ASSOCIATION OF CARDIOVASCULAR RISK IN CHILDREN BORN WITH LOW BIRTH WEIGHT

2021 ◽  
pp. 18-20
Author(s):  
Anand Shanker Singh ◽  
G . Radhika ◽  
R . Praveen Kumar ◽  
Ankita Singh ◽  
Debarshi Jana

INTRODUCTION: Most studies of early programming focus on very LBWor extremely LBW, even though the majority of all LBWchildren are 2 born only with marginally LBW. The pathogenesis behind CVD is multifactorial, and for health care providers to be able to assess the risk of each individual, we need to know more about this common subgroup. AIM:Being born with LBWaffects later cardiovascular risk. RESUILT: In Marginally LBW group, 4.7(0.6) patients had Fasting glucose(mmol/L), 2.7(2.3-3.8) patients had Fasting insulin(µU/mL), 0.57(0.4-0.8) patients had HOMA-IR, 4.4(0.7) patients had Cholesterol(mmol/L), 0.50(0.2) patients had Triglyceride(mmol/L), 2.7(0.6) patients had LDL(mmol/L), 1.5(0.3) patients had HDL(mmol/L), 0.82(0.2) patients had ApoB(g/L), 1.4(0.2) patients had ApoA1 (g/L), 0.51(0.3) patients had ApoB/ApoA1and 0.24(0.1-0.7) patients had hs-CRP(mg/L). In Controls group, 3.5(0.5) patients had Fasting glucose(mmol/L), 2.8(LD-3.5) patients had Fasting insulin(µU/mL), 0.60(LD-0.7) patients had HOMA-IR, 5.5(0.8) patients had Cholesterol(mmol/L), 0.57(0.2) patients had Triglyceride(mmol/L), 2.9(0.7) patients had LDL(mmol/L), 1.4(0.3) patients had HDL(mmol/L), 0.71(0.2) patients had ApoB(g/L), 1.4(0.2) patients had ApoA1 (g/L), 0.57(0.1) patients had ApoB/ApoA1and 0.18(0.1-0.5) patients had hs-CRP(mg/L). CONCLUSION: Some risk factors originating from the fetal environment cannot be changed after birth, good cardiovascular health can be restored by inuencing postnatal risk factors before adulthood. There were no signicant differences in insulin, insulin resistance, hs-CRPor blood lipids between the marginally LBWchildren and controls.

2021 ◽  
pp. 15-17
Author(s):  
Anand Shanker Singh ◽  
G . Radhika ◽  
R . Praveen Kumar ◽  
Ankita Singh ◽  
Debarshi Jana

INTRODUCTION: Children born preterm usually experience an initial growth restriction, suggested to be caused by the immature organs and an inadequate nutritional intake.After this initial growth faltering, healthy preterm born children, and especially those born after 32 gestational weeks, usually fall back to the reference growth curve, following that of term born babies. For children born SGA, 80 % will experience a relative catch-up growth within the rst 6 months of life. OBJECTIVE: Role of different risk proles for children being born preterm vs being born SGA and early iron supplementation affect later cardiovascular risk RESULT: In Placebo group, 4.6(0.5) patients had Fasting glucose (mmol/L), 2.9(2.3-3.5) patients had Fasting insulin(µU/mL), 0.59(0.4-0.7) patients had HOMA-IR, 4.5(0.7) patients had Cholesterol(mmol/L), 0.58(0.2) patients had Triglyceride(mmol/L), 2.8(0.6) patients had LDL(mmol/L), 1.5(0.3) patients had HDL(mmol/L), 0.63(0.4) patients had ApoB(g/L and 0.20(0.1-0.6) patients had hs-CRP(mg/L). In Iron supplements group, 4.4(0.5) patients had Fasting glucose(mmol/L), 2.7(2.0-3.8) patients had Fasting insulin(µU/mL), 0.54(0.4-0.8) patients had HOMA-IR, 4.3(0.8) patients had Cholesterol(mmol/L), 0.59(0.3) patients had Triglyceride(mmol/L), 2.8(0.6) patients had LDL(mmol/L), 1.5(0.4) patients had HDL(mmol/L), 0.61(0.3) patients had ApoB(g/Land 0.24(0.2-0.8) patients had hs-CRP(mg/L). CONCLUSION: This literature showing that there is progression of these risk factors as children enter early adolescence. Further longer longitudinal studies are needed to elucidate the mechanisms responsible for progression of cardio-metabolic risk factors from infancy to adolescence in SGAand LGAsubjects.


Author(s):  
Susan F. Dent ◽  
Robin Kikuchi ◽  
Lavanya Kondapalli ◽  
Roohi Ismail-Khan ◽  
Christine Brezden-Masley ◽  
...  

Advances in cancer screening and improved treatment approaches have led to an increase in survivorship and, consequently, recognition of an association between cancer treatments and the development of cardiovascular complications. In addition, as the population becomes proportionally older, comorbid cardiovascular risk factors are more prevalent in the population and compound the risk of developing cancer treatment–related cardiovascular toxicity. Cardio-oncology has emerged as a new subspecialty of medicine that provides a multidisciplinary approach, bringing together oncologists, cardiologists, and allied health care providers who are tasked with optimizing the cardiovascular health of patients exposed to potentially cardiotoxic cancer therapy. Using a case-based approach, practical advice on how to identify, monitor, and treat patients with cancer who are at risk for developing cancer treatment–related cardiovascular dysfunction is discussed. Cardiovascular risk factors (e.g., age, hypertension, diabetes) and cancer therapies (chemotherapy, targeted therapy, radiation) associated with cardiovascular toxicity are presented. Current cardiac monitoring strategies such as two- and three-dimensional echocardiography, cardiac MRI, and biomarkers (troponin and brain natriuretic peptide [BNP]) are discussed. Last, the current literature on pharmacologic (e.g., angiotensin-converting enzyme inhibitors, β-blockers, statins) and lifestyle (diet and exercise) strategies to mitigate cardiovascular toxicity during and following completion of cancer therapy are reviewed.


2011 ◽  
Vol 19 (4) ◽  
pp. 849-856 ◽  
Author(s):  
Roma Schmitz ◽  
Susanne Jordan ◽  
Stephan Müters ◽  
Hannelore Neuhauser

Background: Behavioural prevention and counselling programmes for lifestyle-related cardiovascular risk factors are widely offered. However, their population-wide use is largely unexplored, particularly in high-risk persons with known CVD or diabetes. Methods: Data were collected within GEDA 2009, a national health survey covering a representative sample of 21,262 adults in Germany. Standardised structured computer-assisted telephone interviews included self-reported physician-diagnosed coronary heart disease, myocardial infarction, heart failure, stroke, diabetes as well as height, weight, usual diet, physical activity, and the use of programmes for weight reduction, healthy diet and improvement of fitness or mobility in the last twelve months. Results: The use of prevention measures was lowest for weight reduction (men 2.1%, women 3.5%), somewhat higher for healthy diet (men 3.2%, women 4.7%), and highest for improvement of fitness or mobility (men 8.6%, women 16.1%). Among individuals with the respective risk factor, programme participation was still low: 5.5% in obese men (women 7.2%) for weight reduction, 2.8% in men (women 3.7%) who did not eat fruit or vegetables daily for healthy diet, and 7.9% in physically inactive men (women 15.7%) for improvement of fitness or mobility. In the presence of known CVD or diabetes, participation increased inconsistently and only moderately. Conclusion: Our results show low participation in behavioural prevention measures for lifestyle-related risk factors even in individuals with known CVD or diabetes. Further studies should investigate knowledge about potential programme benefit, availability and reimbursement in both patients and health care providers.


1994 ◽  
Vol 72 (01) ◽  
pp. 058-064 ◽  
Author(s):  
Goya Wannamethee ◽  
A Gerald Shaper

SummaryThe relationship between haematocrit and cardiovascular risk factors, particularly blood pressure and blood lipids, has been examined in detail in a large prospective study of 7735 middle-aged men drawn from general practices in 24 British towns. The analyses are restricted to the 5494 men free of any evidence of ischaemic heart disease at screening.Smoking, body mass index, physical activity, alcohol intake and lung function (FEV1) were factors strongly associated with haematocrit levels independent of each other. Age showed a significant but small independent association with haematocrit. Non-manual workers had slightly higher haematocrit levels than manual workers; this difference increased considerably and became significant after adjustment for the other risk factors. Diabetics showed significantly lower levels of haematocrit than non-diabetics. In the univariate analysis, haematocrit was significantly associated with total serum protein (r = 0*18), cholesterol (r = 0.16), triglyceride (r = 0.15), diastolic blood pressure (r = 0.17) and heart rate (r = 0.14); all at p <0.0001. A weaker but significant association was seen with systolic blood pressure (r = 0.09, p <0.001). These relationships remained significant even after adjustment for age, smoking, body mass index, physical activity, alcohol intake, lung function, presence of diabetes, social class and for each of the other biological variables; the relationship with systolic blood pressure was considerably weakened. No association was seen with blood glucose and HDL-cholesterol. This study has shown significant associations between several lifestyle characteristics and the haematocrit and supports the findings of a significant relationship between the haematocrit and blood lipids and blood pressure. It emphasises the role of the haematocrit in assessing the risk of ischaemic heart disease and stroke in individuals, and the need to take haematocrit levels into account in determining the importance of other cardiovascular risk factors.


2021 ◽  
Vol 2 ◽  
Author(s):  
N. Haroon ◽  
S. S. Owais ◽  
A. S. Khan ◽  
J. Amin

Summary COVID-19 has challenged the mental health of healthcare workers confronting it world-wide. Our study identifies the prevalence and risk of anxiety among emergency healthcare workers confronting COVID-19 in Pakistan. We conducted a cross-sectional survey in an Emergency Department using the Generalized Anxiety Scale (GAD-7), and questions about sources of anxiety. Of 107 participants, 61.7% were frontline workers. The prevalence of anxiety was 50.5%. Nonparametric tests determined that nurses, younger and inexperienced staff, developed significant anxiety. Multivariate ordinal regression determined independent risk factors for developing anxiety were younger age (OR 2.11, 95% CI 0.89–4.99) and frontline placement (OR 1.34, 95% CI 0.33–1.66). Significant sources of stress were fear of infecting family (P = 0.003), lack of social support when the health care providers were themselves unwell (P = 0.02) and feelings of inadequate work performance (P = 0.05). Our study finds that HCWs’ anxiety is considerable. Appropriate measures for its alleviation and prevention are required.


2021 ◽  
Vol 12 ◽  
pp. 215013272199219
Author(s):  
Danielle J. O’Laughlin ◽  
Brittany Strelow ◽  
Nicole Fellows ◽  
Elizabeth Kelsey ◽  
Sonya Peters ◽  
...  

To review the anxiety and fear risk factors, pathophysiology, symptoms, screening and diagnosis while highlighting treatment considerations for women undergoing a pelvic examination. Methods: We reviewed the literature pertaining to anxiety and fear surrounding the pelvic examination to help guide health care providers’ on available screening options and to review options for individualized patient management. Results: Anxiety and fear are common before and during the pelvic examination. In fact, the pelvic exam is one of the most common anxiety-provoking medical procedures. This exam can provoke negative physical and emotional symptoms such as pain, discomfort, anxiety, fear, embarrassment, and irritability. These negative symptoms can interfere with preventative health screening compliance resulting in delayed or avoided care and significant health consequences. Conclusion: Assessing women for anxiety related to pelvic examinations may help decrease a delay or avoidance of examinations. Risk factor and symptom identification is also a key component in this. General anxiety questionnaires can help identify women with anxiety related to pelvic examinations. Strategies to reduce anxiety, fear and pain during a pelvic examination should routinely be implemented, particularly in women with high-risk factors or those identified with screening techniques as having anxiety, fear or pain with examinations. Treatment options should be targeted at understanding the patient’s concerns, starting conversations about pelvic examinations early, educating patient’s about the examination and offering the presence of a chaperone or support person. During an examination providers should ensure the patient is comfortable, negative phrases are avoided, the correct speculum size is utilized and proper lubrication, draping, dressing and positioning are performed. Treating underlying gynecologic or mental health conditions, consideration of cognitive behavioral therapy and complementary techniques such as lavender aromatherapy and music therapy should also be considered when appropriate.


2011 ◽  
Vol 17 (3) ◽  
pp. 233 ◽  
Author(s):  
Anthea Worley ◽  
Karen Grimmer-Somers

Glaucoma is an insidious eye disease, potentially putting 4% of older Australians at risk of blindness, unless detected sufficiently early for initiation of effective treatment. This paper reports on the strengths of evidence and glaucoma risk factors that can be identified by primary health care providers from a patient’s history. A comprehensive search of peer-reviewed databases identified relevant secondary evidence published between 2002 and 2007. Risk factors that could be determined from a patient’s history were identified. A novel glaucoma risk factor reference guide was constructed according to evidence strength and level of concern regarding risk of developing glaucoma. The evidence is strong and consistent regarding the risk of developing glaucoma, and elevated intraocular pressure, advancing age, non-Caucasian ethnicity and family history of glaucoma. There is moderate evidence of association with glaucoma, and migraine, eye injury, myopia and long-term use of corticosteroids. There is conflicting evidence for living in a rural location, high blood pressure, diabetes and smoking. Early detection of people at risk of developing glaucoma can be initiated using our risk factor guide coupled with a comprehensive patient history. Timely future assessment and subsequent management strategies for at-risk individuals can then be effectively and efficiently actioned.


2005 ◽  
Vol 20 (2) ◽  
pp. 66-69
Author(s):  
William J Dawson

The playing of many musical instruments is performed principally by the small intrinsic muscles of the hands. Practice records were reviewed to investigate the epidemiology, etiology, and risk factors for intrinsic muscle strain. Fifty-one instrumentalists were found, out of 129 having strains of all hand and forearm muscles. These 51 comprised 15.5% of all 329 musicians seen for overuse-related conditions. The patient ages ranged from 10 to 72 years; 20 were male. Forty-one of the 51 played keyboard or stringed instruments; 11 of the 19 stringed instruments were bowed. Twenty-one patients were professionals or university/conservatory music students. Sixty percent of strains were caused by playing music, with slightly more than half being in the professional/collegiate cohort. Pianists were more likely to experience right hand involvement. Seven patients had bilateral intrinsic strains. Thirteen experienced concomitant strains of the extrinsic forearm muscles, either on the same side or bilaterally with bilateral intrinsic strains. Treatment followed standard principles, with hand rest prescribed in 12, musical practice changes in 19, activity modification in 30, and formal exercises/hand therapy in 23. Nonsteroidal medication was prescribed in 17 cases. The data suggest that intrinsic muscle strains related to overuse follow the same etiologic and anatomic patterns as other upper extremity muscle strain and pain syndromes and have the same risk factors. Health care providers should be aware of the role of the hand intrinsic muscles in playing musical instruments and their propensity for overuse-related strain syndromes from both musical and nonmusical activities.


2018 ◽  
Vol 34 (2) ◽  
pp. 118-123 ◽  
Author(s):  
Tracy Wharton ◽  
Daniel Paulson ◽  
Kimberly Burcher ◽  
Heather Lesch

For individuals with dementia, disorientation and both external and internal stimuli may trigger behaviors that are difficult to manage or dangerous to health-care providers. Identification of correlational risk factors to aggressive behavior in patients who are unknown to the hospital can allow providers to adapt patient care quickly. Records for patients aged 60+ who spent at least 24 hours at the hospital other than in the psychiatric unit were used (N = 14 080). The first 4000 records and every 10th person who met criteria (N = 5008) were searched for documentation of dementia (n = 505). Logistic regressions and χ2 tests were used to examine relationships between variables. Recognition of delirium ( P = .014, Exp(B) = 2.53), coupled with an existing prescription for antipsychotic medication at intake ( P < .001, Exp(B) < 4.37), may be a reliable means of screening for risk and intervening at the earliest possible contact, improving quality of care and safety in acute care for individuals with dementia.


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