Finding COVID-19 from Chest X-rays using Deep Learning on a Small Dataset

The trending global pandemic of COVID-19 is the fastest ever impact which caused people worldwide by severe acute respiratory syndrome~(SARS)-driven coronavirus. However, several countries suffer from the shortage of test kits and high false negative rate in PCR test. Enhancing the chest X-ray or CT detection rate becomes critical. The patient triage is of utmost importance and the use of machine learning can drive the diagnosis of chest X-ray or CT image by identifying COVID-19 cases. To tackle this problem, we propose~COVIDPEN~-~a transfer learning approach on Pruned EfficientNet-based model for the detection of COVID-19 cases. The proposed model is further interpolated by post-hoc analysis for the explainability of the predictions. The effectiveness of our proposed model is demonstrated on two systematic datasets of chest radiographs and computed tomography scans. Experimental results with several baseline comparisons show that our method is on par and confers clinically explicable instances, which are meant for healthcare providers.

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Finding COVID-19 from Chest X-rays using Deep Learning on a Small Dataset

10.36227/techrxiv.12083964.v1 ◽

2020 ◽

Cited By ~ 2

Author(s):

Lawrence Hall ◽

Dmitry Goldgof ◽

Rahul Paul ◽

Gregory M. Goldgof

Keyword(s):

False Negative ◽

False Negative Rate ◽

Disease Process ◽

Small Data ◽

X Rays ◽

Data Set ◽

X Ray ◽

Set Size ◽

Lack Of Information ◽

Chest X Ray

<p>Testing for COVID-19 has been unable to keep up with the demand. Further, the false negative rate is projected to be as high as 30% and test results can take some time to obtain. X-ray machines are widely available and provide images for diagnosis quickly. This paper explores how useful chest X-ray images can be in diagnosing COVID-19 disease. We have obtained 122 chest X-rays of COVID-19 and over 4,000 chest X-rays of viral and bacterial pneumonia. A pre-trained deep convolutional neural network has been tuned on 102 COVID-19 cases and 102 other pneumonia cases in a 10-fold cross validation. The results were all 102 COVID-19 cases were correctly classified and there were 8 false positives resulting in an AUC of 0.997. On a test set of 20 unseen COVID-19 cases all were correctly classified and more than 95% of 4,171 other pneumonia examples were correctly classified. This study has flaws, most critically a lack of information about where in the disease process the COVID-19 cases were and the small data set size. More COVID-19 case images will enable a better answer to the question of how useful chest X-rays can be for diagnosing COVID-19 (so please send them). </p>

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Detection of Tuberculosis in Chest X-rays using U-Net Architecture

International Journal of Innovative Technology and Exploring Engineering - Special Issue ◽

10.35940/ijitee.a4834.119119 ◽

2019 ◽

Vol 9 (1) ◽

pp. 2514-2519

Keyword(s):

Deep Learning ◽

False Negative ◽

Learning System ◽

X Rays ◽

X Ray ◽

Intelligence System ◽

Chest X Ray ◽

Learning Architectures ◽

Aided Diagnosis ◽

Negative Detection

x-rays are the most commonly performed which are costly diagnostic imaging tests ordered by physicians. Here we are proposing an artificial intelligence system that can reliably separate normal from abnormal would be invaluable in addressing the problem of undiagnosed disease and the lack of radiologists in low-resource settings. The aim of this study is to develop and validate a deep learning system to detect chest x-ray abnormalities and hence detect Tuberculosis (TB) and to provide a tool for Computer Aided Diagnosis (CAD).In this paper by trying to explore existing systems of Image Processing and Deep learning architectures, we are trying to achieve radiologist level detection as well as lower False Negative detection of TB by using ensemble datasets and algorithms. The prototype of a WebApp is created and can be checked on https://parth-patel12.github.io where one can upload the chest x-ray which give probabilities of the chest x-ray to be normal or TB affected.

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Accessory pathway analysis using a multimodal deep learning model

Scientific Reports ◽

10.1038/s41598-021-87631-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Makoto Nishimori ◽

Kunihiko Kiuchi ◽

Kunihiro Nishimura ◽

Kengo Kusano ◽

Akihiro Yoshida ◽

...

Keyword(s):

Deep Learning ◽

Electrophysiological Study ◽

Accessory Pathway ◽

Learning Model ◽

X Rays ◽

X Ray ◽

Wpw Syndrome ◽

Chest X Ray ◽

Deep Learning Model ◽

Ecg Data

AbstractCardiac accessory pathways (APs) in Wolff–Parkinson–White (WPW) syndrome are conventionally diagnosed with decision tree algorithms; however, there are problems with clinical usage. We assessed the efficacy of the artificial intelligence model using electrocardiography (ECG) and chest X-rays to identify the location of APs. We retrospectively used ECG and chest X-rays to analyse 206 patients with WPW syndrome. Each AP location was defined by an electrophysiological study and divided into four classifications. We developed a deep learning model to classify AP locations and compared the accuracy with that of conventional algorithms. Moreover, 1519 chest X-ray samples from other datasets were used for prior learning, and the combined chest X-ray image and ECG data were put into the previous model to evaluate whether the accuracy improved. The convolutional neural network (CNN) model using ECG data was significantly more accurate than the conventional tree algorithm. In the multimodal model, which implemented input from the combined ECG and chest X-ray data, the accuracy was significantly improved. Deep learning with a combination of ECG and chest X-ray data could effectively identify the AP location, which may be a novel deep learning model for a multimodal model.

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A Deep-Learning-Based Framework for Automated Diagnosis of COVID-19 Using X-ray Images

Information ◽

10.3390/info11090419 ◽

2020 ◽

Vol 11 (9) ◽

pp. 419 ◽

Cited By ~ 1

Author(s):

Irfan Ullah Khan ◽

Nida Aslam

Keyword(s):

Deep Learning ◽

False Negative ◽

False Negative Rate ◽

Complex Nature ◽

Learning Models ◽

Daily Lives ◽

X Ray ◽

High False Negative Rate ◽

Diagnosis Method ◽

Novel Coronavirus

The emergence and outbreak of the novel coronavirus (COVID-19) had a devasting effect on global health, the economy, and individuals’ daily lives. Timely diagnosis of COVID-19 is a crucial task, as it reduces the risk of pandemic spread, and early treatment will save patients’ life. Due to the time-consuming, complex nature, and high false-negative rate of the gold-standard RT-PCR test used for the diagnosis of COVID-19, the need for an additional diagnosis method has increased. Studies have proved the significance of X-ray images for the diagnosis of COVID-19. The dissemination of deep-learning techniques on X-ray images can automate the diagnosis process and serve as an assistive tool for radiologists. In this study, we used four deep-learning models—DenseNet121, ResNet50, VGG16, and VGG19—using the transfer-learning concept for the diagnosis of X-ray images as COVID-19 or normal. In the proposed study, VGG16 and VGG19 outperformed the other two deep-learning models. The study achieved an overall classification accuracy of 99.3%.

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Detecting Coronavirus from Chest X-rays Using Transfer Learning

COVID ◽

10.3390/covid1010034 ◽

2021 ◽

Vol 1 (1) ◽

pp. 403-415

Author(s):

Abeer Badawi ◽

Khalid Elgazzar

Keyword(s):

Deep Learning ◽

Binary Classification ◽

Healthcare Providers ◽

Large Set ◽

X Rays ◽

Learning Models ◽

X Ray ◽

Chest X Ray ◽

Multi Class Classification ◽

Novel Coronavirus

Coronavirus disease (COVID-19) is an illness caused by a novel coronavirus family. One of the practical examinations for COVID-19 is chest radiography. COVID-19 infected patients show abnormalities in chest X-ray images. However, examining the chest X-rays requires a specialist with high experience. Hence, using deep learning techniques in detecting abnormalities in the X-ray images is presented commonly as a potential solution to help diagnose the disease. Numerous research has been reported on COVID-19 chest X-ray classification, but most of the previous studies have been conducted on a small set of COVID-19 X-ray images, which created an imbalanced dataset and affected the performance of the deep learning models. In this paper, we propose several image processing techniques to augment COVID-19 X-ray images to generate a large and diverse dataset to boost the performance of deep learning algorithms in detecting the virus from chest X-rays. We also propose innovative and robust deep learning models, based on DenseNet201, VGG16, and VGG19, to detect COVID-19 from a large set of chest X-ray images. A performance evaluation shows that the proposed models outperform all existing techniques to date. Our models achieved 99.62% on the binary classification and 95.48% on the multi-class classification. Based on these findings, we provide a pathway for researchers to develop enhanced models with a balanced dataset that includes the highest available COVID-19 chest X-ray images. This work is of high interest to healthcare providers, as it helps to better diagnose COVID-19 from chest X-rays in less time with higher accuracy.

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An Effective Convolutional Neural Network Model for the Early Detection of COVID-19 Using Chest X-ray Images

Applied Sciences ◽

10.3390/app112110301 ◽

2021 ◽

Vol 11 (21) ◽

pp. 10301

Author(s):

Muhammad Shoaib Farooq ◽

Attique Ur Rehman ◽

Muhammad Idrees ◽

Muhammad Ahsan Raza ◽

Jehad Ali ◽

...

Keyword(s):

Neural Network ◽

Deep Learning ◽

Convolutional Neural Network ◽

Real World ◽

Early Stage ◽

Binary Classification ◽

X Rays ◽

X Ray ◽

Proposed Model ◽

Chest X Ray

COVID-19 has been difficult to diagnose and treat at an early stage all over the world. The numbers of patients showing symptoms for COVID-19 have caused medical facilities at hospitals to become unavailable or overcrowded, which is a major challenge. Studies have recently allowed us to determine that COVID-19 can be diagnosed with the aid of chest X-ray images. To combat the COVID-19 outbreak, developing a deep learning (DL) based model for automated COVID-19 diagnosis on chest X-ray is beneficial. In this research, we have proposed a customized convolutional neural network (CNN) model to detect COVID-19 from chest X-ray images. The model is based on nine layers which uses a binary classification method to differentiate between COVID-19 and normal chest X-rays. It provides COVID-19 detection early so the patients can be admitted in a timely fashion. The proposed model was trained and tested on two publicly available datasets. Cross-dataset studies are used to assess the robustness in a real-world context. Six hundred X-ray images were used for training and two hundred X-rays were used for validation of the model. The X-ray images of the dataset were preprocessed to improve the results and visualized for better analysis. The developed algorithm reached 98% precision, recall and f1-score. The cross-dataset studies also demonstrate the resilience of deep learning algorithms in a real-world context with 98.5 percent accuracy. Furthermore, a comparison table was created which shows that our proposed model outperforms other relative models in terms of accuracy. The quick and high-performance of our proposed DL-based customized model identifies COVID-19 patients quickly, which is helpful in controlling the COVID-19 outbreak.

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Deep-learning convolutional neural networks with transfer learning accurately classify COVID-19 lung infection on portable chest radiographs

PeerJ ◽

10.7717/peerj.10309 ◽

2020 ◽

Vol 8 ◽

pp. e10309

Author(s):

Shreeja Kikkisetti ◽

Jocelyn Zhu ◽

Beiyi Shen ◽

Haifang Li ◽

Tim Q. Duong

Keyword(s):

Deep Learning ◽

Transfer Learning ◽

Bacterial Pneumonia ◽

Lung Infection ◽

Accurate Diagnosis ◽

Viral Pneumonia ◽

X Ray ◽

Portable Chest ◽

Chest X Ray ◽

Lung Infections

Portable chest X-ray (pCXR) has become an indispensable tool in the management of Coronavirus Disease 2019 (COVID-19) lung infection. This study employed deep-learning convolutional neural networks to classify COVID-19 lung infections on pCXR from normal and related lung infections to potentially enable more timely and accurate diagnosis. This retrospect study employed deep-learning convolutional neural network (CNN) with transfer learning to classify based on pCXRs COVID-19 pneumonia (N = 455) on pCXR from normal (N = 532), bacterial pneumonia (N = 492), and non-COVID viral pneumonia (N = 552). The data was randomly split into 75% training and 25% testing, randomly. A five-fold cross-validation was used for the testing set separately. Performance was evaluated using receiver-operating curve analysis. Comparison was made with CNN operated on the whole pCXR and segmented lungs. CNN accurately classified COVID-19 pCXR from those of normal, bacterial pneumonia, and non-COVID-19 viral pneumonia patients in a multiclass model. The overall sensitivity, specificity, accuracy, and AUC were 0.79, 0.93, and 0.79, 0.85 respectively (whole pCXR), and were 0.91, 0.93, 0.88, and 0.89 (CXR of segmented lung). The performance was generally better using segmented lungs. Heatmaps showed that CNN accurately localized areas of hazy appearance, ground glass opacity and/or consolidation on the pCXR. Deep-learning convolutional neural network with transfer learning accurately classifies COVID-19 on portable chest X-ray against normal, bacterial pneumonia or non-COVID viral pneumonia. This approach has the potential to help radiologists and frontline physicians by providing more timely and accurate diagnosis.

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COVIDScreen: Explainable deep learning framework for differential diagnosis of COVID-19 using chest X-Rays

10.21203/rs.3.rs-61891/v1 ◽

2020 ◽

Cited By ~ 1

Author(s):

Rajeev Kumar Singh ◽

Rohan Pandey ◽

Rishie Nandhan Babu

Keyword(s):

Deep Learning ◽

Model Performance ◽

Alternative Methods ◽

Model Complexity ◽

X Rays ◽

Kappa Score ◽

X Ray ◽

Pruning Strategy ◽

Chest X Ray ◽

To Come

Abstract COVID-19 has emerged as a global crisis with unprecedented socio-economic challenges, jeopardizing our lives and livelihoods for years to come. The unavailability of vaccines for COVID-19 has rendered rapid testing of the population instrumental in order to contain the exponential rise in cases of infection. Shortage of RT-PCR test kits and delay in obtaining test results calls for alternative methods of rapid and reliable diagnosis. In this article, we propose a novel Deep Learning based solution to rapidly classify COVID -19 patient using chest X-Ray. The proposed solution uses image enhancement, image segmentation and employs a modified stacked ensemble model consisting of four CNN base-learners along with Naive Bayes as meta-learner to classify Chest X-Ray into three classes viz. COVID-19, Pneumonia and Normal. An effective pruning strategy as introduced in the proposed framework results in increased model performance, generalisability, and decreased model complexity. We incorporate explainability in our article by using Grad-CAM visualisation in order to establish trust in the medical AI system. Furthermore, we evaluate multiple state of the art GAN architectures and their ability to generate realistic synthetic samples of COVID-19 chest X-Rays to deal with limited numbers of training samples. The proposed solution significantly outperforms existing methods, with 98.67\% accuracy, 0.98 Kappa score, and F-1 scores of 100, 98, and 98 for COVID-19, Normal, and Pneumonia classes respectively on standard datasets. The proposed solution can be used as one element of patient evaluation along with gold standard clinical and laboratory testing.

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An Exploration into the Detection of COVID-19 from Chest X-ray Scans Using the xRGM-NET Convolutional Neural Network

Technologies ◽

10.3390/technologies9040098 ◽

2021 ◽

Vol 9 (4) ◽

pp. 98

Author(s):

Gabriel Ackall ◽

Mohammed Elmzoudi ◽

Richard Yuan ◽

Cuixian Chen

Keyword(s):

Neural Network ◽

High School Students ◽

Convolutional Neural Network ◽

Rural Areas ◽

False Negative ◽

False Negative Rate ◽

Mapping Technique ◽

X Rays ◽

School Students ◽

X Ray

COVID-19 has spread rapidly across the world since late 2019. As of December, 2021, there are over 250 million documented COVID-19 cases and over 5 million deaths worldwide, which have caused businesses, schools, and government operations to shut down. The most common method of detecting COVID-19 is the RT-PCR swab test, which suffers from a high false-negative rate and a very slow turnaround for results, often up to two weeks. Because of this, specialists often manually review X-ray images of the lungs to detect the presence of COVID-19 with up to 97% accuracy. Neural network algorithms greatly accelerate this review process, analyzing hundreds of X-rays in seconds. Using the Cohen COVID-19 X-ray Database and the NIH ChestX-ray8 Database, we trained and constructed the xRGM-NET convolutional neural network (CNN) to detect COVID-19 in X-ray scans of the lungs. To further aid medical professionals in the manual review of X-rays, we implemented the CNN activation mapping technique Score-CAM, which generates a heat map over an X-ray to illustrate which areas in the scan are most influential over the ultimate diagnosis. xRGM-NET achieved an overall classification accuracy of 97% with a sensitivity of 94% and specificity of 97%. Lightweight models like xRGM-NET can serve to improve the efficiency and accuracy of COVID-19 detection in developing countries or rural areas. In this paper, we report on our model and methods that were developed as part of a STEM enrichment summer program for high school students. We hope that our model and methods will allow other researchers to create lightweight and accurate models as more COVID-19 X-ray scans become available.

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