or other pathogens. The purpose of this study was to determine the effectiveness of boiled figs leaves (Ficus carica L.), Rosy Periwinkle (Catharanthus roseus), and cherry (Muntingia Calabura L.) on decreasing serum levels of SGOT and SGPT. The objects in this study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams. Rats were randomly divided into 3 groups: the treatment group, positive control and negative control. The treatment group and positive control group were induced paracetamol 120 mg / day orally for 7 days. Boiled water of 0.3 grams Figs (Ficus carica L.), 3.5 grams of rosy Periwinkle (Catharanthus roseus), and 3.5 grams of cherry (Muntingia Calabura L.) was given as much as 3.6 cc orally for 7 days to treatment group. Data were analyzed with SPSS version 24, One Way ANOVA test was performed to compare SGOT and SGPT levels. The results showed a significant difference in SGOT levels between the treatment group, positive control group, and negative control group (p <0.05) and there were significant differences in SGPT levels between the treatment group and positive control group (p <0.05). The conclusions of this study were mixed  boiled of Figs (Ficus carica L.), rosy Periwinkle (Catharanthus roseus), and and Cherry (Muntingia Calabura L.) had an effect in decreasing serum SGOT and SGPT in male rats with acute hepatitis model.

scholarly journals The Effectiveness of Boiled Rosy Periwinkle (Catharanthus roseus) in Decreasing SGOT and SGPT Value of Male Wistar Strain Rats with Acute Hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 780-791
Author(s):  
Rutdiana Zai ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Acute Hepatitis ◽  
Catharanthus Roseus ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Wistar Strain ◽  
Significant Difference

Acute hepatitis is a disease that attacks the liver and causes inflammation in the liver cells which is characterized by swelling, damage, death, and even disruption of liver function, so that it can result in increased values of Serum Glutamic Pyruvic Oxaloactic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aims to determine the effectiveness of the Rosy Periwinkle  (Catharanthus roseus) on decreasing SGOT and SGPT level. The object of this research is 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams which were adapted for 7 days. The object of this study was divided into 3 groups, namely the treatment group, the positive control group and the negative control group. The treatment group and positive control group were induced Paracetamol 120 mg / day orally for 7 days. 5.2 grams of boiled Rosy Periwinkle (Catharanthus roseus) as much as 3.6 cc orally for 7 days was given to the treatment group. Data were analyzed with SPSS version 24, One Way ANOVA test to compare SGOT and SGPT values. The results of this study found that there were a significant difference in the SGOT value between the treatment group, the positive control group and the negative control group (p <0.05) and there were significant differences in the SGPT value between the treatment group and the positive control group (p <0.05) . The conclusion of this study is that the boiled Rosy Periwinkle (Catharanthus roseus) has an effect on the decrease in SGOT and SGPT values in male wistar strain Rats with acute hepatitis model.

scholarly journals Effectiveness of Boiled Comfrey Leaves (Symphytum Officinale L) on SGOT SGPT Serum in Male Wistar Strain Rats With Acute Hepatitis Models

2019 ◽  
Vol 7 (1) ◽  
pp. 756-767
Author(s):  
Rois Sahidin ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Acute Hepatitis ◽  
Serum Levels ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Symphytum Officinale ◽  
Wistar Strain

Acute hepatitis is an acute disease caused by viruses, alcohol and drugs, which is characterized by an increase in SGOT SGPT serum. The purpose of this study was to determine the effectiveness of boiled comfrey leaves (Symphytum Officinale L) levels of SGOT and SGPT serum in male wistar strain rats with acute hepatitis models. The objects in this study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams. The objects were randomly divided into 3 groups: the treatment group, positive control and negative control. The treatment group and positive control group were induced paracetamol 120 mg / day orally for 7 days. Boiled water of 2.8 grams of comfrey (symphytum officinale L) leaves was given as much as 2.7 cc orally for 7 days to the treatment group. Data were analyzed with SPSS version 24, one way ANOVA test was performed to compare serum levels of SGOT & SGPT. The results showed there were significant differences in serum levels of SGOT between the treatment group, positive control and negative control (p <0.05) and there were significant differences in SGPT results between the treatment group and positive control group (p <0.05) but there were no significant differences between the SGPT levels of the treatment group and the negative control group (p = 0.173). As Conclusion, boiled Comfrey leaf has an effect in decreasing serum SGOT & SGPT in male wistar strain rats with acute hepatitis model.

scholarly journals NEFROPROTECTOR EFFECT OF CURCUMIN (CURCUMA LONGA) AND VITAMIN E (α-TOCOPHEROL) IN WISTAR STRAIN RATS AFTER CISPLATIN TREATMENT

2021 ◽  
Vol 28 (1) ◽  
pp. 98-108
Author(s):  
Binsar Marshall Maranatha Sirait ◽  
Wahjoe Djatisoesanto ◽  
Soetojo
Keyword(s):  
Vitamin E ◽  
Treatment Group ◽  
Inflammatory Response ◽  
Serum Creatinine ◽  
Positive Control ◽  
Positive Control Group ◽  
Control Group ◽  
Wistar Strain ◽  
Tnf Α ◽  
Significant Difference

Objective: To analyze the effect of curcumin and vitamin E on kidney function and inflammatory response of Wistar strain rats that received cisplatin. Material & Methods: An experimental laboratory study with a post-test only control design, using male Wistar strain rats (Rattus norwegicus). Rats were randomized using the simple randomized sampling method. Samples were treated with cisplatin 5 mg/kg (positive control group), vitamin E 100 mg/kg, curcumin 100 mg/kg body, and a combination of both (treatment group), to evaluate its effect on and kidney function and inflammatory response as measured by tumor necrosis factor-α (TNF-α), blood urea nitrogen (BUN) and serum creatinine. Results: There were differences in TNF-α levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). Further analysis showed that there was a significant difference between the treatment group that received vitamin E and curcumin from the treatment group that received a combination of both (P<0.05). In addition, there were differences in BUN and serum creatinine levels in the positive control group (cisplatin 5 mg/kg) against each treatment group (p<0.05). However, there was no significant difference in BUN levels in the treatment group that received vitamin E with the treatment group that received curcumin or a combination of both (p>0.05). No differences were found in serum creatinine levels between treatment groups receiving vitamin E, curcumin, or a combination of both. Conclusion: Vitamin E 100 mg/kg, curcumin 100 mg/kg, and the combination of both have a nephroprotector feature in Wistar rats exposed to cisplatin.

scholarly journals Effectiveness of Boiled Rosy Periwinkle (Catharantus roseus), Cherry (Muntingia calabura L.), comfrey (Symphytum officinale), and Figs (Ficus carica) Toward the reduction of SGOT and SGPT serum in male Wistar strain rats with acute hepatitis model

2019 ◽  
Vol 7 (1) ◽  
pp. 814-825
Author(s):  
Desi Saputri Manurung ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Ficus Carica ◽  
Positive Control Group ◽  
Control Group ◽  
Symphytum Officinale ◽  
Wistar Strain ◽  
Muntingia Calabura

Hepatitis is inflammation of the liver caused by viruses, alcohol and drugs or other pathogens. The purpose of this study was to compare the effectiveness of rosy periwinkle (Catharantus roseus), cherry (Muntingia calabura L.), comfrey (Symphytum officinale), and figs (Ficus carica) toward decreasing serum levels of SGOT and SGPT. The object of this study were 30 male Wistar strain rats aged 2-3 months with a weight of 180-200 grams which were adapted for 7 days. The rats then divided into 3 groups, namely the positive control group, the negative control group, and the treatment group. After 7 days of the adaptation process, the liver of the treatment group and the positive control group was induced Paracetamol 120 mg / day orally for 7 days. Boiled water therapy of 3.5 grams of Rosy Periwinkle (Catharantus roseus), 3.5 grams of cherry (Muntingia calabura L.), half a sheet of comfrey (Symphytum officinale), and 0.3 gram of figs (Ficus carica) was given to the treatment group during the treatment group in 7 days as much as 3.6 cc / orally per day. Data were analyzed using SPSS version 24, One Way ANOVA test to compare SGOT SGPT levels. The results showed a significant difference in SGOT levels between the treatment group, positive control group, and negative control group (p <0.05) and there were significant differences in SGPT levels between the treatment group and positive control group (p <0.05) . The conclusion of this study is the mixed boiled water of Rosy Periwinkle (Catharantus roseus), Cherry (Muntingia calabura L.), comfrey (Symphytum officinale), and Figs (Ficus carica) have an effect on decreasing SGOT SGPT serum in male wistar rats with acute hepatitis model.

scholarly journals Effectiveness of boiled Comfrey Leaf (Symphytum Officinale L) on Ureum Creatinine Serum in Male Wistar Strain of Acute Kidney Failure model.

2019 ◽  
Vol 7 (1) ◽  
pp. 705-715
Author(s):  
Pelagia Sedyati ◽  
Untung Sudharmono
Keyword(s):  
Treatment Group ◽  
Kidney Failure ◽  
Male Rats ◽  
Acute Kidney Failure ◽  
Failure Model ◽  
Negative Group ◽  
Positive Group ◽  
Symphytum Officinale ◽  
Wistar Strain ◽  
Significant Difference

Acute kidney failure is a decrease in kidney that occurs only in a matter of hours even days which can be seen from decreased urine production and increased blood urea nitrogen and creatinine. This study aims to determine the effectiveness of boiled comfrey leaf (symphytum officinale L) on Ureum Creatinine Serum in Male Wistar Strain of Acute Kidney Failure model. This research used 30 male Wistar strain rats weighing 180-200 grams and aged 2-3 months that were divided into 3 groups, namely negative group (only given minerals), positive group (kidney damaged by gentamicin 0.3cc IP / day) and the treatment group (the kidneys were damaged with gentamicin 0.3cc IP / day and 2.8 g of boiled comfrey leaf in 150 cc of water and 2.7 cc were given orally for 7 days). Data were analyzed with SPSS version 24, one way ANOVA test was performed to compare the levels of ureum and creatinine. The results showed that there was a significant difference in the ureum of the treatment group and the positive group (p <0.05) but there was no significant difference in the ureum value between the treatment group and the negative group. There was a significant difference in creatinine values between the treatment group, positive group and negative group (p <0.05). As a Conclusion boiled comfrey leaf (symphytum officinale L) water has an effect on decreasing serum levels of ureum creatinine in male rats wistar strain of acute kidney failure model.

scholarly journals Efficacy of mengkudu leaves extract (morinda citrifolia) on wound healing rate post tooth extraction in white rats (rattus norvegicus)

2018 ◽  
Vol 3 (1) ◽  
pp. 28
Author(s):  
Irfan Rasul ◽  
Desy Setiady
Keyword(s):  
Wound Healing ◽  
Treatment Group ◽  
Tooth Extraction ◽  
Positive Control ◽  
Negative Control ◽  
Male Rats ◽  
Positive Control Group ◽  
Control Group ◽  
Accelerate Wound Healing ◽  
White Rats

Objective:  This study aims to determine the efficacy of mengkudu leaves extract to accelerate wound healing post tooth extraction in white rats.Material and Methods: Laboratory experimental study was carried out using post-test only and control group design. This study was measured by observing the duration of wound healing post tooth extraction, starting from the formation of sockets after tooth extraction until the socket closed, with sample of 27 white rats in three study groups in accordance with inclusion and exclusion criteria that have been determined.Results: The average healing time in the negative control group is 19 days, the positive control group is 9 days, and the treatment group with mengkudu leaves extract is 7 days. Therefore, the fastest time of wound healing occurs in the treatment group, followed by the positive control group and lastly, in the negative control group.Conclusion: Mengkudu leaves accelerate wound healing post tooth extraction in white male rats.

scholarly journals The effectiveness of Boiled figs leaf (FIcus Carica L) and Rosy Periwinkle (Catharantus roseus) on SGOT and SGPT levels of male wistar strain rats with hepatitis Model

2019 ◽  
Vol 7 (1) ◽  
pp. 850-859
Author(s):  
Debora Oktaviani
Keyword(s):  
Treatment Group ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Ficus Carica ◽  
Positive Control Group ◽  
Control Group ◽  
Control Groups ◽  
Wistar Strain ◽  
Significant Difference

Hepatitis is an inflammatory disease of liver cells that is contagious in the low category, the cause of it is bacteria, viruses, drugs and alcohol. The purpose of this study was to determine the effectiveness of boiled figs leaf (Ficus Carica L) and Rosy periwinkle (Catharantus roseus ) in reducing SGOT and SGPT levels. The subjects of this study were 30 male Wistar strain rats with age of 2-3 months, body weight 180-200 grams. Rats were divided into 3 groups; treatment groups, negative control groups and positive control groups. The treatment group and positive control group were induced paracetamol 120 mg / day orally for 7 days. The treatment group was given 0.4 grams boiled figs leaf (Ficus Carica L) and 2.6 grams boiled rosy periwinkle  (Catharantus roseus) it given as much as 3.6 cc / day orally for 7 days. Data were analyzed with SPSS version 24, one way ANOVA test was performed to compare SGOT and SGPT levels. The results showed there were significant differences in SGOT levels between the treatment group, the positive control group, and the negative control group (p <0.05) and there was a significant difference in the SGPT value between the treatment group and the positive control group (p <0.05), while the negative control group and the treatment group there was no significant difference (p = 0.75). The conclusion of this study was the water extraction of figs leaf (Ficus Carica L), Rosy periwinkle (Catharantus roseus) had an effect in decreasing the SGOT and SGPT values of male wistar strain rats induced by paracetamol.

scholarly journals Efektivitas Ekstrak Artemisia vulgaris L. sebagai Hepatoprotektor pada sel-sel Hati Tikus yang Diinduksi Niasin

2018 ◽  
Vol 6 (2) ◽  
pp. 251
Author(s):  
Laily Rahmawati ◽  
Erma Sulistyaningsih ◽  
Rosita Dewi
Keyword(s):  
Treatment Group ◽  
Liver Damage ◽  
Negative Control Group ◽  
Positive Control ◽  
Negative Control ◽  
Positive Control Group ◽  
Control Group ◽  
Artemisia Vulgaris ◽  
Group I ◽  
Group Ii

  The niacin in energy drinks has metabolic product that cause oxidative stress and liver damage, while the liver damage can be prevented by hepatoprotective agents. Scoparone in Artemisia vulgaris L. can act as a hepatoprotector by its antioxidant effect. This study aimed to investigate the effectivity of Artemisia vulgaris L. extract as a hepatoprotector in wistar hepatocytes induced by niacin. This study used 25 male rats which were divided into 5 groups: normal, the negative control, the positive control, the treatment group I, and II. Treatment was conducted for 28 days. The samples were terminated and the hepatocyte were prepared for histological examination. Histological appearance was catagorized as mild, moderate, and severe damage with or without inflamatory cells activity. The data analysis by Kruskal Wallis showed significant difference (p<0,001). Further analysis by Mann Whitney revealed significantly difference (p<0,05) between normal group and all groups, negative control group and positive control group, and positive control group and treatment group I, but not significantly difference between negative control group and treatment group I, negative control group and treatment group II, positive control group and treatment group II, and between treatment groups. The study concluded that the effectivity of Artemisia vulgaris L. extract has not been proven as a hepatoprotector but further study is needed to draw a definite conclusion.   Keywords: energy drink, niacin, Artemisia vulgaris L., hepatoprotector  

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