scholarly journals Primary Adenocarcinoma of middle ear with intracranial and parotid extension A rare case and literature review

2018 ◽  
Vol VOLUME 6 (VOLUME 6 NUMBER 2 DECEMBER 2018) ◽  
pp. 27-32
Author(s):  
Chhavi Gupta
Keyword(s):  
Middle Ear ◽  
Rare Case ◽  
Slow Growth ◽  
Primary Adenocarcinoma ◽  
Low Grade ◽  
Rare Tumor ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Lytic Lesions ◽  
Proven Case

Adenocarcinoma of middle ear is a rare tumor, few cases were reported in literature. Primary middle ear adenocarcinoma is locally invasive neoplasm arises from middle ear mucosa. These tumors may or may not be associated with Chronic Suppurative Otitis media. These tumors tend to have slow growth pattern and have an infrequent incidence of distant metastasis, recurrence is also a common problem. . They should be considered in the differential diagnosis of lytic lesions of the temporal bone on imaging. We reported a histologically proven case of adenocarcinoma of middle ear with intracranial and parotid extension in 24yr old female patient that was successfully managed. If managed early they have a very god prognosis with a 5-year survival of 70% has been reported for low-grade adenocarcinomas. Keywords: Adenocarcinoma, middle ear, invasive neoplasm.

Primary Adenocarcinoma of the Middle Ear

1983 ◽  
Vol 91 (3) ◽  
pp. 280-283 ◽  
Author(s):  
David E. Schuller ◽  
John J. Conley ◽  
Joseph H. Goodman ◽  
Kathryn P. Clausen ◽  
William J. Miller
Keyword(s):  
Local Recurrence ◽  
Middle Ear ◽  
Growth Pattern ◽  
Slow Growth ◽  
Distant Metastases ◽  
Primary Adenocarcinoma ◽  
Rare Tumor ◽  
Locoregional Treatment

Adenocarcinoma arising from the mucosa of the middle ear is a rare tumor. This report adds four new cases to the 13 cases that have been previously reported in the literature. These neoplasms tend to have a rather slow growth pattern and have an infrequent incidence of distant metastases. The observations that local recurrence is the major problem with adenocarcinoma of the middle ear suggest that aggressive locoregional treatment should be strongly considered.

Atypical Pharyngitis In Suppurative Otitis Media Cases

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P98-P99
Author(s):  
Alaa A Abou-Bieh ◽  
Mona F Salama
Keyword(s):  
Middle Ear ◽  
Causative Organism ◽  
Isolation And Identification ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Gram Negative ◽  
Middle Ear Infection ◽  
Gram Negative Organisms ◽  
Micro Organisms ◽  
Middle Ear Cleft

Problem Unexplained persistent or recurrent bacterial pharyngitis in some patients who suffer from infected middle ear cleft. Methods Bacteriological swabs were obtained from both the ears and the pharynx of 37 cases with chronic otorrhea and perforation, whom complain of recurrent or persistent sore-throat. Then isolation and identification of the micro-organisms were done. This included examination of direct Gram stained films and cultures. Isolated Gram negative bacilli were subjected to further identification by the biochemical reactions and antibiotyping. Identical isolates from the same patient (ear and pharyngeal swabs) were subjected to further identification by genotyping using the pulsed field gel electrophoresis technique. Results 6 cases (16%) showed identity in phenotypes and genotypes for ear and pharyngeal samples from the same patient. All pharyngeal isolates were Gram negative organisms. 4 of them were Pseudomonas aeruginosa, 1 was Proteus sp., and 1 was Escherichia coli. All of these 3 species are not known to be among the primary organisms which may cause pharyngitis. Conclusion Bacterial pharyngitis in patients with chronically infected middle ear cleft may be attributed to the same organism invaded the middle ear mucosa. Also this study highlights some organisms as a pharyngeal invaders although they are not among the previously documented causatives of bacterial pharyngitis. But the study do not confirm the method of spread of these organisms and whether this was directly via the eustachian tube. Significance The study correlates the causative organism of the middle ear infection and that infected the pharyngeal mucosa utilizing the advanced bacteriological identification and genotyping techniques.

Acute Suppurative Otitis Media

PEDIATRICS ◽  
1975 ◽  
Vol 56 (2) ◽  
pp. 285-294
Author(s):  
D. Stewart Rowe
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Pathogenic Bacteria ◽  
Acute Otitis Media ◽  
Polymorphonuclear Cells ◽  
Secretory Otitis Media ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Middle Ear Fluid ◽  
Purulent Fluid

Most pediatricians recognize and treat acute otitis media several times each day. Yet there is wide disagreement about certain aspects of its diagnosis and treatment, despite a large and growing literature on the subject. This review attempts to summarize what is known about acute otitis media in children. DEFINITION Acute suppurative otitis media is distinguished from secretory (serous) otitis media by the presence of purulent fluid in the middle ear. Pathogenic bacteria may be cultured from the majority of needle aspirates of this purulent fluid. In secretory otitis media, relatively few polymorphonuclear cells are present in the middle ear fluid, which is either thin and straw-colored (serous) or thick and translucent grey (mucoid). The fluid has the chemical characteristics either of a transudate of plasma or of a mucoid secretion, presumably produced by goblet cells and mucous glands which are greatly increased in the middle ear mucosa of patients with secretory otitis media. Cultures of this middle ear fluid are usually negative for pathogenic bacteria and viruses. Suppurative otitis media can be diagnosed positively only by aspiration of purulent fluid from the middle ear, but this procedure is rarely necessary for initial diagnosis and management. Clinical findings helpful in distinguishing suppurative from secretory otitis media are discussed below. INCIDENCE In a study of 847 British children during the first five years of life, 19% had at least one episode of otitis media; one third of these had more than one episode. This was considered to be a minimal estimate in these children, since otorrhea was the chief criterion for diagnosis.

scholarly journals High Human Papillomavirus DNA loads in Inflammatory Middle Ear Diseases

Pathogens ◽  
2020 ◽  
Vol 9 (3) ◽  
pp. 224 ◽  
Author(s):  
Nicola Malagutti ◽  
John Charles Rotondo ◽  
Luca Cerritelli ◽  
Claudio Melchiorri ◽  
Monica De Mattei ◽  
...  
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Dna Sequences ◽  
Direct Sequencing ◽  
Chronic Otitis Media ◽  
Human Papillomaviruses ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Ear Diseases ◽  
Hpv Dna

Background. Previous studies reported human papillomaviruses (HPVs) in middle ear tumors, whereas these viruses have been poorly investigated in chronic inflammatory middle ear diseases. We investigated HPVs in non-tumor middle ear diseases, including chronic otitis media (COM). Methods. COM specimens (n = 52), including chronic suppurative otitis media (CSOM) (n =38) and cholesteatoma (COMC) (n = 14), as well as normal middle ear (NME) specimens (n = 56) were analyzed. HPV sequences and DNA loads were analyzed by quantitative-PCR. HPV genotyping was performed by direct sequencing. Results. HPV DNA was detected in 23% (12/52) of COM and in 30.4% (17/56) of NME (p > 0.05). Specifically, HPV DNA sequences were found in 26.3% (10/38) of CSOM and in 14.3% (2/14) of COMC (p > 0.05). Interestingly, the HPV DNA load was higher in COMC (mean 7.47 copy/cell) than in CSOM (mean 1.02 copy/cell) and NME (mean 1.18 copy/cell) (P = 0.03 and P = 0.017 versus CSOM and NME, respectively). HPV16 and HPV18 were the main genotypes detected in COMC, CSOM and NME. Conclusions. These data suggest that HPV may infect the middle ear mucosa, whereas HPV-positive COMCs are associated with higher viral DNA loads as compared to NME.

scholarly journals Investigation of the Presence of Biofilms in Chronic Suppurative Otitis Media, Nonsuppurative Otitis Media, and Chronic Otitis Media with Cholesteatoma by Scanning Electron Microscopy

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Ercan Kaya ◽  
Ilknur Dag ◽  
Armagan Incesulu ◽  
Melek Kezban Gurbuz ◽  
Mustafa Acar ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Otitis Media ◽  
Middle Ear ◽  
Chronic Otitis Media ◽  
Chronic Suppurative Otitis Media ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Tissue Samples ◽  
Scanning Electron

Objective. Biofilms have been shown to play a major role in the pathogenesis of otolaryngologic infections. However, very limited studies have been undertaken to demonstrate the presence of biofilms in tissues from patients with chronic otitis media (COM) with or without cholesteatoma. Our objective is to study the presence of biofilms in humans with chronic suppurative and nonsuppurative otitis media and cholesteatoma.Study Design. In all, 102 tissue specimens (middle ear, mastoid tissue, and ossicle samples) were collected during surgery from 34 patients.Methods. The samples were processed for the investigation of biofilms by scanning electron microscopy (SEM).Results. Our research supports the hypothesis in which biofilms are involved in chronic suppurative otitis media, cholesteatoma, and, to a lesser degree, chronic nonsuppurative otitis media. There were higher rates in hypertrophic and granulated tissue samples than in normal mucosa. In addition, the presence of biofilms was significantly higher in the middle ear mucosa compared with the mastoid and ossicle samples.Conclusion. In the clinic, the careful use of topical or systemic antimicrobials is essential, and, during surgery, hypertrophic tissue must be carefully removed from normal tissue.

scholarly journals Clinical study on type 1 tympanoplasty: anatomical and functional outcomes

2019 ◽  
Vol 5 (5) ◽  
pp. 1197
Author(s):  
A. Kusumanjali ◽  
V. Krishna Chaitanya
Keyword(s):  
Success Rate ◽  
Middle Ear ◽  
Pure Tone Audiometry ◽  
Type I ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Type 1 Tympanoplasty ◽  
Cortical Mastoidectomy ◽  
Type I Tympanoplasty

<p class="abstract"><strong>Background:</strong> Tympanoplasty is operation to eradicate disease in middle ear and to reconstruct the hearing mechanism. Present study aims at assessment of success rate and hearing improvement following type I tympanoplasty.</p><p class="abstract"><strong>Methods:</strong> 50 patients with chronic suppurative otitis media, tubotympanic type attending department of ENT are taken up for study screened with clinical history and examination. Type I tympanoplasty performed in all patients. Simple mastoidectomy with type I tympanoplasty performed in 8 patients. Patients are followed after surgery on 7<sup>th</sup>, 14th days and end of 3 months. Anatomical outcome is assessed in terms of graft uptake. Pure tone audiometry was performed at 3 months and air bone gap is considered to assess outcome.  </p><p class="abstract"><strong>Results:</strong> Out of 50 cases, 43 cases (86%) showed good success rate by means of graft uptake. Remaining 5 cases showed residual perforation and 3 cases medialization of graft. In 42 patients type1 tympanoplasty is performed, success rate was 80.95% and in cases with where type1 tympanoplasty with cortical Mastoidectomy was done and the success rate was 100%. In the present study mean pre op AB gap was 27.65 dB and mean post op AB gap was 19.07 dB. The difference between the two, i.e., AB gap closure was 8.52 dB which is statistically significant.</p><p class="abstract"><strong>Conclusions:</strong> Type-1 tympanoplasty using temporalis fascia with underlay technique have good surgical success rate with excellent improvement of hearing. Cortical mastoidectomy can be planned depending on the status of the middle ear mucosa.</p>

scholarly journals Correlation between histomorphometric changes and the type of aerobic bacteria isolated in chronic suppurative otitis media

2011 ◽  
Vol 68 (1) ◽  
pp. 46-50
Author(s):  
Emilija Zivkovic-Marinkov ◽  
Milan Stankovic ◽  
Dragan Mihailovic ◽  
Mila Bojanovic
Keyword(s):  
Staphylococcus Aureus ◽  
Otitis Media ◽  
Middle Ear ◽  
Granulation Tissue ◽  
Bacterial Flora ◽  
Inflammatory Cells ◽  
Chronic Suppurative Otitis Media ◽  
Aerobic Bacteria ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media

Background/Aim. Bacterial flora is a very important factor in pathogenesis of chronic suppurative otitis media (CSOM) and significantly influences the type and intensity of osteolytic process. There are few histomorphometric investigations of middle ear mucosa in chronic otitis. The aim of this study was to identify aerobic bacteria responsible for chronic suppurative otitis media as well as their association with histomorphometric changes of middle ear mucosa. Methods. A prospective study that comprised 153 patients treated in the Clinc for Ear, Thorat and Nose Diseases, Nis, was conducted. Bacteriologic analysis of diseased ear secretion was carried out in all patients. Intraoperatively removed granulation tissue was used for histomorphometry. The analysed parameters were: the number of inflammatory cells, as well as vascularization and vasodilatation. Results. The most frequently isolated aerobic bacteria from chronic suppurative otitis media were Staphylococcus aureus (29.02%), Pseudomonas aeruginosa (29.02%) and Proteus spp. (21.76%). There was no correlation between the type of pathologic process and the type of bacteria.The number of inflammatory cells in the granulation tissue in pure cultures of Staphylococcus aureus was 1,597.33 ? 549.45 and in Pseudomonas auriginosa cultures was 2,639 ? 648. Conclusion. This study showed that there is a statistically significant correlation between the number of inflammatory cells in the granulation tissue and the type of aerobic bacteria we isolated. The intensity of the infection in chronic suppurative otitis media depends on the type of the isolated bacteria, which emphasizes the importance of adequate preoperative antimicrobial therapy.

scholarly journals The intraoperative pathological findings in cases of chronic suppurative otitis media with central perforation of tympanic membrane at a tertiary care centre in Eastern Nepal

2017 ◽  
Vol 8 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Sanjeev Kumar Thakur ◽  
Nisha Ghimire ◽  
Rabin Acharya ◽  
Sanjay Kumar Singh ◽  
Anwar Afaque
Keyword(s):  
Otitis Media ◽  
Middle Ear ◽  
Tertiary Care ◽  
Pure Tone Audiometry ◽  
Chronic Suppurative Otitis Media ◽  
Pathological Findings ◽  
Tertiary Care Centre ◽  
Middle Ear Mucosa ◽  
Suppurative Otitis Media ◽  
Central Perforation

Background: Chronic suppurative otitis media (CSOM) is the chronic inflammation of the middle ear cleft. The atticoantral type is called unsafe type because of the associated complications due to granulations and cholesteatoma which may be life-threatening. CSOM with central perforation (tubotympanic type) is usually not associated with major complications such as cholesteatoma formation.Aims and Objectives: To find out the intraoperative pathological findings in cases of CSOM with central perforation (tubotympanic type)Materials and Methods: This descriptive, cross sectional study has been conducted in the Department of Ear, Biratnagar Eye Hospital in Nepal over 2 years. Study group includes 172 patients having CSOM with central perforations in the tympanic membranes who underwent different types of procedures. Preoperatively, all the patients were evaluated with otoscopy, microscopy, pure-tone audiometry, and some patients with computed tomography scan. The pathological findings were confirmed with biopsy. The findings were tabulated and analysed.Results: 21(12.2%) patients were having dry central perforation with normal Eustachian tube function.  95 patients, i.e., 55.23% were having granulations in attic, aditus, antrum.  25 (14.53%) cases were having ossicular erosion.5 (2.9%) cases had tympanosclerosis in middle ear. 1 (0.58%) case had facial nerve dehiscence. 16 (9.3%) cases had oedema of middle ear mucosa/aural polyp from middle ear. Surprisingly 9 patients, i.e., 5.23% were having cholesteatoma which was confirmed by histopathological study.Conclusion: This study shows that cholesteatoma can be found in tubotympanic type of CSOM, along with other pathological findings. Hence it is on the part of the surgeon to be careful while planning surgery on their patients with CSOM (tubotympanic type), remembering that all safe CSOM might not always be safe. Asian Journal of Medical Sciences Vol.8(1) 2017 42-47

A rare case of primary otoscleroma of the middle ear

2012 ◽  
Vol 126 (12) ◽  
pp. 1276-1277
Author(s):  
A R Kakeri ◽  
A H Patel
Keyword(s):  
Hearing Loss ◽  
Case Report ◽  
Middle Ear ◽  
World Literature ◽  
Rare Case ◽  
Conductive Hearing Loss ◽  
Histopathological Examination ◽  
Suppurative Otitis Media ◽  
The World ◽  
Conductive Hearing

AbstractObjective:We report an extremely rare case of primary otoscleroma.Method:We present a case report and a review of the world literature concerning otoscleroma.Results:An adult woman presented with chronic suppurative otitis media with tubotympanic disease and conductive hearing loss. On mastoid exploration, dark granulations were seen, which were identified as otoscleroma on histopathological examination. The patient responded well to streptomycin.Conclusion:To the best of our knowledge, this is the first report of primary otoscleroma in the world literature. This case indicates that Frisch's bacillus can also spread to the middle ear.

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