RELATIONSHIP OF CARDIOVASCULAR RISK MARKERS IN CHILDREN SGAAND AGA

2021 ◽  
pp. 15-17
Author(s):  
Anand Shanker Singh ◽  
G . Radhika ◽  
R . Praveen Kumar ◽  
Ankita Singh ◽  
Debarshi Jana
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Fasting Glucose ◽  
Initial Growth ◽  
Fasting Insulin ◽  
Growth Faltering ◽  
Risk Result ◽  
Hs Crp ◽  
Preterm Born ◽  
Relationship Of

INTRODUCTION: Children born preterm usually experience an initial growth restriction, suggested to be caused by the immature organs and an inadequate nutritional intake.After this initial growth faltering, healthy preterm born children, and especially those born after 32 gestational weeks, usually fall back to the reference growth curve, following that of term born babies. For children born SGA, 80 % will experience a relative catch-up growth within the rst 6 months of life. OBJECTIVE: Role of different risk proles for children being born preterm vs being born SGA and early iron supplementation affect later cardiovascular risk RESULT: In Placebo group, 4.6(0.5) patients had Fasting glucose (mmol/L), 2.9(2.3-3.5) patients had Fasting insulin(µU/mL), 0.59(0.4-0.7) patients had HOMA-IR, 4.5(0.7) patients had Cholesterol(mmol/L), 0.58(0.2) patients had Triglyceride(mmol/L), 2.8(0.6) patients had LDL(mmol/L), 1.5(0.3) patients had HDL(mmol/L), 0.63(0.4) patients had ApoB(g/L and 0.20(0.1-0.6) patients had hs-CRP(mg/L). In Iron supplements group, 4.4(0.5) patients had Fasting glucose(mmol/L), 2.7(2.0-3.8) patients had Fasting insulin(µU/mL), 0.54(0.4-0.8) patients had HOMA-IR, 4.3(0.8) patients had Cholesterol(mmol/L), 0.59(0.3) patients had Triglyceride(mmol/L), 2.8(0.6) patients had LDL(mmol/L), 1.5(0.4) patients had HDL(mmol/L), 0.61(0.3) patients had ApoB(g/Land 0.24(0.2-0.8) patients had hs-CRP(mg/L). CONCLUSION: This literature showing that there is progression of these risk factors as children enter early adolescence. Further longer longitudinal studies are needed to elucidate the mechanisms responsible for progression of cardio-metabolic risk factors from infancy to adolescence in SGAand LGAsubjects.

ASSOCIATION OF CARDIOVASCULAR RISK IN CHILDREN BORN WITH LOW BIRTH WEIGHT

2021 ◽  
pp. 18-20
Author(s):  
Anand Shanker Singh ◽  
G . Radhika ◽  
R . Praveen Kumar ◽  
Ankita Singh ◽  
Debarshi Jana
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Health Care Providers ◽  
Blood Lipids ◽  
Cardiovascular Health ◽  
Fasting Glucose ◽  
Fasting Insulin ◽  
Care Providers ◽  
Postnatal Risk Factors ◽  
Hs Crp

INTRODUCTION: Most studies of early programming focus on very LBWor extremely LBW, even though the majority of all LBWchildren are 2 born only with marginally LBW. The pathogenesis behind CVD is multifactorial, and for health care providers to be able to assess the risk of each individual, we need to know more about this common subgroup. AIM:Being born with LBWaffects later cardiovascular risk. RESUILT: In Marginally LBW group, 4.7(0.6) patients had Fasting glucose(mmol/L), 2.7(2.3-3.8) patients had Fasting insulin(µU/mL), 0.57(0.4-0.8) patients had HOMA-IR, 4.4(0.7) patients had Cholesterol(mmol/L), 0.50(0.2) patients had Triglyceride(mmol/L), 2.7(0.6) patients had LDL(mmol/L), 1.5(0.3) patients had HDL(mmol/L), 0.82(0.2) patients had ApoB(g/L), 1.4(0.2) patients had ApoA1 (g/L), 0.51(0.3) patients had ApoB/ApoA1and 0.24(0.1-0.7) patients had hs-CRP(mg/L). In Controls group, 3.5(0.5) patients had Fasting glucose(mmol/L), 2.8(LD-3.5) patients had Fasting insulin(µU/mL), 0.60(LD-0.7) patients had HOMA-IR, 5.5(0.8) patients had Cholesterol(mmol/L), 0.57(0.2) patients had Triglyceride(mmol/L), 2.9(0.7) patients had LDL(mmol/L), 1.4(0.3) patients had HDL(mmol/L), 0.71(0.2) patients had ApoB(g/L), 1.4(0.2) patients had ApoA1 (g/L), 0.57(0.1) patients had ApoB/ApoA1and 0.18(0.1-0.5) patients had hs-CRP(mg/L). CONCLUSION: Some risk factors originating from the fetal environment cannot be changed after birth, good cardiovascular health can be restored by inuencing postnatal risk factors before adulthood. There were no signicant differences in insulin, insulin resistance, hs-CRPor blood lipids between the marginally LBWchildren and controls.

scholarly journals Patterns of Cardiovascular Risk Factors in the Years Before Pregnancy in Nulliparous Women With and Without Preterm Birth and Small‐for‐Gestational‐Age Delivery

2021 ◽  
Author(s):  
Ravi Retnakaran ◽  
Baiju R. Shah
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Cardiovascular Risk ◽  
Preterm Delivery ◽  
Alanine Aminotransferase ◽  
Fasting Glucose ◽  
Glycosylated Hemoglobin ◽  
Density Lipoprotein ◽  
Nulliparous Women ◽  
Over Time

Background Women with either preterm or small‐for‐gestational‐age (SGA) delivery have an elevated lifetime risk of cardiovascular disease that has been attributed to the accrual of vascular risk factors over time. We sought to determine whether an adverse cardiovascular risk factor profile develops in the years before pregnancies complicated by preterm delivery or SGA. Methods and Results Using administrative databases, we identified all 156 278 nulliparous women in Ontario, Canada, who had singleton pregnancies between January 2011 and December 2018 and ≥2 measurements of the following analytes between January 2008 and the start of pregnancy: glycosylated hemoglobin, glucose, lipids, and alanine aminotransferase. There were 11 078 women with preterm delivery and 19 367 with SGA. The 2 most recent pregravid tests were performed at median 0.6 (interquartile range, 0.3–1.4) and 1.9 (interquartile range, 1.1–3.3) years before pregnancy, respectively. Women with preterm delivery had higher pregravid glycosylated hemoglobin, glucose, low‐density lipoprotein cholesterol, triglycerides, and alanine aminotransferase, and lower high‐density lipoprotein cholesterol, than those without preterm delivery. In contrast, women with SGA had lower pregravid fasting glucose, random glucose, and triglycerides than those without SGA. In the years before pregnancy, women with preterm delivery had higher annual increases than their peers in glycosylated hemoglobin (0.7‐times higher), triglycerides (7.9‐times higher), and alanine aminotransferase (2.2‐times higher). During this time, fasting glucose increased in women who developed preterm delivery but decreased in their peers. Conclusions An adverse cardiovascular risk factor profile evolves over time in the years before pregnancy complicated by preterm delivery, but does not necessarily precede SGA.

Skin cholesterol: test performance, evaluation of potential determinants and correlation analysis with cardiovascular risk factors and circulating markers of inflammation

VASA ◽  
2006 ◽  
Vol 35 (3) ◽  
pp. 167-173 ◽  
Author(s):  
Reiter ◽  
Wirth ◽  
Pourazim ◽  
Exner ◽  
Baghestanian ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Body Fat ◽  
Test Performance ◽  
Cardiovascular Events ◽  
Serum Lipids ◽  
Markers Of Inflammation ◽  
History Of ◽  
Hs Crp

Background: Skin cholesterol (SkC) has been suggested to be an additional risk predictor, so we evaluated the test performance, potential determinants of this marker as well as a potential correlation of SkC with markers of inflammation and the history of cardiovascular events. Patients and methods: SkC, determined by the non-invasive PREVU POC Skin Sterol test, as well as serum lipids, the body fat status, high-sensitive CRP (hs-CRP) and serum amyloid A (SAA) were evaluated in consecutive patients with and without documented atherosclerotic disease. Results: SkC was assessed in 201 patients. The within-day precision (CV) was 3.8%, the day-to-day CV of the right hand was 8.6% and 4.3% for the left hand, respectively. Neither univariate analysis nor multiple regressions identified a significant influence of age, sex, serum lipids, body fat status, smoking or diabetes mellitus on SkC, corresponding results were observed in a further analysis including 174 of these patients concerning hs-CRP and SAA (all p > 0.05). T-test analyses detected no significant differences between patients with and without a history of coronary, peripheral vascular and cerebrovascular events (all p > 0.05). Conclusions: The PREVU POC Skin Sterol test for the assessment of SkC proved an acceptable test performance. SkC is independent from serum lipids, traditional cardiovascular risk factors, two sensitive markers of systemic inflammation as well as the history of cardiovascular events indicating that the perception of this parameter as an established marker of vascular disease is premature.

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