A CORRELATION OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS OF CENTRAL NERVES SYSTEM TUMOURS

2021 ◽  
pp. 17-20
Author(s):  
Monika hemin Shroff ◽  
Abhishek Rajawat ◽  
Kavita choudhary ◽  
Geeta w. Mukhiya
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Posterior Fossa ◽  
Annual Incidence ◽  
Cerebral Hemispheres ◽  
Cns Tumors ◽  
Intracranial Tumors ◽  
Radiological Findings ◽  
The Central Nervous System

The annual incidence of tumors of the central nervous system ranges from 10 to 17 per 100,000 persons for intracranial tumors and 1 to 2 per 100,000 persons for intraspinal tumors. Tumors of the CNS account for nearly 20% of all cancers of childhood. Seventy percent of childhood CNS tumors arise in the posterior fossa; a comparable number of tumors in adults arise within the cerebral hemispheres above the tentorium

scholarly journals Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 3028
Author(s):  
George I. Lambrou ◽  
Apostolos Zaravinos ◽  
Maria Braoudaki
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cns Tumors ◽  
Normal Brain ◽  
Cns Tumor ◽  
Different Types ◽  
Receiver Operator Curve Analysis ◽  
The Central Nervous System ◽  
Tumor Types ◽  
Operator Curve

Despite extensive experimentation on pediatric tumors of the central nervous system (CNS), related to both prognosis, diagnosis and treatment, the understanding of pathogenesis and etiology of the disease remains scarce. MicroRNAs are known to be involved in CNS tumor oncogenesis. We hypothesized that CNS tumors possess commonly deregulated miRNAs across different CNS tumor types. Aim: The current study aims to reveal the co-deregulated miRNAs across different types of pediatric CNS tumors. Materials: A total of 439 CNS tumor samples were collected from both in-house microarray experiments as well as data available in public databases. Diagnoses included medulloblastoma, astrocytoma, ependydoma, cortical dysplasia, glioblastoma, ATRT, germinoma, teratoma, yoc sac tumors, ocular tumors and retinoblastoma. Results: We found miRNAs that were globally up- or down-regulated in the majority of the CNS tumor samples. MiR-376B and miR-372 were co-upregulated, whereas miR-149, miR-214, miR-574, miR-595 and miR-765 among others, were co-downregulated across all CNS tumors. Receiver-operator curve analysis showed that miR-149, miR-214, miR-574, miR-595 and miR765 could distinguish between CNS tumors and normal brain tissue. Conclusions: Our approach could prove significant in the search for global miRNA targets for tumor diagnosis and therapy. To the best of our knowledge, there are no previous reports concerning the present approach.

scholarly journals Epidemiologic Study of Central Nervous System Tumors in Rwanda

2020 ◽  
pp. 1-14
Author(s):  
David Hakizimana ◽  
Agabe Emmy Nkusi ◽  
David Hakizimana ◽  
Eric Shingiro ◽  
Paulin Munyemana ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Brain Tumors ◽  
Age Groups ◽  
Epidemiologic Study ◽  
Cns Tumors ◽  
Central Nervous System Tumors ◽  
Secondary Neoplasms ◽  
Nervous System Tumors ◽  
The Central Nervous System

Introduction: Tumors of the central nervous system (CNS) are primary or secondary neoplasms located within the craniovertebral cavity. The incidence of CNS tumors is not uniform with variation between different countries, age groups and races. Objective: Our study aim was to generate new knowledge of the epidemiology of central nervous system tumors in Rwanda. Method: This was an observational retrospective study of all patients diagnosed with CNS tumors in Rwanda over a period of 10 years, from 1st January 2006 to 31st December 2015. Results: 466 patients enrolled, (52.2% females, 47.8% males). The median age at diagnosis of was 37 years. Brain tumors were 82.7%; spine tumor patients were 16.4%. The average annual age-standardized incidence of CNS tumors was 0.43/100, 0000 person-years and varied with age groups. Tumors of meningothelial cells represented the majority of brain tumors (31.8%). Metastatic tumors were the far most common spine tumors category. 55.8 % of CNS tumors reported in our study were histologically confirmed and of nonmalignant meningiomas were the commonest (33.9%). Conclusion: This is the very first study done on epidemiology of CNS tumors in Rwanda, and generated data about incidence of CNS tumors in Rwanda and their location and histological distribution.

scholarly journals GENE-05. THE LOSS OF SUCCINATE DEHYDROGENASE B EXPRESSION IS FREQUENTLY IDENTIFIED IN HEMANGIOBLASTOMA OF THE CENTRAL NERVOUS SYSTEM

2019 ◽  
Vol 21 (Supplement_6) ◽  
pp. vi98-vi98
Author(s):  
Se-Hyuk Kim ◽  
Tae Hoon Roh ◽  
Hyunee Yim ◽  
Jin Roh ◽  
Kyi Beom Lee ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Succinate Dehydrogenase ◽  
Alternative Pathway ◽  
Krebs Cycle ◽  
High Sensitivity ◽  
Cns Tumors ◽  
Transport Chain ◽  
Assembly Factor ◽  
The Central Nervous System

Abstract Succinate dehydrogenase (SDH) is a mitochondrial enzyme that plays an important role in both the Krebs cycle and the electron transport chain. SDH inactivation is associated with tumorigenesis in certain types of tumor. SDH consists of subunits A, B, C and D (SDHA, SDHB, SDHC, and SDHD, respectively). Immunohistochemistry for SDHB is a reliable method for detecting the inactivation of SDH by mutations in SDHA, SDHB, SDHC, SDHD and SDH complex assembly factor 2 (SDHAF2) genes with high sensitivity and specificity. SDHB immunohistochemistry has been used to examine the inactivation of SDH in various types of tumors. However, data on central nervous system (CNS) tumors are very limited. In the present study, we investigated the loss of SDHB immunoexpression in 90 cases of CNS tumors. Among the 90 cases of CNS tumors, only three cases of hemangioblastoma showed loss of SDHB immunoexpression. We further investigated SDHB immunoexpression in 35 cases of hemangioblastoma and found that 28 (80%) showed either negative or weak-diffuse pattern of SDHB immunoexpression, which suggests the inactivation of SDH. Our results suggest that SDH inactivation may represent an alternative pathway in the tumorigenesis of hemangioblastoma.

scholarly journals Cerebral Wegener’s Granuloma: Surgery Mandatory for Diagnosis and Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Federico Nicolosi ◽  
Giovanni Nodari ◽  
Giannantonio Spena ◽  
Elena Roca ◽  
Karol Migliorati ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Radiological Findings ◽  
Wegener Granulomatosis ◽  
Meningeal Involvement ◽  
Cerebrovascular Events ◽  
Immunosuppressed Patients ◽  
History Of ◽  
The Central Nervous System ◽  
Wegener's Granuloma

The involvement of the central nervous system in case of Wegener granulomatosis (WG) is infrequent and usually leads to cranial nerve abnormalities, cerebrovascular events, and seizures. Meningeal involvement is quite rare and usually is due to the spreading from adjacent disease in the skull base. We described the case of a remote intraparenchymal Wegener’s granuloma in a 55-year-old man presenting with seizures and a history of severe generalized WG. The radiological findings were not useful for the diagnosis, and the pharmacological treatment was ineffective. The importance of a surgery in case of localized WG has been emphasized, in order to confirm the diagnosis and to avoid additional medicaments, like antiepileptic drugs, potentially harmful in immunosuppressed patients.

scholarly journals Computed Tomography of Posterior Fossa in Hereditary Ataxias

1979 ◽  
Vol 6 (2) ◽  
pp. 195-198 ◽  
Author(s):  
R. Langelier ◽  
J.P. Bouchard ◽  
R.B Ouchard
Keyword(s):  
Computed Tomography ◽  
Central Nervous System ◽  
Nervous System ◽  
Posterior Fossa ◽  
Autosomal Recessive ◽  
Cerebellar Atrophy ◽  
Friedreich’S Ataxia ◽  
Friedreich's Ataxia ◽  
Hereditary Ataxias ◽  
The Central Nervous System

SummaryNine cases of Friedreich's ataxia and seven cases of autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) were submitted to neuroradiological procedures to determine the extent of atrophie processes in the central nervous system. All cases had a computerized cerebral tomography and five were studied with pneumencephalo-graphy. The results show a correlation between the two tests and the comparison between Friedreich's ataxia and ARS ACS.In Friedreich's ataxia, the radiological signs are variable and discrete in most of the cases. In A RSA CS there are constant signs of cerebellar atrophy almost limited to the superior parts of the vermis and anterior lobes.

scholarly journals A Complete Constellation of Nervous System Lesions of NF2: Imaging Evaluation

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Kiran Gangadhar ◽  
Sandeep Kumar ◽  
Lovekesh Bhatia ◽  
Arjit Agarwal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Hearing Loss ◽  
Neurofibromatosis Type ◽  
Radiological Findings ◽  
Case Patient ◽  
Cutaneous Lesions ◽  
Imaging Evaluation ◽  
The Central Nervous System

The radiological findings fulfilling the criteria of neurofibromatosis type 2 (NF2) were reviewed. NF2 is a rare disease with few cutaneous but frequent, typical radiological findings in the central nervous system. The presenting symptom is most commonly hearing loss due to acoustic schwannomas, although symptoms emanating from other intracranial or tumors are not uncommon. The discovery of multiple spinal neurofibromas or multiple meningiomas without cutaneous lesions should initiate a search for acoustic schwannomas even when the patient has normal hearing as in our case patient who actually presented for weakness of all four limbs.

scholarly journals A study on morphologic and histological pattern of the central nervous system tumors

2018 ◽  
Vol 6 (12) ◽  
pp. 3879
Author(s):  
Ajay Singh Thakur ◽  
Renuka Gahine ◽  
Vishal Kulkarni
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Who Classification ◽  
Epidemiologic Studies ◽  
Cns Tumors ◽  
International Agency ◽  
Metastatic Tumors ◽  
Medical College ◽  
Oligodendroglial Tumors ◽  
The Central Nervous System

Background: It has been revealed by International Agency for Research on Cancer that the worldwide incidence rate of CNS tumors in 2002 was 3.7/100,000 population among males and 2.6/100,000 population among females. Central Nervous System (CNS) tumors account for 85% of brain tumors and 15 % of spinal cord tumors, however metastatic tumors are usually extradural. According to the WHO classification tumors of CNS comprise more than 50 clinico-pathological entities. The major categories include the tumors of neuroepithelial tissue, cranial and paraspinal nerves, meninges, sellar region, lymphomas haematopoietic neoplasms, germ cell and metastatic tumors. An understanding of the epidemiology is needed to facilitate prevention, early detection and treatment of CNS tumours.Methods: The study was conducted in the Department of Pathology, Pt. J.N.M. Medical College Raipur, India from January 2009 to August 2017. The present study was a retrospective study, hence H and E section of every case was re-examined and histopathological reports were reviewed. Sections were stained with H&E. Diagnosis is made according to the WHO classification and diagnostic criteria for CNS neoplasms.Results: CNS tumours occur more frequently in the age group of 41-50 years (57 cases -21.1%) followed by 31-40 years (53 cases -19.7%). The most common entity in the present study were tumours of neuroepithelial tissue 127 cases (47.2%) followed by tumors of meninges 59 cases (22%) and nerve sheath tumours 42 cases (15.6%). The tumors of neuroepithelial tissue comprised mainly of astrocytic tumors 86 cases (32%) followed by embryonal tumors 15 cases (5.6%), ependymal tumors 11 cases (4.1%), oligodendroglial tumors 09 cases (3.3%).Conclusions: Within the scope and limitations of the present study we believe that this effort would help in establishing the grounds for future epidemiologic studies that would, eventually, contribute to give insight into the epidemiology of CNS tumors.

Sign in / Sign up

Export Citation Format

Share Document