INVASIVE FUNGAL VASCULOPATHY AND CENTRAL NERVOUS SYSTEM COMPLICATIONS

2021 ◽  
pp. 21-22
Author(s):  
Moses .P. Moorthy ◽  
Av. srinivasan ◽  
k. prasanthi
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetic Ketoacidosis ◽  
Blood Sugar ◽  
Lower Limb ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Random Blood Sugar ◽  
The Past ◽  
Left Eyelid

60 years female admitted with subacute onset of pain left side of face , swelling around left eye , drooping of left eyelid , loss of vision in left eye of 3 days duration . After admission in the hospital course she developed weakness of right upper and lower limb, congestion and proptosis of left eye. She was having diabetes for the past three years, poorly controlled. Random blood sugar was 450mg/dl and urine acetone was positive. During the hospital course she developed diabetic ketoacidosis for which she was treated. ENT and Ophthalmology opinion was obtained as left orbital apex syndrome.

scholarly journals Orbital apex syndrome due to aspergillosis: case report

2001 ◽  
Vol 59 (3B) ◽  
pp. 806-808 ◽  
Author(s):  
Yvens B. Fernandes ◽  
Ricardo Ramina ◽  
Guilherme Borges ◽  
Luciano S. Queiroz ◽  
Marcos V.C. Maldaun ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Renal Failure ◽  
Nervous System ◽  
Rare Case ◽  
Visual Loss ◽  
Orbital Apex ◽  
Orbital Apex Syndrome ◽  
Facial Numbness ◽  
The Central Nervous System ◽  
The Right

We report the case of a 73-year-old female who presented facial numbness and pain in the first division of the trigeminal nerve, ptosis, diplopia and visual loss on the right side for the previous four months. The neurological, radiological and histological examination demonstrated a rare case of invasive fungal aspergillosis of the central nervous system, causing orbital apex syndrome, later transformed in temporal brain abscess. She died ten months later due to respiratory and renal failure in spite of specific antimycotic therapy.

scholarly journals The Past, Present and Future of Flow Cytometry in Central Nervous System Malignancies

2021 ◽  
Vol 4 (1) ◽  
pp. 11
Author(s):  
Evrysthenis Vartholomatos ◽  
George Vartholomatos ◽  
George A. Alexiou ◽  
Georgios S. Markopoulos
Keyword(s):  
Central Nervous System ◽  
Flow Cytometry ◽  
Nervous System ◽  
Therapeutic Agents ◽  
Phenotypic Characterization ◽  
Cell Phenotype ◽  
Analytical Technique ◽  
The Past ◽  
Current Review

Central nervous system malignancies (CNSMs) are categorized among the most aggressive and deadly types of cancer. The low median survival in patients with CNSMs is partly explained by the objective difficulties of brain surgeries as well as by the acquired chemoresistance of CNSM cells. Flow Cytometry is an analytical technique with the ability to quantify cell phenotype and to categorize cell populations on the basis of their characteristics. In the current review, we summarize the Flow Cytometry methodologies that have been used to study different phenotypic aspects of CNSMs. These include DNA content analysis for the determination of malignancy status and phenotypic characterization, as well as the methodologies used during the development of novel therapeutic agents. We conclude with the historical and current utility of Flow Cytometry in the field, and we propose how we can exploit current and possible future methodologies in the battle against this dreadful type of malignancy.

scholarly journals Vesicular dysfunction and pathways to neurodegeneration

2021 ◽  
Author(s):  
Patrick A. Lewis
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Human Brain ◽  
Cell Viability ◽  
Case Studies ◽  
Neurological Diseases ◽  
The Past ◽  
Cellular Events ◽  
The Central Nervous System ◽  
Cellular Control

Abstract Cellular control of vesicle biology and trafficking is critical for cell viability, with disruption of these pathways within the cells of the central nervous system resulting in neurodegeneration and disease. The past two decades have provided important insights into both the genetic and biological links between vesicle trafficking and neurodegeneration. In this essay, the pathways that have emerged as being critical for neuronal survival in the human brain will be discussed – illustrating the diversity of proteins and cellular events with three molecular case studies drawn from different neurological diseases.

scholarly journals Current State and Future Directions of Intranasal Delivery Route for Central Nervous System Disorders: A Scientometric and Visualization Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Haiyang Wu ◽  
Yan Zhou ◽  
Yulin Wang ◽  
Linjian Tong ◽  
Fanchen Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Central Nervous System ◽  
Nervous System ◽  
Brain Targeting ◽  
Nanostructured Lipid Carrier ◽  
Intranasal Delivery ◽  
Research Focus ◽  
Future Directions ◽  
The Past ◽  
Delivery Route

Background: The management of various central nervous system (CNS) disorders has been challenging, due to highly compact blood-brain barrier (BBB) impedes the access of most pharmacological agents to the brain. Among multiple strategies proposed to circumvent this challenge, intranasal delivery route has sparked great interest for brain targeting in the past decades. The aim of this study was to apply scientometric method to estimate the current status and future trends of the field from a holistic perspective.Methods: All relevant publications during 1998–2020 were retrieved from the Web of Science Core Collection (SCIE, 1998-present). Two different scientometric software including VOS viewer and CiteSpace, and one online platform were used to conduct co-authorship, co-citation, and co-occurrence analysis of journals, countries, institutes, authors, references and keywords.Results: A total of 2,928 documents, including 2,456 original articles and 472 reviews, were retrieved. Our analysis revealed a significant increasing trend in the total number of scientific publications over the past 2 decades (R2 = 0.98). The United States dominated the field, reflecting in the largest amount of publications (971), the highest H-index (99), and extensive international collaboration. Jamia Hamdard contributed to most publications. Frey WH and Illum L were key researchers with the highest number of publications and citations, respectively. The International Journal of Pharmaceutics was the most influential academic journal, and Pharmacology/Pharmacy and Neurosciences/Neurology were the hottest research categories in this field. Based on keywords occurrence analysis, four main topics were identified, and the current research focus of this field has shifted from cluster 4 (pathways and mechanisms of intranasal delivery) to cluster 2 (the study of nasal drug delivery systems), especially the nanostructured and nano-sized carrier systems. Keywords burst detection revealed that the research focus on oxidative stress, drug delivery, neuroinflammation, nanostructured lipid carrier, and formulation deserves our continued attention.Conclusion: To the authors’ knowledge, this is the first scientometric analysis regarding intranasal delivery research. This study has demonstrated a comprehensive knowledge map, development landscape and future directions of intranasal delivery research, which provides a practical and valuable reference for scholars and policymakers in this field.

scholarly journals Treating Complex Nervous System Vascular Disorders through a “Needle Stick”: Origins, Evolution, and Future of Neuroendovascular Therapy

Neurosurgery ◽  
2001 ◽  
Vol 48 (3) ◽  
pp. 463-475 ◽  
Author(s):  
L. Nelson Hopkins ◽  
Giuseppe Lanzino ◽  
Lee R. Guterman
Keyword(s):  
Gene Therapy ◽  
Central Nervous System ◽  
Nervous System ◽  
Molecular Basis ◽  
Nervous System Diseases ◽  
Central Nervous System Diseases ◽  
Biological Factors ◽  
Device Development ◽  
The Past ◽  
Established Treatment

Abstract IN THE PAST few decades, dramatic improvements have occurred in the field of neuroendovascular surgery. Endovascular therapy today is a well-established treatment modality for a variety of cerebrovascular and nonvascular central nervous system diseases. The foundation of this spectacular evolution was laid by the efforts of pioneering visionaries who often worked alone and under difficult, almost impossible, conditions. Ongoing device development and refinement have revolutionized the field at a dizzying, exhilarating pace. With a better understanding of the molecular basis of diseases and further advancements in gene therapy, neuroendovascular techniques have an enormous potential for application to the entire spectrum of central nervous system diseases as a minimally invasive vehicle for the delivery of biological factors.

Diseases of the central nervous system after malaria

2021 ◽  
Vol 20 (5) ◽  
pp. 500-508
Author(s):  
G. V. Pervushin
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
The Past ◽  
The Central Nervous System

Despite the enormous incidence of malaria over the past 2 years, complications of this disease from the nervous system are relatively rare.

Effect of Hypoglycemia on Auditory Cortex and Cochlear Receptor in the Cat

1957 ◽  
Vol 188 (2) ◽  
pp. 249-254 ◽  
Author(s):  
César Fernández ◽  
Arnold Brenman
Keyword(s):  
Blood Pressure ◽  
Central Nervous System ◽  
Nervous System ◽  
Auditory Cortex ◽  
Blood Sugar ◽  
Cochlear Function ◽  
The Central Nervous System ◽  
Sugar Levels

Effect of hypoglycemia induced by insulin and/or functional evisceration on auditory cortex and cochlear responses to sound stimuli was studied in cats. Both responses remained unchanged at blood sugar levels as low as 5 mg %. They diminished in size whenever blood pressure was allowed to fall to low values, and returned to nearly normal when it was restored. The observations suggest that carbohydrates are not essential for cochlear function or that the structure contains a large store of them. The presence of responses from auditory cortex during medullary stage of coma suggests that this area does not conform well to the concept of phyletic organization of the central nervous system.

Imaging of primary central nervous system lymphoma

2006 ◽  
Vol 21 (5) ◽  
pp. 1-6 ◽  
Author(s):  
John L. Go ◽  
Sandy C. Lee ◽  
Paul E. Kim
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Lymphoma ◽  
Demographic Characteristics ◽  
Steady Increase ◽  
Imaging Features ◽  
Immunocompromised Patients ◽  
The Past ◽  
Neoplastic Process ◽  
Salient Features

✓Primary central nervous system lymphoma (PCNSL) is an aggressive neoplastic process that occurs in both immuno-competent and immunocompromised patients. Over the past 30 years there has been a steady increase in the number of cases in both patient populations. The imaging features for the disease and demographic characteristics within these patient populations vary, and in this article the authors describe the salient features of these two groups.

Central Nervous System Processing of Human Visceral Pain in Health and Disease

Physiology ◽  
2003 ◽  
Vol 18 (3) ◽  
pp. 109-114 ◽  
Author(s):  
Anthony R. Hobson ◽  
Qasim Aziz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Visceral Pain ◽  
Functional Gastrointestinal Disorders ◽  
Functional Brain Imaging ◽  
Gastrointestinal Disorders ◽  
The Past ◽  
Body Of Knowledge ◽  
The Central Nervous System ◽  
Health And Disease

To understand the pathophysiology of anomalous pain in functional gastrointestinal disorders, we must increase our understanding of how the central nervous system processes visceral pain. Over the past decade, novel application of functional brain imaging and electrophysiological techniques has given us the opportunity to study these processes in humans, and this review summarizes the current body of knowledge.

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