scholarly journals DOPAMINE, AND ITS EFFECT ON THE HUMAN BRAIN

Author(s):  
Sherzod Ibrahimov

In this article, we look at how dopamine acts on our body, and what positive and negative can be seen behind dopamine. Of course, such an important hormone deserves much more careful consideration. Dopamine is responsible for motivation in our body. But do not think that "this is why I am so lazy - dopamine is not enough," no you are lazy simply, because lazy or there is no need to strain. Dopamine is produced behind the "motivation," and not in front of it. Because there is no desire - then there is no dopamine. There is a desire - here is dopamine to help, just act. Yes, people are different, someone can naturally have an overpriced background of dopamine, impulsive people who 5 minutes ago decided to buy a mobile phone and are already calling the store, even if they do not need it. But the vast majority live stably and smoothly and strain, there is no need to try. The association of a lack of dopamine with Parkinson's disease was established by Gornikevich using a fairly simple color reaction. However, the role of dopamine as a neurotransmitter was revealed by another scientist - Arvid Karlsson (Nobel Prize in Physiology or Medicine for 2000). Before him, dopamine was considered only a precursor to noradrenaline, and not a signalling substance. It was in Karlsson's experiments with reserpine that a direct connection was established between the level of dopamine and motor functions. With the development of biochemistry and molecular biology, it became possible to study in more detail the functions of this neurotransmitter. From his role in coordinating movements to explaining the actions of some antipsychotics and psychostimulants. Also, many researchers consider metabolic disorders of this neurotransmitter as one of the causes of schizophrenia, i.e., there is a "dopamine theory of schizophrenia."

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
C Helmchen ◽  
J Klinkenstein ◽  
T Sander ◽  
J Gliemroth ◽  
B Machner ◽  
...  

Author(s):  
Huyen Thi Nguyen ◽  
Ngoc Minh Nguyen

The purpose of this study is to examine the effect of prestige sensitivity on mobile phone customer’s price acceptance in Vietnam and the mediating role of product knowledge and price mavenism on this relationship. We used the convenience sampling method for data collection via questionnaires with a sample of 605 consumers who purchased mobile phones. The collected data was analysed by applying a structural equation modelling method. The result indicates that prestige sensitivity has both direct and indirect effects on price acceptance via product knowledge and price mavenism. The findings suggest that prestige sensitivity can be used as a market segmentation criterion for mobile phones when making price decisions and providing customers with adequate information could improve price acceptance.


1990 ◽  
Vol 2 (3) ◽  
pp. 55-66
Author(s):  
John S. Hatcher

The Bahá’í teachings simultaneously assert the equality of men and women while advocating in some cases distinct duties according to gender. Since the Bahá’í Faith also teaches that religious convictions should be examined by the “standards of science,” this ostensible paradox invites careful study. At the heart of the response to this query is the Universal House of Justice statement that “equality between men and women does not, indeed physiologically it cannot, mean identity of functions.” To appreciate and to accept this thesis that there can be gender distinction, even insofar as the assignment of fundamental tasks is concerned, without any attendant diminution in the role of women, we must turn to statements in the Bahá’í writings about the complementary relationship between men and women. Through a careful consideration of this principle, we can discover how there can indeed be gender distinction without inequality in status or function.


2020 ◽  
Vol 4 (2) ◽  
pp. 69-80
Author(s):  
Mohamed Ibrahim Eymoi ◽  
Patrick Mbataru

The unprecedented global adoption of information and communication technologies (ICTs) is rapidly changing the way people are communicating in solving problems. For several years now, the role of ICTs has become important in the way people construct their relationships in conflict resolution. Yet little is known on the dynamism of this interaction. It is not clear how mobile technology has contributed toward conflict resolution, and this study will contribute to the knowledge on the role of mobile telephones in conflict resolution. The purpose of this study was to explore how the mobile phone technology contributed in resolving communal conflicts in Mandera County, Kenya. This study was guided by three theories: conflict transformation theory, diffusion of innovations theory and social representation theory. The conflict Tansformation Theory is adopted as the main theory of analysis.  The main idea of this theory is transforming negative conflict into constructive conflict, deals with structural, behavioural and attitudinal aspects of conflict. This study adopted a descriptive survey. The population for this study consisted of 301 employees in ICT and security department where stakeholders in technology and security sectors and the public. Primary and secondary  data was analysed according to the objectives. Primary data was derived from questionnaires formulated to target employees in ICT and security department. The data analysis included qualitative and quantitative techniques.  Qualitative data was summarized and categorized according to common themes and was presented using frequency distribution tables, graphs and charts. Content analysis was used mostly to arrive at inferences through a systematic and objective identification of the specific messages. The quantitative data collected was analyzed using descriptive statistics. The results confirmed that short message service, social media plateform, instant messaging applications, and video conferencing play a role in resolving communal conflicts in Mandera County. The study concludes that Short Message Service, Social Media Platforms and Instant Messaging Applications can be used conflict such as communal conflicts. Video Conferencing can be used to solve conflict such as relationship conflict, arises from differences in personality, style, matters of taste, and even conflict style as well as conflict in the workplace like task conflict. County government of Mandera must come up with ways of incorporating mobile phone technologies such as Short Message Service, Social Media Platforms, Instant Messaging and Video Conferencing on matters conflict resolution. The study recommends that the County Government of Mandera in collaboration with the National Government need to come up with agencies to regulate the use of social media as a medium to communicate in times of conflict since they are sometimes prone to misuse.


Author(s):  
Ирина Викторовна Евстафьева

В статье исследуются вопросы попечительства в отношении несовершеннолетних, отбывающих наказание в виде лишения свободы. Проблема, поднимаемая автором настоящей статьи, многогранна, касается различных аспектов отбывания наказания несовершеннолетними в воспитательных колониях и требует комплексного исследования, способного ответить на определенно значимый вопрос: является ли колония законным представителем находящихся в ней несовершеннолетних со всеми вытекающими из статуса законных представителей последствиями. При этом необходимо обращать внимание на специфику правового статуса лиц, отбывающих наказание в воспитательных колониях, которые, во-первых, являются несовершеннолетними, то есть не обладают дееспособностью в полном объеме и нуждаются в особой заботе, защите и представительстве, а во-вторых, осуждены за совершение тяжкого или особо тяжкого преступления, влекущего изоляцию от общества и определенные ограничения и лишения. Отечественное законодательство достаточно детально регламентирует особенности режима отбывания наказания в виде лишения свободы несовершеннолетними, не определяя при этом статуса воспитательных колоний, кем они являются: воспитателями, попечителями или исключительно учреждениями исполнения наказаний. Между тем правильное понимание значения и роли воспитательной колонии в жизни находящихся в ней несовершеннолетних преступников, по мнению автора, поможет избежать ряда проблем, объективно складывающихся в учреждениях подобного рода. С этой точки зрения предлагаемая тема представляет интерес не только для ученых-теоретиков, но и для практиков - сотрудников соответствующих учреждений. Особо следует подчеркнуть, что исследований по данной тематике в специальной литературе нет. Отдельные исследования, встречающиеся в современной литературе, касаются исключительно общего гражданско-правового статуса несовершеннолетних осужденных. Однако это обстоятельство может свидетельствовать только о новизне данной темы, но никак не об отсутствии самой проблемы. The article analyzes the issues of the status of educational colonies as guardians of minors serving a sentence of imprisonment. In fact, the problem raised by the author of this article is multifaceted, concerns various aspects of the serving of punishment by minors in educational colonies and requires a comprehensive study that can answer, it seems, a definitely significant question: whether the colony is the legal representative of the minors in it with all the consequences arising from the status of legal representatives in the form of duties and responsibilities. At the same time, it seems, it is necessary to pay attention to the specifics of the legal status of citizens serving sentences in educational colonies, who, firstly, are minors, i.e. do not have full legal capacity and need special care, protection and representation, and, secondly, are convicted of committing a serious or particularly serious crime, entailing isolation from society and certain restrictions and deprivation. Domestic legislation regulates in sufficient detail the peculiarities of the regime of serving sentences in the form of deprivation of liberty by minors, without determining the status of educational colonies. Who are they: educators, Trustees or only institutions of execution of punishments. Meanwhile, the correct understanding of the importance and role of the educational colony in the life of juvenile offenders in it, according to the author, will help to avoid a number of problems that objectively develop in institutions of this kind. From this point of view, the proposed topic is of interest not only for theoretical scientists, but for practitioners-employees of relevant institutions. It should be emphasized that there are no studies on this subject in the special literature. However, this circumstance can testify only about novelty of the given subject, but in any way about absence of the problem. It seems that the relevance and importance of a problem is not always measured by the number of studies devoted to it. Sometimes these its traits are manifest only under particularly careful consideration.


Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 554
Author(s):  
Stefania Croce ◽  
Maria Antonietta Avanzini ◽  
Corrado Regalbuto ◽  
Erika Cordaro ◽  
Federica Vinci ◽  
...  

In the last few decades, obesity has increased dramatically in pediatric patients. Obesity is a chronic disease correlated with systemic inflammation, characterized by the presence of CD4 and CD8 T cell infiltration and modified immune response, which contributes to the development of obesity related diseases and metabolic disorders, including impaired glucose metabolism. In particular, Treg and Th17 cells are dynamically balanced under healthy conditions, but imbalance occurs in inflammatory and pathological states, such as obesity. Some studies demonstrated that peripheral Treg and Th17 cells exhibit increased imbalance with worsening of glucose metabolic dysfunction, already in children with obesity. In this review, we considered the role of adipose tissue immunomodulation and the potential role played by Treg/T17 imbalance on the impaired glucose metabolism in pediatric obesity. In the patient care, immune monitoring could play an important role to define preventive strategies of pediatric metabolic disease treatments.


Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1158
Author(s):  
Lizeth Cifuentes ◽  
Michael Camilleri ◽  
Andres Acosta

Sensory and motor functions of the stomach, including gastric emptying and accommodation, have significant effects on energy consumption and appetite. Obesity is characterized by energy imbalance; altered gastric functions, such as rapid gastric emptying and large fasting gastric volume in obesity, may result in increased food intake prior to reaching usual fullness and increased appetite. Thus, many different interventions for obesity, including different diets, anti-obesity medications, bariatric endoscopy, and surgery, alter gastric functions and gastrointestinal motility. In this review, we focus on the role of the gastric and intestinal functions in food intake, pathophysiology of obesity, and obesity management.


2021 ◽  
Vol 31 (1) ◽  
pp. 49-55
Author(s):  
Bin Zhang ◽  
Yu Peng ◽  
Xin-sen Luo ◽  
Hui-li Mao ◽  
Yan-hong Luo ◽  
...  

Agriculture ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 157
Author(s):  
Jean Trap ◽  
Patricia Mahafaka Ranoarisoa ◽  
Usman Irshad ◽  
Claude Plassard

Plants evolve complex interactions with diverse soil mutualist organisms to enhance P mobilization from the soil. These strategies are particularly important when P is poorly available. It is still unclear how the soil P source (e.g., mineral P versus recalcitrant organic P) and its mobility in the soil (high or low) affect soil mutualist biological (ectomycorrhizal fungi, bacteria and bacterial-feeding nematodes) richness—plant P acquisition relationships. Using a set of six microcosm experiments conducted in growth chamber across contrasting P situations, we tested the hypothesis that the relationship between the increasing addition of soil mutualist organisms in the rhizosphere of the plant and plant P acquisition depends on P source and mobility. The highest correlation (R2 = 0.70) between plant P acquisition with soil rhizosphere biological richness was found in a high P-sorbing soil amended with an organic P source. In the five other situations, the relationships became significant either in soil conditions, with or without mineral P addition, or when the P source was supplied as organic P in the absence of soil, although with a low correlation coefficient (0.09 < R2 < 0.15). We thus encourage the systematic and careful consideration of the form and mobility of P in the experimental trials that aim to assess the role of biological complexity on plant P nutrition.


2021 ◽  
pp. jech-2020-216108 ◽  
Author(s):  
Malcolm Campbell ◽  
Lukas Marek ◽  
Jesse Wiki ◽  
Matthew Hobbs ◽  
Clive E Sabel ◽  
...  

BackgroundThe COVID-19 pandemic has asked unprecedented questions of governments around the world. Policy responses have disrupted usual patterns of movement in society, locally and globally, with resultant impacts on national economies and human well-being. These interventions have primarily centred on enforcing lockdowns and introducing social distancing recommendations, leading to questions of trust and competency around the role of institutions and the administrative apparatus of state. This study demonstrates the unequal societal impacts in population movement during a national ‘lockdown’.MethodsWe use nationwide mobile phone movement data to quantify the effect of an enforced lockdown on population mobility by neighbourhood deprivation using an ecological study design. We then derive a mobility index using anonymised aggregated population counts for each neighbourhood (2253 Census Statistical Areas; mean population n=2086) of national hourly mobile phone location data (7.45 million records, 1 March 2020–20 July 2020) for New Zealand (NZ).ResultsCurtailing movement has highlighted and exacerbated underlying social and spatial inequalities. Our analysis reveals the unequal movements during ‘lockdown’ by neighbourhood socioeconomic status in NZ.ConclusionIn understanding inequalities in neighbourhood movements, we are contributing critical new evidence to the policy debate about the impact(s) and efficacy of national, regional or local lockdowns which have sparked such controversy.


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