Assessment of Vitamin D Levels in Patients with Acute Coronary Syndrome and Its Risk Factors

Aim. To assess vitamin D level in patients with acute coronary syndrome and to determine the relationships of vitamin D level with specific patterns of cardiovascular disease in this group of patients.Methods. 50 patients (35 (70%) males and 15 (30%) females) urgently admitted to the emergency cardiology department of Kaliningrad Regional Hospital were enrolled in the cross-sectional observational study. Patients with diabetes mellitus, autoimmune diseases and cancer were excluded from the study. The mean age of patients was 60 (55; 66) years. Cardiovascular risk factors (obesity, smoking, physical activity, alcohol consumption, genetic predisposition) were assessed in all patients. Total serum cholesterol levels, GFR (CKD-EPI) and troponin levels were measured in all participants. Echocardiography included the measurement of the left ventricular mass index. Coronary angiography with omnipaque contrast was performed in all cases. 25-OH vitamin D was measured with enzyme-linked immunosorbent assay (ELISA).Results. The majority of patients with acute coronary syndrome had vitamin D deficiency. 3 (6%) patients had severe vitamin D deficiency. The subgroup of patients with marked vitamin D deficiency (n = 39) more often had elevated blood pressure probably related to the left ventricular hypertrophy and left atrial enlargement. Left ventricular systolic dysfunction and occlusive coronary artery disease were more common in patients with lower vitamin D levels. Statistically significant correlations had not been found between vitamin D levels and cardiovascular risk factors as well as laboratory data.Conclusion. Vitamin D level below normal range was detected in the vast majority of patients with acute coronary syndrome, of them 6 % of patients had critically low vitamin D levels.

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VITAMIN-D DEFICIENCY AND RISK OF ACUTE CORONARY SYNDROME

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2018v10i6.26469 ◽

2018 ◽

Vol 10 (6) ◽

pp. 171 ◽

Cited By ~ 1

Author(s):

Aya Hallak ◽

Mahmoud Malhis ◽

Mohammad Yaser Abajy

Keyword(s):

Risk Factors ◽

Vitamin D ◽

Acute Coronary Syndrome ◽

Risk Factor ◽

Cardiovascular Risk ◽

Vitamin D Deficiency ◽

Independent Risk Factor ◽

Plasma Vitamin ◽

Coronary Syndrome ◽

Vitamin D Levels

Objective: This study aimed to investigate the relation between vitamin D plasma concentrations and prevalence of prespecified coronary risk factors, and to assess the role of vitamin D deficiency as an independent risk factor for the acute coronary syndrome (ACS).Methods: In this study, plasma 25-hydroxyvitamin D [25(OH)D] levels were measured in 60 consecutive ACS patients at hospital presentation, and patient data including socio-demographics and clinical variables were recorded at the time of admission. We used the Independent samples T-test and the chi-square test to compare differences in the continuous and categorical variables, respectively. The partial correlation coefficient was used to measure association between plasma vitamin D levels and acute coronary syndrome while controlling for traditional cardiovascular risk factors.Results: This study found significant associations between low plasma vitamin D levels and prevalence of hypertension and smoking. Whereas, no significant association between low plasma vitamin D levels and prevalence of diabetes mellitus (DM) was found. There was a statistically significant correlation between vitamin D deficiency and acute coronary syndrome, even after controlling for traditional cardiovascular risk factors (P = 0.028).Conclusion: Vitamin D deficiency is independently associated with acute coronary syndromes, and could be an independent risk factor for the acute coronary syndrome (ACS).

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Study on Vitamin D deficiency in patients of diabetes mellitus presenting with Acute Coronary syndrome in a tertiary care hospital in South India

Asian Journal of Medical Sciences ◽

10.3126/ajms.v11i5.29206 ◽

2020 ◽

Vol 11 (5) ◽

pp. 49-53

Author(s):

Archana Bhat ◽

Arunachalam Ramachandran ◽

Pradeep Periera ◽

Akshatha Rao Aroor

Keyword(s):

Diabetes Mellitus ◽

Coronary Artery Disease ◽

Vitamin D ◽

Acute Coronary Syndrome ◽

Coronary Artery ◽

Vitamin D Deficiency ◽

Coronary Syndrome ◽

Vitamin D Levels ◽

Luminal Stenosis ◽

Artery Disease

Background: Vitamin D, a fat-soluble vitamin has its receptor present in myriad of tissues and it modulates multiple cellular processes. Vitamin D deficiency is reported to be associated with coronary artery disease. Cardiovascular disease is the leading cause of mortality worldwide. Aims and Objective: The primary outcome was to investigate if there is a correlation of 25-OH levels with the percentage of luminal stenosis, as measured with coronary angiogram. The secondary outcome was to determine the differences in angiographically proven luminal stenosis across categories of 25-OH vitamin D levels. Materials and Methods: Thirty patients with acute coronary syndrome with diabetes mellitus were included in this cross-sectional descriptive study. All patients were tested for fasting vitamin D levels, fasting blood sugar, HbA1C and serum creatinine. Detailed history of the patients was recorded. Data was analyzed by the statistical software SPSS version 19 and p value <0.05 was considered significant. Statistical tests like Chi- square, independent t test and log regression was used. Results: In this study 30 patients undergoing coronary angiography for acute coronary syndrome, Vitamin D levels showed severe deficiency in 6.7% (2) cases while mild deficiency was seen in 50% of the cases. Patients with single vessel disease on the coronary angiogram had lower mean HbA1C (9.18) levels in our study. Patients with triple vessel disease had poorly controlled mean HbA1C levels (10.42). Conclusion: In this study we did not find any significant difference between the serum Vitamin D deficiency levels with patients with angiographic severity of the coronary artery disease. Patients with poorly controlled diabetes mellitus had more severe angiographic proven coronary artery disease.

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Prevalence of Vitamin-D Deficiency in Patients with Acute Coronary Syndrome in Syria

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2016.9.6.5 ◽

2016 ◽

Vol 9 (6) ◽

pp. 3544-3548

Author(s):

Aya Hallak ◽

Malhis Mahmoud ◽

Yaser Abajy Mohammad

Keyword(s):

Vitamin D ◽

Acute Coronary Syndrome ◽

Vitamin D Deficiency ◽

Hypovitaminosis D ◽

Control Group ◽

Coronary Syndrome ◽

Normal Individuals ◽

Vitamin D Levels ◽

25 Hydroxy Vitamin D ◽

Coronary Syndromes

The objectives of this study were to estimate the prevalence of vitamin D deficiency in patients with acute coronary syndrome in comparison with normal individuals and study the correlation between these two conditions. We measured the plasma 25-hydroxy vitamin D (25-OH-D) levels in 60 patients with acute coronary syndromes (ACS) of both gender and in 30 age matched control individuals of both gender without any known cardiovascular or systemic diseases. The levels of 25-OH-D were measured by ELISA method and the results were statically analyzed to find out any possible correlation. We classified the cases according to their plasma 25(OH)D levels. 25(OH)D levels of ≥ 30 ng/ml were considered normal, levels < 30 and > 20 ng/ml were classified as insufficient, while levels of ≤ 20 ng/ml were classified as deficient. In the current study the prevalence of hypovitaminosis D in the patients group was much higher than it was in the control group. Vitamin D deficiency was observed in 80% and insufficiency in 13% of total patients of ACS, there by bringing the total count to 93%. Whereas only 7% of the patients had adequate vitamin D levels. Thus, these results indicate the existence of a significant correlation between the vitamin D deficiency and ACS in comparison to healthy controls

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57 Serum total vitamin d levels are not associated with endothelial dysfunction, vascular stiffness or early adverse outcomes after invasive management of non-st elevation acute coronary syndrome in older patients

Heart ◽

10.1136/heartjnl-2017-311726.56 ◽

2017 ◽

Vol 103 (Suppl 5) ◽

pp. A44.1-A44

Author(s):

Benjamin Beska ◽

Dermot Neely ◽

Harish Datta ◽

Sophie Zhaotao Gu ◽

Jonathan Batty ◽

...

Keyword(s):

Vitamin D ◽

Acute Coronary Syndrome ◽

Endothelial Dysfunction ◽

Older Patients ◽

Adverse Outcomes ◽

Total Vitamin ◽

Coronary Syndrome ◽

Vitamin D Levels ◽

St Elevation ◽

Invasive Management

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Contribution of CYP27B1 and CYP24A1 genetic variations to the incidence of acute coronary syndrome and to vitamin D serum level

Canadian Journal of Physiology and Pharmacology ◽

10.1139/cjpp-2019-0258 ◽

2019 ◽

Vol 97 (12) ◽

pp. 1152-1158 ◽

Cited By ~ 2

Author(s):

Marina Sherif Fam ◽

Sally I. Hassanein ◽

Mohamed Farouk Abdel Rahman ◽

Reem Amr Assal ◽

Rasha Sayed Hanafi ◽

...

Keyword(s):

Vitamin D ◽

Acute Coronary Syndrome ◽

Ultra Performance Liquid Chromatography ◽

Genetic Variations ◽

Nucleotide Polymorphisms ◽

Vitamin D Metabolism ◽

Public Health Burden ◽

Hydroxyvitamin D ◽

Coronary Syndrome ◽

Vitamin D Levels

Cardiovascular diseases remain a major public health burden worldwide. It was reported that vitamin D protects the cardiovascular system through several mechanisms mainly by hindering atherosclerosis development. Genetic variations in vitamin D metabolic pathway were found to affect vitamin D levels. This study aimed at investigating the association between single nucleotide polymorphisms in genes involved in vitamin D metabolism, CYP27B and CYP24A1; 25-hydroxyvitamin D (25(OH)D) levels; and susceptibility to acute coronary syndrome (ACS). One hundred and eighty-five patients and 138 healthy controls were recruited. CYP24A1 rs2762939 was genotyped using fast real-time PCR, while CYP24A1 rs4809960 and CYP27B1 rs703842 were genotyped using polymerase chain reaction followed by restriction fragment length polymorphism (PCR–RFLP). 25(OH)D3 and 25(OH)D2 levels were measured using ultra-performance liquid chromatography tandem mass spectrum. Vitamin D level was significantly lower in patients than controls (p < 0.05). The GG genotype of rs2762939 was significantly associated with the risk of ACS development, but not correlated to the vitamin D level. rs4809960 and rs703842 genetic variations were not associated with ACS nor with 25(OH)D level. The genetic variant rs2762939 of CYP24A1 is remarkably associated with ACS. Meanwhile, the variants rs4809960 and rs703842 are not associated with ACS incidence.

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Vitamin D Deficiency is Associated with Severity of Acute Coronary Syndrome in Patients with Type 2 Diabetes and High Rates of Sun Exposure

Clinical Medicine Insights Endocrinology and Diabetes ◽

10.4137/cmed.s39427 ◽

2016 ◽

Vol 9 ◽

pp. CMED.S39427 ◽

Cited By ~ 6

Author(s):

Fernando Gondim ◽

Ana Caribé ◽

Karine Ferreira Vasconcelos ◽

Alexandre Dantas Segundo ◽

Francisco Bandeira

Keyword(s):

Risk Factors ◽

Type 2 Diabetes ◽

Vitamin D ◽

Acute Coronary Syndrome ◽

Vitamin D Deficiency ◽

Severe Disease ◽

Sun Exposure ◽

Serum 25Ohd ◽

Coronary Syndrome

Background Vitamin D deficiency has been associated with cardiovascular risk factors, including type 2 diabetes mellitus (T2DM). Evidence shows that patients with low serum 25-hydroxyvitamin D (25OHD) concentrations have a higher risk of developing coronary artery disease. Objective The objective of this study was to assess vitamin D as a predictor of the severity in diabetics with acute coronary syndrome (ACS). Methods A total of 166 patients were diagnosed with ACS. Serum 25OHD concentrations were analyzed, and risk factors for ACS were evaluated. Results Patients diagnosed as having acute myocardial infarction with elevation of the ST segment had a higher rate of 25OHD, <20 ng/mL compared to ≤30 ng/mL (47.8% × 13.4%, P = 0.03). Diabetics with vitamin D deficiency had more multivessel lesions in the coronary angiography than non-diabetics (69% × 31.8%, P = 0.007). After adjustments for confounders, serum 25OHD remained associated with more severe disease. Conclusion Vitamin D deficiency is associated with more severe ACS and is a predictor of more extensive coronary lesions in patients with T2DM.

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