scholarly journals A STUDY ON THE PREVALENCE AND SEASONAL VARIATION OF HEPATITIS A IN PATIENTS ATTENDING JNIMS HOSPITAL

2018 ◽  
pp. 1-2
Author(s):  
Dr. Dayananda Ingudam
Keyword(s):  
Seasonal Variation ◽  
Viral Hepatitis ◽  
Liver Dysfunction ◽  
Rainy Season ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Developing Nations ◽  
Serum Samples ◽  
Fatal Disease ◽  
Common Cause

BACKGROUND: Hepatitis is the most common cause of acute viral hepatitis. It causes severe, often fatal disease in adults especially in those with underlying liver dysfunction but is mostly asymptomatic in children. The present study was conducted with the aimed to nd the prevalence and seasonal variation of HAVinfection in patients attending JNIMS hospital. METHODOLOGY:Across sectional hospital based study was conducted in the department of Microbiology, JNIMS, Imphal, Manipur. Rapid immunochromatographic assay was performed for the detection of IgM antibody to HAVin human serum. RESULTS: Out of the 84 serum samples 20(23.80%) was found to be positive for hepatitis IgM, of which 11 (55%) were found in males and 9(45%) were found in females. A seasonal increase in incidence of HAV infection was found during the rainy season of January – March (50%) and April – June (35%). CONCLUSION: The global seroepidemiology of hepatitis A is changing in many developing nations giving rise to unique non immune adolescent and adult populations emerging in endemic regions thereby conferring a risk of developing severe hepatitis A. Hence, nding the prevalence, seasonal variation and timely detection of HAVinfection will help in minimising the development of further complication

scholarly journals The Frequency of Hepatitis Virus Infection Markers Among Highly Qualified Sportsmen

2020 ◽  
Vol 10 (4) ◽  
pp. 305-313
Author(s):  
L. Yu. Ilchenko ◽  
I. A. Morozov ◽  
T. V. Kozhanova ◽  
N. V. Soboleva ◽  
L. I. Melnikova ◽  
...  
Keyword(s):  
Virus Infection ◽  
Blood Serum ◽  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Hepatitis Virus ◽  
Highly Qualified ◽  
Serum Samples ◽  
Study Results ◽  
Infection Markers

Study Objective is to evaluate prevalence of hepatitis A, B, C, E, and TT virus infection markers in highly qualified sportsmen. Study Design: multicenter open single-site clinical study.Materials and Methods: 100 blood serum samples of sportsmen (game, complex coordination, technical, etc.) were studied. Biological material (blood serum) was obtained from 54 men and 46 women aged 16 to 45 years during an in-depth medical examination. All sportsmen filled out a questionnaire, including demographic data, description of the sport, information about infection risk factors, information about the presence of acute viral hepatitis and vaccination. Anti-HAV IgG, HBsAg, anti-HBcore, anti-HCV, anti-HEV IgG, anti-HEV IgM were determined in the blood serum by enzyme immunoassay; using polymerase chain reaction — DNA Anelloviridae (TTV, TTMDV, TTMV). Study Results: Anti-HAV IgG was detected in 57/66 (86,4%) sportsmen, women (91,2%) predominated, among them a third were engaged in synchronized swimming. 7/57 (12,3%) of the examined had indications of vaccination against hepatitis A. The frequency of anti-HEV IgG did not exceed 3% (2/66). anti-HEV IgM were not detected in any case. Also, none of the examined sportsmen in the blood serum was not determined HBsAg. However, anti-HBcore (marker of latent HBV infection) was detected in 13% (13/100) of the samples. The detection rate of anti-HCV was low, combined with the presence of anti-HBcore was 2% (2/100). In addition, DNA TTV, TTMDV and TTMV, respectively, were found in serum samples from 66/100 (86%), 79/100 (79%), 71/100 of sportsmen. Conclusion: The high frequency of hepatitis virus markers was found (HAV — 74,1%, TTV/TTMDV /TTMV — 71-86%), HBV — 13%, HEV — 3%, HCV — 2%). All patients denied a history of acute viral hepatitis. Vaccination against hepatitis A and B is a modern strategy that prevents infection and the development of acute viral hepatitis. Its mandatory holding should become part of the targeted preparation of sportsmen to achieve the highest sports results. 

scholarly journals Seroprevalence of Enterically Transmitted Hepatitis Viruses in Patients Attending a Tertiary Care Hospital in Maharashtra, India

2021 ◽  
Vol 10 (30) ◽  
pp. 2310-2313
Author(s):  
Suvarna Vaibhav Sande
Keyword(s):  
Acute Hepatitis ◽  
Viral Hepatitis ◽  
Predictive Value ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Tertiary Care ◽  
Hepatitis E ◽  
Care Hospital ◽  
Serum Samples ◽  
Hepatitis Viruses

BACKGROUND Hepatitis A & E viruses are enterically transmitted viruses responsible for acute viral hepatitis in developing countries. Hepatitis A virus (HAV) has worldwide distribution while hepatitis E virus (HEV) is restricted to tropical countries. HAV affects infants and young children while HEV affects older children and young adults. This study was conducted to determine the seroprevalence of HAV and HEV and their co-infection in patients presenting with acute viral hepatitis (AVH). METHODS 200 sera of patients suffering from suspected acute viral hepatitis (AVH) attending tertiary care rural hospital JNMC Sawangi, Wardha were included in the study. Serum samples were tested for IgM anti HAV and IgM anti - HEV for the detection of acute hepatitis A and acute hepatitis E using commercially available ELISA kit & Immunochromatography test (ICT) for comparison of ELISA and ICT. RESULTS The overall seroprevalence of HAV and HEV infection was found to be 19 %. The seroprevalence of HAV infection was found to be 13 %, HEV infection 5 % and HAV - HEV co - infection 1 %. HAV infection in males and females was found to be 16.07 % and 9.09 % respectively & HEV infection was found to be 5.35 % and 4.54 % respectively. In case of detection of HAV IgM, two serum samples were negative by ICT but positive by ELISA & for HEV IgM, one serum sample was negative by ICT but positive by ELISA. The sensitivity, specificity, positive predictive value and negative predictive value of HAV IgM was found to be 96 %, 98.8 %, 92.30 % & 99.43 % and for HEV IgM was found to be 90 %, 99.47 %, 90 % & 99.47 % respectively. CONCLUSIONS It is evident from this study that infection with enteric hepatitis viruses is not infrequent. Findings from this study emphasize the need to establish regular seroepidemiological surveys to keep track of epidemiology of these viruses. Results from rapid tests are comparable to ELISA with additional advantage of ease of interpretation and neither time consuming nor requiring special instruments. KEY WORDS Hepatitis A, Hepatitis E, Seroprevalence

Acute viral hepatitis A presented with myopericarditis

2011 ◽  
Vol 153 (2) ◽  
pp. e34-e36 ◽  
Author(s):  
Yae Min Park ◽  
Woong Chol Kang ◽  
Kwen-Chul Shin ◽  
Mi Seung Shin ◽  
Wook Jin Chung ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Viral Hepatitis A ◽  
Acute Viral Hepatitis A

scholarly journals A Study on the Role of N-Acetyl Cysteine Therapy in Acute Viral Hepatitis A

2020 ◽  
Vol 7 (22) ◽  
pp. 1068-1072
Author(s):  
Vinod V. S ◽  
Vijithkumar K ◽  
Riyas C ◽  
Malini V. S ◽  
Arun S. Menon
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Acute Viral Hepatitis ◽  
Acetyl Cysteine ◽  
Viral Hepatitis A ◽  
Acute Viral Hepatitis A

scholarly journals Enteric viral hepatitis in the Socialist Republic of Vietnam (Southern Vietnam)

2021 ◽  
Vol 13 (4) ◽  
pp. 72-78
Author(s):  
Yu. V. Ostankova ◽  
A. V. Semenov ◽  
D. E. Valutite ◽  
E. B. Zueva ◽  
E. N. Serikova ◽  
...  
Keyword(s):  
Viral Hepatitis ◽  
Hepatitis A ◽  
Local Population ◽  
Hepatitis E ◽  
Chronic Viral Hepatitis ◽  
Diagnostic Methods ◽  
Serum Samples ◽  
General Group ◽  
Socialist Republic ◽  
Increased Risk

Aim: To study the hepatitis A (HAV) and hepatitis Е (HEV) prevalence in the Southern region of Vietnam based on the frequency analysis of the antibodies to hepatitis A and E viruses detection in the local population and groups at increased risk of infection.Materials and methods. Serological markers of enteral viral hepatitis were determined in blood serum samples from adults aged 18 to 65 years of three groups: conditionally healthy individuals (n = 397), HIV-infected (n = 316), and patients with chronic viral hepatitis (n = 268). The ELISA method was used for the qualitative detection of anti-HAV IgG, anti-HAV IgM, anti-HEV IgG, anti-HEV IgM.Results. When analyzing the prevalence of anti-HAV IgG in samples obtained from conditionally healthy, HIV-infected, and patients with chronic viral hepatitis, no differences were found between the groups. The incidence of anti-HAV IgG in the general group (n = 981) was 80.1%, in the absence of anti-HAV IgM. There were no gender-age differences in the frequency of anti-HAV IgG in the examined groups. Antibodies anti-HEV IgG in the groups of conditionally healthy, patients with chronic viral hepatitis, and HIV-infected were present in the samples in 36,2%, 33,2%, and 39,8% of cases, respectively. The prevalence of anti-HEV IgM in these groups was 3,27%, 4,1%, and 3,79%, respectively. In the general group (n = 981), anti-HEV IgG was detected in 36,6% of cases, anti-HEV IgM in 3,66%, which corresponds to the prevalence of antibodies to HEV in endemic regions.Conclusion. A high incidence of enteral viral hepatitis markers was shown in residents of South Vietnam, including the groups of conditionally healthy, patients with chronic viral hepatitis, and HIV-infected. There is an obvious need for further studies of the spread extent of hepatitis A and hepatitis E in the Socialist Republic of Vietnam using currently available highly sensitive diagnostic methods, including sequencing of the virus›s nucleotide sequences.

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