scholarly journals COMPARATIVE EVALUATION OF THE BENEFITS OF ADJUNCTIVE USE OF LYCOPENE AND VITAMIN E IN NON-SURGICAL TREATMENT OF PERIODONTITIS : A RANDOMISED CLINICALAND MICROBIOLOGICAL STUDY

2020 ◽  
pp. 3-5
Author(s):  
Shrutika B. Borade ◽  
Akshaya Banodkar ◽  
Rajesh Gaikwad
Keyword(s):  
Surgical Treatment ◽  
Vitamin E ◽  
Test Score ◽  
Periodontal Diseases ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Periodontal Healing ◽  
Non Surgical Treatment ◽  
Bana Test

Background-This study was aimed to compare and evaluate the benefits of adjunctive use of lycopene and vitamin E in the non-surgical treatment of periodontal diseases and effect of this treatment on the periodontal microflora. Methodology-Systemically healthy 30 chronic periodontitis patients were included in the study. periodontal examination was performed and BANA test score were obtained. patients were randomly divided into group-I, group-II and group-III. scaling and root planing was performed for all three groups. group-II and group-III were supplimented with lycopene (Lycostar) and Vit E(Evion 400mg)respectively for 1 month. PI, BOP, PPD, CAL and BANA test score were re-evaluated after 1 month. Result-Periodontal parameters and BANA test score were significantly reduced in both group-II and group-III as compared to group-I. Conclusion-Systemic administration of antioxidants improved periodontal healing and significantly reduced microbial load and can be used as an adjunct to non-surgical periodontal therapy.

Genoprotective role of vitamin E and selenium in rabbits anaesthetized with sevoflurane

2004 ◽  
Vol 23 (8) ◽  
pp. 413-419 ◽  
Author(s):  
Cetin Kaymak ◽  
Ela Kadioglu ◽  
Hulya Basar ◽  
Semra Sardas
Keyword(s):  
Dna Damage ◽  
Vitamin E ◽  
Comet Assay ◽  
Antioxidant Supplementation ◽  
Group Iii ◽  
Sevoflurane Anaesthesia ◽  
Group I ◽  
The Mean ◽  
Group Ii

In this study, genotoxic effects of repeated sevoflurane anaesthesia were investigated in rabbits with or without antioxidant supplementation. Twenty-one New Zealand male rabbits were included in the study and randomized into three groups as: placebo treated (Group I), vitamin E supplemented (Group II) and selenium supplemented (Group III). Vitamin E and selenium were given intraperitoneally for 15 days before anaesthesia treatment. Anaesthesia was administered using 3% sevoflurane in 4 L/min oxygen for a 3-hour period and continued for 3 days. Blood samples were collected before anaesthesia (Sample 1), after the first, second and third days of sevoflurane administration (Sample 2, Sample 3 and Sample 4 respectively) and the last samples were taken 5 days after the last sevoflurane administration (Sample 5). Genotoxic damage was examined using the comet assay. The degree of damage is assessed by grading the cells into three categories of no migration (NM), low migration (LM) and high migration (HM) depending on the fraction of DNA pulled out into the tail under the influence of the electric field. The number of comets in each sample was calculated (1 × number of comets in category NM + 2 × number of comets in category LM + 3 ×number of comets in category HM) and expressed as the total comet score (TCS), which summarizes the damage frequencies. In Group I, a significant increase in the mean TCSs was observed for Samples 3 and 4 as compared with Sample 1. However, there were no significant differences between Samples 1, 2 and 5. The mean TCS of Sample 4 was significantly higher than Sample 1, 2 and 3 in Group II. Group III demonstrated no significant mean TCSs for any experimental conditions. Statistical differences were also observed between the groups with significant P values. This experimental study points out the presence of DNA damage with repeated sevoflurane anaesthesia and the genoprotective role of antioxidant supplementation on DNA damage in mononuclear leukocytes of rabbits by highly sensitive comet assay.

scholarly journals Outcomes of ophtalmologic surgical procedures of esotropia in children and adolescents

2008 ◽  
Vol 65 (8) ◽  
pp. 627-631
Author(s):  
Tamara Kljakovic-Avramovic ◽  
Miroslav Vukosavljevic ◽  
Sinisa Avramovic
Keyword(s):  
Surgical Treatment ◽  
Prospective Study ◽  
Children And Adolescents ◽  
Deviation Angle ◽  
Group Iii ◽  
Military Medical Academy ◽  
Group I ◽  
Medical Academy ◽  
Group Ii ◽  
Common Manifestation

Background/Aim. Esotropia is the most common manifestation form of strabism accompanied by refraction deviations and amblyopia. The aim of this prospective study was to present the outcomes of surgical treatment of esotropia in children and adolescents. Methods. Within the period from January 1st 2006 to February 1st 2007 at the Clinic for Ophtalmology, Military Medical Academy, Belgrade a total of 25 patients with esotropia (34 eyes) and previously corrected refraction anomaly and treated amblyopia were operated on. The patients were 4-19-year of age. All of the patients were submitted to a complete ophtalmologic and orthoptic examination prior to the surgery, and a month, three months and six months after the surgery. The surgery was performed under general anesthesia. Out of the total number of the patients nine were operated on both eyes, while 16 patients on one eye with amblyopia or frequent esodeviation. Nine patients were submitted to retroposition of the inner straight muscle, two to myectomy of the outer straight muscle, while in 14 of the patients a combination of retroposition and myectomy was performed. The patients were divided into three groups according to the preoperative angle at the distance and followed-up accordingly after the surgery. Deviation angle at the distance in the group I was 18-25 DP, in the group II 26-35 PD, while in the group III it was 36-60 PD. Results. The most numerous, group I (12 patients; 48%), a month following the surgery showed angle reduction by 55.58%, after three months 63.25%, and after six months 63.92%. The group II consisted of 8 patients (32%) showed angle reduction by 70.75% a month following the surgery, by 76% after three months, and by 79.12% after six months. The group III (5 patients; 20%) showed angle reduction by 72.20% a month following the surgery, 79.20 after three months, and 80.12% after six months following the surgery. Conclusion. The best postoperative outcomes after a month, three and six months were obtained in the group of patients with the highest esodeviation angle at the distance solved by the surgery on both eyes. Timely surgical treatment befell into major precondition for developing and maintaining the elements of binocular vision in the operated on patients. .

Hormonal status of patients after surgical treatment of fibrocystic mastopathy and possibilityes of its corrections

2017 ◽  
pp. 128-131
Author(s):  
Yu.Ya. Pryshash ◽  
Keyword(s):  
Surgical Treatment ◽  
Standard Dose ◽  
Treatment Phase ◽  
Nodule Formation ◽  
Double Dose ◽  
Postoperative Rehabilitation ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
High Doses

The purpose of the study was to investigate the efficacy of Mastodynon in terms of indications in elevated doses versus the standard dose. Materials and methods. Data were analyzed for 60 patients after surgical treatment of fibro-cystic mastopathy. Depending on the postoperative therapy received by the patients, they were divided into three groups. Group I (n = 20): patients were observed in accordance with the standards established in mammal practice and did not receive special agents that affect hormonal homeostasis. Group II (n = 20): In addition to observation, patients received Mastodynon® (1 tablet or 30 drops 2 times a day) for 6 months. Group III (n = 20): Patients were given for a post-operative rehabilitation Mastodynon® in a double dose (2 tablets or 60 drops 2 times a day) for 6 months. Results Surgical treatment without conservative therapy eliminates organic changes in the thoracic glands (GH), but hormonal disorders that have led to pathologic and histological changes in the tissues of GZ continue to exist for a long time and can lead to repeated nodal formations. In group І, 25% of patients within 2 years performed repeated sectoral resections on recurrence of nodule formation. In group І, 25% of patients within 2 years performed repeated sectoral resections on recurrence of nodule formation. The use of Mastodynon® in standard doses (group II) for postoperative rehabilitation contributes to a significant improvement in hormonal homeostasis (normalization of prolactin, estradiol and progesterone levels), a 24.7 mm decrease in the degree of cyclic mastodynia according to the visual analog scale (VAS), and the improvement of ultrasound scan Pictures of GZ in 75% of patients. The most pronounced effect of this rehabilitation approach after the surgical treatment phase was noted for the use of Mastodynone in doble doses (2 tablets or 60 drops 2 times a day) in Group III. In these patients, the degree of reduction of cyclic mastodynia was 30 mm for VAS and positive changes in the tissues of GH were noted in 85% of patients. However, the highest incidence of adverse events was also noted in Group III, although they were temporary in nature and did not require withdrawal or dose reduction. Conclusion. Despite the presence of short-term side effects and rapid rebounding in the double-dose Mastodynon® group, our study showed better results than standard doses, faster and more stable therapeutic effect. Taking into account the results obtained, it can be argued that the use of high doses of Mastodynon® may be recommended to patients for the treatment of mastopathy. For a more complete study of such an important aspect as the tolerability of high doses of Mastodynon®, it is advisable to conduct more extensive studies, taking into account the dosage form and the use of other drugs. Key words: mastopathy, postoperative rehabilitation, Mastodynon®, mastodynia.

scholarly journals Palliative surgical treatment of patients, suffering proximal tumoral affection of biliary ducts and the jaundice syndrome

2020 ◽  
Vol 87 (11-12) ◽  
pp. 40-47
Author(s):  
Ya. M. Susak ◽  
R. Ya. Palytsya ◽  
L. Yu. Markulan ◽  
O. O. Dyrda
Keyword(s):  
Surgical Treatment ◽  
Palliative Treatment ◽  
Biliary Stenting ◽  
Technical Success ◽  
Endoscopic Retrograde ◽  
Group Iii ◽  
Group I ◽  
Priority Method ◽  
Biliary Ducts ◽  
Group Ii

Objective. To compare the efficacy of methods of miniinvasive palliative treatment of malignant hilar strictures with the jaundice syndrome. Materials and methods. Into the investigation 71 patients, suffering proximal obturation jaundice of tumoral genesis, were included. The patients were divided into three Groups: Group I - 26 patients, to whom external-internal suprapapillary cholangiostomy was done; Group II - 28 patients, in whom transcutaneous transhepatic antegrade endobiliary stenting was performed; Group III -17 patients, to whom endoscopic retrograde biliary stenting was accomplished. Results. Technical success in all the Groups have constituted 100%; clinical one - in 94.0%: in Group I - 96.2%, in Group II - 89.3%, and in group III - 82.4% (p>0.05). In Group I general rate of morbidity was lesser, including cholangitis and pancreatitis. The duration of cholangitis was lesser as well. Cumulative survival were the highest in Group of patients, to whom external-internal suprapapillary cholangiostomy was performed (135 days at average), while the least one - in Group of the patients, in whom endoscopic retrograde biliary stenting was done (90,6 days). In Group of patients, to whom transcutaneous transhepatic antegrade endobiliary stenting was performed, this index have constitited 101.2 days. Conclusion. In proximal strictures of biliary ducts of tumoral genesis on background of jaundice the priority method of palliative treatment must be external-internal suprapapillary cholangiostomy, while the second-line of surgical treatment must constitute transcutaneous transhepatic antegrade endobiliary stenting. Endoscopic retrograde biliary stenting owes the lowest priority.

scholarly journals Frequency of Acetabulum Retroversion Formation after Reorienting Pelvic Osteotomies in Children Over 7 Years Old with Developmental Dysplasia of the Hip

2021 ◽  
Vol 27 (1) ◽  
pp. 121-130
Author(s):  
P. I. Bortulev ◽  
S. V. Vissarionov ◽  
V. E. Baskov ◽  
D. B. Barsukov ◽  
I. Yu. Pozdnikin ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Pelvic Osteotomy ◽  
Developmental Dysplasia ◽  
Acetabular Retroversion ◽  
Hip Joints ◽  
Group Iii ◽  
Acetabular Fragment ◽  
Group I ◽  
Group Ii ◽  
Dysplasia Of The Hip

Background. One of the reasons for the development of the “pincer” type of femoroacetabular impingement are various reorienting pelvic osteotomies, which are widely used in the treatment of children with developmental dysplasia of the hip (DDH).The aim of the study was to evaluate the frequency of formation of retroversion of the acetabulum after reorienting pubic-iliac, iliac-sciatic and triple pelvic osteotomies in children over 7 years old with DDH I–II degree according to Crowe.Material and Methods. The retrospective study is based on the results of radiometry of 60 patients (69 hip joints) at an average age of 11.6±2.9 years with DDH I–II degree according to Crowe who underwent surgical treatment in 2014-2016. The patients were divided into three groups of 20 patients each. Group I underwent an iliac osteotomy. Group II underwent an ilio-sciatic osteotomy. In group III patients, the acetabulum was reoriented by triple (pubo-ilio-sciatic) pelvic osteotomy. In addition to standard radiometry of the hip joints, the following indicators were evaluated: signs of acetabular retroversion (“cross-over”, “posterior wall”, “ischial spine”), as well as the index of acetabular retroversion (ARI).Results. The assessment of the main radiometric parameters of the spatial position and the correction value of the acetabulum was carried out at least 36 months after the surgical treatment. There were no statistically significant differences in the radiometric parameters of the spatial orientation of the acetabulum in group I and II patients (p>0.05), except for the degree of bone coverage, which was significantly higher in group II patients (p<0.05) than in group II patients, which indicated the presence of hypercorrection. In patients of group III, the values of the above-mentioned indicators varied within the physiological values. Retroversion of the acetabulum was observed in more than half of the patients in group I and in almost all patients in group II. In group III patients, acetabular retroversion was observed in only 3 patients.Conclusion. In the vast majority of cases, a double pelvic osteotomy (pubo-iliac and ilio-sciatic) leads to the formation of hypercorrection of the acetabular fragment and its retroversion in comparison with a triple pelvic osteotomy. The pathological orientation of the acetabulum, despite the achieved stability of the hip joint, can be a morphological substrate for the development of femoro-acetabular impingement and, as a result, coxarthrosis. In the treatment of children with DDH over 7 years old the operation of choice is a triple pelvic osteotomy.

scholarly journals COMPARATIVE CHARACTERISTICS OF DIFFERENT METHODS OF TREATMENT OF CHRONIC COMPLICATED HEMORRHOIDS

2021 ◽  
pp. 36-42
Author(s):  
A. V. Makukha ◽  
M. A. Kashtalyan ◽  
V. Yu. Shapovalov ◽  
R. V. Enin
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Postoperative Bleeding ◽  
Stage Ii ◽  
Group Iii ◽  
Early Postoperative Complications ◽  
Group I ◽  
External Component ◽  
Group Ii ◽  
Methods Of Treatment

Abstract. Introduction. In recent years, a method of surgical treatment of hemorrhoids by the method of ligation of hemorrhoidal arteries under Doppler control (THD technique), as well as with additional rectoanal reconstruction (HAL-RAR) has been developed and widely used. The aim of the study. The aim of our study was to compare methods of treatment of chronic complicated hemorrhoids stage II-III: classical Milligan-Morgan surgery, staple mucopexy according to Longo, as well as a combined technique: Doppler desarterization by HAL-RAR with additional removal of the external anodermal component. Materials and methods. In the clinic of coloproctology of Military medical: Clinical Center of the Southern Region of Odessa performed an analysis of three groups of patients for the period from 2011 to 2021, who underwent hemorrhoidectomy for complicated forms of hemorrhoids (bleeding, nodular prolapse, mucosal prolapse, anal fissure). All patients suffered from chronic complications of stage II or III hemorrhoids, with one or more of the above complications. Selected cases are divided into three groups: Group I (control) operations on Milligan-Morgan — 240 patients, including -64 women and 176 men; Distribution by age from 18 to 75 years; Group II staple hemorrhoidopexy for Longo — 276 patients, including 89 women and 115 men. Distribution by age from 18 to 72 years; Combined interventions using the wireless Doppler surgical complex Wi-3 HAL-RAR and additional removal of excess anoderm (from January 2019 to May 2021) operated on 53 patients, including 31 (58%) men and 22 (42%) women . Distribution by age from 28 to 62 years. Results and discussion. According to our data: bed day ranged from 1 to 8 days, mostly it was lower in group III — 1.3 (± 0.4) bed per day compared to 3.1 (± 0.8) in group II and 4.8 (± 1,7) in group III resorptive fever was not observed; the highest pain syndrome for VASH (average 7 points) in the group of patients of group I — compared with patients from group II (average 4 points) and patients of group III (average 2 points); the highest number of early postoperative complications was found in the group of patients operated on Milligan- Morgan: 1) acute urinary retention was observed in 43 cases (18%) of group I, compared with 38 cases (14%) of group II. The lowest number of cases of urinary retention was observed in group III — 2 cases (4%) (p <0.05). 2) postoperative bleeding from the wound was significantly more common in group I — 9 cases (3.75%), compared with group II — 6 cases (2.5%). No postoperative bleeding was observed in group III. 3) resorptive fever was most common in group I — 43 cases (18%) compared with group II - 33 cases (12%). Resorptive fever did not occur in group III (p<0.05). In all patients using the combined intervention HAL-RAR + excision of the external component of the anoderm, the pain was acquired by taking nonspecific anti-inflammatory drugs without the use of narcotic analgesics. No complications were observed. All patients noted no reduction in quality of life in the postoperative period. Conclusions. 1. Surgical treatment of hemorrhoids by the combined method of HAL-RAR + excision of the external component is a simple and effective method that in the postoperative period reduces the patient’s stay in the hospital, relatively lower in pain and the frequency of early postoperative complications. 2. HAL-RAR technology with excision of the outer component of the anoderm can be the operation of choice in the surgical treatment of chronic complicated hemorrhoids stage II-III.

scholarly journals Characteristics of Periodontal Tissues in Prosthetic Treatment with Fixed Dental Prostheses

Molecules ◽  
2021 ◽  
Vol 26 (5) ◽  
pp. 1331
Author(s):  
Anna Avetisyan ◽  
Marina Markaryan ◽  
Dinesh Rokaya ◽  
Marcos Roberto Tovani-Palone ◽  
Muhammad Sohail Zafar ◽  
...  
Keyword(s):  
Periodontal Diseases ◽  
Group Iii ◽  
Periodontal Tissues ◽  
Dental Prostheses ◽  
Group I ◽  
Periodontal Index ◽  
Computer Aided ◽  
Cad Cam ◽  
Group Ii ◽  
Gingival Biotype

The objective of the present study was to investigate the effects of various types of fixed prostheses on periodontal tissues and explore the association of gingival biotype and gum recession in relation to prosthesis types. The study participants (N = 95) were divided into three groups based on the type of dental prosthesis: Group-I: cobalt-chrome (Co-Cr) ceramic prosthesis fabricated by the conventional method (n = 35); Group-II: consisted of patients with Co-Cr ceramic prostheses fabricated by a computer-aided design and computer aided manufacturing (CAD/CAM) technique (n = 30); and Group-III: zirconia-based prostheses fabricated by the CAD/CAM technique (n = 30). Following the use of prostheses, periodontal examinations were performed using the Community Periodontal Index (CPI) and Modified Approximal Plaque Index (MAPI). In addition, the gingival biotype was examined using a probe transparency method. The Statistical Package for the Social Sciences (SPSS), Version 20 (IBM Company, Chicago, IL, USA), was used to analyze the results, and the significance level was set at p = 0.05. It showed the MAPI results after the use of prosthetic rehabilitation for 12 months of periodontitis in 87.9% ± 15.4 of patients in Group-I, in 80.6% ± 17.97 in those in Group-II, and in 62.5% ± 21.4 in those in Group-III (p < 0.01). The CPI index results indicated a high prevalence of periodontal disease in all groups. The number of people with healthy periodontium constituted 17.1% of patients in Group-I, 24.2% in Group-II, and 37.1% in Group-III. Our study concluded that prosthetic treatment with periodontal diseases showed better outcomes while using dental prostheses fabricated by the CAD/CAM technique compared to the conventionally fabricated dental prostheses. The thin gingival biotype is more often associated with gingival recession than the thick biotype.

scholarly journals The surgical correction of refractory venous trophic ulcers

2021 ◽  
pp. 38-46
Author(s):  
S. E. Katorkin ◽  
M. J. Kushnarchuk ◽  
M. A. Melnikov ◽  
A. A. Zhukov ◽  
P. F. Kravtsov ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Comparison Group ◽  
Complete Healing ◽  
Long Term Results ◽  
Group Iii ◽  
Results Of Treatment ◽  
Group I ◽  
Group Ii ◽  
Shave Therapy

Objectives. To study the effectiveness of layered dermatolipectomy and endoscopic fasciotomy in the surgical treatment of refractory venous trophic ulcers.Materials and methods. Patients (n = 105) of the C6 clinical class underwent crossectomy and short stripping. In group I (n = 35), free autodermoplasty of trophic ulcers with a perforated flap was performed. In group II (n = 36), shave therapy and autodermoplasty were performed. In group IIІ (n = 34), fasciotomy, shave therapy and autodermoplasty were performed. Long-term results of treatment were studied in the period from 1 to 12 months.Results. Complete healing of venous trophic ulcers was observed in group I at 49,4 ± 7,2, in II – at 31,4 ± 4,7, in III – at 32,1 ± 3,6 days сутки (t1-2 = 2,09; p1-2 = 0,049; t1-3 = 2,24; p1-3 = 0,024; t2-3 = 0,03; p2-3 = 0,763). Full engraftment of an autograft graft was recorded in 7 (19,4 %) patients of group I, in 27 (77,1 %) cases in group II and in 27 (79,4 %) patients of comparison group III (χ21-2 = 23,674; p1-2 = 0,001; χ21-3 = 25,173; p1-3 = χ22-3 = 0,052; p2-3 = 0,826).Conclusion. Layered dermatolipectomy with autodermoplasty and endoscopic decompression fasciotomy is an effective method for the treatment of persistent refractory venous trophic ulcers.

Prolactin dynamics in patients with non-secreting tumours of the hypothalamic-pituitary region

1985 ◽  
Vol 110 (1) ◽  
pp. 10-16 ◽  
Author(s):  
Antonino Barbarino ◽  
Laura De Marinis ◽  
Antonio Mancini ◽  
Edoardo Menini ◽  
Colomba D'Amico ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Positive Response ◽  
Dynamic Tests ◽  
Group Iii ◽  
Reliable Tool ◽  
Group I ◽  
Before And After ◽  
Tumour Group ◽  
Group Ii ◽  
Plasma Prl

Abstract. Twenty-four patients with non-secreting tumours of the hypothalamic-pituitary region, diagnosed by radiographic procedures and confirmed at surgery, were examined before and after the surgical treatment to establish a correlation between Prl responsiveness to dynamic tests and the location of pathological tissue. Three groups of patients were identified. In 10 patients with an intrasellar tumour (group I), Prl had a positive response to TRH, metoclopramide (MCP), and nomifensine (NOM), both pre- and postoperatively. In 4 patients with tumours located entirely in the hypothalamus (group II), Prl responded to TRH, but remained unresponsive to MCP and NOM. Only a partial normalization of the Prl responses was obtained after surgery. Finally, 10 patients had an intra- and extrasellar tumour (group III). In 8 of them Prl responded to TRH, but the increment was lesser than that observed in hypothalmic tumours. Prl did not respond to MCP and NOM. After surgery, Prl responsiveness reappeared in some patients (6 after TRH, 4 after MCP, 3 after NOM). In 2 patients with extensive pituitary damage, Prl did not respond to all dynamic tests pre- or postoperatively. In conclusion, Prl dynamic tests are a reliable tool for studying the altered control of Prl secretion in these patients, since plasma Prl stems from only normal lactotropes surrounding the tumoural tissue. The location of the tumour has a key role in influencing the pattern of Prl response to direct and indirect dynamic tests.

scholarly journals Ameliorative effect of Alpha-tocopherol on E-cigarette liquid induced histomorphological changes in adrenal cortex of male Albino rats.

2021 ◽  
Vol 28 (04) ◽  
pp. 520-526
Author(s):  
Ali Ahmed ◽  
Mehreen Lashari ◽  
Muhammad Imran Bajwa ◽  
Jahanzaib Lashari ◽  
Syeda Sara Bano ◽  
...  
Keyword(s):  
Body Weight ◽  
Vitamin E ◽  
Adrenal Cortex ◽  
Alpha Tocopherol ◽  
Control Group ◽  
Albino Rats ◽  
Group Iii ◽  
Group I ◽  
Ameliorative Effect ◽  
Group Ii

Objective: To study the ameliorative effect of Alpha-Tocopherol (Vitamin E) against E-cigarette induced histomorphalogical changes in adrenal cortex of male Albino rats. Study Design: Randomized Animal Control Trial. Setting: Department of Anatomy, Islamic International Medical College Rawalpindi in collaboration with National Institute of Health (NIH), Islamabad. Period: September 2018 to September 2019. Material & Methods: 30 adult male albino rats were divided in three groups having 10 rats each. Normal diet and distilled water was given to control group (Group I) including 10 rats, for 4 weeks. The Rats of Group II were injected E-cigarette liquid 0.5mg per kg body weight per day diluted in 500ul normal saline intraperitoneally for 4 weeks. The experimental rats in Group III, in addition to E-cigarette liquid also received Vitamin E, 100mg per kg body weight per day mixed in daily diet. Dissection of the animals was done after completion of 4 weeks and adrenal gland was removed for histological analysis. Data was recorded and analyzed in SPSS™ version 21. Results: Alpha-Tocopherol restored the quantitative changes induced by E-Cigarette liquid in adrenal cortex in Group III, which was increased in the rats of Group II who were injected E-Cigarette liquid. Among microscopic parameters Orientation of cells, sinusoidal dilatation was significantly reduced in all adrenal cortex zones by Alpha-Tocopherol in Group III animals. Conclusion: The current study demonstrated that Alpha-Tocopherol had an ameliorative effect on histological changes caused by E-cigarette liquid on adrenal cortex.

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