CORRELATION BETWEEN CT CHEST SEVERITY SCORE AND CLINICAL PARAMETERS AND BIOCHEMICAL MARKERS IN COVID 19 PATIENTS

2021 ◽  
pp. 25-28
Author(s):  
Pramodh Kumar ◽  
Konduru Aneesha ◽  
Ch. Radhika ◽  
Elaya Kumar ◽  
R. Srinivasan
Keyword(s):  
Severity Score ◽  
Biochemical Markers ◽  
Tamil Nadu ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Parameters ◽  
Care Hospital ◽  
Rt Pcr ◽  
The Relationship ◽  
D Dimer

AIM: To correlate between CT chest severity score in COVID 19 patients with Clinical [SpO2, RR, PaO2/FiO2] and Biochemical parameters [NLR ratio, CRP, D- Dimer values]. METHODS: A Retrospective, observational study was conducted in a tertiary care hospital in Kanchipuram, Tamil Nadu. 110 patients were admitted to the hospital with COVID 19 [RT PCR swab for COVID 19 positive and radiologically positive] between March 2021 to June 2021. The patient was clinically, radiologically, and biochemically evaluated. CT chest severity score was used to differentiate the patients into mild, moderate, and severe groups. The relationship between CT Severity score and Clinical parameters such as SpO2, RR, PaO2/FiO2 and Biochemical markers [ NLR ratio, CRP, D-Dimer] were studied. RESULTS: CT chest severity score was found to be positively correlated with decreased SpO2 levels, decreased PaO2/ FiO2, increased RR and elevated NLR ratio, D Dimer and CRP levels(P < 0.001). CONCLUSION: The 25 CT Severity score scores well with the Clinical parameters and biochemical markers. Our data suggest that CT Chest Severity Score correlates well with clinical parameters and biochemical markers.

scholarly journals Prognostic significance of various biochemical markers in Corona virus disease (COVID)-19: A tertiary care hospital study in Kakinada East Godavari district, Andhra Pradesh

2021 ◽  
Vol 8 (3) ◽  
pp. 226-229
Author(s):  
G Rajeswari ◽  
P Satya Gopal ◽  
G.B.V.V.S.V Prasad
Keyword(s):  
Biochemical Markers ◽  
Inflammatory Markers ◽  
Andhra Pradesh ◽  
Liver Enzymes ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Markers Of Inflammation ◽  
The Relationship ◽  
D Dimer

This study was conducted on covid 19 patients who admitted in various wards in tertiary care centre (Government general hospital, Kakinada) E.G, Dt, Andhra Pradesh, from the 1st November 2020 to 15th January 2021 before Immunization. And divided in to two groups male and female cases. This study involves estimation of Biochemical profile in all the admitted patients to predict the severity of the covid 19 disease at the time of admission in to the Hospital. To analyse and estimate the serum inflammatory markers like D dimer, Ferritin, C-Reactive Protein, LFT and RFT in Covid 19 patients and evaluate the relationship of inflammatory marker se D-Dimer with other inflammatory markers like Ferritin, CRP and biochemical markers like Creatinine and liver enzymes (OT, PT). We retrospectively analysed the Clinical features and lab parameters of 393 cases of Covid-19 admitted to tertiary care hospital GGH Kakinada. Plasma d dimer, serum CRP and ferritin were significantly raised in total covid 19 patients and more increased in males when compared with females. Biochemical parameters like creatinine and liver enzymes also elevated in total cases and more increased in males as compared with females suggest organ dysfunction and systemic inflammation. The most typical finding in patients with COVID-19 coagulopathy is an increased D dimer concentration, and the relationship between D-dimer levels and the other markers of inflammation like Ferritin, CRP in COVID-19 shows disease progression. We conclude that biochemical monitoring of Covid-19 patients helps in identifying critically ill patients even earlier, aiming to reduce mortality and improve the recovery rate.

scholarly journals Prevalence and characteristics of venous thromboembolism in severe exacerbation of chronic obstructive pulmonary disease in a tertiary care hospital in India

2021 ◽  
Author(s):  
Soibam Pahel Meitei ◽  
Sudheer Tale ◽  
Arjun Kumar Negi ◽  
Ruchi Dua ◽  
Rohit Walia ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Venous Thromboembolism ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Lower Limbs ◽  
Chronic Obstructive ◽  
Care Hospital ◽  
Obstructive Pulmonary Disease ◽  
Test Probability ◽  
D Dimer

Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) carries a high risk of venous thromboembolism (VTE). Pulmonary embolism (PE) and AECOPD increase the mortality and morbidity risk associated with each other. Racial and ethnic differences in VTE risk have been documented in multiple studies. However, there is a dearth of reliable Indian data on the same. This study was planned to find the prevalence of VTE in the setting of severe AECOPD in a tertiary care hospital in India and to identify the clinical, laboratory and radiological characteristics of VTE in severe AECOPD. A total of 156 consecutive patients admitted with severe AECOPD and meeting the specified inclusion and exclusion criteria were recruited. Thorough workup of all patients was done including ABG, serum D dimer, ECG, compression ultrasound of lower limbs and 2-D echocardiography. Patients with high pre-test probability score, or intermediate pre-test probability score at presentation with serum D dimer above the age adjusted cut-off underwent computerised tomography pulmonary angiography (CTPA).  Results were analysed using SPSS version 23.  Sixteen (10.3%) patients had VTE, 15 (93.75%) of them being cases of isolated PE. Female gender, higher cumulative past exposure to corticosteroid, higher alveolar-arterial gradient, right ventricular dysfunction, and higher mean pulmonary artery pressure were associated with increased risk for VTE. The prevalence of VTE in AECOPD in this study among an Indian population is higher than among other Asians, but lower than among the Blacks, the Caucasians and the Middle-East ethnicities. Since a vast majority of VTE presents as PE without DVT in the setting of AECOPD, the absence of deep vein thrombosis of lower limbs does not rule PE in the setting.

scholarly journals A Comparative study of RT-PCR and TRUENAT BETA-CoV TEST in a tertiary care hospital

2021 ◽  
Vol 39 ◽  
pp. S57
Author(s):  
Sandhya rani Pagidirai ◽  
A. Renuka Devi ◽  
A. Surekha ◽  
Shanthi Reddy
Keyword(s):  
Comparative Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital ◽  
Rt Pcr

scholarly journals Lung cancer profile at tertiary care hospital, South Tamil Nadu

2019 ◽  
Vol 4 (4) ◽  
pp. 245-251
Author(s):  
Prem Ananth P ◽  
◽  
R Gnanasekaran ◽  
N Nagarajan ◽  
Deiveegan ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tamil Nadu ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

scholarly journals OBSERVATIONAL STUDY ON POISON CASES IN A TERTIARY CARE HOSPITAL

2019 ◽  
pp. 80-83
Author(s):  
RAMYA A. ◽  
ANDHUVAN G. ◽  
RAGHUPATHI V.
Keyword(s):  
Social Sciences ◽  
Statistical Analysis ◽  
Observational Study ◽  
Severity Score ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Food Poisoning ◽  
Common Type ◽  
Cow Dung ◽  
Care Hospital

Objective: To evaluate the prevalence, pattern, and cause of poisoning. To characterize the poisoning cases admitted in a tertiary care hospital; followed by the outcome and to observe the antidote given for the poison cases. Methods: This observational study was undertaken in emergency departments (EMD) and Medical Record Department (MRD). Totally 557 poison cases was recruited in this study. Grade of poison was assessed by using poison severity score. Statistical analysis was done by using Statistical Package for Social Sciences (SPSS). Results: A total of 557 poison cases were identified in 2, 39, 828 patients out of which 360(64%) were suicidal and 189(34) cases admitted were accidental. The patients who were admitted between 2-5 h after exposed to poison were found to be more followed by 0-1 hr,>1-2 h,>6-24 h,>24 h and>5-6 h. More number of cases were seen in the others (Synthetic cow dung powder and medicine) type of poison 296(53%) followed by household poisoning 93(17%), bites 86 (15%), insecticide poisoning 64(12%) and food poisoning 16(3%). Activated charcoal was the maximum used antidote. Conclusion: Through this study, it was found that suicidal poisoning was the most common type.

scholarly journals Cross sectional study on different doses of acenocoumarol with INR in a tertiary care hospital

2018 ◽  
Vol 7 (9) ◽  
pp. 1738
Author(s):  
Keerthi E. ◽  
Bhuvaneshwari S. ◽  
Periyanarkunan Ramaiya Murugesan ◽  
Priyadharshini T. ◽  
Sri Subiksha P.
Keyword(s):  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Cross Sectional Study ◽  
Individual Variability ◽  
Care Hospital ◽  
Simple Linear Regression ◽  
Cross Sectional ◽  
Narrow Therapeutic Range ◽  
The Relationship ◽  
Different Doses

Background: It is of high value to be assess the relationship between doses of Acenocoumarol and the INR values to offer better patient care. Since Acenocoumarol is a commonly used drug with a narrow therapeutic range it is essential to monitor the variations encountered in response to it to avoid drastic complications and to provide better health care. Aim: The aim of this study is to compare the INR values with different doses of Acenocoumarol, to compare the association of dose of Acenocoumarol with their respective INR and to find out the occurrence of bleeding with different doses of Acenocoumarol.Methods: The study was conducted in a Tertiary care hospital. 40 patients taking Acenocoumarol were recruited in the study. Relevant details like age, weight, dose of Acenocoumarol, INR and other concomitant drugs were obtained in a prospective manner. Correlation of dose of Acenocoumarol with respective INR was done by simple linear regression.Results: The relationship between dose and INR was analyzed using Simple linear regression and the scatter plot revealed no significant correlation between the dose and INR values. There is a lot of inter-individual variability in the dose response and thereafter the INR values.Conclusions: The dose of Acenocoumarol cannot predict INR values. Patient can ideally be started treatment on a low dose of Acenocoumarol and based on the INR values, dose can be titrated. There is a need for consideration of other factors which influence the dose and INR values. 

scholarly journals Vertical transmission and clinical outcome of the neonates born to SARS-CoV-2-positive mothers: a tertiary care hospital-based observational study

2021 ◽  
Vol 5 (1) ◽  
pp. e001193
Author(s):  
Pradeep Kumar ◽  
Fadila ◽  
Arun Prasad ◽  
Ambrin Akhtar ◽  
Bhabesh Kant Chaudhary ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Observational Study ◽  
Vertical Transmission ◽  
Prospective Observational Study ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Stable Condition ◽  
Nasopharyngeal Swab ◽  
Care Hospital ◽  
Rt Pcr

BackgroundNeonatal transmission of SARS-CoV-2 from positive mothers to their babies has been a real concern, opening the arena of research in this area.ObjectiveTo detect the possibility of vertical transmission of SARS-CoV-2 from COVID-19-positive mothers to their neonates and the clinicopathological outcome in them.DesignA single-centre, prospective, observational study involving 47 COVID-19-positive mothers and their neonates.SettingA tertiary care hospital in Eastern India.ParticipantsNeonates born to SARS-CoV-2-infected mothers.Main outcome measuresWe investigated the SARS-CoV-2 positivity rate by real-time reverse transcriptase-PCR (RT-PCR) done twice (on admission and after 24 hours of admission) in neonates born to SARS-CoV-2-positive mothers, who tested RT-PCR positive for this virus in their nasopharyngeal swab. Clinical outcome was also assessed in these neonates during their hospital stay.ResultsOut of 47 neonates born to SARS-CoV-2-positive mothers, four were SARS-CoV-2 positive by RT-PCR. All the neonates in our study were discharged home in stable condition after management of acute complications. None of them required readmission.ConclusionVertical transmission occurs in neonates born to COVID-19-positive mothers; however, the risk is small. Majority of the neonates remain asymptomatic with good clinical outcome.

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